YIL016W / SNL1

Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL016W / SNL1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:-3.26|P-value:3.43E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.38|P-value:2.59E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:4.11|P-value:9.40E-6 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.66|P-value:7.08E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:4.72|P-value:4.59E-7 ID:SGTC_343|Compound:4130-2827|FD-Score:3.11|P-value:6.00E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-4.49|P-value:1.48E-6 ID:SGTC_480|Compound:am 92016|FD-Score:3.52|P-value:1.23E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.15|P-value:5.29E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.97|P-value:1.17E-7 ID:SGTC_605|Compound:1315-0399|FD-Score:4.36|P-value:2.86E-6 ID:SGTC_618|Compound:k072-0232|FD-Score:3.54|P-value:1.16E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.60|P-value:9.08E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.19|P-value:4.45E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.01|P-value:1.53E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.64|P-value:7.54E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:3.09|P-value:6.44E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.12|P-value:5.82E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.36|P-value:2.35E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:-2.97|P-value:9.96E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.97|P-value:9.92E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.44|P-value:1.91E-6 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.26|P-value:3.43E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.47|P-value:1.62E-6 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.56|P-value:1.08E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.19|P-value:4.49E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.46|P-value:1.60E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.14|P-value:5.33E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.18|P-value:4.61E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.25|P-value:3.56E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.12|P-value:5.86E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.75|P-value:4.80E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.71|P-value:5.53E-5 ID:SGTC_1719|Compound:st032227|FD-Score:5.14|P-value:4.54E-8 ID:SGTC_1754|Compound:st042065|FD-Score:3.06|P-value:7.25E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.73|P-value:5.09E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.46|P-value:1.56E-4 ID:SGTC_1969|Compound:st069479|FD-Score:-3.27|P-value:3.36E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.28|P-value:3.17E-4 ID:SGTC_1974|Compound:st069448|FD-Score:2.99|P-value:9.24E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.86|P-value:2.94E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.05|P-value:7.47E-4 ID:SGTC_2008|Compound:4012253|FD-Score:4.94|P-value:1.36E-7 ID:SGTC_2010|Compound:4012422|FD-Score:9.65|P-value:4.78E-24 ID:SGTC_2026|Compound:5148700|FD-Score:3.77|P-value:4.34E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.23|P-value:3.88E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.03|P-value:7.94E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.03|P-value:7.98E-4 ID:SGTC_2330|Compound:7979373|FD-Score:5.80|P-value:7.90E-10 ID:SGTC_2424|Compound:5537928|FD-Score:3.07|P-value:6.94E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:5.31|P-value:1.68E-8 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:2.99|P-value:9.32E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.13|P-value:5.59E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.63|P-value:8.02E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-3.01|P-value:8.75E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.59|P-value:9.37E-5 ID:SGTC_2982|Compound:9019404|FD-Score:3.14|P-value:5.38E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.63|P-value:8.02E-5 ID:SGTC_3085|Compound:9117376|FD-Score:-3.00|P-value:9.00E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.03|P-value:1.38E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.04|P-value:7.74E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:-3.26|P-value:3.43E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.38|P-value:2.59E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:4.11|P-value:9.40E-6 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.66|P-value:7.08E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:4.72|P-value:4.59E-7 ID:SGTC_343|Compound:4130-2827|FD-Score:3.11|P-value:6.00E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-4.49|P-value:1.48E-6 ID:SGTC_480|Compound:am 92016|FD-Score:3.52|P-value:1.23E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.15|P-value:5.29E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.97|P-value:1.17E-7 ID:SGTC_605|Compound:1315-0399|FD-Score:4.36|P-value:2.86E-6 ID:SGTC_618|Compound:k072-0232|FD-Score:3.54|P-value:1.16E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.60|P-value:9.08E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.19|P-value:4.45E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.01|P-value:1.53E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.64|P-value:7.54E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:3.09|P-value:6.44E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.12|P-value:5.82E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.36|P-value:2.35E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:-2.97|P-value:9.96E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.97|P-value:9.92E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.44|P-value:1.91E-6 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.43|P-value:1.82E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.26|P-value:3.43E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.47|P-value:1.62E-6 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.56|P-value:1.08E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.19|P-value:4.49E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.46|P-value:1.60E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.14|P-value:5.33E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.18|P-value:4.61E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.25|P-value:3.56E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.12|P-value:5.86E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.75|P-value:4.80E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.71|P-value:5.53E-5 ID:SGTC_1719|Compound:st032227|FD-Score:5.14|P-value:4.54E-8 ID:SGTC_1754|Compound:st042065|FD-Score:3.06|P-value:7.25E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.73|P-value:5.09E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.46|P-value:1.56E-4 ID:SGTC_1969|Compound:st069479|FD-Score:-3.27|P-value:3.36E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.28|P-value:3.17E-4 ID:SGTC_1974|Compound:st069448|FD-Score:2.99|P-value:9.24E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.86|P-value:2.94E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.05|P-value:7.47E-4 ID:SGTC_2008|Compound:4012253|FD-Score:4.94|P-value:1.36E-7 ID:SGTC_2010|Compound:4012422|FD-Score:9.65|P-value:4.78E-24 ID:SGTC_2026|Compound:5148700|FD-Score:3.77|P-value:4.34E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.23|P-value:3.88E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.03|P-value:7.94E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.03|P-value:7.98E-4 ID:SGTC_2330|Compound:7979373|FD-Score:5.80|P-value:7.90E-10 ID:SGTC_2424|Compound:5537928|FD-Score:3.07|P-value:6.94E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:5.31|P-value:1.68E-8 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:2.99|P-value:9.32E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.13|P-value:5.59E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.63|P-value:8.02E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-3.01|P-value:8.75E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.59|P-value:9.37E-5 ID:SGTC_2982|Compound:9019404|FD-Score:3.14|P-value:5.38E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.63|P-value:8.02E-5 ID:SGTC_3085|Compound:9117376|FD-Score:-3.00|P-value:9.00E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.03|P-value:1.38E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.04|P-value:7.74E-4

Top fitness defect scores for YIL016W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2010 4012422 9.65 159.0 µM 4.78E-24 1 2.39E-22
2 SGTC_2330 7979373 5.80 200.0 µM 7.90E-10 60S ribosome export 10 3.32E-9
3 SGTC_2521 angolensin 5.31 13.4 µM 1.68E-8 3 5.62E-8
4 SGTC_1719 st032227 5.14 49.2 µM 4.54E-8 8 1.41E-7
5 SGTC_594 1487-1584 4.97 10.8 µM 1.17E-7 10 3.39E-7
6 SGTC_2008 4012253 4.94 172.0 µM 1.36E-7 6 3.90E-7
7 SGTC_167 3672-0051 4.72 66.2 µM 4.59E-7 27 1.20E-6
8 SGTC_1166 k206-0078 4.47 225.0 µM 1.62E-6 11 3.85E-6
9 SGTC_1006 4099-6547 4.44 255.0 µM 1.91E-6 12 4.49E-6
10 SGTC_60 0986-0278 4.38 202.0 µM 2.59E-6 7 5.97E-6
11 SGTC_605 1315-0399 4.36 119.0 µM 2.86E-6 Golgi 18 6.53E-6
12 SGTC_73 0327-0325 4.11 16.2 µM 9.40E-6 DNA damage response 45 1.97E-5
13 SGTC_3234 9132280 4.03 49.5 µM 1.38E-5 16 2.81E-5
14 SGTC_672 1441-0018 4.01 53.7 µM 1.53E-5 20 3.09E-5
15 SGTC_1977 st070720 3.86 65.3 µM 2.94E-5 11 5.66E-5
16 SGTC_2026 5148700 3.77 152.0 µM 4.34E-5 20 8.13E-5
17 SGTC_1653 st012112 3.75 65.0 µM 4.80E-5 17 8.91E-5
18 SGTC_1902 st060212 3.73 70.5 µM 5.09E-5 16 9.41E-5
19 SGTC_1718 roemerine 3.71 11.9 µM 5.53E-5 redox potentiating 64 1.02E-4
20 SGTC_692 k241-0027 3.64 77.8 µM 7.54E-5 14 1.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.90E-13 YNL137C NAM9 het Mitochondrial ribosomal component of the small subunit
0.105 1.16E-9 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.093 5.81E-8 YNL253W TEX1 hom Protein involved in mRNA export, component of the transcription export (TREX) complex
0.084 1.05E-6 YPR196W_p YPR196W_p hom Putative maltose-responsive transcription factor
0.082 1.77E-6 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.082 1.93E-6 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.081 2.54E-6 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.077 7.88E-6 YOR351C MEK1 hom Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
0.076 1.10E-5 YJL190C RPS22A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication
0.074 1.68E-5 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.074 1.81E-5 YKL015W PUT3 hom Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain
0.073 2.40E-5 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.073 2.37E-5 YGR152C RSR1 hom GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
0.071 3.69E-5 YJR124C_p YJR124C_p hom Putative protein of unknown function; expression induced under calcium shortage
0.070 4.38E-5 YDR301W CFT1 het RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF