HIPHOP chemogenomics database
YIL004C / BET1 
Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YIL004C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.147 | 9.21E-18 | YOR116C | RPO31 | het | RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 |
| 0.093 | 7.03E-8 | YML101C-A_d | YML101C-A_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.093 | 7.88E-8 | YPR001W | CIT3 | hom | Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate |
| 0.088 | 3.61E-7 | YOR021C | SFM1 | hom | SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism |
| 0.082 | 1.82E-6 | YER004W | FMP52 | hom | Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation |
| 0.080 | 3.23E-6 | YJL143W | TIM17 | het | Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex |
| 0.080 | 3.31E-6 | YHR204W | MNL1 | hom | Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation |
| 0.078 | 6.17E-6 | YBL005W | PDR3 | hom | Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
| 0.076 | 9.67E-6 | YBR154C | RPB5 | het | RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation |
| 0.076 | 1.06E-5 | YHR079C-A | SAE3 | hom | Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p |
| 0.076 | 1.08E-5 | YJR137C | MET5 | hom | Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine |
| 0.076 | 1.12E-5 | YER067W | RGI1 | hom | Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress |
| 0.075 | 1.41E-5 | YKR027W | BCH2 | hom | Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication |
| 0.073 | 2.18E-5 | YDR112W_d | IRC2_d | hom | Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci |
| 0.073 | 2.06E-5 | YGR249W | MGA1 | hom | Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants |