YIL004C / BET1

Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL004C / BET1

Click on Significant Values for Screen Details ID:SGTC_151|Compound:3013-0144|FD-Score:3.90|P-value:8.04E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.80|P-value:9.76E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:3.31|P-value:6.98E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:5.26|P-value:1.73E-7 ID:SGTC_385|Compound:1494-0393|FD-Score:4.48|P-value:7.20E-6 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.56|P-value:2.92E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.25|P-value:8.53E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.75|P-value:2.14E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.28|P-value:1.74E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-3.26|P-value:6.76E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.35|P-value:6.02E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:4.83|P-value:1.49E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:3.37|P-value:5.60E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.06|P-value:4.27E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:3.41|P-value:4.93E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.12|P-value:3.33E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:6.10|P-value:1.70E-9 ID:SGTC_1497|Compound:4476-2978|FD-Score:5.64|P-value:2.35E-8 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.02|P-value:5.76E-7 ID:SGTC_1594|Compound:piperine|FD-Score:3.68|P-value:1.89E-4 ID:SGTC_1607|Compound:st000305|FD-Score:4.11|P-value:3.57E-5 ID:SGTC_1642|Compound:st009582|FD-Score:4.19|P-value:2.55E-5 ID:SGTC_1659|Compound:st012954|FD-Score:3.25|P-value:8.38E-4 ID:SGTC_1669|Compound:st015249|FD-Score:3.42|P-value:4.82E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.33|P-value:6.49E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.96|P-value:6.37E-5 ID:SGTC_1902|Compound:st060212|FD-Score:4.73|P-value:2.35E-6 ID:SGTC_1930|Compound:st074634|FD-Score:5.40|P-value:8.47E-8 ID:SGTC_1964|Compound:st076914|FD-Score:3.40|P-value:5.16E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:5.55|P-value:3.85E-8 ID:SGTC_2283|Compound:7944793|FD-Score:3.73|P-value:1.57E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.54|P-value:5.59E-6 ID:SGTC_2325|Compound:6158266|FD-Score:3.77|P-value:1.33E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.25|P-value:6.98E-4 ID:SGTC_2465|Compound:5809242|FD-Score:3.25|P-value:8.51E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.60|P-value:2.56E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.63|P-value:2.27E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.71|P-value:1.71E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.78|P-value:1.02E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.31|P-value:6.95E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.28|P-value:6.44E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.97|P-value:6.13E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.53|P-value:3.21E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.21|P-value:2.34E-5 ID:SGTC_2985|Compound:9022375|FD-Score:-3.32|P-value:5.57E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.39|P-value:5.35E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.49|P-value:3.72E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.52|P-value:3.37E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.61|P-value:4.03E-6 ID:SGTC_3134|Compound:9127454|FD-Score:3.39|P-value:5.24E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.58|P-value:2.74E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.90|P-value:8.04E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.80|P-value:9.76E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:3.31|P-value:6.98E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:5.26|P-value:1.73E-7 ID:SGTC_385|Compound:1494-0393|FD-Score:4.48|P-value:7.20E-6 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.56|P-value:2.92E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.25|P-value:8.53E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.75|P-value:2.14E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.28|P-value:1.74E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-3.26|P-value:6.76E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.35|P-value:6.02E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:4.83|P-value:1.49E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:3.37|P-value:5.60E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.06|P-value:4.27E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:3.41|P-value:4.93E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.12|P-value:3.33E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:6.10|P-value:1.70E-9 ID:SGTC_1497|Compound:4476-2978|FD-Score:5.64|P-value:2.35E-8 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.02|P-value:5.76E-7 ID:SGTC_1594|Compound:piperine|FD-Score:3.68|P-value:1.89E-4 ID:SGTC_1607|Compound:st000305|FD-Score:4.11|P-value:3.57E-5 ID:SGTC_1642|Compound:st009582|FD-Score:4.19|P-value:2.55E-5 ID:SGTC_1659|Compound:st012954|FD-Score:3.25|P-value:8.38E-4 ID:SGTC_1669|Compound:st015249|FD-Score:3.42|P-value:4.82E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.33|P-value:6.49E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.96|P-value:6.37E-5 ID:SGTC_1902|Compound:st060212|FD-Score:4.73|P-value:2.35E-6 ID:SGTC_1930|Compound:st074634|FD-Score:5.40|P-value:8.47E-8 ID:SGTC_1964|Compound:st076914|FD-Score:3.40|P-value:5.16E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:5.55|P-value:3.85E-8 ID:SGTC_2283|Compound:7944793|FD-Score:3.73|P-value:1.57E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.54|P-value:5.59E-6 ID:SGTC_2325|Compound:6158266|FD-Score:3.77|P-value:1.33E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.25|P-value:6.98E-4 ID:SGTC_2465|Compound:5809242|FD-Score:3.25|P-value:8.51E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.60|P-value:2.56E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.63|P-value:2.27E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.71|P-value:1.71E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.78|P-value:1.02E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.31|P-value:6.95E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.28|P-value:6.44E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.97|P-value:6.13E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.53|P-value:3.21E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.21|P-value:2.34E-5 ID:SGTC_2985|Compound:9022375|FD-Score:-3.32|P-value:5.57E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.39|P-value:5.35E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.49|P-value:3.72E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.52|P-value:3.37E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.61|P-value:4.03E-6 ID:SGTC_3134|Compound:9127454|FD-Score:3.39|P-value:5.24E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.58|P-value:2.74E-4

Top fitness defect scores for YIL004C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1006 4099-6547 6.10 255.0 µM 1.70E-9 1 5.39E-10 1.03
2 SGTC_1497 4476-2978 5.64 41.3 µM 2.35E-8 1 8.68E-9 1.26
3 SGTC_2131 toluylene red 5.55 5.3 µM 3.85E-8 60S ribosome export 7 1.46E-8 0.55
4 SGTC_1930 st074634 5.40 34.3 µM 8.47E-8 RNA pol III & RNase P/MRP 10 3.37E-8 0.51
5 SGTC_384 k007-0144 5.26 5.2 µM 1.73E-7 ERAD & cell cycle 5 7.16E-8 0.27
6 SGTC_1513 0337-0559 5.02 19.0 µM 5.76E-7 4 2.56E-7 0.72
7 SGTC_532 1548-0774 4.83 215.0 µM 1.49E-6 3 6.99E-7 0.72
8 SGTC_453 enantio-paf c16 4.75 10.0 µM 2.14E-6 14 1.03E-6 0.05
9 SGTC_1902 st060212 4.73 70.5 µM 2.35E-6 4 1.13E-6 0.58
10 SGTC_3132 9126706 4.61 49.5 µM 4.03E-6 6 2.00E-6 0.25
11 SGTC_2313 7726885 4.54 200.0 µM 5.59E-6 RPP1 & pyrimidine depletion 4 2.83E-6 0.73
12 SGTC_385 1494-0393 4.48 12.4 µM 7.20E-6 2 3.70E-6 0.54
13 SGTC_481 bay k-8644 4.28 50.0 µM 1.74E-5 3 9.43E-6 0.45
14 SGTC_2821 7996764 4.21 71.4 µM 2.34E-5 10 1.29E-5 0.22
15 SGTC_1642 st009582 4.19 77.7 µM 2.55E-5 RPP1 & pyrimidine depletion 5 1.41E-5 0.03
16 SGTC_1005 4092-0690 4.12 4.4 µM 3.33E-5 plasma membrane duress 8 1.87E-5 0.25
17 SGTC_1607 st000305 4.11 50.6 µM 3.57E-5 4 2.01E-5 0.48
18 SGTC_970 1315-0089 4.06 19.5 µM 4.27E-5 RSC & ERG11 10 2.43E-5 0.01
19 SGTC_2720 fluspirilene 3.97 36.9 µM 6.13E-5 ERG2 4 3.57E-5 0.41
20 SGTC_1901 st060216 3.96 58.6 µM 6.37E-5 4 3.72E-5 0.19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 9.21E-18 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.093 7.03E-8 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 7.88E-8 YPR001W CIT3 hom Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
0.088 3.61E-7 YOR021C SFM1 hom SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
0.082 1.82E-6 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.080 3.23E-6 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.080 3.31E-6 YHR204W MNL1 hom Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation
0.078 6.17E-6 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.076 9.67E-6 YBR154C RPB5 het RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
0.076 1.06E-5 YHR079C-A SAE3 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
0.076 1.08E-5 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.076 1.12E-5 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.075 1.41E-5 YKR027W BCH2 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication
0.073 2.18E-5 YDR112W_d IRC2_d hom Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.073 2.06E-5 YGR249W MGA1 hom Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants