YIL006W / YIA6

Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL006W / YIA6

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:-3.43|P-value:3.70E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.64|P-value:1.73E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.48|P-value:3.70E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.65|P-value:2.05E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.68|P-value:1.83E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.43|P-value:3.68E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.36|P-value:4.82E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.86|P-value:7.56E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.72|P-value:1.28E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.52|P-value:3.28E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.51|P-value:3.37E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.71|P-value:1.33E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.37|P-value:5.46E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.32|P-value:1.41E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.48|P-value:3.73E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.40|P-value:5.01E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.34|P-value:6.01E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.60|P-value:2.45E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.40|P-value:4.20E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-4.36|P-value:9.20E-6 ID:SGTC_1948|Compound:st076329|FD-Score:-4.96|P-value:5.83E-7 ID:SGTC_2049|Compound:5262831|FD-Score:3.51|P-value:3.37E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.57|P-value:2.23E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.15|P-value:9.57E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.82|P-value:8.87E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.11|P-value:3.40E-5 ID:SGTC_2678|Compound:equilin|FD-Score:-3.39|P-value:4.28E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.54|P-value:3.03E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.58|P-value:2.59E-4 ID:SGTC_2927|Compound:9011802|FD-Score:5.63|P-value:2.23E-8 ID:SGTC_3078|Compound:9116413|FD-Score:3.33|P-value:6.29E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.55|P-value:2.85E-4 ID:SGTC_3107|Compound:9121808|FD-Score:3.47|P-value:3.81E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.46|P-value:3.96E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.43|P-value:3.70E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.64|P-value:1.73E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.48|P-value:3.70E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.65|P-value:2.05E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.68|P-value:1.83E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.43|P-value:3.68E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.36|P-value:4.82E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.86|P-value:7.56E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.72|P-value:1.28E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.52|P-value:3.28E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.51|P-value:3.37E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.71|P-value:1.33E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.37|P-value:5.46E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.32|P-value:1.41E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.48|P-value:3.73E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.40|P-value:5.01E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.34|P-value:6.01E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.60|P-value:2.45E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.40|P-value:4.20E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-4.36|P-value:9.20E-6 ID:SGTC_1948|Compound:st076329|FD-Score:-4.96|P-value:5.83E-7 ID:SGTC_2049|Compound:5262831|FD-Score:3.51|P-value:3.37E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.57|P-value:2.23E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.15|P-value:9.57E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.82|P-value:8.87E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.11|P-value:3.40E-5 ID:SGTC_2678|Compound:equilin|FD-Score:-3.39|P-value:4.28E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.54|P-value:3.03E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.58|P-value:2.59E-4 ID:SGTC_2927|Compound:9011802|FD-Score:5.63|P-value:2.23E-8 ID:SGTC_3078|Compound:9116413|FD-Score:3.33|P-value:6.29E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.55|P-value:2.85E-4 ID:SGTC_3107|Compound:9121808|FD-Score:3.47|P-value:3.81E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.46|P-value:3.96E-4

Top fitness defect scores for YIL006W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2927 9011802 5.63 47.9 µM 2.23E-8 6 8.98E-9
2 SGTC_1053 3366-3204 4.32 134.0 µM 1.41E-5 cell wall 29 7.98E-6
3 SGTC_2615 purpurogallin-4-carboxylic acid 4.11 100.0 µM 3.40E-5 redox potentiating 62 2.02E-5
4 SGTC_279 1273-0055 3.68 2.9 µM 1.83E-4 azole & statin 45 1.19E-4
5 SGTC_154 3389-1638 3.65 511.1 µM 2.05E-4 34 1.34E-4
6 SGTC_1353 1498-1206 3.60 8.1 µM 2.45E-4 mitochondrial response to ROS 67 1.62E-4
7 SGTC_2925 9010536 3.58 32.5 µM 2.59E-4 azole & statin 64 1.71E-4
8 SGTC_3104 9120930 3.55 49.5 µM 2.85E-4 21 1.89E-4
9 SGTC_2679 rapamycin 3.54 1.0 nM 3.03E-4 176 2.02E-4
10 SGTC_617 3770-0098 3.52 35.0 µM 3.28E-4 exosome 22 2.19E-4
11 SGTC_821 1114-0266 3.51 29.2 µM 3.37E-4 33 2.26E-4
12 SGTC_2049 5262831 3.51 67.2 µM 3.37E-4 47 2.26E-4
13 SGTC_150 3970-0969 3.48 77.2 µM 3.70E-4 86 2.49E-4
14 SGTC_1059 3448-6867 3.48 171.0 µM 3.73E-4 22 2.52E-4
15 SGTC_3107 9121808 3.47 49.5 µM 3.81E-4 12 2.57E-4
16 SGTC_3265 9137266 3.46 49.5 µM 3.96E-4 16 2.68E-4
17 SGTC_1061 3448-9325 3.40 110.0 µM 5.01E-4 38 3.43E-4
18 SGTC_955 1216-0110 3.37 33.0 µM 5.46E-4 sphingolipid biosynthesis & PDR1 97 3.76E-4
19 SGTC_1078 idebenone 3.34 36.1 µM 6.01E-4 Golgi 65 4.16E-4
20 SGTC_3078 9116413 3.33 49.5 µM 6.29E-4 unfolded protein response 55 4.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.73E-10 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.098 1.27E-8 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.097 2.12E-8 YBR157C ICS2 hom Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.096 2.37E-8 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.093 6.87E-8 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.084 9.92E-7 YIL041W GVP36 hom BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis
0.081 2.35E-6 YDR472W TRS31 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.079 4.67E-6 YBR044C TCM62 hom Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
0.078 5.80E-6 YPL199C_p YPL199C_p hom Putative protein of unknown function, predicted to be palmitoylated
0.078 6.16E-6 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.077 7.21E-6 YMR241W YHM2 hom Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome
0.076 9.70E-6 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.076 1.14E-5 YGL151W NUT1 hom Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
0.075 1.53E-5 YBR111W-A SUS1 hom Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP
0.074 1.74E-5 YBL071W-A KTI11 hom Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs