YIL002W-A_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL002W-A / YIL002W-A

Click on Significant Values for Screen Details ID:SGTC_90|Compound:0870-0863|FD-Score:4.99|P-value:4.33E-7 ID:SGTC_97|Compound:0535-0701|FD-Score:8.87|P-value:1.71E-18 ID:SGTC_103|Compound:0844-0104|FD-Score:-10.50|P-value:1.77E-24 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.79|P-value:1.50E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.74|P-value:1.03E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:4.30|P-value:1.05E-5 ID:SGTC_292|Compound:k038-0015|FD-Score:3.42|P-value:3.40E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.11|P-value:2.40E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.16|P-value:8.25E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.52|P-value:3.95E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-6.21|P-value:1.20E-9 ID:SGTC_516|Compound:3992-2719|FD-Score:-9.58|P-value:1.20E-20 ID:SGTC_519|Compound:k048-0011|FD-Score:4.18|P-value:1.80E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:3.30|P-value:5.21E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.18|P-value:7.89E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.57|P-value:2.00E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.33|P-value:9.24E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:3.62|P-value:1.64E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.13|P-value:9.24E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.20|P-value:7.28E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:5.62|P-value:1.57E-8 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.99|P-value:3.90E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.20|P-value:7.25E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.45|P-value:5.39E-6 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.34|P-value:7.33E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.35|P-value:4.33E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.14|P-value:9.05E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.18|P-value:1.79E-5 ID:SGTC_1635|Compound:st007035|FD-Score:7.66|P-value:2.84E-14 ID:SGTC_1694|Compound:st024011|FD-Score:3.26|P-value:5.88E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-4.46|P-value:9.74E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.93|P-value:5.00E-5 ID:SGTC_1901|Compound:st060216|FD-Score:4.11|P-value:2.39E-5 ID:SGTC_1932|Compound:st074806|FD-Score:-3.60|P-value:3.04E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-4.19|P-value:3.16E-5 ID:SGTC_1937|Compound:st074714|FD-Score:-4.34|P-value:1.65E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.29|P-value:8.67E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.41|P-value:3.50E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.36|P-value:4.16E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.45|P-value:5.10E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.21|P-value:1.53E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-4.39|P-value:1.32E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.59|P-value:1.83E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.28|P-value:9.04E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.96|P-value:4.42E-5 ID:SGTC_2452|Compound:5863136|FD-Score:4.26|P-value:1.28E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.30|P-value:2.88E-10 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.20|P-value:7.24E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.90|P-value:5.50E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.58|P-value:1.94E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.50|P-value:2.99E-8 ID:SGTC_2850|Compound:9015429|FD-Score:-3.40|P-value:6.09E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.34|P-value:4.59E-4 ID:SGTC_2933|Compound:9026794|FD-Score:6.89|P-value:6.53E-12 ID:SGTC_2974|Compound:9094440|FD-Score:4.54|P-value:3.62E-6 ID:SGTC_2975|Compound:9084847|FD-Score:4.10|P-value:2.45E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.14|P-value:8.85E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.40|P-value:3.72E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-4.60|P-value:5.32E-6 ID:SGTC_3153|Compound:9100258|FD-Score:3.55|P-value:2.12E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.69|P-value:1.26E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.73|P-value:1.10E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.99|P-value:4.33E-7 ID:SGTC_97|Compound:0535-0701|FD-Score:8.87|P-value:1.71E-18 ID:SGTC_103|Compound:0844-0104|FD-Score:-10.50|P-value:1.77E-24 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.79|P-value:1.50E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.74|P-value:1.03E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:4.30|P-value:1.05E-5 ID:SGTC_292|Compound:k038-0015|FD-Score:3.42|P-value:3.40E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.11|P-value:2.40E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.16|P-value:8.25E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.52|P-value:3.95E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-6.21|P-value:1.20E-9 ID:SGTC_516|Compound:3992-2719|FD-Score:-9.58|P-value:1.20E-20 ID:SGTC_519|Compound:k048-0011|FD-Score:4.18|P-value:1.80E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:3.30|P-value:5.21E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.18|P-value:7.89E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.57|P-value:2.00E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.33|P-value:9.24E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:3.62|P-value:1.64E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.13|P-value:9.24E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.20|P-value:7.28E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:5.62|P-value:1.57E-8 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.99|P-value:3.90E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.20|P-value:7.25E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.45|P-value:5.39E-6 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.34|P-value:7.33E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.35|P-value:4.33E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.14|P-value:9.05E-4 ID:SGTC_1633|Compound:st005664|FD-Score:4.18|P-value:1.79E-5 ID:SGTC_1635|Compound:st007035|FD-Score:7.66|P-value:2.84E-14 ID:SGTC_1694|Compound:st024011|FD-Score:3.26|P-value:5.88E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-4.46|P-value:9.74E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.93|P-value:5.00E-5 ID:SGTC_1901|Compound:st060216|FD-Score:4.11|P-value:2.39E-5 ID:SGTC_1932|Compound:st074806|FD-Score:-3.60|P-value:3.04E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-4.19|P-value:3.16E-5 ID:SGTC_1937|Compound:st074714|FD-Score:-4.34|P-value:1.65E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.29|P-value:8.67E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.41|P-value:3.50E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.36|P-value:4.16E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.45|P-value:5.10E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.21|P-value:1.53E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-4.39|P-value:1.32E-5 ID:SGTC_2396|Compound:5342950|FD-Score:3.59|P-value:1.83E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.28|P-value:9.04E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.96|P-value:4.42E-5 ID:SGTC_2452|Compound:5863136|FD-Score:4.26|P-value:1.28E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.30|P-value:2.88E-10 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.20|P-value:7.24E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.90|P-value:5.50E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.58|P-value:1.94E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.50|P-value:2.99E-8 ID:SGTC_2850|Compound:9015429|FD-Score:-3.40|P-value:6.09E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.34|P-value:4.59E-4 ID:SGTC_2933|Compound:9026794|FD-Score:6.89|P-value:6.53E-12 ID:SGTC_2974|Compound:9094440|FD-Score:4.54|P-value:3.62E-6 ID:SGTC_2975|Compound:9084847|FD-Score:4.10|P-value:2.45E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.14|P-value:8.85E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.40|P-value:3.72E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-4.60|P-value:5.32E-6 ID:SGTC_3153|Compound:9100258|FD-Score:3.55|P-value:2.12E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.69|P-value:1.26E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.73|P-value:1.10E-4

Top fitness defect scores for YIL002W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_97 0535-0701 8.87 19.1 µM 1.71E-18 60S ribosome export 2 3.66E-19
2 SGTC_1635 st007035 7.66 42.4 µM 2.84E-14 99 9.63E-15
3 SGTC_2933 9026794 6.89 32.5 µM 6.53E-12 1 2.85E-12
4 SGTC_2582 agaric acid 6.30 100.0 µM 2.88E-10 redox potentiating 147 1.49E-10
5 SGTC_1324 1418-0026 5.62 34.4 µM 1.57E-8 1 9.70E-9
6 SGTC_2788 5282734 5.50 71.4 µM 2.99E-8 16 1.90E-8
7 SGTC_90 0870-0863 4.99 4.6 µM 4.33E-7 21 3.07E-7
8 SGTC_2974 9094440 4.54 9.7 µM 3.62E-6 ergosterol biosynthesis 34 2.80E-6
9 SGTC_1405 3909-7894 4.45 12.0 µM 5.39E-6 60S ribosome export 8 4.24E-6
10 SGTC_967 1306-0166 4.33 352.0 µM 9.24E-6 21 7.42E-6
11 SGTC_280 3448-3607 4.30 3.0 µM 1.05E-5 60S ribosome export 3 8.45E-6
12 SGTC_2452 5863136 4.26 48.4 µM 1.28E-5 17 1.04E-5
13 SGTC_2289 7946404 4.21 165.1 µM 1.53E-5 85 1.25E-5
14 SGTC_1633 st005664 4.18 67.9 µM 1.79E-5 23 1.47E-5
15 SGTC_519 k048-0011 4.18 62.8 µM 1.80E-5 16 1.49E-5
16 SGTC_1901 st060216 4.11 58.6 µM 2.39E-5 20 1.99E-5
17 SGTC_379 3970-0972 4.11 5.9 µM 2.40E-5 tubulin folding & SWR complex 34 2.00E-5
18 SGTC_2975 9084847 4.10 53.7 µM 2.45E-5 20 2.05E-5
19 SGTC_1335 1486-0900 3.99 202.0 µM 3.90E-5 24 3.31E-5
20 SGTC_2412 st077135 3.96 33.4 µM 4.42E-5 23 3.77E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 6.16E-28 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.171 1.51E-23 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.170 3.47E-23 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.167 2.32E-22 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.163 2.43E-21 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.159 2.02E-20 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.154 2.87E-19 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.144 5.99E-17 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.143 1.02E-16 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.140 4.18E-16 YGR277C CAB4 het Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved
0.129 6.23E-14 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.127 1.34E-13 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.125 3.28E-13 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.124 5.02E-13 YHR087W RTC3 hom Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress
0.122 1.41E-12 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p