YIL038C / NOT3

Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL038C / NOT3

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.13|P-value:7.93E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:3.70|P-value:3.43E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-7.16|P-value:1.05E-10 ID:SGTC_142|Compound:0335-0849|FD-Score:-6.91|P-value:4.33E-10 ID:SGTC_158|Compound:k038-0087|FD-Score:-6.20|P-value:2.02E-8 ID:SGTC_187|Compound:1488-2104|FD-Score:-3.94|P-value:2.61E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.80|P-value:4.22E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:-3.54|P-value:9.41E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.40|P-value:8.96E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:-3.70|P-value:5.76E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:-4.45|P-value:4.42E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.55|P-value:4.64E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.77|P-value:1.30E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.49|P-value:6.75E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.64|P-value:4.12E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.85|P-value:2.08E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-4.45|P-value:4.37E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:-3.80|P-value:4.25E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.44|P-value:7.91E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.57|P-value:1.46E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:4.36|P-value:3.31E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.66|P-value:3.92E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.75|P-value:2.90E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.86|P-value:3.41E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.73|P-value:3.09E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.66|P-value:6.66E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.96|P-value:1.41E-4 ID:SGTC_1624|Compound:st003710|FD-Score:6.20|P-value:8.68E-9 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.54|P-value:9.53E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.52|P-value:1.77E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-4.31|P-value:7.24E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-6.42|P-value:6.42E-9 ID:SGTC_1720|Compound:st037298|FD-Score:-3.53|P-value:9.83E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-5.83|P-value:1.25E-7 ID:SGTC_1750|Compound:st081859|FD-Score:4.32|P-value:3.91E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.68|P-value:6.25E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-5.87|P-value:1.01E-7 ID:SGTC_1801|Compound:st050089|FD-Score:-3.79|P-value:4.31E-4 ID:SGTC_1803|Compound:st050068|FD-Score:-4.52|P-value:3.33E-5 ID:SGTC_1809|Compound:st050081|FD-Score:-3.56|P-value:8.85E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-6.87|P-value:5.31E-10 ID:SGTC_1870|Compound:st057514|FD-Score:3.74|P-value:2.97E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.07|P-value:1.71E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-4.97|P-value:5.61E-6 ID:SGTC_1982|Compound:st072467|FD-Score:3.41|P-value:8.49E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.72|P-value:3.25E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.27|P-value:8.45E-5 ID:SGTC_2139|Compound:5578692|FD-Score:3.56|P-value:5.33E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.72|P-value:3.24E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-3.88|P-value:3.20E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.55|P-value:5.51E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.42|P-value:4.91E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.80|P-value:2.49E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.60|P-value:7.85E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-4.70|P-value:1.66E-5 ID:SGTC_2993|Compound:9054257|FD-Score:4.02|P-value:1.17E-4 ID:SGTC_2999|Compound:9069765|FD-Score:5.49|P-value:2.81E-7 ID:SGTC_3037|Compound:9091026|FD-Score:-7.93|P-value:9.30E-13 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.89|P-value:1.84E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.09|P-value:8.91E-5 ID:SGTC_3074|Compound:9116018|FD-Score:-4.27|P-value:8.38E-5 ID:SGTC_3106|Compound:9121286|FD-Score:3.98|P-value:1.33E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.41|P-value:8.74E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.59|P-value:4.90E-4 ID:SGTC_3127|Compound:9126946|FD-Score:4.33|P-value:3.72E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.94|P-value:1.55E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.96|P-value:5.83E-6 ID:SGTC_3157|Compound:9099274|FD-Score:3.93|P-value:1.56E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.62|P-value:4.43E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-4.00|P-value:2.15E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.79|P-value:2.55E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.55|P-value:5.53E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.13|P-value:7.93E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:3.70|P-value:3.43E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-7.16|P-value:1.05E-10 ID:SGTC_142|Compound:0335-0849|FD-Score:-6.91|P-value:4.33E-10 ID:SGTC_158|Compound:k038-0087|FD-Score:-6.20|P-value:2.02E-8 ID:SGTC_187|Compound:1488-2104|FD-Score:-3.94|P-value:2.61E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.80|P-value:4.22E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:-3.54|P-value:9.41E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.40|P-value:8.96E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:-3.70|P-value:5.76E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:-4.45|P-value:4.42E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.55|P-value:4.64E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.77|P-value:1.30E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.49|P-value:6.75E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.64|P-value:4.12E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.85|P-value:2.08E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-4.45|P-value:4.37E-5 ID:SGTC_846|Compound:0335-0850|FD-Score:-3.80|P-value:4.25E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.44|P-value:7.91E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.57|P-value:1.46E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:4.36|P-value:3.31E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.66|P-value:3.92E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.75|P-value:2.90E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.86|P-value:3.41E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.73|P-value:3.09E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.66|P-value:6.66E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.96|P-value:1.41E-4 ID:SGTC_1624|Compound:st003710|FD-Score:6.20|P-value:8.68E-9 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.54|P-value:9.53E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.52|P-value:1.77E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-4.31|P-value:7.24E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-6.42|P-value:6.42E-9 ID:SGTC_1720|Compound:st037298|FD-Score:-3.53|P-value:9.83E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-5.83|P-value:1.25E-7 ID:SGTC_1750|Compound:st081859|FD-Score:4.32|P-value:3.91E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.68|P-value:6.25E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-5.87|P-value:1.01E-7 ID:SGTC_1801|Compound:st050089|FD-Score:-3.79|P-value:4.31E-4 ID:SGTC_1803|Compound:st050068|FD-Score:-4.52|P-value:3.33E-5 ID:SGTC_1809|Compound:st050081|FD-Score:-3.56|P-value:8.85E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-6.87|P-value:5.31E-10 ID:SGTC_1870|Compound:st057514|FD-Score:3.74|P-value:2.97E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.07|P-value:1.71E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-4.97|P-value:5.61E-6 ID:SGTC_1982|Compound:st072467|FD-Score:3.41|P-value:8.49E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.72|P-value:3.25E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.27|P-value:8.45E-5 ID:SGTC_2139|Compound:5578692|FD-Score:3.56|P-value:5.33E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.72|P-value:3.24E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-3.88|P-value:3.20E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.55|P-value:5.51E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.42|P-value:4.91E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.80|P-value:2.49E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.60|P-value:7.85E-4 ID:SGTC_2989|Compound:9073649|FD-Score:-4.70|P-value:1.66E-5 ID:SGTC_2993|Compound:9054257|FD-Score:4.02|P-value:1.17E-4 ID:SGTC_2999|Compound:9069765|FD-Score:5.49|P-value:2.81E-7 ID:SGTC_3037|Compound:9091026|FD-Score:-7.93|P-value:9.30E-13 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.89|P-value:1.84E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.09|P-value:8.91E-5 ID:SGTC_3074|Compound:9116018|FD-Score:-4.27|P-value:8.38E-5 ID:SGTC_3106|Compound:9121286|FD-Score:3.98|P-value:1.33E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.41|P-value:8.74E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.59|P-value:4.90E-4 ID:SGTC_3127|Compound:9126946|FD-Score:4.33|P-value:3.72E-5 ID:SGTC_3133|Compound:9127736|FD-Score:3.94|P-value:1.55E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.96|P-value:5.83E-6 ID:SGTC_3157|Compound:9099274|FD-Score:3.93|P-value:1.56E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.62|P-value:4.43E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-4.00|P-value:2.15E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.79|P-value:2.55E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.55|P-value:5.53E-4

Top fitness defect scores for YIL038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1624 st003710 6.20 6.2 µM 8.68E-9 calcium & mitochondrial duress 10 2.89E-10
2 SGTC_2999 9069765 5.49 71.4 µM 2.81E-7 amide catabolism 5 1.99E-8
3 SGTC_948 3448-0295 4.57 75.3 µM 1.46E-5 14 2.40E-6
4 SGTC_1694 st024011 4.52 44.9 µM 1.77E-5 ERG2 24 3.03E-6
5 SGTC_959 1222-0044 4.36 107.0 µM 3.31E-5 12 6.43E-6
6 SGTC_3127 9126946 4.33 49.5 µM 3.72E-5 ERG2 12 7.42E-6
7 SGTC_1750 st081859 4.32 2.4 µM 3.91E-5 endomembrane recycling 162 7.88E-6
8 SGTC_58 0957-0393 4.13 9.0 µM 7.93E-5 cell wall 361 1.85E-5
9 SGTC_3063 1327-0034 4.09 4.0 µM 8.91E-5 43 2.13E-5
10 SGTC_2993 9054257 4.02 71.4 µM 1.17E-4 fatty acid desaturase (OLE1) 42 2.95E-5
11 SGTC_3106 9121286 3.98 49.5 µM 1.33E-4 10 3.44E-5
12 SGTC_1607 st000305 3.96 50.6 µM 1.41E-4 12 3.70E-5
13 SGTC_3133 9127736 3.94 49.5 µM 1.55E-4 17 4.13E-5
14 SGTC_3157 9099274 3.93 49.5 µM 1.56E-4 21 4.16E-5
15 SGTC_3061 glucosamine 3.89 200.0 µM 1.84E-4 11 5.11E-5
16 SGTC_841 0251-0215 3.85 91.2 µM 2.08E-4 76 5.89E-5
17 SGTC_2759 disulfiram 3.80 3.4 µM 2.49E-4 42 7.31E-5
18 SGTC_3323 9138564 3.79 53.9 µM 2.55E-4 28 7.54E-5
19 SGTC_1168 k815-0004 3.75 80.5 µM 2.90E-4 DNA damage response 20 8.80E-5
20 SGTC_1870 st057514 3.74 26.5 µM 2.97E-4 RSC & ERG11 30 9.04E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 2.09E-14 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.119 4.89E-12 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.112 6.70E-11 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.110 1.86E-10 YGR192C TDH3 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication
0.108 3.12E-10 YIL039W TED1 hom Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.106 8.54E-10 YLL018C DPS1 het Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation
0.105 9.38E-10 YGL251C HFM1 hom Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
0.105 1.27E-9 YBR162C TOS1 hom Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
0.103 2.44E-9 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.102 2.71E-9 YBR221C PDB1 hom E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
0.102 3.44E-9 YDR161W_p YDR161W_p hom Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
0.101 4.78E-9 YDL172C_d YDL172C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.101 4.85E-9 YGL135W RPL1B hom Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.099 8.70E-9 YOL067C RTG1 hom Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus
0.099 8.90E-9 YGL250W RMR1 hom Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus