YIL022W / TIM44

Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL022W / TIM44

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.02|P-value:3.93E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.74|P-value:6.97E-8 ID:SGTC_91|Compound:0417-1751|FD-Score:-2.81|P-value:9.40E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:5.36|P-value:1.30E-9 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.90|P-value:2.69E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.66|P-value:2.49E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:-2.93|P-value:5.76E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:10.90|P-value:3.63E-34 ID:SGTC_168|Compound:3970-0862|FD-Score:2.78|P-value:9.87E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.77|P-value:1.47E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:-4.20|P-value:1.59E-6 ID:SGTC_235|Compound:0330-0087|FD-Score:3.81|P-value:1.15E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.10|P-value:2.84E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:2.96|P-value:4.92E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.12|P-value:6.24E-9 ID:SGTC_288|Compound:1315-0019|FD-Score:-2.84|P-value:8.36E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.53|P-value:4.42E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:3.26|P-value:1.42E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.47|P-value:3.39E-7 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.72|P-value:1.84E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.00|P-value:4.26E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.96|P-value:5.18E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:2.82|P-value:8.45E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.86|P-value:3.44E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.14|P-value:2.38E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-5.70|P-value:1.27E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:5.17|P-value:4.74E-9 ID:SGTC_629|Compound:3448-6466|FD-Score:3.15|P-value:2.27E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:2.85|P-value:7.58E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-2.97|P-value:4.91E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.70|P-value:9.20E-8 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.10|P-value:2.90E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:-2.87|P-value:7.25E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.22|P-value:1.74E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:2.81|P-value:8.98E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.47|P-value:5.69E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.21|P-value:1.90E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.12|P-value:2.76E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:2.87|P-value:7.21E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.53|P-value:2.41E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.82|P-value:5.01E-11 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.59|P-value:3.49E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:-5.51|P-value:4.94E-10 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.59|P-value:3.27E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.28|P-value:1.04E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:-2.93|P-value:5.95E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.60|P-value:1.27E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.99|P-value:1.59E-8 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.31|P-value:1.20E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.76|P-value:1.53E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:3.73|P-value:1.73E-5 ID:SGTC_1652|Compound:st011932|FD-Score:2.98|P-value:4.56E-4 ID:SGTC_1658|Compound:st012944|FD-Score:6.91|P-value:8.22E-15 ID:SGTC_1666|Compound:st014829|FD-Score:3.58|P-value:3.42E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.84|P-value:1.06E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.28|P-value:1.34E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-2.87|P-value:7.46E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.08|P-value:3.07E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.17|P-value:1.78E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:2.99|P-value:4.51E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.72|P-value:1.88E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.54|P-value:4.09E-5 ID:SGTC_2342|Compound:7990637|FD-Score:-3.39|P-value:8.42E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.75|P-value:8.14E-11 ID:SGTC_2601|Compound:securinine|FD-Score:-3.43|P-value:7.21E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:2.95|P-value:5.21E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.32|P-value:1.16E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-5.54|P-value:4.18E-10 ID:SGTC_2651|Compound:1327-0036|FD-Score:12.80|P-value:2.05E-46 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.24|P-value:1.61E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.14|P-value:5.48E-9 ID:SGTC_2739|Compound:tacrine|FD-Score:-2.99|P-value:4.68E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.27|P-value:1.42E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-3.51|P-value:5.03E-5 ID:SGTC_3347|Compound:9188721|FD-Score:3.04|P-value:3.67E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.02|P-value:3.93E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.74|P-value:6.97E-8 ID:SGTC_91|Compound:0417-1751|FD-Score:-2.81|P-value:9.40E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:5.36|P-value:1.30E-9 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.90|P-value:2.69E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.66|P-value:2.49E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:-2.93|P-value:5.76E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:10.90|P-value:3.63E-34 ID:SGTC_168|Compound:3970-0862|FD-Score:2.78|P-value:9.87E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.77|P-value:1.47E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:-4.20|P-value:1.59E-6 ID:SGTC_235|Compound:0330-0087|FD-Score:3.81|P-value:1.15E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.10|P-value:2.84E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:2.96|P-value:4.92E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.12|P-value:6.24E-9 ID:SGTC_288|Compound:1315-0019|FD-Score:-2.84|P-value:8.36E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.53|P-value:4.42E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:3.26|P-value:1.42E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.47|P-value:3.39E-7 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.72|P-value:1.84E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.00|P-value:4.26E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-2.96|P-value:5.18E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:2.82|P-value:8.45E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:4.86|P-value:3.44E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.14|P-value:2.38E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-5.70|P-value:1.27E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:5.17|P-value:4.74E-9 ID:SGTC_629|Compound:3448-6466|FD-Score:3.15|P-value:2.27E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:2.85|P-value:7.58E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-2.97|P-value:4.91E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.70|P-value:9.20E-8 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.10|P-value:2.90E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:-2.87|P-value:7.25E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.22|P-value:1.74E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:2.81|P-value:8.98E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.47|P-value:5.69E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:-3.21|P-value:1.90E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.12|P-value:2.76E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:2.87|P-value:7.21E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.53|P-value:2.41E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.82|P-value:5.01E-11 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.59|P-value:3.49E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:-5.51|P-value:4.94E-10 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.59|P-value:3.27E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.28|P-value:1.04E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:-2.93|P-value:5.95E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.60|P-value:1.27E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.99|P-value:1.59E-8 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.31|P-value:1.20E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.76|P-value:1.53E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:3.73|P-value:1.73E-5 ID:SGTC_1652|Compound:st011932|FD-Score:2.98|P-value:4.56E-4 ID:SGTC_1658|Compound:st012944|FD-Score:6.91|P-value:8.22E-15 ID:SGTC_1666|Compound:st014829|FD-Score:3.58|P-value:3.42E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.84|P-value:1.06E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.28|P-value:1.34E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-2.87|P-value:7.46E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.08|P-value:3.07E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.17|P-value:1.78E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:2.99|P-value:4.51E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.72|P-value:1.88E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.54|P-value:4.09E-5 ID:SGTC_2342|Compound:7990637|FD-Score:-3.39|P-value:8.42E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.75|P-value:8.14E-11 ID:SGTC_2601|Compound:securinine|FD-Score:-3.43|P-value:7.21E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:2.95|P-value:5.21E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.32|P-value:1.16E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-5.54|P-value:4.18E-10 ID:SGTC_2651|Compound:1327-0036|FD-Score:12.80|P-value:2.05E-46 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.24|P-value:1.61E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.14|P-value:5.48E-9 ID:SGTC_2739|Compound:tacrine|FD-Score:-2.99|P-value:4.68E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.27|P-value:1.42E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-3.51|P-value:5.03E-5 ID:SGTC_3347|Compound:9188721|FD-Score:3.04|P-value:3.67E-4

Top fitness defect scores for YIL022W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2651 1327-0036 12.80 5.0 µM 2.05E-46 9 4.93E-38 0.64
2 SGTC_163 1327-0036 10.90 7.5 µM 3.63E-34 13 4.40E-28 0.13
3 SGTC_1658 st012944 6.91 20.0 µM 8.22E-15 iron homeostasis 3 2.41E-12 0.70
4 SGTC_1161 k007-0610 5.82 110.0 µM 5.01E-11 ERAD & cell cycle 18 2.92E-9 0.29
5 SGTC_2567 aureobasidin a 5.75 60.0 nM 8.14E-11 20 4.34E-9 0.17
6 SGTC_137 0438-0332 5.36 85.4 µM 1.30E-9 ubiquinone biosynthesis & proteasome 23 4.16E-8 0.09
7 SGTC_514 4466-0038 5.17 2.6 nM 4.74E-9 cell wall 26 1.19E-7 0.38
8 SGTC_2688 kanamycin b 5.14 96.7 µM 5.48E-9 calcium & mitochondrial duress 3 1.34E-7 0.05
9 SGTC_266 formosanin C 5.12 406.0 nM 6.24E-9 sphingolipid biosynthesis & PDR1 13 1.49E-7 0.10
10 SGTC_435 c-PAF 4.86 6.7 µM 3.44E-8 12 6.01E-7 0.57
11 SGTC_70 0141-0289 4.74 43.3 µM 6.97E-8 mitochondrial stress 14 1.07E-6 0.09
12 SGTC_1116 jasmonic acid 4.53 1.6 µM 2.41E-7 3 2.95E-6 0.62
13 SGTC_373 0844-0104 4.47 25.9 µM 3.39E-7 ERAD & cell cycle 8 3.90E-6 0.34
14 SGTC_1935 st074532 4.17 41.6 µM 1.78E-6 5 1.51E-5 0.09
15 SGTC_58 0957-0393 4.02 9.0 µM 3.93E-6 cell wall 50 2.90E-5 0.06
16 SGTC_235 0330-0087 3.81 5.0 mM 1.15E-5 TSC3-RPN4 4 6.97E-5 0.04
17 SGTC_1568 digitonin 3.73 820.0 nM 1.73E-5 sphingolipid biosynthesis & PDR1 18 9.75E-5 0.05
18 SGTC_1348 1493-0373 3.59 93.8 µM 3.27E-5 8 1.64E-4 0.19
19 SGTC_1666 st014829 3.58 29.0 µM 3.42E-5 calcium & mitochondrial duress 8 1.70E-4 0.09
20 SGTC_2340 7987427 3.54 183.4 µM 4.09E-5 9 1.97E-4 0.36

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.426 4.38E-148 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.414 3.73E-139 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.381 2.02E-116 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.366 4.04E-107 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.361 7.41E-104 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.329 3.11E-85 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.325 1.44E-83 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.313 4.60E-77 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.311 2.58E-76 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.266 3.07E-55 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.257 1.30E-51 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.251 3.35E-49 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.247 1.15E-47 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.243 1.86E-46 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.238 2.29E-44 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis