YIL002C / INP51

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL002C / INP51

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:5.30|P-value:9.11E-7 ID:SGTC_201|Compound:4262-0159|FD-Score:4.56|P-value:2.10E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:5.24|P-value:1.16E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:3.70|P-value:4.60E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.76|P-value:3.69E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.09|P-value:1.13E-8 ID:SGTC_490|Compound:phenamil|FD-Score:3.58|P-value:6.73E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.92|P-value:2.16E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:5.93|P-value:4.47E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:3.95|P-value:1.99E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:5.39|P-value:6.02E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:3.99|P-value:1.71E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:6.07|P-value:2.18E-8 ID:SGTC_668|Compound:1682-0499|FD-Score:3.65|P-value:5.38E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.36|P-value:4.44E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:3.90|P-value:2.33E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.68|P-value:4.84E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.71|P-value:1.15E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:5.70|P-value:1.40E-7 ID:SGTC_948|Compound:3448-0295|FD-Score:4.42|P-value:3.62E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:4.81|P-value:7.44E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:5.03|P-value:2.93E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.03|P-value:2.93E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.75|P-value:9.50E-6 ID:SGTC_1184|Compound:1269-1718|FD-Score:6.10|P-value:1.87E-8 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.03|P-value:1.47E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.58|P-value:6.62E-4 ID:SGTC_1620|Compound:st003704|FD-Score:4.96|P-value:3.95E-6 ID:SGTC_1624|Compound:st003710|FD-Score:3.51|P-value:8.42E-4 ID:SGTC_1633|Compound:st005664|FD-Score:6.39|P-value:4.12E-9 ID:SGTC_1656|Compound:st012921|FD-Score:4.08|P-value:1.25E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.71|P-value:4.45E-4 ID:SGTC_1700|Compound:st030840|FD-Score:5.23|P-value:1.26E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.75|P-value:3.85E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.32|P-value:5.16E-5 ID:SGTC_2054|Compound:5233173|FD-Score:4.75|P-value:9.67E-6 ID:SGTC_2075|Compound:5212009|FD-Score:5.30|P-value:9.14E-7 ID:SGTC_2237|Compound:6667747|FD-Score:3.94|P-value:2.01E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:8.89|P-value:4.39E-16 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.83|P-value:6.96E-6 ID:SGTC_2311|Compound:7694451|FD-Score:3.80|P-value:3.22E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-4.43|P-value:2.25E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.61|P-value:6.16E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.41|P-value:7.98E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.60|P-value:6.25E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.68|P-value:1.50E-7 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.80|P-value:3.30E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.53|P-value:7.92E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.06|P-value:1.34E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.01|P-value:1.58E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.01|P-value:1.60E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.87|P-value:6.00E-6 ID:SGTC_2978|Compound:9011784|FD-Score:4.42|P-value:3.60E-5 ID:SGTC_3037|Compound:9091026|FD-Score:6.35|P-value:5.17E-9 ID:SGTC_3058|Compound:9093861|FD-Score:5.88|P-value:5.68E-8 ID:SGTC_3152|Compound:9099253|FD-Score:9.32|P-value:1.75E-17 ID:SGTC_3217|Compound:9129673|FD-Score:4.49|P-value:2.70E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.63|P-value:5.62E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.49|P-value:8.78E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.97|P-value:1.82E-4 ID:SGTC_3295|Compound:9122362|FD-Score:4.17|P-value:8.99E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:5.30|P-value:9.11E-7 ID:SGTC_201|Compound:4262-0159|FD-Score:4.56|P-value:2.10E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:5.24|P-value:1.16E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:3.70|P-value:4.60E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.76|P-value:3.69E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.09|P-value:1.13E-8 ID:SGTC_490|Compound:phenamil|FD-Score:3.58|P-value:6.73E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.92|P-value:2.16E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:5.93|P-value:4.47E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:3.95|P-value:1.99E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:5.39|P-value:6.02E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:3.99|P-value:1.71E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:6.07|P-value:2.18E-8 ID:SGTC_668|Compound:1682-0499|FD-Score:3.65|P-value:5.38E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.36|P-value:4.44E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:3.90|P-value:2.33E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.68|P-value:4.84E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.71|P-value:1.15E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:5.70|P-value:1.40E-7 ID:SGTC_948|Compound:3448-0295|FD-Score:4.42|P-value:3.62E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:4.81|P-value:7.44E-6 ID:SGTC_969|Compound:1313-0238|FD-Score:5.03|P-value:2.93E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.03|P-value:2.93E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.75|P-value:9.50E-6 ID:SGTC_1184|Compound:1269-1718|FD-Score:6.10|P-value:1.87E-8 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.03|P-value:1.47E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.58|P-value:6.62E-4 ID:SGTC_1620|Compound:st003704|FD-Score:4.96|P-value:3.95E-6 ID:SGTC_1624|Compound:st003710|FD-Score:3.51|P-value:8.42E-4 ID:SGTC_1633|Compound:st005664|FD-Score:6.39|P-value:4.12E-9 ID:SGTC_1656|Compound:st012921|FD-Score:4.08|P-value:1.25E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.71|P-value:4.45E-4 ID:SGTC_1700|Compound:st030840|FD-Score:5.23|P-value:1.26E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.75|P-value:3.85E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.32|P-value:5.16E-5 ID:SGTC_2054|Compound:5233173|FD-Score:4.75|P-value:9.67E-6 ID:SGTC_2075|Compound:5212009|FD-Score:5.30|P-value:9.14E-7 ID:SGTC_2237|Compound:6667747|FD-Score:3.94|P-value:2.01E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:8.89|P-value:4.39E-16 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.83|P-value:6.96E-6 ID:SGTC_2311|Compound:7694451|FD-Score:3.80|P-value:3.22E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-4.43|P-value:2.25E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.61|P-value:6.16E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.41|P-value:7.98E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.60|P-value:6.25E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.68|P-value:1.50E-7 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.80|P-value:3.30E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.53|P-value:7.92E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.06|P-value:1.34E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.01|P-value:1.58E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.01|P-value:1.60E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.87|P-value:6.00E-6 ID:SGTC_2978|Compound:9011784|FD-Score:4.42|P-value:3.60E-5 ID:SGTC_3037|Compound:9091026|FD-Score:6.35|P-value:5.17E-9 ID:SGTC_3058|Compound:9093861|FD-Score:5.88|P-value:5.68E-8 ID:SGTC_3152|Compound:9099253|FD-Score:9.32|P-value:1.75E-17 ID:SGTC_3217|Compound:9129673|FD-Score:4.49|P-value:2.70E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.63|P-value:5.62E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.49|P-value:8.78E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.97|P-value:1.82E-4 ID:SGTC_3295|Compound:9122362|FD-Score:4.17|P-value:8.99E-5

Top fitness defect scores for YIL002C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3152 9099253 9.32 49.5 µM 1.75E-17 NEO1-PIK1 28 6.05E-21
2 SGTC_2250 alverine citrate 8.89 130.0 µM 4.39E-16 15 3.00E-19
3 SGTC_1633 st005664 6.39 67.9 µM 4.12E-9 1 8.42E-11
4 SGTC_3037 9091026 6.35 49.5 µM 5.17E-9 NEO1-PIK1 40 1.11E-10
5 SGTC_1184 1269-1718 6.10 139.0 µM 1.87E-8 6 5.28E-10
6 SGTC_637 1181-0519 6.07 7.3 µM 2.18E-8 fatty acid desaturase (OLE1) 52 6.33E-10
7 SGTC_526 4469-0568 5.93 170.0 µM 4.47E-8 azole & statin 18 1.51E-9
8 SGTC_3058 9093861 5.88 49.5 µM 5.68E-8 5 2.02E-9
9 SGTC_944 3370-0224 5.70 231.0 µM 1.40E-7 5 6.03E-9
10 SGTC_2582 agaric acid 5.68 100.0 µM 1.50E-7 redox potentiating 178 6.54E-9
11 SGTC_568 1193-0097 5.39 7.5 µM 6.02E-7 ERAD & cell cycle 75 3.53E-8
12 SGTC_141 0443-0274 5.30 32.3 µM 9.11E-7 mitochondrial response to ROS 19 5.83E-8
13 SGTC_2075 5212009 5.30 200.0 µM 9.14E-7 1 5.86E-8
14 SGTC_310 1273-0058 5.24 1.1 µM 1.16E-6 mitochondrial stress 172 7.85E-8
15 SGTC_1700 st030840 5.23 7.9 µM 1.26E-6 PDR1 10 8.64E-8
16 SGTC_969 1313-0238 5.03 134.0 µM 2.93E-6 mitochondrial processes 10 2.40E-7
17 SGTC_1019 4262-0212 5.03 3.4 µM 2.93E-6 ergosterol depletion effects on membrane 33 2.40E-7
18 SGTC_1620 st003704 4.96 16.5 µM 3.95E-6 5 3.45E-7
19 SGTC_2896 9052656 4.87 71.4 µM 6.00E-6 endomembrane recycling 65 5.72E-7
20 SGTC_2251 lansoprazole 4.83 556.0 µM 6.96E-6 8 6.85E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.189 1.96E-28 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.184 6.90E-27 YPL259C APM1 hom Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
0.182 1.75E-26 YKL039W PTM1 hom Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication
0.178 2.33E-25 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.177 4.62E-25 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.173 6.99E-24 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.171 2.72E-23 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.169 5.00E-23 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.169 7.92E-23 YDL001W RMD1 hom Cytoplasmic protein required for sporulation
0.162 4.62E-21 YIL035C CKA1 hom Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching
0.160 9.55E-21 YNL293W MSB3 hom Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.151 1.75E-18 YBL046W PSY4 hom Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
0.147 9.50E-18 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.147 1.23E-17 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.147 1.41E-17 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data