YIL035C / CKA1

Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL035C / CKA1

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:4.69|P-value:5.99E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:3.80|P-value:1.91E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-5.46|P-value:3.26E-7 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.20|P-value:6.59E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.02|P-value:2.37E-6 ID:SGTC_148|Compound:3253-0744|FD-Score:5.15|P-value:8.14E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.49|P-value:7.76E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.77|P-value:2.13E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.97|P-value:1.04E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:4.14|P-value:5.44E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:4.16|P-value:5.00E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:4.35|P-value:2.47E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.46|P-value:6.02E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.02|P-value:8.67E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.33|P-value:8.90E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.34|P-value:8.84E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.47|P-value:5.72E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.02|P-value:1.09E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:5.96|P-value:1.47E-8 ID:SGTC_540|Compound:1187-0821|FD-Score:3.73|P-value:2.43E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.99|P-value:9.59E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.30|P-value:9.84E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.53|P-value:4.79E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.38|P-value:7.74E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.80|P-value:1.88E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:-3.52|P-value:7.16E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-3.47|P-value:8.26E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:7.04|P-value:3.05E-11 ID:SGTC_985|Compound:1493-0307|FD-Score:3.67|P-value:2.95E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:4.00|P-value:9.11E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:5.50|P-value:1.51E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.34|P-value:2.55E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.53|P-value:4.74E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.63|P-value:3.41E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.61|P-value:3.69E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.84|P-value:1.64E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.91|P-value:1.29E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:5.57|P-value:1.07E-7 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.72|P-value:2.50E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.79|P-value:2.92E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-3.60|P-value:5.42E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.44|P-value:6.32E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.70|P-value:2.68E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.43|P-value:9.41E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.81|P-value:1.80E-4 ID:SGTC_1712|Compound:st032288|FD-Score:7.45|P-value:2.28E-12 ID:SGTC_1754|Compound:st042065|FD-Score:3.66|P-value:3.10E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-4.06|P-value:1.11E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.79|P-value:1.95E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.94|P-value:1.13E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.63|P-value:3.44E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.51|P-value:7.39E-4 ID:SGTC_2458|Compound:5808907|FD-Score:-3.74|P-value:3.41E-4 ID:SGTC_2461|Compound:5755302|FD-Score:-4.55|P-value:1.74E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.58|P-value:5.75E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.73|P-value:2.42E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.38|P-value:7.61E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.30|P-value:2.37E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.86|P-value:1.48E-13 ID:SGTC_2789|Compound:5281112|FD-Score:3.64|P-value:3.29E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.16|P-value:5.04E-5 ID:SGTC_2893|Compound:9048488|FD-Score:-3.65|P-value:4.65E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.08|P-value:1.09E-6 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.37|P-value:2.21E-5 ID:SGTC_2904|Compound:7225135|FD-Score:4.09|P-value:6.62E-5 ID:SGTC_2909|Compound:7941780|FD-Score:4.28|P-value:3.17E-5 ID:SGTC_2911|Compound:7942208|FD-Score:3.73|P-value:2.37E-4 ID:SGTC_2970|Compound:9090938|FD-Score:-3.95|P-value:1.64E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.39|P-value:7.50E-4 ID:SGTC_3032|Compound:9089427|FD-Score:4.20|P-value:4.30E-5 ID:SGTC_3207|Compound:9114163|FD-Score:6.14|P-value:5.56E-9 ID:SGTC_3212|Compound:9128307|FD-Score:-5.04|P-value:2.17E-6 ID:SGTC_3247|Compound:9135149|FD-Score:3.72|P-value:2.47E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.38|P-value:7.61E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:4.69|P-value:5.99E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:3.80|P-value:1.91E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-5.46|P-value:3.26E-7 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.20|P-value:6.59E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.02|P-value:2.37E-6 ID:SGTC_148|Compound:3253-0744|FD-Score:5.15|P-value:8.14E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.49|P-value:7.76E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.77|P-value:2.13E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.97|P-value:1.04E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:4.14|P-value:5.44E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:4.16|P-value:5.00E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:4.35|P-value:2.47E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.46|P-value:6.02E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.02|P-value:8.67E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.33|P-value:8.90E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.34|P-value:8.84E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.47|P-value:5.72E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.02|P-value:1.09E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:5.96|P-value:1.47E-8 ID:SGTC_540|Compound:1187-0821|FD-Score:3.73|P-value:2.43E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.99|P-value:9.59E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.30|P-value:9.84E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.53|P-value:4.79E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.38|P-value:7.74E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.80|P-value:1.88E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:-3.52|P-value:7.16E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-3.47|P-value:8.26E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:7.04|P-value:3.05E-11 ID:SGTC_985|Compound:1493-0307|FD-Score:3.67|P-value:2.95E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:4.00|P-value:9.11E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:5.50|P-value:1.51E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.34|P-value:2.55E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.53|P-value:4.74E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.63|P-value:3.41E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.61|P-value:3.69E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.84|P-value:1.64E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.91|P-value:1.29E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:5.57|P-value:1.07E-7 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.72|P-value:2.50E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.79|P-value:2.92E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-3.60|P-value:5.42E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.44|P-value:6.32E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.70|P-value:2.68E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.43|P-value:9.41E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.81|P-value:1.80E-4 ID:SGTC_1712|Compound:st032288|FD-Score:7.45|P-value:2.28E-12 ID:SGTC_1754|Compound:st042065|FD-Score:3.66|P-value:3.10E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-4.06|P-value:1.11E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.79|P-value:1.95E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.94|P-value:1.13E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.63|P-value:3.44E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.51|P-value:7.39E-4 ID:SGTC_2458|Compound:5808907|FD-Score:-3.74|P-value:3.41E-4 ID:SGTC_2461|Compound:5755302|FD-Score:-4.55|P-value:1.74E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.58|P-value:5.75E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.73|P-value:2.42E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.38|P-value:7.61E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.30|P-value:2.37E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.86|P-value:1.48E-13 ID:SGTC_2789|Compound:5281112|FD-Score:3.64|P-value:3.29E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.16|P-value:5.04E-5 ID:SGTC_2893|Compound:9048488|FD-Score:-3.65|P-value:4.65E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.08|P-value:1.09E-6 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.37|P-value:2.21E-5 ID:SGTC_2904|Compound:7225135|FD-Score:4.09|P-value:6.62E-5 ID:SGTC_2909|Compound:7941780|FD-Score:4.28|P-value:3.17E-5 ID:SGTC_2911|Compound:7942208|FD-Score:3.73|P-value:2.37E-4 ID:SGTC_2970|Compound:9090938|FD-Score:-3.95|P-value:1.64E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.39|P-value:7.50E-4 ID:SGTC_3032|Compound:9089427|FD-Score:4.20|P-value:4.30E-5 ID:SGTC_3207|Compound:9114163|FD-Score:6.14|P-value:5.56E-9 ID:SGTC_3212|Compound:9128307|FD-Score:-5.04|P-value:2.17E-6 ID:SGTC_3247|Compound:9135149|FD-Score:3.72|P-value:2.47E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.38|P-value:7.61E-4

Top fitness defect scores for YIL035C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 7.86 96.7 µM 1.48E-13 calcium & mitochondrial duress 68 1.93E-15
2 SGTC_1712 st032288 7.45 53.4 µM 2.28E-12 calcium & mitochondrial duress 50 4.68E-14
3 SGTC_981 1488-1094 7.04 54.9 µM 3.05E-11 5 9.58E-13
4 SGTC_2651 1327-0036 6.30 5.0 µM 2.37E-9 64 1.52E-10
5 SGTC_3207 9114163 6.14 49.5 µM 5.56E-9 4 4.09E-10
6 SGTC_514 4466-0038 6.02 2.6 nM 1.09E-8 cell wall 73 8.91E-10
7 SGTC_528 3492-0019 5.96 172.0 µM 1.47E-8 calcium & mitochondrial duress 123 1.27E-9
8 SGTC_1309 pyrazolanthrone 5.57 13.4 µM 1.07E-7 10 1.26E-8
9 SGTC_1007 4101-0031 5.50 70.0 µM 1.51E-7 4 1.89E-8
10 SGTC_148 3253-0744 5.15 288.0 µM 8.14E-7 8 1.33E-7
11 SGTC_2896 9052656 5.08 71.4 µM 1.09E-6 endomembrane recycling 59 1.86E-7
12 SGTC_40 0327-0103 4.69 19.8 µM 5.99E-6 13 1.34E-6
13 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 4.37 39.7 µM 2.21E-5 2 6.09E-6
14 SGTC_201 4262-0159 4.35 12.8 µM 2.47E-5 ergosterol depletion effects on membrane 38 6.91E-6
15 SGTC_1019 4262-0212 4.34 3.4 µM 2.55E-5 ergosterol depletion effects on membrane 49 7.19E-6
16 SGTC_2909 7941780 4.28 10.5 µM 3.17E-5 14 9.23E-6
17 SGTC_3032 9089427 4.20 49.5 µM 4.30E-5 60S ribosome export 10 1.31E-5
18 SGTC_187 1488-2104 4.16 32.7 µM 5.00E-5 calcium & mitochondrial duress 32 1.56E-5
19 SGTC_2858 9025781 4.16 9.0 µM 5.04E-5 sphingolipid biosynthesis & PDR1 91 1.57E-5
20 SGTC_179 1273-0063 4.14 6.8 µM 5.44E-5 18 1.72E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 4.61E-48 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.235 3.28E-43 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.233 9.76E-43 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.231 9.40E-42 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.216 1.12E-36 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.183 8.25E-27 YBL046W PSY4 hom Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
0.183 1.05E-26 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.180 7.46E-26 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.176 6.78E-25 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.176 9.16E-25 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.170 3.13E-23 YNL293W MSB3 hom Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.168 1.12E-22 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.166 3.17E-22 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.165 7.17E-22 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.162 2.95E-21 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family