YIL012W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL012W / YIL012W

Click on Significant Values for Screen Details ID:SGTC_97|Compound:0535-0701|FD-Score:3.30|P-value:4.80E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.20|P-value:6.91E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.10|P-value:1.70E-7 ID:SGTC_564|Compound:3555-0129|FD-Score:3.36|P-value:3.98E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:4.56|P-value:2.56E-6 ID:SGTC_654|Compound:1124-0271|FD-Score:4.38|P-value:5.86E-6 ID:SGTC_679|Compound:0422-0091|FD-Score:3.96|P-value:3.79E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.29|P-value:5.05E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.63|P-value:1.44E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:5.13|P-value:1.44E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.26|P-value:5.34E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.87|P-value:5.49E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.62|P-value:1.49E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:4.07|P-value:2.38E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.17|P-value:1.55E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.15|P-value:8.28E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.83|P-value:6.76E-7 ID:SGTC_1291|Compound:0993-0025|FD-Score:5.04|P-value:2.32E-7 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.24|P-value:1.12E-5 ID:SGTC_1655|Compound:st012546|FD-Score:3.67|P-value:1.21E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.42|P-value:2.95E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.84|P-value:6.15E-5 ID:SGTC_1678|Compound:st019265|FD-Score:6.21|P-value:2.54E-10 ID:SGTC_1771|Compound:st048882|FD-Score:3.16|P-value:8.06E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-3.11|P-value:8.82E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.53|P-value:2.12E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.66|P-value:1.24E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.16|P-value:7.85E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.25|P-value:5.87E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.26|P-value:5.64E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.66|P-value:1.28E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.63|P-value:1.42E-4 ID:SGTC_2030|Compound:5175110|FD-Score:5.14|P-value:1.39E-7 ID:SGTC_2210|Compound:7115885|FD-Score:3.16|P-value:8.03E-4 ID:SGTC_2330|Compound:7979373|FD-Score:5.74|P-value:4.64E-9 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.26|P-value:1.00E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.13|P-value:8.87E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.16|P-value:7.92E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.62|P-value:1.37E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-3.58|P-value:1.60E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.56|P-value:1.86E-4 ID:SGTC_3072|Compound:9116419|FD-Score:4.68|P-value:1.40E-6 ID:SGTC_3182|Compound:9108849|FD-Score:-3.28|P-value:4.86E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.19|P-value:7.17E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.18|P-value:7.52E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.11|P-value:9.38E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.30|P-value:4.80E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.20|P-value:6.91E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.10|P-value:1.70E-7 ID:SGTC_564|Compound:3555-0129|FD-Score:3.36|P-value:3.98E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:4.56|P-value:2.56E-6 ID:SGTC_654|Compound:1124-0271|FD-Score:4.38|P-value:5.86E-6 ID:SGTC_679|Compound:0422-0091|FD-Score:3.96|P-value:3.79E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.29|P-value:5.05E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.63|P-value:1.44E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:5.13|P-value:1.44E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.26|P-value:5.34E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.87|P-value:5.49E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.62|P-value:1.49E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:4.07|P-value:2.38E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.17|P-value:1.55E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.15|P-value:8.28E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.83|P-value:6.76E-7 ID:SGTC_1291|Compound:0993-0025|FD-Score:5.04|P-value:2.32E-7 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.24|P-value:1.12E-5 ID:SGTC_1655|Compound:st012546|FD-Score:3.67|P-value:1.21E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.42|P-value:2.95E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.84|P-value:6.15E-5 ID:SGTC_1678|Compound:st019265|FD-Score:6.21|P-value:2.54E-10 ID:SGTC_1771|Compound:st048882|FD-Score:3.16|P-value:8.06E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-3.11|P-value:8.82E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.53|P-value:2.12E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.66|P-value:1.24E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.16|P-value:7.85E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.25|P-value:5.87E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.26|P-value:5.64E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.66|P-value:1.28E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.63|P-value:1.42E-4 ID:SGTC_2030|Compound:5175110|FD-Score:5.14|P-value:1.39E-7 ID:SGTC_2210|Compound:7115885|FD-Score:3.16|P-value:8.03E-4 ID:SGTC_2330|Compound:7979373|FD-Score:5.74|P-value:4.64E-9 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.26|P-value:1.00E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.13|P-value:8.87E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.16|P-value:7.92E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.62|P-value:1.37E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-3.58|P-value:1.60E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.56|P-value:1.86E-4 ID:SGTC_3072|Compound:9116419|FD-Score:4.68|P-value:1.40E-6 ID:SGTC_3182|Compound:9108849|FD-Score:-3.28|P-value:4.86E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.19|P-value:7.17E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.18|P-value:7.52E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.11|P-value:9.38E-4

Top fitness defect scores for YIL012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1678 st019265 6.21 80.2 µM 2.54E-10 60S ribosome export 3 2.61E-10
2 SGTC_2330 7979373 5.74 200.0 µM 4.64E-9 60S ribosome export 14 4.73E-9
3 SGTC_2030 5175110 5.14 200.0 µM 1.39E-7 Golgi 12 1.40E-7
4 SGTC_1018 4259-0013 5.13 28.1 µM 1.44E-7 4 1.45E-7
5 SGTC_365 0121-0052 5.10 13.6 µM 1.70E-7 mitochondrial response to ROS 29 1.72E-7
6 SGTC_1291 0993-0025 5.04 5.8 µM 2.32E-7 4 2.34E-7
7 SGTC_1284 0929-0043 4.83 16.0 µM 6.76E-7 13 6.81E-7
8 SGTC_3072 9116419 4.68 49.5 µM 1.40E-6 ERG2 5 1.41E-6
9 SGTC_589 1227-0070 4.56 34.1 µM 2.56E-6 17 2.57E-6
10 SGTC_654 1124-0271 4.38 80.9 µM 5.86E-6 14 5.88E-6
11 SGTC_2501 sodium tetradecyl sulfate 4.26 13.4 µM 1.00E-5 25 1.01E-5
12 SGTC_1416 3966-0321 4.24 25.3 µM 1.12E-5 9 1.12E-5
13 SGTC_1231 0242-0792 4.17 125.0 µM 1.55E-5 16 1.55E-5
14 SGTC_1208 2323-2347 4.07 50.3 µM 2.38E-5 4 2.38E-5
15 SGTC_679 0422-0091 3.96 41.4 µM 3.79E-5 Golgi 29 3.79E-5
16 SGTC_1167 k781-0610 3.87 148.0 µM 5.49E-5 RNA processing & uracil transport 29 5.48E-5
17 SGTC_1671 st016596 3.84 74.5 µM 6.15E-5 16 6.13E-5
18 SGTC_1655 st012546 3.67 55.1 µM 1.21E-4 36 1.20E-4
19 SGTC_1940 st075990 3.66 51.1 µM 1.24E-4 60S ribosome export 29 1.24E-4
20 SGTC_2020 4017018 3.66 200.0 µM 1.28E-4 30 1.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.54E-11 YKL086W SRX1 hom Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress
0.096 2.56E-8 YBL037W APL3 hom Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport
0.089 2.10E-7 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.080 3.39E-6 YBL007C SLA1 hom Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
0.080 3.80E-6 YJL010C NOP9 het Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain
0.070 4.56E-5 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.067 9.20E-5 YDR062W LCB2 het Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.067 9.75E-5 YLR363W-A YLR363W-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
0.067 1.06E-4 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.066 1.20E-4 YDR338C_p YDR338C_p hom Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily
0.066 1.28E-4 YPL071C_p YPL071C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.066 1.43E-4 YHR081W LRP1 hom Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
0.065 1.76E-4 YMR278W PGM3 hom Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential
0.064 1.99E-4 YER033C ZRG8 hom Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
0.064 2.29E-4 YKL151C YKL151C hom NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress