YIL014C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL014C-A / YIL014C-A

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.31|P-value:3.21E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.67|P-value:3.27E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.81|P-value:2.02E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.89|P-value:1.53E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.05|P-value:8.54E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:4.50|P-value:1.49E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.47|P-value:7.16E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.83|P-value:3.26E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:7.08|P-value:2.85E-11 ID:SGTC_119|Compound:0121-0043|FD-Score:6.42|P-value:1.41E-9 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.57|P-value:4.54E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.45|P-value:6.84E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.90|P-value:1.48E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.91|P-value:2.20E-8 ID:SGTC_211|Compound:3455-0679|FD-Score:3.57|P-value:4.62E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.15|P-value:1.30E-17 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.74|P-value:5.31E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:8.30|P-value:7.71E-15 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.12|P-value:7.63E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.57|P-value:5.21E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.54|P-value:1.66E-7 ID:SGTC_444|Compound:curcumin|FD-Score:-3.77|P-value:2.61E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.11|P-value:9.14E-9 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-4.60|P-value:1.13E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:4.58|P-value:1.07E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.33|P-value:9.92E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.45|P-value:7.61E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.51|P-value:6.23E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.49|P-value:6.70E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.35|P-value:2.73E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-3.61|P-value:4.51E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.67|P-value:3.30E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.40|P-value:8.01E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.42|P-value:7.54E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.70|P-value:2.95E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.35|P-value:9.50E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.55|P-value:4.88E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.57|P-value:4.63E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.45|P-value:7.61E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.61|P-value:4.09E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.62|P-value:4.34E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.64|P-value:3.69E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.71|P-value:7.35E-6 ID:SGTC_2077|Compound:5212015|FD-Score:4.20|P-value:4.88E-5 ID:SGTC_2167|Compound:5876490|FD-Score:4.31|P-value:3.26E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.37|P-value:8.91E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.18|P-value:5.31E-5 ID:SGTC_2314|Compound:7727897|FD-Score:3.35|P-value:9.32E-4 ID:SGTC_2349|Compound:9023730|FD-Score:-4.12|P-value:7.39E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.48|P-value:6.16E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.39|P-value:8.36E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:5.78|P-value:4.26E-8 ID:SGTC_2556|Compound:citropten|FD-Score:5.22|P-value:6.57E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.90|P-value:1.68E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.54|P-value:5.06E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.05|P-value:8.47E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.25|P-value:3.98E-5 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.72|P-value:3.12E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-8.13|P-value:3.44E-14 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.18|P-value:5.98E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-3.73|P-value:2.99E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-5.53|P-value:1.77E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-4.86|P-value:3.81E-6 ID:SGTC_2959|Compound:9079155|FD-Score:4.36|P-value:2.66E-5 ID:SGTC_2960|Compound:9079389|FD-Score:6.29|P-value:2.92E-9 ID:SGTC_3019|Compound:9081971|FD-Score:-6.86|P-value:1.29E-10 ID:SGTC_3033|Compound:9090887|FD-Score:3.54|P-value:5.02E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.43|P-value:7.19E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.31|P-value:3.21E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.67|P-value:3.27E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.81|P-value:2.02E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.89|P-value:1.53E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.05|P-value:8.54E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:4.50|P-value:1.49E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.47|P-value:7.16E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.83|P-value:3.26E-8 ID:SGTC_118|Compound:0083-0097|FD-Score:7.08|P-value:2.85E-11 ID:SGTC_119|Compound:0121-0043|FD-Score:6.42|P-value:1.41E-9 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.57|P-value:4.54E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.45|P-value:6.84E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.90|P-value:1.48E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.91|P-value:2.20E-8 ID:SGTC_211|Compound:3455-0679|FD-Score:3.57|P-value:4.62E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.15|P-value:1.30E-17 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.74|P-value:5.31E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:8.30|P-value:7.71E-15 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.12|P-value:7.63E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.57|P-value:5.21E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.54|P-value:1.66E-7 ID:SGTC_444|Compound:curcumin|FD-Score:-3.77|P-value:2.61E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.11|P-value:9.14E-9 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-4.60|P-value:1.13E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:4.58|P-value:1.07E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.33|P-value:9.92E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.45|P-value:7.61E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.51|P-value:6.23E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.49|P-value:6.70E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.35|P-value:2.73E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:-3.61|P-value:4.51E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.67|P-value:3.30E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.40|P-value:8.01E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.42|P-value:7.54E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.70|P-value:2.95E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.35|P-value:9.50E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.55|P-value:4.88E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.57|P-value:4.63E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.45|P-value:7.61E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.61|P-value:4.09E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.62|P-value:4.34E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.64|P-value:3.69E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.71|P-value:7.35E-6 ID:SGTC_2077|Compound:5212015|FD-Score:4.20|P-value:4.88E-5 ID:SGTC_2167|Compound:5876490|FD-Score:4.31|P-value:3.26E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.37|P-value:8.91E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.18|P-value:5.31E-5 ID:SGTC_2314|Compound:7727897|FD-Score:3.35|P-value:9.32E-4 ID:SGTC_2349|Compound:9023730|FD-Score:-4.12|P-value:7.39E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.48|P-value:6.16E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.39|P-value:8.36E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:5.78|P-value:4.26E-8 ID:SGTC_2556|Compound:citropten|FD-Score:5.22|P-value:6.57E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.90|P-value:1.68E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.54|P-value:5.06E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.05|P-value:8.47E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.25|P-value:3.98E-5 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.72|P-value:3.12E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-8.13|P-value:3.44E-14 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.18|P-value:5.98E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-3.73|P-value:2.99E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-5.53|P-value:1.77E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-4.86|P-value:3.81E-6 ID:SGTC_2959|Compound:9079155|FD-Score:4.36|P-value:2.66E-5 ID:SGTC_2960|Compound:9079389|FD-Score:6.29|P-value:2.92E-9 ID:SGTC_3019|Compound:9081971|FD-Score:-6.86|P-value:1.29E-10 ID:SGTC_3033|Compound:9090887|FD-Score:3.54|P-value:5.02E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.43|P-value:7.19E-4

Top fitness defect scores for YIL014C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.15 5.3 µM 1.30E-17 212 2.96E-20
2 SGTC_310 1273-0058 8.30 1.1 µM 7.71E-15 mitochondrial stress 79 5.11E-17
3 SGTC_118 0083-0097 7.08 135.3 µM 2.85E-11 translation 8 7.41E-13
4 SGTC_119 0121-0043 6.42 24.8 µM 1.41E-9 mitochondrial stress 22 7.00E-11
5 SGTC_2960 9079389 6.29 6.0 µM 2.92E-9 4 1.63E-10
6 SGTC_173 1273-0061 5.91 2.7 µM 2.20E-8 mitochondrial stress 113 1.72E-9
7 SGTC_116 0155-0182 5.83 31.8 µM 3.26E-8 mitochondrial response to ROS 26 2.71E-9
8 SGTC_2555 cholic acid 5.78 100.0 µM 4.26E-8 4 3.70E-9
9 SGTC_275 trichlorophene 5.74 5.7 µM 5.31E-8 mitochondrial stress 128 4.78E-9
10 SGTC_2556 citropten 5.22 84.6 µM 6.57E-7 7 8.92E-8
11 SGTC_676 falcarinol 4.58 140.0 µM 1.07E-5 41 2.29E-6
12 SGTC_70 0141-0289 4.50 43.3 µM 1.49E-5 mitochondrial stress 136 3.36E-6
13 SGTC_2959 9079155 4.36 11.0 µM 2.66E-5 18 6.55E-6
14 SGTC_1036 k216-0215 4.35 33.5 µM 2.73E-5 mitochondrial response to ROS 40 6.77E-6
15 SGTC_10 0279-0212 4.31 42.6 µM 3.21E-5 TRP & mitochondrial translation 104 8.16E-6
16 SGTC_2167 5876490 4.31 200.0 µM 3.26E-5 23 8.29E-6
17 SGTC_2688 kanamycin b 4.25 96.7 µM 3.98E-5 calcium & mitochondrial duress 326 1.05E-5
18 SGTC_2077 5212015 4.20 200.0 µM 4.88E-5 59 1.33E-5
19 SGTC_2250 alverine citrate 4.18 130.0 µM 5.31E-5 140 1.46E-5
20 SGTC_2626 ethyl orsellinate 4.05 100.0 µM 8.47E-5 32 2.51E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.432 1.48E-152 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.422 3.83E-145 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.416 2.36E-140 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.413 1.37E-138 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.412 1.96E-137 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.409 7.57E-136 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.408 4.83E-135 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.389 6.55E-122 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.387 5.30E-120 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.382 1.01E-116 YCR046C IMG1 hom Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome
0.381 3.93E-116 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.378 1.34E-114 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.376 6.35E-113 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.371 3.67E-110 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.371 6.64E-110 YGR222W PET54 hom Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing