YIL001W_p

Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL001W / YIL001W

Click on Significant Values for Screen Details ID:SGTC_350|Compound:k064-0020|FD-Score:3.36|P-value:8.26E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.92|P-value:1.22E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.97|P-value:9.91E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:4.84|P-value:3.03E-6 ID:SGTC_489|Compound:paxilline|FD-Score:3.87|P-value:1.50E-4 ID:SGTC_490|Compound:phenamil|FD-Score:5.13|P-value:7.78E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.54|P-value:1.07E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.43|P-value:6.64E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.43|P-value:6.68E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.17|P-value:4.66E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.33|P-value:9.14E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:4.03|P-value:8.02E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.38|P-value:7.96E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.38|P-value:7.94E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:5.40|P-value:2.22E-7 ID:SGTC_1338|Compound:1486-1223|FD-Score:-4.09|P-value:6.46E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.37|P-value:2.14E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.72|P-value:2.52E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.41|P-value:7.08E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.38|P-value:7.73E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.46|P-value:5.99E-4 ID:SGTC_1738|Compound:st035555|FD-Score:5.96|P-value:1.25E-8 ID:SGTC_1739|Compound:st037196|FD-Score:-4.24|P-value:3.63E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-3.36|P-value:8.22E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.39|P-value:7.70E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.52|P-value:4.85E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.31|P-value:9.72E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-3.88|P-value:1.38E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-4.15|P-value:5.10E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.39|P-value:7.71E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.40|P-value:7.33E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.53|P-value:1.11E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-3.48|P-value:5.65E-4 ID:SGTC_3128|Compound:9127691|FD-Score:-4.22|P-value:3.85E-5 ID:SGTC_3276|Compound:9139060|FD-Score:3.47|P-value:5.85E-4 ID:SGTC_3280|Compound:9140961|FD-Score:5.97|P-value:1.16E-8 ID:SGTC_3286|Compound:9117135|FD-Score:4.22|P-value:3.97E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:3.36|P-value:8.26E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.92|P-value:1.22E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.97|P-value:9.91E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:4.84|P-value:3.03E-6 ID:SGTC_489|Compound:paxilline|FD-Score:3.87|P-value:1.50E-4 ID:SGTC_490|Compound:phenamil|FD-Score:5.13|P-value:7.78E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.54|P-value:1.07E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.43|P-value:6.64E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.43|P-value:6.68E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.17|P-value:4.66E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.33|P-value:9.14E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:4.03|P-value:8.02E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.38|P-value:7.96E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.38|P-value:7.94E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:5.40|P-value:2.22E-7 ID:SGTC_1338|Compound:1486-1223|FD-Score:-4.09|P-value:6.46E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.37|P-value:2.14E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.72|P-value:2.52E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.41|P-value:7.08E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.38|P-value:7.73E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.46|P-value:5.99E-4 ID:SGTC_1738|Compound:st035555|FD-Score:5.96|P-value:1.25E-8 ID:SGTC_1739|Compound:st037196|FD-Score:-4.24|P-value:3.63E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-3.36|P-value:8.22E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.39|P-value:7.70E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-3.52|P-value:4.85E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.31|P-value:9.72E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-3.88|P-value:1.38E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:-4.15|P-value:5.10E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.39|P-value:7.71E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.40|P-value:7.33E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.53|P-value:1.11E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-3.48|P-value:5.65E-4 ID:SGTC_3128|Compound:9127691|FD-Score:-4.22|P-value:3.85E-5 ID:SGTC_3276|Compound:9139060|FD-Score:3.47|P-value:5.85E-4 ID:SGTC_3280|Compound:9140961|FD-Score:5.97|P-value:1.16E-8 ID:SGTC_3286|Compound:9117135|FD-Score:4.22|P-value:3.97E-5

Top fitness defect scores for YIL001W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3280 9140961 5.97 49.5 µM 1.16E-8 60S ribosome export 4 1.19E-9
2 SGTC_1738 st035555 5.96 74.0 µM 1.25E-8 TSC3-RPN4 6 1.29E-9
3 SGTC_1235 benzylparaben 5.40 21.5 µM 2.22E-7 3 3.40E-8
4 SGTC_490 phenamil 5.13 164.0 µM 7.78E-7 heme requiring 3 1.42E-7
5 SGTC_427 1354-0053 4.84 47.3 µM 3.03E-6 7 6.64E-7
6 SGTC_501 nsc-95397 4.54 161.0 µM 1.07E-5 7 2.79E-6
7 SGTC_2974 9094440 4.53 9.7 µM 1.11E-5 ergosterol biosynthesis 35 2.90E-6
8 SGTC_1362 1611-0397 4.37 101.0 µM 2.14E-5 11 6.11E-6
9 SGTC_3286 9117135 4.22 37.2 µM 3.97E-5 8 1.23E-5
10 SGTC_980 1473-0395 4.03 201.0 µM 8.02E-5 11 2.73E-5
11 SGTC_382 3229-0966 3.92 23.2 µM 1.22E-4 21 4.39E-5
12 SGTC_489 paxilline 3.87 115.0 µM 1.50E-4 PDR1 16 5.55E-5
13 SGTC_1389 3405-0187 3.72 19.0 µM 2.52E-4 21 1.00E-4
14 SGTC_3276 9139060 3.47 49.5 µM 5.85E-4 60S ribosome export 10 2.60E-4
15 SGTC_696 1560-0013 3.43 611.0 µM 6.68E-4 40 3.02E-4
16 SGTC_1395 3486-0190 3.41 4.3 µM 7.08E-4 31 3.23E-4
17 SGTC_1970 st070122 3.39 35.8 µM 7.70E-4 TSC3-RPN4 43 3.55E-4
18 SGTC_2794 7785382 3.39 27.3 µM 7.71E-4 60 3.56E-4
19 SGTC_1451 4152-0210 3.38 104.0 µM 7.73E-4 45 3.56E-4
20 SGTC_1130 3454-2858 3.38 15.9 µM 7.94E-4 NEO1 118 3.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 8.10E-10 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.085 7.44E-7 YFR028C CDC14 het Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis
0.082 2.13E-6 YAL065C_p YAL065C_p hom Putative protein of unknown function; has homology to FLO1; possible pseudogene
0.081 2.29E-6 YIL146C ATG32 hom Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane
0.080 3.34E-6 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.078 6.16E-6 YBR198C TAF5 het Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
0.077 8.14E-6 YPR049C ATG11 hom Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)
0.077 8.18E-6 YPL191C_p YPL191C_p hom Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.076 9.15E-6 YDL043C PRP11 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.076 1.07E-5 YMR148W OSW5 hom Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
0.076 1.12E-5 YNL024C_p YNL024C_p hom Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern
0.075 1.46E-5 YBR157C ICS2 hom Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.073 2.35E-5 YGR086C PIL1 hom Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.073 2.42E-5 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.072 2.78E-5 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle