YIL034C / CAP2

Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL034C / CAP2

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.29|P-value:4.35E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.49|P-value:2.18E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.05|P-value:2.58E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.58|P-value:1.54E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:5.31|P-value:8.54E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:3.58|P-value:1.54E-4 ID:SGTC_476|Compound:mead acid|FD-Score:4.09|P-value:2.24E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:4.38|P-value:6.48E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:3.66|P-value:1.16E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.10|P-value:8.04E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.25|P-value:4.84E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:6.14|P-value:8.97E-10 ID:SGTC_776|Compound:4476-4378|FD-Score:3.54|P-value:1.81E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.60|P-value:2.19E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:4.83|P-value:8.89E-7 ID:SGTC_945|Compound:3381-0768|FD-Score:3.26|P-value:4.80E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.26|P-value:4.82E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.80|P-value:6.77E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.45|P-value:2.52E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.32|P-value:3.92E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.68|P-value:1.10E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.11|P-value:2.25E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.30|P-value:4.09E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.31|P-value:3.97E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:5.10|P-value:2.39E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.28|P-value:9.95E-6 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.62|P-value:2.26E-6 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.69|P-value:1.04E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:6.96|P-value:5.85E-12 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.05|P-value:9.35E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:5.47|P-value:3.63E-8 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.46|P-value:2.39E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.72|P-value:9.29E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.29|P-value:9.13E-8 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.43|P-value:2.66E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.41|P-value:2.82E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:7.07|P-value:2.96E-12 ID:SGTC_1605|Compound:st000082|FD-Score:3.32|P-value:3.94E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.36|P-value:7.15E-6 ID:SGTC_1609|Compound:st001574|FD-Score:4.10|P-value:2.13E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.44|P-value:5.00E-6 ID:SGTC_1794|Compound:st048918|FD-Score:3.10|P-value:8.12E-4 ID:SGTC_1841|Compound:st054148|FD-Score:5.66|P-value:1.37E-8 ID:SGTC_1876|Compound:myriocin|FD-Score:3.58|P-value:1.58E-4 ID:SGTC_1938|Compound:st074717|FD-Score:6.47|P-value:1.31E-10 ID:SGTC_1940|Compound:st075990|FD-Score:4.18|P-value:1.50E-5 ID:SGTC_2009|Compound:4012297|FD-Score:3.64|P-value:1.25E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.25|P-value:1.15E-5 ID:SGTC_2147|Compound:5545932|FD-Score:6.11|P-value:1.09E-9 ID:SGTC_2149|Compound:5554786|FD-Score:5.02|P-value:3.62E-7 ID:SGTC_2154|Compound:5570129|FD-Score:3.45|P-value:2.44E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.93|P-value:5.35E-7 ID:SGTC_2295|Compound:7971645|FD-Score:3.83|P-value:6.09E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.26|P-value:4.80E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-5.63|P-value:2.17E-7 ID:SGTC_2366|Compound:9070441|FD-Score:3.49|P-value:2.16E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.31|P-value:4.01E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.99|P-value:3.33E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.35|P-value:3.52E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.85|P-value:5.68E-5 ID:SGTC_2643|Compound:anethole|FD-Score:3.28|P-value:4.49E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.05|P-value:9.51E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.91|P-value:4.50E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.22|P-value:5.50E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.87|P-value:7.33E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.36|P-value:7.03E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.91|P-value:4.60E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.11|P-value:2.04E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:6.03|P-value:1.73E-9 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.06|P-value:9.25E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.41|P-value:5.72E-6 ID:SGTC_2894|Compound:9048625|FD-Score:6.12|P-value:1.01E-9 ID:SGTC_2912|Compound:7964298|FD-Score:3.08|P-value:8.61E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.12|P-value:7.56E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.45|P-value:2.49E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.29|P-value:4.35E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.49|P-value:2.18E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.05|P-value:2.58E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.58|P-value:1.54E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:5.31|P-value:8.54E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:3.58|P-value:1.54E-4 ID:SGTC_476|Compound:mead acid|FD-Score:4.09|P-value:2.24E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:4.38|P-value:6.48E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:3.66|P-value:1.16E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:3.10|P-value:8.04E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.25|P-value:4.84E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:6.14|P-value:8.97E-10 ID:SGTC_776|Compound:4476-4378|FD-Score:3.54|P-value:1.81E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.60|P-value:2.19E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:4.83|P-value:8.89E-7 ID:SGTC_945|Compound:3381-0768|FD-Score:3.26|P-value:4.80E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.26|P-value:4.82E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.80|P-value:6.77E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.45|P-value:2.52E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.32|P-value:3.92E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.68|P-value:1.10E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.11|P-value:2.25E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.30|P-value:4.09E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.31|P-value:3.97E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:5.10|P-value:2.39E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.28|P-value:9.95E-6 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.62|P-value:2.26E-6 ID:SGTC_1336|Compound:1486-0901|FD-Score:3.69|P-value:1.04E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:6.96|P-value:5.85E-12 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.05|P-value:9.35E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:5.47|P-value:3.63E-8 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.46|P-value:2.39E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.72|P-value:9.29E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:5.29|P-value:9.13E-8 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.43|P-value:2.66E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.41|P-value:2.82E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:7.07|P-value:2.96E-12 ID:SGTC_1605|Compound:st000082|FD-Score:3.32|P-value:3.94E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.36|P-value:7.15E-6 ID:SGTC_1609|Compound:st001574|FD-Score:4.10|P-value:2.13E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.44|P-value:5.00E-6 ID:SGTC_1794|Compound:st048918|FD-Score:3.10|P-value:8.12E-4 ID:SGTC_1841|Compound:st054148|FD-Score:5.66|P-value:1.37E-8 ID:SGTC_1876|Compound:myriocin|FD-Score:3.58|P-value:1.58E-4 ID:SGTC_1938|Compound:st074717|FD-Score:6.47|P-value:1.31E-10 ID:SGTC_1940|Compound:st075990|FD-Score:4.18|P-value:1.50E-5 ID:SGTC_2009|Compound:4012297|FD-Score:3.64|P-value:1.25E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.25|P-value:1.15E-5 ID:SGTC_2147|Compound:5545932|FD-Score:6.11|P-value:1.09E-9 ID:SGTC_2149|Compound:5554786|FD-Score:5.02|P-value:3.62E-7 ID:SGTC_2154|Compound:5570129|FD-Score:3.45|P-value:2.44E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.93|P-value:5.35E-7 ID:SGTC_2295|Compound:7971645|FD-Score:3.83|P-value:6.09E-5 ID:SGTC_2320|Compound:7373003|FD-Score:3.26|P-value:4.80E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-5.63|P-value:2.17E-7 ID:SGTC_2366|Compound:9070441|FD-Score:3.49|P-value:2.16E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.31|P-value:4.01E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.99|P-value:3.33E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.35|P-value:3.52E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.85|P-value:5.68E-5 ID:SGTC_2643|Compound:anethole|FD-Score:3.28|P-value:4.49E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.05|P-value:9.51E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.91|P-value:4.50E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.22|P-value:5.50E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.87|P-value:7.33E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.36|P-value:7.03E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.91|P-value:4.60E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.11|P-value:2.04E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:6.03|P-value:1.73E-9 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.06|P-value:9.25E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.41|P-value:5.72E-6 ID:SGTC_2894|Compound:9048625|FD-Score:6.12|P-value:1.01E-9 ID:SGTC_2912|Compound:7964298|FD-Score:3.08|P-value:8.61E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.12|P-value:7.56E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.45|P-value:2.49E-4

Top fitness defect scores for YIL034C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1574 spiramycin 7.07 23.7 µM 2.96E-12 2 7.96E-13
2 SGTC_1344 1488-0097 6.96 29.1 µM 5.85E-12 1 1.68E-12
3 SGTC_1938 st074717 6.47 56.4 µM 1.31E-10 1 4.95E-11
4 SGTC_774 k060-0086 6.14 136.0 µM 8.97E-10 6 4.01E-10
5 SGTC_2894 9048625 6.12 32.5 µM 1.01E-9 1 4.56E-10
6 SGTC_2147 5545932 6.11 89.7 µM 1.09E-9 ergosterol biosynthesis 2 4.98E-10
7 SGTC_2771 fluoxetine 6.03 41.0 µM 1.73E-9 4 8.18E-10
8 SGTC_1841 st054148 5.66 70.0 µM 1.37E-8 1 7.72E-9
9 SGTC_1465 k213-0056 5.47 144.0 µM 3.63E-8 DNA intercalators 6 2.21E-8
10 SGTC_354 2783-3500 5.31 4.9 µM 8.54E-8 cell wall 23 5.56E-8
11 SGTC_1513 0337-0559 5.29 19.0 µM 9.13E-8 4 5.97E-8
12 SGTC_1119 parthenolide 5.11 318.5 nM 2.25E-7 TSC3-RPN4 19 1.58E-7
13 SGTC_1238 0333-0287 5.10 48.8 µM 2.39E-7 Golgi 11 1.68E-7
14 SGTC_2149 5554786 5.02 194.8 µM 3.62E-7 cell wall signaling 15 2.64E-7
15 SGTC_2166 5933061 4.93 31.5 µM 5.35E-7 tubulin folding & SWR complex 19 4.01E-7
16 SGTC_2752 diclazuril 4.87 33.1 µM 7.33E-7 78 5.64E-7
17 SGTC_911 3456-4043 4.83 236.0 µM 8.89E-7 mitochondrial processes 13 6.93E-7
18 SGTC_1321 1326-2144 4.62 215.0 µM 2.26E-6 3 1.89E-6
19 SGTC_1635 st007035 4.44 42.4 µM 5.00E-6 187 4.42E-6
20 SGTC_2825 7998094 4.41 58.4 µM 5.72E-6 fatty acid desaturase (OLE1) 22 5.10E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.34E-9 YJR135W-A TIM8 hom Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome
0.099 8.43E-9 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.096 2.25E-8 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.093 5.76E-8 YOL132W GAS4 hom 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall
0.092 1.03E-7 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.090 1.84E-7 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.089 2.65E-7 YNL057W_d YNL057W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.089 2.81E-7 YNL277W-A_p YNL277W-A_p hom Putative protein of unknown function
0.088 3.34E-7 YIL053W RHR2 hom Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication
0.088 3.81E-7 YLR357W RSC2 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
0.083 1.29E-6 YOR161C-C_p YOR161C-C_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.083 1.35E-6 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.082 1.76E-6 YBR173C UMP1 hom Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly
0.082 1.90E-6 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.080 3.67E-6 YNR019W ARE2 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication