YIL026C / IRR1

Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL026C / IRR1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:10.20|P-value:5.40E-20 ID:SGTC_19|Compound:0279-0214|FD-Score:5.62|P-value:2.77E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:11.20|P-value:7.47E-24 ID:SGTC_103|Compound:0844-0104|FD-Score:5.50|P-value:4.74E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:3.84|P-value:3.25E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:7.51|P-value:1.03E-11 ID:SGTC_131|Compound:0141-0277|FD-Score:6.56|P-value:2.42E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:10.20|P-value:4.02E-20 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.46|P-value:8.29E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:12.10|P-value:9.12E-28 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:6.36|P-value:7.17E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:5.59|P-value:3.13E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:4.79|P-value:1.03E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.53|P-value:6.86E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.68|P-value:5.48E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:5.37|P-value:8.76E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:4.77|P-value:1.12E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.97|P-value:1.60E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:6.10|P-value:2.76E-8 ID:SGTC_576|Compound:1073-0113|FD-Score:5.15|P-value:2.32E-6 ID:SGTC_596|Compound:1155-0152|FD-Score:5.90|P-value:7.42E-8 ID:SGTC_614|Compound:0462-0418|FD-Score:3.55|P-value:8.29E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.24|P-value:8.15E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:4.32|P-value:6.16E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.84|P-value:8.18E-6 ID:SGTC_816|Compound:0325-0417|FD-Score:-9.32|P-value:2.22E-17 ID:SGTC_817|Compound:1391-0715|FD-Score:-10.90|P-value:3.54E-23 ID:SGTC_818|Compound:4072-2707|FD-Score:-8.66|P-value:2.82E-15 ID:SGTC_933|Compound:2914-0560|FD-Score:3.88|P-value:2.90E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.51|P-value:3.23E-7 ID:SGTC_991|Compound:3996-0057|FD-Score:7.61|P-value:5.58E-12 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.41|P-value:4.42E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.88|P-value:7.12E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.92|P-value:6.03E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:9.09|P-value:2.38E-16 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.57|P-value:7.76E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.77|P-value:4.08E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.31|P-value:6.34E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.88|P-value:2.20E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.48|P-value:3.45E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.31|P-value:6.40E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.71|P-value:5.03E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:7.24|P-value:5.41E-11 ID:SGTC_1574|Compound:spiramycin|FD-Score:5.30|P-value:1.19E-6 ID:SGTC_1616|Compound:st002734|FD-Score:3.63|P-value:6.44E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.08|P-value:1.47E-4 ID:SGTC_1629|Compound:st005085|FD-Score:7.17|P-value:7.99E-11 ID:SGTC_1635|Compound:st007035|FD-Score:7.17|P-value:7.73E-11 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.26|P-value:7.61E-5 ID:SGTC_1763|Compound:st044482|FD-Score:4.35|P-value:5.44E-5 ID:SGTC_1822|Compound:st052468|FD-Score:3.64|P-value:6.12E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.69|P-value:5.33E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:7.37|P-value:2.34E-11 ID:SGTC_1939|Compound:st074455|FD-Score:8.03|P-value:3.92E-13 ID:SGTC_2014|Compound:4013930|FD-Score:3.87|P-value:2.99E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.45|P-value:3.75E-5 ID:SGTC_2160|Compound:5660466|FD-Score:4.32|P-value:6.18E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.15|P-value:1.15E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.51|P-value:9.32E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.53|P-value:2.79E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.70|P-value:1.47E-5 ID:SGTC_2253|Compound:7938677|FD-Score:6.27|P-value:1.14E-8 ID:SGTC_2254|Compound:7938975|FD-Score:4.87|P-value:7.23E-6 ID:SGTC_2257|Compound:7960413|FD-Score:-3.85|P-value:2.37E-4 ID:SGTC_2260|Compound:7964312|FD-Score:4.97|P-value:4.80E-6 ID:SGTC_2273|Compound:7815444|FD-Score:5.33|P-value:1.05E-6 ID:SGTC_2307|Compound:7538926|FD-Score:5.71|P-value:1.80E-7 ID:SGTC_2452|Compound:5863136|FD-Score:4.89|P-value:6.80E-6 ID:SGTC_2513|Compound:baicalein|FD-Score:10.60|P-value:1.83E-21 ID:SGTC_2516|Compound:gossypol|FD-Score:4.77|P-value:1.11E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.41|P-value:3.19E-5 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:4.05|P-value:1.61E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.47|P-value:5.64E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.19|P-value:7.41E-5 ID:SGTC_2699|Compound:st077704|FD-Score:5.63|P-value:2.64E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:9.78|P-value:1.17E-18 ID:SGTC_2905|Compound:7799065|FD-Score:-3.76|P-value:3.22E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.56|P-value:7.92E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.67|P-value:4.35E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.98|P-value:4.58E-6 ID:SGTC_2995|Compound:9067767|FD-Score:4.12|P-value:1.27E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.54|P-value:8.40E-4 ID:SGTC_3091|Compound:9116372|FD-Score:5.43|P-value:6.60E-7 ID:SGTC_3243|Compound:9134147|FD-Score:-4.25|P-value:6.00E-5 ID:SGTC_3355|Compound:9151058|FD-Score:4.39|P-value:4.78E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:10.20|P-value:5.40E-20 ID:SGTC_19|Compound:0279-0214|FD-Score:5.62|P-value:2.77E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:11.20|P-value:7.47E-24 ID:SGTC_103|Compound:0844-0104|FD-Score:5.50|P-value:4.74E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:3.84|P-value:3.25E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:7.51|P-value:1.03E-11 ID:SGTC_131|Compound:0141-0277|FD-Score:6.56|P-value:2.42E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:10.20|P-value:4.02E-20 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.46|P-value:8.29E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:12.10|P-value:9.12E-28 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:6.36|P-value:7.17E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:5.59|P-value:3.13E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:4.79|P-value:1.03E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.53|P-value:6.86E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.68|P-value:5.48E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:5.37|P-value:8.76E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:4.77|P-value:1.12E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.97|P-value:1.60E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:6.10|P-value:2.76E-8 ID:SGTC_576|Compound:1073-0113|FD-Score:5.15|P-value:2.32E-6 ID:SGTC_596|Compound:1155-0152|FD-Score:5.90|P-value:7.42E-8 ID:SGTC_614|Compound:0462-0418|FD-Score:3.55|P-value:8.29E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.24|P-value:8.15E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:4.32|P-value:6.16E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.84|P-value:8.18E-6 ID:SGTC_816|Compound:0325-0417|FD-Score:-9.32|P-value:2.22E-17 ID:SGTC_817|Compound:1391-0715|FD-Score:-10.90|P-value:3.54E-23 ID:SGTC_818|Compound:4072-2707|FD-Score:-8.66|P-value:2.82E-15 ID:SGTC_933|Compound:2914-0560|FD-Score:3.88|P-value:2.90E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-5.51|P-value:3.23E-7 ID:SGTC_991|Compound:3996-0057|FD-Score:7.61|P-value:5.58E-12 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.41|P-value:4.42E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.88|P-value:7.12E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:4.92|P-value:6.03E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:9.09|P-value:2.38E-16 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.57|P-value:7.76E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.77|P-value:4.08E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.31|P-value:6.34E-5 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.88|P-value:2.20E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.48|P-value:3.45E-5 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.31|P-value:6.40E-5 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.71|P-value:5.03E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:7.24|P-value:5.41E-11 ID:SGTC_1574|Compound:spiramycin|FD-Score:5.30|P-value:1.19E-6 ID:SGTC_1616|Compound:st002734|FD-Score:3.63|P-value:6.44E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.08|P-value:1.47E-4 ID:SGTC_1629|Compound:st005085|FD-Score:7.17|P-value:7.99E-11 ID:SGTC_1635|Compound:st007035|FD-Score:7.17|P-value:7.73E-11 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.26|P-value:7.61E-5 ID:SGTC_1763|Compound:st044482|FD-Score:4.35|P-value:5.44E-5 ID:SGTC_1822|Compound:st052468|FD-Score:3.64|P-value:6.12E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.69|P-value:5.33E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:7.37|P-value:2.34E-11 ID:SGTC_1939|Compound:st074455|FD-Score:8.03|P-value:3.92E-13 ID:SGTC_2014|Compound:4013930|FD-Score:3.87|P-value:2.99E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.45|P-value:3.75E-5 ID:SGTC_2160|Compound:5660466|FD-Score:4.32|P-value:6.18E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.15|P-value:1.15E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.51|P-value:9.32E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.53|P-value:2.79E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.70|P-value:1.47E-5 ID:SGTC_2253|Compound:7938677|FD-Score:6.27|P-value:1.14E-8 ID:SGTC_2254|Compound:7938975|FD-Score:4.87|P-value:7.23E-6 ID:SGTC_2257|Compound:7960413|FD-Score:-3.85|P-value:2.37E-4 ID:SGTC_2260|Compound:7964312|FD-Score:4.97|P-value:4.80E-6 ID:SGTC_2273|Compound:7815444|FD-Score:5.33|P-value:1.05E-6 ID:SGTC_2307|Compound:7538926|FD-Score:5.71|P-value:1.80E-7 ID:SGTC_2452|Compound:5863136|FD-Score:4.89|P-value:6.80E-6 ID:SGTC_2513|Compound:baicalein|FD-Score:10.60|P-value:1.83E-21 ID:SGTC_2516|Compound:gossypol|FD-Score:4.77|P-value:1.11E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.41|P-value:3.19E-5 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:4.05|P-value:1.61E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.47|P-value:5.64E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.19|P-value:7.41E-5 ID:SGTC_2699|Compound:st077704|FD-Score:5.63|P-value:2.64E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:9.78|P-value:1.17E-18 ID:SGTC_2905|Compound:7799065|FD-Score:-3.76|P-value:3.22E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.56|P-value:7.92E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.67|P-value:4.35E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.98|P-value:4.58E-6 ID:SGTC_2995|Compound:9067767|FD-Score:4.12|P-value:1.27E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.54|P-value:8.40E-4 ID:SGTC_3091|Compound:9116372|FD-Score:5.43|P-value:6.60E-7 ID:SGTC_3243|Compound:9134147|FD-Score:-4.25|P-value:6.00E-5 ID:SGTC_3355|Compound:9151058|FD-Score:4.39|P-value:4.78E-5

Top fitness defect scores for YIL026C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_168 3970-0862 12.10 530.5 µM 9.12E-28 1 3.15E-34 1.67
2 SGTC_70 0141-0289 11.20 43.3 µM 7.47E-24 mitochondrial stress 2 2.33E-29 2.37
3 SGTC_2513 baicalein 10.60 25.6 µM 1.83E-21 calcium & mitochondrial duress 2 2.19E-26 6.10
4 SGTC_134 0269-0018 10.20 6.9 µM 4.02E-20 1 1.02E-24 1.27
5 SGTC_10 0279-0212 10.20 42.6 µM 5.40E-20 TRP & mitochondrial translation 2 1.48E-24 3.65
6 SGTC_2759 disulfiram 9.78 3.4 µM 1.17E-18 1 6.80E-23 1.12
7 SGTC_1188 1403-0014 9.09 4.6 µM 2.38E-16 mitochondrial stress 2 5.06E-20 1.64
8 SGTC_1939 st074455 8.03 53.6 µM 3.92E-13 1 5.07E-16 2.48
9 SGTC_991 3996-0057 7.61 64.7 µM 5.58E-12 1 1.38E-14 2.89
10 SGTC_119 0121-0043 7.51 24.8 µM 1.03E-11 mitochondrial stress 4 2.94E-14 0.47
11 SGTC_1883 5-benzylidenerhodanine 7.37 20.0 µM 2.34E-11 TRP & mitochondrial translation 2 8.22E-14 0.73
12 SGTC_1565 sinapyl alcohol 7.24 95.1 µM 5.41E-11 1 2.32E-13 3.25
13 SGTC_1635 st007035 7.17 42.4 µM 7.73E-11 2 3.63E-13 0.38
14 SGTC_1629 st005085 7.17 44.9 µM 7.99E-11 RPP1 & pyrimidine depletion 3 3.78E-13 0.93
15 SGTC_131 0141-0277 6.56 33.9 µM 2.42E-9 2 2.63E-11 0.69
16 SGTC_226 1,3-diallylurea 6.36 8.3 mM 7.17E-9 3 1.01E-10 0.18
17 SGTC_2253 7938677 6.27 135.8 µM 1.14E-8 1 1.79E-10 1.53
18 SGTC_525 k781-2675 6.10 26.7 µM 2.76E-8 redox potentiating 17 5.41E-10 0.03
19 SGTC_596 1155-0152 5.90 116.0 µM 7.42E-8 TRP & mitochondrial translation 2 1.85E-9 0.83
20 SGTC_2307 7538926 5.71 6.3 µM 1.80E-7 7 5.57E-9 0.28

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.347 1.46E-95 YBR002C RER2 het Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
0.296 1.10E-68 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.291 1.31E-66 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.290 8.34E-66 YKL068W-A_p YKL068W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii
0.289 1.55E-65 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.276 1.50E-59 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.262 7.33E-54 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.259 2.11E-52 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.257 7.25E-52 YHL004W MRP4 hom Mitochondrial ribosomal protein of the small subunit
0.255 6.96E-51 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.254 2.26E-50 YOR305W RRG7 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene
0.252 1.10E-49 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.252 1.19E-49 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.249 2.10E-48 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.245 4.32E-47 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER