YIL029C_p

Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL029C / YIL029C

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:-3.89|P-value:1.45E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.34|P-value:2.63E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.41|P-value:7.59E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.96|P-value:1.14E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.54|P-value:4.95E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:3.47|P-value:6.16E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.35|P-value:9.16E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:5.25|P-value:5.17E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.58|P-value:1.02E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:5.57|P-value:1.09E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:3.95|P-value:1.17E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.35|P-value:9.20E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.64|P-value:3.51E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.66|P-value:3.31E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:6.37|P-value:1.59E-9 ID:SGTC_658|Compound:3253-0951|FD-Score:3.78|P-value:2.20E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.44|P-value:6.84E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:5.35|P-value:3.24E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:4.78|P-value:4.27E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.36|P-value:8.76E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.30|P-value:4.13E-7 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.78|P-value:2.13E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:4.82|P-value:3.69E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:4.81|P-value:3.76E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:-4.28|P-value:3.35E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:4.26|P-value:3.76E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:4.22|P-value:4.31E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.70|P-value:6.11E-6 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.72|P-value:2.71E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.70|P-value:2.85E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:6.59|P-value:4.42E-10 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.15|P-value:5.75E-5 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.65|P-value:3.45E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.70|P-value:2.85E-4 ID:SGTC_1530|Compound:rhein|FD-Score:5.25|P-value:5.29E-7 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.53|P-value:5.02E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.36|P-value:1.67E-9 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.39|P-value:7.97E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.70|P-value:5.80E-8 ID:SGTC_1769|Compound:st044406|FD-Score:3.98|P-value:1.06E-4 ID:SGTC_1800|Compound:st050079|FD-Score:6.91|P-value:6.28E-11 ID:SGTC_1803|Compound:st050068|FD-Score:3.81|P-value:1.95E-4 ID:SGTC_1944|Compound:st076371|FD-Score:5.41|P-value:2.45E-7 ID:SGTC_1974|Compound:st069448|FD-Score:5.03|P-value:1.44E-6 ID:SGTC_2019|Compound:4016004|FD-Score:3.54|P-value:4.89E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.95|P-value:1.21E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.39|P-value:8.05E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.36|P-value:8.84E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.20|P-value:4.72E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.42|P-value:7.41E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.52|P-value:5.17E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.24|P-value:4.04E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.31|P-value:3.00E-5 ID:SGTC_2643|Compound:anethole|FD-Score:4.59|P-value:9.69E-6 ID:SGTC_2698|Compound:st077697|FD-Score:4.65|P-value:7.70E-6 ID:SGTC_2701|Compound:st077767|FD-Score:4.39|P-value:2.26E-5 ID:SGTC_2793|Compound:7325131|FD-Score:-3.41|P-value:7.58E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.93|P-value:1.29E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.98|P-value:1.08E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.49|P-value:5.77E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.64|P-value:3.53E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.66|P-value:3.27E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.36|P-value:8.93E-4 ID:SGTC_3145|Compound:9085516|FD-Score:4.37|P-value:2.35E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.42|P-value:7.21E-4 ID:SGTC_3237|Compound:9133362|FD-Score:-3.38|P-value:8.33E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.06|P-value:7.86E-5 ID:SGTC_3275|Compound:9138069|FD-Score:5.01|P-value:1.59E-6 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.89|P-value:1.45E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-4.34|P-value:2.63E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.41|P-value:7.59E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.96|P-value:1.14E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.54|P-value:4.95E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:3.47|P-value:6.16E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.35|P-value:9.16E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:5.25|P-value:5.17E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.58|P-value:1.02E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:5.57|P-value:1.09E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:3.95|P-value:1.17E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.35|P-value:9.20E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.64|P-value:3.51E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-3.66|P-value:3.31E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:6.37|P-value:1.59E-9 ID:SGTC_658|Compound:3253-0951|FD-Score:3.78|P-value:2.20E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.44|P-value:6.84E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:5.35|P-value:3.24E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:4.78|P-value:4.27E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.36|P-value:8.76E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.30|P-value:4.13E-7 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.78|P-value:2.13E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:4.82|P-value:3.69E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:4.81|P-value:3.76E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:-4.28|P-value:3.35E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:4.26|P-value:3.76E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:4.22|P-value:4.31E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.70|P-value:6.11E-6 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.72|P-value:2.71E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.70|P-value:2.85E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:6.59|P-value:4.42E-10 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.15|P-value:5.75E-5 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.65|P-value:3.45E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.70|P-value:2.85E-4 ID:SGTC_1530|Compound:rhein|FD-Score:5.25|P-value:5.29E-7 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.53|P-value:5.02E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.36|P-value:1.67E-9 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.39|P-value:7.97E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.70|P-value:5.80E-8 ID:SGTC_1769|Compound:st044406|FD-Score:3.98|P-value:1.06E-4 ID:SGTC_1800|Compound:st050079|FD-Score:6.91|P-value:6.28E-11 ID:SGTC_1803|Compound:st050068|FD-Score:3.81|P-value:1.95E-4 ID:SGTC_1944|Compound:st076371|FD-Score:5.41|P-value:2.45E-7 ID:SGTC_1974|Compound:st069448|FD-Score:5.03|P-value:1.44E-6 ID:SGTC_2019|Compound:4016004|FD-Score:3.54|P-value:4.89E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.95|P-value:1.21E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.39|P-value:8.05E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.36|P-value:8.84E-4 ID:SGTC_2330|Compound:7979373|FD-Score:4.20|P-value:4.72E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.42|P-value:7.41E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.52|P-value:5.17E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.24|P-value:4.04E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.31|P-value:3.00E-5 ID:SGTC_2643|Compound:anethole|FD-Score:4.59|P-value:9.69E-6 ID:SGTC_2698|Compound:st077697|FD-Score:4.65|P-value:7.70E-6 ID:SGTC_2701|Compound:st077767|FD-Score:4.39|P-value:2.26E-5 ID:SGTC_2793|Compound:7325131|FD-Score:-3.41|P-value:7.58E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.93|P-value:1.29E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.98|P-value:1.08E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.49|P-value:5.77E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.64|P-value:3.53E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.66|P-value:3.27E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.36|P-value:8.93E-4 ID:SGTC_3145|Compound:9085516|FD-Score:4.37|P-value:2.35E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.42|P-value:7.21E-4 ID:SGTC_3237|Compound:9133362|FD-Score:-3.38|P-value:8.33E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.06|P-value:7.86E-5 ID:SGTC_3275|Compound:9138069|FD-Score:5.01|P-value:1.59E-6

Top fitness defect scores for YIL029C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1800 st050079 6.91 29.1 µM 6.28E-11 NEO1-PIK1 26 2.36E-12
2 SGTC_1380 2291-0730 6.59 164.0 µM 4.42E-10 2 2.23E-11
3 SGTC_641 4092-0595 6.37 30.0 µM 1.59E-9 3 9.75E-11
4 SGTC_1635 st007035 6.36 42.4 µM 1.67E-9 132 1.03E-10
5 SGTC_1720 st037298 5.70 9.5 µM 5.80E-8 14 6.10E-9
6 SGTC_513 4245-1575 5.57 41.7 µM 1.09E-7 unfolded protein response 61 1.26E-8
7 SGTC_1944 st076371 5.41 56.9 µM 2.45E-7 7 3.20E-8
8 SGTC_693 4161-2696 5.35 114.0 µM 3.24E-7 2 4.41E-8
9 SGTC_778 3456-2434 5.30 196.0 µM 4.13E-7 mitochondrial response to ROS 35 5.83E-8
10 SGTC_377 3970-0964 5.25 33.1 µM 5.17E-7 24 7.55E-8
11 SGTC_1530 rhein 5.25 70.4 µM 5.29E-7 6 7.75E-8
12 SGTC_1974 st069448 5.03 26.9 µM 1.44E-6 7 2.44E-7
13 SGTC_3275 9138069 5.01 49.5 µM 1.59E-6 3 2.76E-7
14 SGTC_866 0495-0101 4.82 262.0 µM 3.69E-6 60S ribosome export 7 7.23E-7
15 SGTC_884 0851-0618 4.81 334.0 µM 3.76E-6 6 7.39E-7
16 SGTC_710 3448-4187 4.78 58.0 µM 4.27E-6 fatty acid desaturase (OLE1) 30 8.56E-7
17 SGTC_1076 itraconazole 4.70 331.0 nM 6.11E-6 19 1.29E-6
18 SGTC_2698 st077697 4.65 67.5 µM 7.70E-6 11 1.68E-6
19 SGTC_2643 anethole 4.59 100.0 µM 9.69E-6 9 2.19E-6
20 SGTC_2701 st077767 4.39 14.7 µM 2.26E-5 30 5.78E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.77E-17 YDL023C_d YDL023C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
0.139 4.98E-16 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.136 2.49E-15 YIL098C FMC1 hom Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
0.132 1.79E-14 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.128 8.42E-14 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.127 1.95E-13 YIL041W GVP36 hom BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis
0.121 1.95E-12 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.120 2.68E-12 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.116 1.74E-11 YOR043W WHI2 hom Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
0.116 1.77E-11 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.113 5.93E-11 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.113 6.14E-11 YIL065C FIS1 hom Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation
0.112 7.94E-11 YGL089C MF(ALPHA)2 hom Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
0.110 1.88E-10 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.106 7.73E-10 YOR015W_d YOR015W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data