YIL020C / HIS6

Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL020C / HIS6

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:3.29|P-value:7.18E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.26|P-value:2.59E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.38|P-value:6.70E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:-3.78|P-value:1.64E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.86|P-value:9.45E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:3.95|P-value:6.51E-5 ID:SGTC_154|Compound:3389-1638|FD-Score:3.81|P-value:1.11E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.34|P-value:5.90E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.35|P-value:5.82E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:4.62|P-value:3.97E-6 ID:SGTC_393|Compound:acivicin|FD-Score:3.88|P-value:8.45E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:3.91|P-value:7.58E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.47|P-value:5.01E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.41|P-value:4.68E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:3.27|P-value:7.61E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.55|P-value:7.53E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.01|P-value:5.24E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.44|P-value:4.21E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.78|P-value:1.26E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:4.36|P-value:1.24E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.51|P-value:3.29E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-4.17|P-value:3.75E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.30|P-value:8.67E-4 ID:SGTC_1790|Compound:st045711|FD-Score:-3.69|P-value:2.30E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.39|P-value:5.09E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.21|P-value:9.31E-4 ID:SGTC_1967|Compound:st070177|FD-Score:5.27|P-value:1.80E-7 ID:SGTC_1972|Compound:st070201|FD-Score:6.90|P-value:1.46E-11 ID:SGTC_1975|Compound:st070967|FD-Score:-3.57|P-value:3.59E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.31|P-value:6.64E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.98|P-value:7.73E-5 ID:SGTC_2356|Compound:9061756|FD-Score:-3.61|P-value:3.02E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.52|P-value:8.66E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:5.53|P-value:4.54E-8 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.48|P-value:3.66E-4 ID:SGTC_2505|Compound:galangin|FD-Score:6.15|P-value:1.51E-9 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.56|P-value:5.15E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.29|P-value:7.15E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.71|P-value:1.62E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.37|P-value:5.50E-4 ID:SGTC_2926|Compound:9010726|FD-Score:5.51|P-value:5.06E-8 ID:SGTC_2942|Compound:9052777|FD-Score:-3.59|P-value:3.30E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.53|P-value:4.10E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.76|P-value:1.78E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.28|P-value:7.25E-4 ID:SGTC_3142|Compound:9086498|FD-Score:6.01|P-value:3.25E-9 ID:SGTC_3181|Compound:9108277|FD-Score:-4.97|P-value:1.11E-6 ID:SGTC_3183|Compound:9108214|FD-Score:3.75|P-value:1.43E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.35|P-value:5.87E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.72|P-value:1.56E-4 ID:SGTC_13|Compound:0199-0087|FD-Score:3.29|P-value:7.18E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.26|P-value:2.59E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.38|P-value:6.70E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:-3.78|P-value:1.64E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.86|P-value:9.45E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:3.95|P-value:6.51E-5 ID:SGTC_154|Compound:3389-1638|FD-Score:3.81|P-value:1.11E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.34|P-value:5.90E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.35|P-value:5.82E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:4.62|P-value:3.97E-6 ID:SGTC_393|Compound:acivicin|FD-Score:3.88|P-value:8.45E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:3.91|P-value:7.58E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.47|P-value:5.01E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.41|P-value:4.68E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:3.27|P-value:7.61E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.55|P-value:7.53E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.01|P-value:5.24E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.44|P-value:4.21E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.78|P-value:1.26E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:4.36|P-value:1.24E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.51|P-value:3.29E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-4.17|P-value:3.75E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.30|P-value:8.67E-4 ID:SGTC_1790|Compound:st045711|FD-Score:-3.69|P-value:2.30E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.39|P-value:5.09E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.21|P-value:9.31E-4 ID:SGTC_1967|Compound:st070177|FD-Score:5.27|P-value:1.80E-7 ID:SGTC_1972|Compound:st070201|FD-Score:6.90|P-value:1.46E-11 ID:SGTC_1975|Compound:st070967|FD-Score:-3.57|P-value:3.59E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.31|P-value:6.64E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.98|P-value:7.73E-5 ID:SGTC_2356|Compound:9061756|FD-Score:-3.61|P-value:3.02E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-4.52|P-value:8.66E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:5.53|P-value:4.54E-8 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.48|P-value:3.66E-4 ID:SGTC_2505|Compound:galangin|FD-Score:6.15|P-value:1.51E-9 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.56|P-value:5.15E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.29|P-value:7.15E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.71|P-value:1.62E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.37|P-value:5.50E-4 ID:SGTC_2926|Compound:9010726|FD-Score:5.51|P-value:5.06E-8 ID:SGTC_2942|Compound:9052777|FD-Score:-3.59|P-value:3.30E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.53|P-value:4.10E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.76|P-value:1.78E-4 ID:SGTC_3076|Compound:9116187|FD-Score:3.28|P-value:7.25E-4 ID:SGTC_3142|Compound:9086498|FD-Score:6.01|P-value:3.25E-9 ID:SGTC_3181|Compound:9108277|FD-Score:-4.97|P-value:1.11E-6 ID:SGTC_3183|Compound:9108214|FD-Score:3.75|P-value:1.43E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.35|P-value:5.87E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.72|P-value:1.56E-4

Top fitness defect scores for YIL020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1972 st070201 6.90 17.4 µM 1.46E-11 5 2.66E-12
2 SGTC_2505 galangin 6.15 7.9 µM 1.51E-9 RPP1 & pyrimidine depletion 2 3.98E-10
3 SGTC_3142 9086498 6.01 49.5 µM 3.25E-9 iron homeostasis 6 9.06E-10
4 SGTC_2420 aureobasidin a 5.53 50.0 nM 4.54E-8 15 1.56E-8
5 SGTC_2926 9010726 5.51 65.2 µM 5.06E-8 10 1.75E-8
6 SGTC_1967 st070177 5.27 51.4 µM 1.80E-7 3 6.87E-8
7 SGTC_385 1494-0393 4.62 12.4 µM 3.97E-6 10 1.92E-6
8 SGTC_2651 1327-0036 4.56 5.0 µM 5.15E-6 133 2.54E-6
9 SGTC_1472 k841-0093 4.36 193.0 µM 1.24E-5 10 6.52E-6
10 SGTC_1133 3473-0247 4.01 50.0 µM 5.24E-5 RSC complex & mRNA processing 46 3.07E-5
11 SGTC_139 0099-0334 3.95 718.6 µM 6.51E-5 28 3.88E-5
12 SGTC_404 fumagillin 3.91 50.0 µM 7.58E-5 22 4.56E-5
13 SGTC_393 acivicin 3.88 6.2 µM 8.45E-5 24 5.13E-5
14 SGTC_136 0097-0015 3.86 404.5 µM 9.45E-5 60S ribosome export 18 5.78E-5
15 SGTC_154 3389-1638 3.81 511.1 µM 1.11E-4 26 6.86E-5
16 SGTC_1164 k060-0068 3.78 93.7 µM 1.26E-4 33 7.90E-5
17 SGTC_3183 9108214 3.75 49.5 µM 1.43E-4 RPP1 & pyrimidine depletion 3 9.00E-5
18 SGTC_3308 9128332 3.72 17.6 µM 1.56E-4 plasma membrane duress 86 9.94E-5
19 SGTC_2797 7859098 3.71 81.8 µM 1.62E-4 32 1.03E-4
20 SGTC_1533 dihydroergotamine mesylate 3.51 29.4 µM 3.29E-4 DNA intercalators 20 2.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.51E-13 YPL218W SAR1 het GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport
0.109 2.71E-10 YJL028W YJL028W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.102 3.27E-9 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.098 1.09E-8 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.097 1.71E-8 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.094 4.39E-8 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.094 4.49E-8 YKL120W OAC1 hom Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family
0.089 2.40E-7 YNL201C PSY2 hom Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3
0.088 3.21E-7 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.082 1.77E-6 YNL306W MRPS18 het Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
0.079 4.44E-6 YDL141W BPL1 het Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
0.077 7.24E-6 YML085C TUB1 het Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication
0.076 1.12E-5 YPR035W GLN1 het Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.075 1.23E-5 YDR128W MTC5 hom Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress
0.074 1.58E-5 YDR453C TSA2 hom Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress