YIL011W / TIR3

Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL011W / TIR3

Click on Significant Values for Screen Details ID:SGTC_97|Compound:0535-0701|FD-Score:3.02|P-value:6.97E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.93|P-value:9.61E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-5.22|P-value:4.70E-8 ID:SGTC_653|Compound:0203-0016|FD-Score:4.32|P-value:2.90E-6 ID:SGTC_654|Compound:1124-0271|FD-Score:3.06|P-value:6.16E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.31|P-value:2.38E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.66|P-value:9.93E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.58|P-value:1.47E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.29|P-value:4.23E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-5.55|P-value:6.75E-9 ID:SGTC_882|Compound:0843-0131|FD-Score:2.99|P-value:7.78E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:2.98|P-value:8.12E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.23|P-value:3.26E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.03|P-value:1.12E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.55|P-value:9.09E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.55|P-value:1.58E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.41|P-value:2.72E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.94|P-value:1.74E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-4.35|P-value:4.57E-6 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.53|P-value:1.00E-6 ID:SGTC_1676|Compound:st018489|FD-Score:3.19|P-value:3.85E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.51|P-value:1.09E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.46|P-value:1.32E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.35|P-value:2.09E-4 ID:SGTC_1809|Compound:st050081|FD-Score:4.47|P-value:1.35E-6 ID:SGTC_1847|Compound:st056231|FD-Score:-3.77|P-value:6.33E-5 ID:SGTC_1852|Compound:st056254|FD-Score:-3.07|P-value:9.30E-4 ID:SGTC_1861|Compound:st057647|FD-Score:4.41|P-value:1.87E-6 ID:SGTC_1900|Compound:st060200|FD-Score:-3.57|P-value:1.46E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.52|P-value:1.05E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.67|P-value:5.54E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.73|P-value:4.33E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.88|P-value:2.24E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.16|P-value:4.18E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.21|P-value:5.78E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.81|P-value:5.30E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.20|P-value:5.82E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.63|P-value:6.55E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.53|P-value:9.96E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.81|P-value:5.44E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.02|P-value:1.21E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:2.99|P-value:7.95E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.10|P-value:1.51E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.21|P-value:5.66E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.96|P-value:2.00E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.40|P-value:1.67E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:2.98|P-value:8.16E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.18|P-value:5.59E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.07|P-value:9.23E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.38|P-value:1.85E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.11|P-value:8.28E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-5.51|P-value:9.06E-9 ID:SGTC_2915|Compound:7971052|FD-Score:3.53|P-value:9.92E-5 ID:SGTC_2940|Compound:9060638|FD-Score:-3.47|P-value:2.11E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-4.26|P-value:7.03E-6 ID:SGTC_2945|Compound:9067681|FD-Score:4.62|P-value:6.25E-7 ID:SGTC_2993|Compound:9054257|FD-Score:3.07|P-value:5.96E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.18|P-value:3.88E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.89|P-value:3.72E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.09|P-value:8.85E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.02|P-value:6.97E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.93|P-value:9.61E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-5.22|P-value:4.70E-8 ID:SGTC_653|Compound:0203-0016|FD-Score:4.32|P-value:2.90E-6 ID:SGTC_654|Compound:1124-0271|FD-Score:3.06|P-value:6.16E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.31|P-value:2.38E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.66|P-value:9.93E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.58|P-value:1.47E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.29|P-value:4.23E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-5.55|P-value:6.75E-9 ID:SGTC_882|Compound:0843-0131|FD-Score:2.99|P-value:7.78E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:2.98|P-value:8.12E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.23|P-value:3.26E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.03|P-value:1.12E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.55|P-value:9.09E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.55|P-value:1.58E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.41|P-value:2.72E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.94|P-value:1.74E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-4.35|P-value:4.57E-6 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.53|P-value:1.00E-6 ID:SGTC_1676|Compound:st018489|FD-Score:3.19|P-value:3.85E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.51|P-value:1.09E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.46|P-value:1.32E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.35|P-value:2.09E-4 ID:SGTC_1809|Compound:st050081|FD-Score:4.47|P-value:1.35E-6 ID:SGTC_1847|Compound:st056231|FD-Score:-3.77|P-value:6.33E-5 ID:SGTC_1852|Compound:st056254|FD-Score:-3.07|P-value:9.30E-4 ID:SGTC_1861|Compound:st057647|FD-Score:4.41|P-value:1.87E-6 ID:SGTC_1900|Compound:st060200|FD-Score:-3.57|P-value:1.46E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.52|P-value:1.05E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.67|P-value:5.54E-5 ID:SGTC_2038|Compound:4100038|FD-Score:3.73|P-value:4.33E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.88|P-value:2.24E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.16|P-value:4.18E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.21|P-value:5.78E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.81|P-value:5.30E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.20|P-value:5.82E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.63|P-value:6.55E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.53|P-value:9.96E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:-3.81|P-value:5.44E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.02|P-value:1.21E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:2.99|P-value:7.95E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.10|P-value:1.51E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.21|P-value:5.66E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.96|P-value:2.00E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.40|P-value:1.67E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:2.98|P-value:8.16E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.18|P-value:5.59E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.07|P-value:9.23E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.38|P-value:1.85E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.11|P-value:8.28E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-5.51|P-value:9.06E-9 ID:SGTC_2915|Compound:7971052|FD-Score:3.53|P-value:9.92E-5 ID:SGTC_2940|Compound:9060638|FD-Score:-3.47|P-value:2.11E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-4.26|P-value:7.03E-6 ID:SGTC_2945|Compound:9067681|FD-Score:4.62|P-value:6.25E-7 ID:SGTC_2993|Compound:9054257|FD-Score:3.07|P-value:5.96E-4 ID:SGTC_3329|Compound:9141233|FD-Score:3.18|P-value:3.88E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.89|P-value:3.72E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.09|P-value:8.85E-4

Top fitness defect scores for YIL011W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2945 9067681 4.62 61.8 µM 6.25E-7 9 1.91E-6
2 SGTC_1483 3453-0561 4.53 55.9 µM 1.00E-6 13 2.96E-6
3 SGTC_1809 st050081 4.47 57.6 µM 1.35E-6 12 3.89E-6
4 SGTC_1861 st057647 4.41 17.4 µM 1.87E-6 11 5.26E-6
5 SGTC_653 0203-0016 4.32 55.2 µM 2.90E-6 9 7.88E-6
6 SGTC_2651 1327-0036 4.18 5.0 µM 5.59E-6 147 1.45E-5
7 SGTC_960 1222-0186 4.03 7.7 µM 1.12E-5 32 2.75E-5
8 SGTC_2519 cryptotanshinone 4.02 88.0 µM 1.21E-5 heme biosynthesis & mitochondrial translocase 12 2.96E-5
9 SGTC_1079 idarubicin 3.94 2.4 µM 1.74E-5 DNA damage response 23 4.13E-5
10 SGTC_2064 5220758 3.88 200.0 µM 2.24E-5 38 5.21E-5
11 SGTC_2038 4100038 3.73 31.0 µM 4.33E-5 plasma membrane duress 61 9.58E-5
12 SGTC_2028 5153890 3.67 36.4 µM 5.54E-5 cell wall signaling 39 1.21E-4
13 SGTC_2416 tofa 3.63 880.0 nM 6.55E-5 sphingolipid biosynthesis & PDR1 63 1.41E-4
14 SGTC_967 1306-0166 3.55 352.0 µM 9.09E-5 51 1.90E-4
15 SGTC_2915 7971052 3.53 15.2 µM 9.92E-5 11 2.06E-4
16 SGTC_2502 avocadyne acetate 3.53 18.6 µM 9.96E-5 42 2.07E-4
17 SGTC_1958 st076513 3.52 41.9 µM 1.05E-4 60S ribosome export 45 2.18E-4
18 SGTC_1721 st082152 3.51 9.3 µM 1.09E-4 60S ribosome export 33 2.25E-4
19 SGTC_1781 st038725 3.46 66.3 µM 1.32E-4 NEO1 126 2.68E-4
20 SGTC_2582 agaric acid 3.40 100.0 µM 1.67E-4 redox potentiating 378 3.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.46E-13 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.121 1.94E-12 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.115 2.23E-11 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.103 1.94E-9 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.100 7.03E-9 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.097 2.11E-8 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.096 2.62E-8 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.093 7.89E-8 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.093 7.98E-8 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.091 1.21E-7 YDR193W_d YDR193W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.091 1.37E-7 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.091 1.44E-7 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.090 1.74E-7 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.090 1.97E-7 YKL028W TFA1 het TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
0.087 4.92E-7 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p