YIL018W / RPL2B

Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL018W / RPL2B

Click on Significant Values for Screen Details ID:SGTC_165|Compound:k038-0023|FD-Score:-3.93|P-value:4.99E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.36|P-value:2.91E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.14|P-value:2.09E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.49|P-value:2.87E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-5.15|P-value:1.57E-7 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.25|P-value:4.72E-8 ID:SGTC_552|Compound:k242-0005|FD-Score:3.31|P-value:3.57E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.36|P-value:2.99E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.05|P-value:8.90E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:4.37|P-value:4.22E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:3.33|P-value:3.30E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.37|P-value:2.83E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.90|P-value:5.65E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:3.15|P-value:6.31E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.79|P-value:9.08E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:3.15|P-value:6.23E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.27|P-value:4.08E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.41|P-value:2.48E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.19|P-value:5.54E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.74|P-value:1.07E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.88|P-value:3.82E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.54|P-value:1.51E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.18|P-value:8.55E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.17|P-value:8.80E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.10|P-value:7.57E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.40|P-value:2.54E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.20|P-value:9.48E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.15|P-value:9.56E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.81|P-value:4.96E-5 ID:SGTC_2025|Compound:5147754|FD-Score:-3.58|P-value:2.06E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.98|P-value:2.46E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.24|P-value:4.58E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.63|P-value:2.19E-6 ID:SGTC_2435|Compound:5706476|FD-Score:4.77|P-value:5.99E-7 ID:SGTC_2517|Compound:totarol|FD-Score:3.39|P-value:2.59E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.32|P-value:5.26E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:6.15|P-value:2.26E-10 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.61|P-value:1.13E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-4.29|P-value:1.07E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.55|P-value:2.55E-18 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.86|P-value:6.81E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.67|P-value:9.05E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.32|P-value:5.20E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.37|P-value:4.49E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.11|P-value:7.16E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.53|P-value:3.98E-11 ID:SGTC_2950|Compound:9072895|FD-Score:4.85|P-value:4.13E-7 ID:SGTC_3131|Compound:9127911|FD-Score:-3.37|P-value:4.44E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.09|P-value:7.74E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.02|P-value:2.08E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.93|P-value:4.99E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.36|P-value:2.91E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.14|P-value:2.09E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.49|P-value:2.87E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-5.15|P-value:1.57E-7 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.25|P-value:4.72E-8 ID:SGTC_552|Compound:k242-0005|FD-Score:3.31|P-value:3.57E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:3.36|P-value:2.99E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.05|P-value:8.90E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:4.37|P-value:4.22E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:3.33|P-value:3.30E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.37|P-value:2.83E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.90|P-value:5.65E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:3.15|P-value:6.31E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.79|P-value:9.08E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:3.15|P-value:6.23E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.27|P-value:4.08E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.41|P-value:2.48E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.19|P-value:5.54E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.74|P-value:1.07E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.88|P-value:3.82E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.54|P-value:1.51E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.18|P-value:8.55E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.17|P-value:8.80E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.10|P-value:7.57E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.40|P-value:2.54E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.20|P-value:9.48E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.15|P-value:9.56E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.81|P-value:4.96E-5 ID:SGTC_2025|Compound:5147754|FD-Score:-3.58|P-value:2.06E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.98|P-value:2.46E-5 ID:SGTC_2248|Compound:tofa|FD-Score:3.24|P-value:4.58E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.63|P-value:2.19E-6 ID:SGTC_2435|Compound:5706476|FD-Score:4.77|P-value:5.99E-7 ID:SGTC_2517|Compound:totarol|FD-Score:3.39|P-value:2.59E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.32|P-value:5.26E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:6.15|P-value:2.26E-10 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.61|P-value:1.13E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-4.29|P-value:1.07E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.55|P-value:2.55E-18 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.86|P-value:6.81E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.67|P-value:9.05E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.32|P-value:5.20E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.37|P-value:4.49E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.11|P-value:7.16E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.53|P-value:3.98E-11 ID:SGTC_2950|Compound:9072895|FD-Score:4.85|P-value:4.13E-7 ID:SGTC_3131|Compound:9127911|FD-Score:-3.37|P-value:4.44E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.09|P-value:7.74E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.02|P-value:2.08E-5

Top fitness defect scores for YIL018W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 8.55 100.0 µM 2.55E-18 redox potentiating 94 6.09E-18
2 SGTC_2563 tomatine 6.15 8.5 µM 2.26E-10 7 3.97E-10
3 SGTC_391 gliotoxin 5.25 8.3 µM 4.72E-8 35 7.51E-8
4 SGTC_2950 9072895 4.85 21.5 µM 4.13E-7 18 6.29E-7
5 SGTC_2435 5706476 4.77 10.6 µM 5.99E-7 13 9.05E-7
6 SGTC_735 3076-0345 4.37 636.0 µM 4.22E-6 19 6.13E-6
7 SGTC_1881 5652484 4.20 16.0 µM 9.48E-6 TRP & mitochondrial translation 26 1.35E-5
8 SGTC_3218 9131285 4.02 49.5 µM 2.08E-5 endomembrane recycling 40 2.92E-5
9 SGTC_2048 5246248 3.98 200.0 µM 2.46E-5 5 3.44E-5
10 SGTC_1280 0880-0253 3.88 10.1 µM 3.82E-5 19 5.29E-5
11 SGTC_1929 genistein trimethyl ether 3.81 50.5 µM 4.96E-5 19 6.83E-5
12 SGTC_2596 sinensetin 3.67 100.0 µM 9.05E-5 40 1.23E-4
13 SGTC_1067 clotrimazole 3.64 1.4 µM 1.02E-4 azole & statin 49 1.39E-4
14 SGTC_2565 isoliquiritigenin 3.61 100.0 µM 1.13E-4 42 1.52E-4
15 SGTC_1285 0929-0069 3.54 65.5 µM 1.51E-4 32 2.02E-4
16 SGTC_1059 3448-6867 3.41 171.0 µM 2.48E-4 24 3.29E-4
17 SGTC_1844 rapamycin 3.40 4.0 nM 2.54E-4 203 3.37E-4
18 SGTC_2517 totarol 3.39 10.0 µM 2.59E-4 38 3.43E-4
19 SGTC_815 1582-0027 3.37 36.9 µM 2.83E-4 58 3.75E-4
20 SGTC_321 4534-3890 3.36 65.3 µM 2.91E-4 RPP1 & pyrimidine depletion 11 3.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.235 3.70E-43 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.206 1.30E-33 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.184 5.41E-27 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.180 7.70E-26 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.167 1.78E-22 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.166 3.46E-22 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.157 5.89E-20 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.156 7.83E-20 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.154 2.82E-19 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.153 4.49E-19 YOR189W IES4 hom Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses
0.153 4.90E-19 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.146 1.64E-17 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.146 1.76E-17 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.144 5.40E-17 YKL028W TFA1 het TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
0.143 8.68E-17 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide