YIL031W / ULP2

Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL031W / ULP2

Click on Significant Values for Screen Details ID:SGTC_108|Compound:0509-0257|FD-Score:3.36|P-value:9.53E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.49|P-value:1.61E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:8.20|P-value:1.56E-14 ID:SGTC_266|Compound:formosanin C|FD-Score:5.88|P-value:2.58E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:4.31|P-value:3.32E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.57|P-value:4.74E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.34|P-value:9.98E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.93|P-value:2.51E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.95|P-value:1.29E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.44|P-value:7.20E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.68|P-value:3.34E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.67|P-value:3.48E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.63|P-value:3.87E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.40|P-value:2.33E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-4.04|P-value:9.22E-5 ID:SGTC_1917|Compound:st066507|FD-Score:4.44|P-value:2.01E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.98|P-value:1.17E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:6.72|P-value:2.44E-10 ID:SGTC_2256|Compound:7954252|FD-Score:3.68|P-value:3.26E-4 ID:SGTC_2317|Compound:5986382|FD-Score:4.39|P-value:2.38E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-4.14|P-value:6.26E-5 ID:SGTC_2324|Compound:6149169|FD-Score:-4.24|P-value:4.25E-5 ID:SGTC_2403|Compound:6032726|FD-Score:3.62|P-value:4.10E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-4.16|P-value:5.76E-5 ID:SGTC_2446|Compound:5162541|FD-Score:4.39|P-value:2.41E-5 ID:SGTC_2447|Compound:5741742|FD-Score:-3.81|P-value:2.04E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.92|P-value:1.45E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.19|P-value:5.26E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.48|P-value:1.97E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.63|P-value:9.25E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.85|P-value:1.15E-10 ID:SGTC_2992|Compound:9074591|FD-Score:3.64|P-value:3.77E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.00|P-value:1.84E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:3.36|P-value:9.53E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.49|P-value:1.61E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:8.20|P-value:1.56E-14 ID:SGTC_266|Compound:formosanin C|FD-Score:5.88|P-value:2.58E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:4.31|P-value:3.32E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.57|P-value:4.74E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.34|P-value:9.98E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:4.93|P-value:2.51E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.95|P-value:1.29E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.44|P-value:7.20E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.68|P-value:3.34E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.67|P-value:3.48E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.63|P-value:3.87E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.40|P-value:2.33E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-4.04|P-value:9.22E-5 ID:SGTC_1917|Compound:st066507|FD-Score:4.44|P-value:2.01E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.98|P-value:1.17E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:6.72|P-value:2.44E-10 ID:SGTC_2256|Compound:7954252|FD-Score:3.68|P-value:3.26E-4 ID:SGTC_2317|Compound:5986382|FD-Score:4.39|P-value:2.38E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-4.14|P-value:6.26E-5 ID:SGTC_2324|Compound:6149169|FD-Score:-4.24|P-value:4.25E-5 ID:SGTC_2403|Compound:6032726|FD-Score:3.62|P-value:4.10E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-4.16|P-value:5.76E-5 ID:SGTC_2446|Compound:5162541|FD-Score:4.39|P-value:2.41E-5 ID:SGTC_2447|Compound:5741742|FD-Score:-3.81|P-value:2.04E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.92|P-value:1.45E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.19|P-value:5.26E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.48|P-value:1.97E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.63|P-value:9.25E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.85|P-value:1.15E-10 ID:SGTC_2992|Compound:9074591|FD-Score:3.64|P-value:3.77E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.00|P-value:1.84E-6

Top fitness defect scores for YIL031W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_163 1327-0036 8.20 7.5 µM 1.56E-14 20 1.17E-16 0.19
2 SGTC_2651 1327-0036 6.85 5.0 µM 1.15E-10 27 3.70E-12 0.39
3 SGTC_2131 toluylene red 6.72 5.3 µM 2.44E-10 60S ribosome export 3 8.88E-12 0.43
4 SGTC_266 formosanin C 5.88 406.0 nM 2.58E-8 sphingolipid biosynthesis & PDR1 7 2.01E-9 0.12
5 SGTC_2502 avocadyne acetate 5.48 18.6 µM 1.97E-7 4 2.13E-8 0.86
6 SGTC_3211 9128781 5.00 49.5 µM 1.84E-6 8 2.85E-7 0.01
7 SGTC_1126 isoteolin 4.93 1.0 µM 2.51E-6 3 4.09E-7 0.61
8 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 4.63 100.0 µM 9.25E-6 2 1.85E-6 0.08
9 SGTC_137 0438-0332 4.49 85.4 µM 1.61E-5 ubiquinone biosynthesis & proteasome 33 3.51E-6 0.11
10 SGTC_1917 st066507 4.44 28.5 µM 2.01E-5 Golgi 4 4.55E-6 0.19
11 SGTC_1785 bathophenanthroline 4.40 24.0 µM 2.33E-5 heme requiring 18 5.40E-6 0.14
12 SGTC_2317 5986382 4.39 200.0 µM 2.38E-5 1 5.54E-6 0.32
13 SGTC_2446 5162541 4.39 200.0 µM 2.41E-5 3 5.62E-6 0.43
14 SGTC_309 k408-0051 4.31 1.5 µM 3.32E-5 19 8.15E-6 0.10
15 SGTC_2040 5100729 3.98 123.0 µM 1.17E-4 6 3.50E-5 0.40
16 SGTC_1131 3454-3128 3.95 32.3 µM 1.29E-4 14 3.92E-5 0.08
17 SGTC_2471 5466956 3.92 24.8 µM 1.45E-4 mitochondrial processes 19 4.49E-5 0.09
18 SGTC_2256 7954252 3.68 200.0 µM 3.26E-4 mitochondrial processes 12 1.15E-4 0.15
19 SGTC_1678 st019265 3.68 80.2 µM 3.34E-4 60S ribosome export 6 1.18E-4 0.01
20 SGTC_1740 st038286 3.67 13.2 µM 3.48E-4 9 1.24E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.371 3.15E-110 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.356 1.22E-100 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.304 7.15E-73 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.282 2.74E-62 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.271 1.50E-57 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.270 3.39E-57 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.268 3.94E-56 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.267 8.45E-56 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.266 3.07E-55 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.242 3.98E-46 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.238 1.56E-44 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.236 9.37E-44 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.215 1.97E-36 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.203 2.01E-32 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
0.201 5.77E-32 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core