YIL025C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL025C / YIL025C

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.75|P-value:3.58E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.52|P-value:7.56E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.49|P-value:8.21E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.97|P-value:3.27E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:5.55|P-value:2.30E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:3.45|P-value:9.26E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.52|P-value:7.63E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.76|P-value:3.45E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.92|P-value:1.21E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.31|P-value:4.75E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.44|P-value:9.58E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.90|P-value:2.14E-4 ID:SGTC_1758|Compound:st042942|FD-Score:4.13|P-value:9.49E-5 ID:SGTC_1761|Compound:st044296|FD-Score:-3.43|P-value:6.48E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-3.54|P-value:4.50E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.59|P-value:3.82E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.10|P-value:1.07E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.99|P-value:1.56E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-5.62|P-value:8.23E-8 ID:SGTC_2314|Compound:7727897|FD-Score:-3.89|P-value:1.33E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.32|P-value:9.14E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.82|P-value:3.47E-6 ID:SGTC_2427|Compound:5545055|FD-Score:3.98|P-value:1.64E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.33|P-value:8.87E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.07|P-value:1.17E-4 ID:SGTC_2466|Compound:5983409|FD-Score:-3.29|P-value:9.88E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.33|P-value:8.84E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.07|P-value:1.18E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.46|P-value:2.68E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.67|P-value:6.48E-10 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.53|P-value:7.38E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.96|P-value:1.73E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.56|P-value:6.73E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.97|P-value:1.67E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.95|P-value:3.64E-6 ID:SGTC_2951|Compound:9072950|FD-Score:4.18|P-value:7.92E-5 ID:SGTC_2958|Compound:9077254|FD-Score:4.57|P-value:1.74E-5 ID:SGTC_3035|Compound:9091303|FD-Score:4.68|P-value:1.10E-5 ID:SGTC_3112|Compound:9123419|FD-Score:4.15|P-value:8.82E-5 ID:SGTC_3207|Compound:9114163|FD-Score:3.49|P-value:8.21E-4 ID:SGTC_3239|Compound:9133757|FD-Score:3.69|P-value:4.30E-4 ID:SGTC_3254|Compound:9136651|FD-Score:4.94|P-value:3.72E-6 ID:SGTC_3273|Compound:9137859|FD-Score:3.60|P-value:5.92E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.75|P-value:3.58E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.52|P-value:7.56E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.49|P-value:8.21E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.97|P-value:3.27E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:5.55|P-value:2.30E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:3.45|P-value:9.26E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.52|P-value:7.63E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.76|P-value:3.45E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.92|P-value:1.21E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.31|P-value:4.75E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.44|P-value:9.58E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.90|P-value:2.14E-4 ID:SGTC_1758|Compound:st042942|FD-Score:4.13|P-value:9.49E-5 ID:SGTC_1761|Compound:st044296|FD-Score:-3.43|P-value:6.48E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-3.54|P-value:4.50E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.59|P-value:3.82E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.10|P-value:1.07E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.99|P-value:1.56E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-5.62|P-value:8.23E-8 ID:SGTC_2314|Compound:7727897|FD-Score:-3.89|P-value:1.33E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.32|P-value:9.14E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.82|P-value:3.47E-6 ID:SGTC_2427|Compound:5545055|FD-Score:3.98|P-value:1.64E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.33|P-value:8.87E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.07|P-value:1.17E-4 ID:SGTC_2466|Compound:5983409|FD-Score:-3.29|P-value:9.88E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.33|P-value:8.84E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.07|P-value:1.18E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.46|P-value:2.68E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.67|P-value:6.48E-10 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.53|P-value:7.38E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.96|P-value:1.73E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.56|P-value:6.73E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.97|P-value:1.67E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.95|P-value:3.64E-6 ID:SGTC_2951|Compound:9072950|FD-Score:4.18|P-value:7.92E-5 ID:SGTC_2958|Compound:9077254|FD-Score:4.57|P-value:1.74E-5 ID:SGTC_3035|Compound:9091303|FD-Score:4.68|P-value:1.10E-5 ID:SGTC_3112|Compound:9123419|FD-Score:4.15|P-value:8.82E-5 ID:SGTC_3207|Compound:9114163|FD-Score:3.49|P-value:8.21E-4 ID:SGTC_3239|Compound:9133757|FD-Score:3.69|P-value:4.30E-4 ID:SGTC_3254|Compound:9136651|FD-Score:4.94|P-value:3.72E-6 ID:SGTC_3273|Compound:9137859|FD-Score:3.60|P-value:5.92E-4

Top fitness defect scores for YIL025C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2567 aureobasidin a 6.67 60.0 nM 6.48E-10 33 1.31E-11
2 SGTC_515 4092-1064 5.55 102.0 µM 2.30E-7 plasma membrane duress 29 1.41E-8
3 SGTC_391 gliotoxin 4.97 8.3 µM 3.27E-6 40 3.32E-7
4 SGTC_2832 7992762 4.95 52.0 µM 3.64E-6 14 3.78E-7
5 SGTC_3254 9136651 4.94 49.5 µM 3.72E-6 DNA damage response 10 3.87E-7
6 SGTC_3035 9091303 4.68 49.5 µM 1.10E-5 3 1.41E-6
7 SGTC_2958 9077254 4.57 16.7 µM 1.74E-5 14 2.43E-6
8 SGTC_2501 sodium tetradecyl sulfate 4.46 13.4 µM 2.68E-5 22 4.06E-6
9 SGTC_1080 nisoldipine 4.31 24.4 µM 4.75E-5 TSC3-RPN4 19 8.03E-6
10 SGTC_2951 9072950 4.18 58.1 µM 7.92E-5 ERG2 19 1.47E-5
11 SGTC_3112 9123419 4.15 49.5 µM 8.82E-5 RPP1 & pyrimidine depletion 6 1.68E-5
12 SGTC_1758 st042942 4.13 75.2 µM 9.49E-5 14 1.83E-5
13 SGTC_2019 4016004 4.10 108.0 µM 1.07E-4 27 2.11E-5
14 SGTC_2460 5552655 4.07 174.2 µM 1.17E-4 amide catabolism 31 2.36E-5
15 SGTC_2500 5-alpha-androstan-3,17-dione 4.07 61.4 µM 1.18E-4 36 2.37E-5
16 SGTC_2241 6772625 3.99 37.8 µM 1.56E-4 24 3.30E-5
17 SGTC_2427 5545055 3.98 42.8 µM 1.64E-4 14 3.51E-5
18 SGTC_2810 7959871 3.97 45.5 µM 1.67E-4 copper-dependent oxidative stress 39 3.58E-5
19 SGTC_2703 st077852 3.96 53.4 µM 1.73E-4 25 3.73E-5
20 SGTC_1558 st069300 3.90 45.6 µM 2.14E-4 10 4.81E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 1.31E-29 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.136 3.17E-15 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.128 1.21E-13 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.092 8.65E-8 YFR056C_d YFR056C_d hom Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
0.090 1.81E-7 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.086 6.30E-7 YNL062C GCD10 het Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.079 4.26E-6 YLR361C DCR2 hom Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
0.075 1.25E-5 YDR214W AHA1 hom Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress
0.075 1.26E-5 YML049C RSE1 het Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport
0.073 2.47E-5 YOR354C MSC6 hom Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.072 2.85E-5 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.070 5.26E-5 YPR170C_d YPR170C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
0.069 5.80E-5 YIL092W_p YIL092W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
0.069 6.73E-5 YNL318C HXT14 hom Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.068 7.78E-5 YPR027C_p YPR027C_p hom Putative protein of unknown function