YIL036W / CST6

Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL036W / CST6

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.67|P-value:2.13E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:3.05|P-value:9.77E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.44|P-value:2.68E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.17|P-value:6.71E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.84|P-value:6.40E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.23|P-value:5.43E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.34|P-value:3.78E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:5.76|P-value:1.01E-8 ID:SGTC_233|Compound:rapamycin|FD-Score:3.58|P-value:1.63E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.29|P-value:1.08E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.33|P-value:3.90E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.33|P-value:3.99E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.47|P-value:2.48E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:6.51|P-value:1.40E-10 ID:SGTC_528|Compound:3492-0019|FD-Score:3.22|P-value:5.74E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.80|P-value:7.34E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.35|P-value:8.49E-6 ID:SGTC_752|Compound:1896-0090|FD-Score:3.08|P-value:8.97E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.35|P-value:3.68E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.07|P-value:9.21E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.62|P-value:1.46E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:4.20|P-value:1.59E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.70|P-value:7.67E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.18|P-value:1.68E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.91|P-value:5.01E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:6.45|P-value:2.02E-10 ID:SGTC_977|Compound:1348-1378|FD-Score:3.16|P-value:6.92E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.23|P-value:5.59E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.77|P-value:6.17E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:5.43|P-value:5.76E-8 ID:SGTC_1151|Compound:3909-8316|FD-Score:5.51|P-value:3.66E-8 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.67|P-value:1.22E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.41|P-value:2.99E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.12|P-value:7.89E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.07|P-value:2.65E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.45|P-value:2.66E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.26|P-value:5.05E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.92|P-value:4.75E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:5.86|P-value:5.82E-9 ID:SGTC_1687|Compound:st020778|FD-Score:3.15|P-value:7.06E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.28|P-value:1.15E-5 ID:SGTC_1767|Compound:st044992|FD-Score:7.40|P-value:4.95E-13 ID:SGTC_1796|Compound:st049173|FD-Score:4.13|P-value:2.10E-5 ID:SGTC_1937|Compound:st074714|FD-Score:4.97|P-value:5.28E-7 ID:SGTC_1974|Compound:st069448|FD-Score:3.98|P-value:3.73E-5 ID:SGTC_1982|Compound:st072467|FD-Score:8.93|P-value:6.24E-18 ID:SGTC_2111|Compound:5486399|FD-Score:10.20|P-value:7.41E-23 ID:SGTC_2135|Compound:5326629|FD-Score:-4.08|P-value:2.22E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.09|P-value:2.42E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.55|P-value:1.85E-4 ID:SGTC_2248|Compound:tofa|FD-Score:6.51|P-value:1.43E-10 ID:SGTC_2255|Compound:7941087|FD-Score:3.87|P-value:5.70E-5 ID:SGTC_2306|Compound:7482397|FD-Score:-7.09|P-value:1.41E-10 ID:SGTC_2331|Compound:7980721|FD-Score:3.38|P-value:3.35E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.38|P-value:3.29E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:5.71|P-value:1.30E-8 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.83|P-value:6.90E-9 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.84|P-value:6.44E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:4.32|P-value:9.65E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.94|P-value:3.83E-9 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.20|P-value:6.11E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.54|P-value:1.92E-4 ID:SGTC_2744|Compound:captopril|FD-Score:4.16|P-value:1.82E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.05|P-value:9.68E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.70|P-value:1.09E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.22|P-value:5.60E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.20|P-value:6.10E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.29|P-value:4.59E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.91|P-value:6.98E-7 ID:SGTC_3018|Compound:9082602|FD-Score:-3.68|P-value:8.32E-4 ID:SGTC_3025|Compound:9087895|FD-Score:5.53|P-value:3.34E-8 ID:SGTC_3101|Compound:9120531|FD-Score:3.21|P-value:5.83E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.41|P-value:6.64E-6 ID:SGTC_3199|Compound:9111318|FD-Score:4.02|P-value:3.22E-5 ID:SGTC_3295|Compound:9122362|FD-Score:4.53|P-value:3.92E-6 ID:SGTC_7|Compound:0192-1582|FD-Score:4.67|P-value:2.13E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:3.05|P-value:9.77E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.44|P-value:2.68E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.17|P-value:6.71E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.84|P-value:6.40E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.23|P-value:5.43E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.34|P-value:3.78E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:5.76|P-value:1.01E-8 ID:SGTC_233|Compound:rapamycin|FD-Score:3.58|P-value:1.63E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.29|P-value:1.08E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.33|P-value:3.90E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.33|P-value:3.99E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.47|P-value:2.48E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:6.51|P-value:1.40E-10 ID:SGTC_528|Compound:3492-0019|FD-Score:3.22|P-value:5.74E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.80|P-value:7.34E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.35|P-value:8.49E-6 ID:SGTC_752|Compound:1896-0090|FD-Score:3.08|P-value:8.97E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.35|P-value:3.68E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.07|P-value:9.21E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.62|P-value:1.46E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:4.20|P-value:1.59E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.70|P-value:7.67E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.18|P-value:1.68E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:3.91|P-value:5.01E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:6.45|P-value:2.02E-10 ID:SGTC_977|Compound:1348-1378|FD-Score:3.16|P-value:6.92E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.23|P-value:5.59E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.77|P-value:6.17E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:5.43|P-value:5.76E-8 ID:SGTC_1151|Compound:3909-8316|FD-Score:5.51|P-value:3.66E-8 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.67|P-value:1.22E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.41|P-value:2.99E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.12|P-value:7.89E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.07|P-value:2.65E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.45|P-value:2.66E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.26|P-value:5.05E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.92|P-value:4.75E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:5.86|P-value:5.82E-9 ID:SGTC_1687|Compound:st020778|FD-Score:3.15|P-value:7.06E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.28|P-value:1.15E-5 ID:SGTC_1767|Compound:st044992|FD-Score:7.40|P-value:4.95E-13 ID:SGTC_1796|Compound:st049173|FD-Score:4.13|P-value:2.10E-5 ID:SGTC_1937|Compound:st074714|FD-Score:4.97|P-value:5.28E-7 ID:SGTC_1974|Compound:st069448|FD-Score:3.98|P-value:3.73E-5 ID:SGTC_1982|Compound:st072467|FD-Score:8.93|P-value:6.24E-18 ID:SGTC_2111|Compound:5486399|FD-Score:10.20|P-value:7.41E-23 ID:SGTC_2135|Compound:5326629|FD-Score:-4.08|P-value:2.22E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.09|P-value:2.42E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.55|P-value:1.85E-4 ID:SGTC_2248|Compound:tofa|FD-Score:6.51|P-value:1.43E-10 ID:SGTC_2255|Compound:7941087|FD-Score:3.87|P-value:5.70E-5 ID:SGTC_2306|Compound:7482397|FD-Score:-7.09|P-value:1.41E-10 ID:SGTC_2331|Compound:7980721|FD-Score:3.38|P-value:3.35E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.38|P-value:3.29E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:5.71|P-value:1.30E-8 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.83|P-value:6.90E-9 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.84|P-value:6.44E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:4.32|P-value:9.65E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.94|P-value:3.83E-9 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.20|P-value:6.11E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.54|P-value:1.92E-4 ID:SGTC_2744|Compound:captopril|FD-Score:4.16|P-value:1.82E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.05|P-value:9.68E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.70|P-value:1.09E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.22|P-value:5.60E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.20|P-value:6.10E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.29|P-value:4.59E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.91|P-value:6.98E-7 ID:SGTC_3018|Compound:9082602|FD-Score:-3.68|P-value:8.32E-4 ID:SGTC_3025|Compound:9087895|FD-Score:5.53|P-value:3.34E-8 ID:SGTC_3101|Compound:9120531|FD-Score:3.21|P-value:5.83E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.41|P-value:6.64E-6 ID:SGTC_3199|Compound:9111318|FD-Score:4.02|P-value:3.22E-5 ID:SGTC_3295|Compound:9122362|FD-Score:4.53|P-value:3.92E-6

Top fitness defect scores for YIL036W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2111 5486399 10.20 200.0 µM 7.41E-23 2 6.12E-25
2 SGTC_1982 st072467 8.93 71.9 µM 6.24E-18 3 2.18E-19
3 SGTC_1767 st044992 7.40 70.3 µM 4.95E-13 2 6.79E-14
4 SGTC_527 4476-4215 6.51 268.0 µM 1.40E-10 PDR1 10 3.67E-11
5 SGTC_2248 tofa 6.51 1.1 µM 1.43E-10 sphingolipid biosynthesis & PDR1 17 3.74E-11
6 SGTC_951 1171-0579 6.45 82.7 µM 2.02E-10 cell wall 28 5.51E-11
7 SGTC_2567 aureobasidin a 5.94 60.0 nM 3.83E-9 43 1.44E-9
8 SGTC_1568 digitonin 5.86 820.0 nM 5.82E-9 sphingolipid biosynthesis & PDR1 12 2.29E-9
9 SGTC_2502 avocadyne acetate 5.83 18.6 µM 6.90E-9 9 2.76E-9
10 SGTC_127 0180-0333 5.76 59.1 µM 1.01E-8 mitochondrial response to ROS 7 4.22E-9
11 SGTC_2420 aureobasidin a 5.71 50.0 nM 1.30E-8 14 5.55E-9
12 SGTC_3025 9087895 5.53 49.5 µM 3.34E-8 PDR1 18 1.58E-8
13 SGTC_1151 3909-8316 5.51 15.3 µM 3.66E-8 2 1.74E-8
14 SGTC_989 1501-0895 5.43 10.3 µM 5.76E-8 1 2.88E-8
15 SGTC_1937 st074714 4.97 47.2 µM 5.28E-7 21 3.29E-7
16 SGTC_2997 9067075 4.91 71.4 µM 6.98E-7 unfolded protein response 32 4.47E-7
17 SGTC_7 0192-1582 4.67 4.2 µM 2.13E-6 42 1.51E-6
18 SGTC_3295 9122362 4.53 53.6 µM 3.92E-6 7 2.95E-6
19 SGTC_3137 9097352 4.41 49.5 µM 6.64E-6 28 5.24E-6
20 SGTC_673 1082-0474 4.35 110.0 µM 8.49E-6 RSC complex & mRNA processing 51 6.85E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.231 5.07E-42 YGR037C ACB1 hom Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress
0.218 1.60E-37 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.198 4.71E-31 YLR372W SUR4 hom Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
0.184 4.94E-27 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.167 2.85E-22 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.160 1.11E-20 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.141 2.31E-16 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.138 1.17E-15 YKL126W YPK1 hom Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication
0.132 1.53E-14 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.132 1.88E-14 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.131 2.11E-14 YJL059W YHC3 hom Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)
0.130 4.41E-14 YJR059W PTK2 hom Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.129 6.55E-14 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.121 2.15E-12 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.119 4.92E-12 YMR242C RPL20A hom Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication