YIL037C / PRM2

Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL037C / PRM2

Click on Significant Values for Screen Details ID:SGTC_92|Compound:0063-0024|FD-Score:6.31|P-value:3.05E-10 ID:SGTC_94|Compound:0334-0113|FD-Score:3.63|P-value:1.87E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:6.03|P-value:1.63E-9 ID:SGTC_98|Compound:0074-0023|FD-Score:7.65|P-value:2.95E-14 ID:SGTC_103|Compound:0844-0104|FD-Score:4.53|P-value:4.51E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.25|P-value:7.03E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.71|P-value:1.37E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:4.22|P-value:1.73E-5 ID:SGTC_444|Compound:curcumin|FD-Score:3.41|P-value:4.16E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.99|P-value:4.63E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.79|P-value:1.02E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.41|P-value:4.12E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.73|P-value:1.27E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:5.28|P-value:1.09E-7 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.35|P-value:5.10E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.21|P-value:8.21E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.40|P-value:4.35E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.87|P-value:7.47E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.21|P-value:1.83E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.38|P-value:4.55E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.58|P-value:3.59E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.36|P-value:9.33E-6 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.27|P-value:6.74E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.31|P-value:5.79E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.18|P-value:8.97E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.72|P-value:1.34E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.67|P-value:1.55E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.58|P-value:3.53E-6 ID:SGTC_1784|Compound:st039334|FD-Score:3.26|P-value:6.95E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.53|P-value:2.68E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.24|P-value:7.45E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.83|P-value:8.34E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-4.02|P-value:3.86E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.17|P-value:9.49E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.19|P-value:8.80E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.25|P-value:6.87E-4 ID:SGTC_2058|Compound:5236698|FD-Score:4.47|P-value:5.81E-6 ID:SGTC_2085|Compound:5307070|FD-Score:4.90|P-value:7.60E-7 ID:SGTC_2088|Compound:5278280|FD-Score:3.21|P-value:8.30E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-3.32|P-value:5.38E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.17|P-value:9.57E-4 ID:SGTC_2227|Compound:7312221|FD-Score:3.17|P-value:9.51E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.34|P-value:5.35E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-3.36|P-value:4.76E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.68|P-value:1.53E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.23|P-value:7.84E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-3.15|P-value:9.65E-4 ID:SGTC_2846|Compound:9008642|FD-Score:3.46|P-value:3.44E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.53|P-value:2.72E-4 ID:SGTC_3022|Compound:9087993|FD-Score:3.15|P-value:9.91E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.96|P-value:5.19E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.64|P-value:1.77E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:6.31|P-value:3.05E-10 ID:SGTC_94|Compound:0334-0113|FD-Score:3.63|P-value:1.87E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:6.03|P-value:1.63E-9 ID:SGTC_98|Compound:0074-0023|FD-Score:7.65|P-value:2.95E-14 ID:SGTC_103|Compound:0844-0104|FD-Score:4.53|P-value:4.51E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.25|P-value:7.03E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:3.71|P-value:1.37E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:4.22|P-value:1.73E-5 ID:SGTC_444|Compound:curcumin|FD-Score:3.41|P-value:4.16E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.99|P-value:4.63E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.79|P-value:1.02E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.41|P-value:4.12E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.73|P-value:1.27E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:5.28|P-value:1.09E-7 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.35|P-value:5.10E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.21|P-value:8.21E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.40|P-value:4.35E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.87|P-value:7.47E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.21|P-value:1.83E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.38|P-value:4.55E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.58|P-value:3.59E-6 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.36|P-value:9.33E-6 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.27|P-value:6.74E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.31|P-value:5.79E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.18|P-value:8.97E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.72|P-value:1.34E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.67|P-value:1.55E-4 ID:SGTC_1739|Compound:st037196|FD-Score:4.58|P-value:3.53E-6 ID:SGTC_1784|Compound:st039334|FD-Score:3.26|P-value:6.95E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.53|P-value:2.68E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.24|P-value:7.45E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.83|P-value:8.34E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-4.02|P-value:3.86E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.17|P-value:9.49E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.19|P-value:8.80E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.25|P-value:6.87E-4 ID:SGTC_2058|Compound:5236698|FD-Score:4.47|P-value:5.81E-6 ID:SGTC_2085|Compound:5307070|FD-Score:4.90|P-value:7.60E-7 ID:SGTC_2088|Compound:5278280|FD-Score:3.21|P-value:8.30E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-3.32|P-value:5.38E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.17|P-value:9.57E-4 ID:SGTC_2227|Compound:7312221|FD-Score:3.17|P-value:9.51E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.34|P-value:5.35E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-3.36|P-value:4.76E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.68|P-value:1.53E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.23|P-value:7.84E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-3.15|P-value:9.65E-4 ID:SGTC_2846|Compound:9008642|FD-Score:3.46|P-value:3.44E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.53|P-value:2.72E-4 ID:SGTC_3022|Compound:9087993|FD-Score:3.15|P-value:9.91E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.96|P-value:5.19E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.64|P-value:1.77E-4

Top fitness defect scores for YIL037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_98 0074-0023 7.65 107.7 µM 2.95E-14 Golgi 7 9.80E-15
2 SGTC_92 0063-0024 6.31 660.9 µM 3.05E-10 1 1.43E-10
3 SGTC_95 0471-0001 6.03 561.1 µM 1.63E-9 4 8.13E-10
4 SGTC_785 1270-0111 5.28 65.3 µM 1.09E-7 6 6.33E-8
5 SGTC_2085 5307070 4.90 144.1 µM 7.60E-7 superoxide 12 4.74E-7
6 SGTC_1739 st037196 4.58 92.5 µM 3.53E-6 10 2.33E-6
7 SGTC_1156 4092-0367 4.58 4.9 µM 3.59E-6 9 2.37E-6
8 SGTC_103 0844-0104 4.53 51.8 µM 4.51E-6 ERAD & cell cycle 118 3.00E-6
9 SGTC_2058 5236698 4.47 133.0 µM 5.81E-6 17 3.90E-6
10 SGTC_1180 1193-0155 4.36 285.0 µM 9.33E-6 9 6.38E-6
11 SGTC_253 dyclonine 4.22 31.2 µM 1.73E-5 amide catabolism 16 1.21E-5
12 SGTC_1034 k072-0165 4.21 12.7 µM 1.83E-5 Golgi 17 1.29E-5
13 SGTC_481 bay k-8644 3.99 50.0 µM 4.63E-5 26 3.36E-5
14 SGTC_3159 9100096 3.96 49.5 µM 5.19E-5 18 3.78E-5
15 SGTC_1018 4259-0013 3.87 28.1 µM 7.47E-5 23 5.51E-5
16 SGTC_523 1934-0222 3.79 13.7 µM 1.02E-4 34 7.60E-5
17 SGTC_662 k832-1615 3.73 104.0 µM 1.27E-4 22 9.52E-5
18 SGTC_1676 st018489 3.72 23.4 µM 1.34E-4 60S ribosome export 43 1.01E-4
19 SGTC_233 rapamycin 3.71 362.0 pM 1.37E-4 14 1.03E-4
20 SGTC_2589 lobaric acid 3.68 100.0 µM 1.53E-4 29 1.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.54E-8 YKR010C TOF2 hom Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication
0.092 1.05E-7 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.090 2.06E-7 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.086 6.59E-7 YKL006W RPL14A hom Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication
0.081 2.61E-6 YMR032W HOF1 hom Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
0.080 3.87E-6 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.079 4.14E-6 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.079 4.17E-6 YER010C YER010C hom Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction
0.079 4.50E-6 YMR187C_p YMR187C_p hom Putative protein of unknown function; YMR187C is not an essential gene
0.079 4.91E-6 YLR432W IMD3 hom Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
0.079 5.11E-6 YMR258C ROY1 hom GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p
0.078 6.41E-6 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.078 6.77E-6 YDR368W YPR1 hom NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication
0.076 1.00E-5 YHR104W GRE3 hom Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.073 2.08E-5 YMR276W DSK2 hom Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress