YIL008W / URM1

Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL008W / URM1

Click on Significant Values for Screen Details ID:SGTC_89|Compound:0302-0250|FD-Score:4.10|P-value:3.68E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.36|P-value:5.69E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.22|P-value:8.89E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.20|P-value:9.86E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.29|P-value:7.26E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.16|P-value:2.74E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.89|P-value:1.06E-6 ID:SGTC_487|Compound:nimodipine|FD-Score:4.29|P-value:1.63E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.37|P-value:5.49E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.20|P-value:2.39E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:3.30|P-value:6.95E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.88|P-value:8.50E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.36|P-value:5.73E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.33|P-value:6.35E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.86|P-value:9.35E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.14|P-value:3.01E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.30|P-value:7.09E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.27|P-value:1.77E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.35|P-value:1.28E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.56|P-value:2.77E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.42|P-value:9.22E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.92|P-value:9.43E-7 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.25|P-value:8.26E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.32|P-value:6.56E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.66|P-value:1.98E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.43|P-value:4.55E-4 ID:SGTC_1735|Compound:st034310|FD-Score:4.01|P-value:5.23E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.94|P-value:6.80E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.20|P-value:9.92E-33 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.63|P-value:2.23E-4 ID:SGTC_2043|Compound:5101342|FD-Score:4.34|P-value:1.33E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.39|P-value:5.21E-4 ID:SGTC_2155|Compound:5570423|FD-Score:5.27|P-value:1.65E-7 ID:SGTC_2163|Compound:5671233|FD-Score:-3.45|P-value:4.13E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-4.09|P-value:3.65E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.90|P-value:7.81E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.35|P-value:5.75E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.48|P-value:3.73E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.48|P-value:3.78E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.56|P-value:2.78E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.35|P-value:1.26E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:6.92|P-value:1.04E-11 ID:SGTC_2555|Compound:cholic acid|FD-Score:7.30|P-value:7.69E-13 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.53|P-value:3.15E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:4.40|P-value:1.00E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.73|P-value:1.42E-17 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.27|P-value:1.70E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.90|P-value:7.84E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.45|P-value:8.29E-6 ID:SGTC_2790|Compound:5423970|FD-Score:3.97|P-value:6.14E-5 ID:SGTC_2804|Compound:7954240|FD-Score:7.61|P-value:8.31E-14 ID:SGTC_2822|Compound:7994718|FD-Score:5.39|P-value:9.05E-8 ID:SGTC_2828|Compound:7998861|FD-Score:3.50|P-value:3.47E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.50|P-value:3.48E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.30|P-value:7.12E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.36|P-value:5.59E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.40|P-value:5.01E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.45|P-value:4.08E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.18|P-value:2.52E-5 ID:SGTC_2997|Compound:9067075|FD-Score:-3.99|P-value:5.46E-5 ID:SGTC_3010|Compound:9080089|FD-Score:-4.32|P-value:1.44E-5 ID:SGTC_3080|Compound:9117754|FD-Score:-4.55|P-value:5.29E-6 ID:SGTC_3082|Compound:9117008|FD-Score:3.28|P-value:7.56E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.63|P-value:2.18E-4 ID:SGTC_3086|Compound:9117350|FD-Score:-3.37|P-value:5.38E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.45|P-value:4.17E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.19|P-value:9.94E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.77|P-value:1.31E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.36|P-value:5.66E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.47|P-value:3.96E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-4.56|P-value:5.00E-6 ID:SGTC_89|Compound:0302-0250|FD-Score:4.10|P-value:3.68E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.36|P-value:5.69E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.22|P-value:8.89E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.20|P-value:9.86E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.29|P-value:7.26E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.16|P-value:2.74E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.89|P-value:1.06E-6 ID:SGTC_487|Compound:nimodipine|FD-Score:4.29|P-value:1.63E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.37|P-value:5.49E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:4.20|P-value:2.39E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:3.30|P-value:6.95E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.88|P-value:8.50E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.36|P-value:5.73E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.33|P-value:6.35E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.86|P-value:9.35E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.14|P-value:3.01E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.30|P-value:7.09E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.27|P-value:1.77E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.35|P-value:1.28E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.56|P-value:2.77E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.42|P-value:9.22E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.92|P-value:9.43E-7 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.25|P-value:8.26E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.32|P-value:6.56E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.66|P-value:1.98E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.43|P-value:4.55E-4 ID:SGTC_1735|Compound:st034310|FD-Score:4.01|P-value:5.23E-5 ID:SGTC_1755|Compound:st041960|FD-Score:3.94|P-value:6.80E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.20|P-value:9.92E-33 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.63|P-value:2.23E-4 ID:SGTC_2043|Compound:5101342|FD-Score:4.34|P-value:1.33E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.39|P-value:5.21E-4 ID:SGTC_2155|Compound:5570423|FD-Score:5.27|P-value:1.65E-7 ID:SGTC_2163|Compound:5671233|FD-Score:-3.45|P-value:4.13E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-4.09|P-value:3.65E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:-3.90|P-value:7.81E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.35|P-value:5.75E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.48|P-value:3.73E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.48|P-value:3.78E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.56|P-value:2.78E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.35|P-value:1.26E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:6.92|P-value:1.04E-11 ID:SGTC_2555|Compound:cholic acid|FD-Score:7.30|P-value:7.69E-13 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.53|P-value:3.15E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:4.40|P-value:1.00E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.73|P-value:1.42E-17 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.27|P-value:1.70E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.90|P-value:7.84E-5 ID:SGTC_2787|Compound:5284540|FD-Score:4.45|P-value:8.29E-6 ID:SGTC_2790|Compound:5423970|FD-Score:3.97|P-value:6.14E-5 ID:SGTC_2804|Compound:7954240|FD-Score:7.61|P-value:8.31E-14 ID:SGTC_2822|Compound:7994718|FD-Score:5.39|P-value:9.05E-8 ID:SGTC_2828|Compound:7998861|FD-Score:3.50|P-value:3.47E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.50|P-value:3.48E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.30|P-value:7.12E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.36|P-value:5.59E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.40|P-value:5.01E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.45|P-value:4.08E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.18|P-value:2.52E-5 ID:SGTC_2997|Compound:9067075|FD-Score:-3.99|P-value:5.46E-5 ID:SGTC_3010|Compound:9080089|FD-Score:-4.32|P-value:1.44E-5 ID:SGTC_3080|Compound:9117754|FD-Score:-4.55|P-value:5.29E-6 ID:SGTC_3082|Compound:9117008|FD-Score:3.28|P-value:7.56E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.63|P-value:2.18E-4 ID:SGTC_3086|Compound:9117350|FD-Score:-3.37|P-value:5.38E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.45|P-value:4.17E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.19|P-value:9.94E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.77|P-value:1.31E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.36|P-value:5.66E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.47|P-value:3.96E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-4.56|P-value:5.00E-6

Top fitness defect scores for YIL008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1844 rapamycin 12.20 4.0 nM 9.92E-33 20 9.15E-35
2 SGTC_2679 rapamycin 8.73 1.0 nM 1.42E-17 34 1.29E-18
3 SGTC_2804 7954240 7.61 19.5 µM 8.31E-14 1 1.32E-14
4 SGTC_2555 cholic acid 7.30 100.0 µM 7.69E-13 2 1.42E-13
5 SGTC_2539 epi(13)torulosol 6.92 80.0 µM 1.04E-11 1 2.28E-12
6 SGTC_2822 7994718 5.39 71.4 µM 9.05E-8 6 3.54E-8
7 SGTC_2155 5570423 5.27 76.0 µM 1.65E-7 ergosterol biosynthesis 3 6.73E-8
8 SGTC_2688 kanamycin b 5.27 96.7 µM 1.70E-7 calcium & mitochondrial duress 224 6.94E-8
9 SGTC_1381 2324-0066 4.92 62.1 µM 9.43E-7 16 4.29E-7
10 SGTC_2787 5284540 4.45 71.4 µM 8.29E-6 16 4.33E-6
11 SGTC_1266 0828-0227 4.42 32.9 µM 9.22E-6 15 4.85E-6
12 SGTC_2670 beta-carotene 4.40 100.0 µM 1.00E-5 1 5.29E-6
13 SGTC_2517 totarol 4.35 10.0 µM 1.26E-5 13 6.75E-6
14 SGTC_1249 0481-0015 4.35 10.2 µM 1.28E-5 16 6.87E-6
15 SGTC_2043 5101342 4.34 149.0 µM 1.33E-5 SWF1 & branched chain AA biosynthesis 8 7.15E-6
16 SGTC_487 nimodipine 4.29 119.0 µM 1.63E-5 5 8.90E-6
17 SGTC_1248 0469-0687 4.27 58.6 µM 1.77E-5 18 9.69E-6
18 SGTC_652 0437-0092 4.20 114.0 µM 2.39E-5 10 1.33E-5
19 SGTC_1049 3226-0134 4.14 66.0 µM 3.01E-5 22 1.70E-5
20 SGTC_89 0302-0250 4.10 142.1 µM 3.68E-5 15 2.11E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.299 3.66E-70 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.292 1.10E-66 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.268 2.63E-56 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.267 7.35E-56 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.255 8.24E-51 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.252 1.06E-49 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.246 2.03E-47 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.240 2.99E-45 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.229 2.69E-41 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.209 1.59E-34 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.208 3.69E-34 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.200 1.38E-31 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.198 6.22E-31 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.198 5.74E-31 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.197 1.31E-30 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin