YIL039W / TED1

Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL039W / TED1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:5.14|P-value:3.93E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.90|P-value:3.21E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.57|P-value:9.67E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:6.81|P-value:1.61E-9 ID:SGTC_123|Compound:0083-0120|FD-Score:4.50|P-value:4.59E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:4.68|P-value:2.39E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.12|P-value:1.76E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:-4.42|P-value:5.51E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.63|P-value:2.88E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.54|P-value:6.31E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:4.07|P-value:2.08E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:5.84|P-value:1.89E-7 ID:SGTC_451|Compound:chloral hydrate|FD-Score:9.77|P-value:8.86E-18 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.29|P-value:9.77E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:7.04|P-value:4.64E-10 ID:SGTC_533|Compound:1222-0222|FD-Score:4.31|P-value:9.10E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.71|P-value:6.33E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:4.36|P-value:7.71E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:5.22|P-value:2.81E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:9.79|P-value:7.77E-18 ID:SGTC_674|Compound:0498-0004|FD-Score:3.94|P-value:3.13E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.90|P-value:3.52E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:4.78|P-value:1.65E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.64|P-value:8.02E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.68|P-value:7.06E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.01|P-value:8.83E-8 ID:SGTC_830|Compound:4076-0286|FD-Score:6.37|P-value:1.51E-8 ID:SGTC_921|Compound:1561-0023|FD-Score:3.61|P-value:8.77E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:6.22|P-value:3.25E-8 ID:SGTC_960|Compound:1222-0186|FD-Score:4.29|P-value:9.61E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:4.63|P-value:2.88E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.79|P-value:4.98E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-5.77|P-value:2.23E-7 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.48|P-value:4.90E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:8.94|P-value:3.68E-15 ID:SGTC_1368|Compound:1852-0141|FD-Score:-6.65|P-value:3.10E-9 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.97|P-value:2.82E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-6.56|P-value:4.89E-9 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.94|P-value:3.12E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.57|P-value:3.62E-5 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.95|P-value:3.00E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-5.48|P-value:8.07E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:4.79|P-value:1.56E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-4.15|P-value:1.40E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.59|P-value:5.90E-7 ID:SGTC_1818|Compound:st052136|FD-Score:-4.00|P-value:2.30E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-4.21|P-value:1.16E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-3.75|P-value:5.16E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-4.55|P-value:3.43E-5 ID:SGTC_1968|Compound:st069590|FD-Score:3.80|P-value:4.84E-4 ID:SGTC_2004|Compound:4023728|FD-Score:6.72|P-value:2.60E-9 ID:SGTC_2011|Compound:4012611|FD-Score:7.73|P-value:8.86E-12 ID:SGTC_2017|Compound:5132927|FD-Score:5.33|P-value:1.83E-6 ID:SGTC_2067|Compound:5224629|FD-Score:4.12|P-value:1.72E-4 ID:SGTC_2089|Compound:5281248|FD-Score:4.35|P-value:7.99E-5 ID:SGTC_2307|Compound:7538926|FD-Score:5.18|P-value:3.33E-6 ID:SGTC_2309|Compound:7664088|FD-Score:3.89|P-value:3.70E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-5.78|P-value:2.12E-7 ID:SGTC_2388|Compound:9080168|FD-Score:-4.40|P-value:5.79E-5 ID:SGTC_2389|Compound:9091542|FD-Score:4.09|P-value:1.92E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:5.30|P-value:2.02E-6 ID:SGTC_2444|Compound:5485484|FD-Score:3.86|P-value:4.04E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.96|P-value:2.91E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-7.97|P-value:1.68E-12 ID:SGTC_2601|Compound:securinine|FD-Score:5.38|P-value:1.49E-6 ID:SGTC_2676|Compound:harmalol|FD-Score:3.96|P-value:2.90E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.01|P-value:2.25E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-5.35|P-value:1.45E-6 ID:SGTC_2781|Compound:5567276|FD-Score:4.39|P-value:6.80E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-4.93|P-value:8.05E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-3.62|P-value:7.54E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.98|P-value:2.76E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.71|P-value:6.39E-4 ID:SGTC_3026|Compound:9090633|FD-Score:6.41|P-value:1.24E-8 ID:SGTC_3037|Compound:9091026|FD-Score:-3.64|P-value:7.13E-4 ID:SGTC_3141|Compound:9094609|FD-Score:5.58|P-value:6.09E-7 ID:SGTC_3142|Compound:9086498|FD-Score:4.31|P-value:9.16E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-3.70|P-value:5.91E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.51|P-value:7.30E-7 ID:SGTC_3346|Compound:9158254|FD-Score:-3.92|P-value:2.99E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:5.14|P-value:3.93E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.90|P-value:3.21E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.57|P-value:9.67E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:6.81|P-value:1.61E-9 ID:SGTC_123|Compound:0083-0120|FD-Score:4.50|P-value:4.59E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:4.68|P-value:2.39E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.12|P-value:1.76E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:-4.42|P-value:5.51E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.63|P-value:2.88E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.54|P-value:6.31E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:4.07|P-value:2.08E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:5.84|P-value:1.89E-7 ID:SGTC_451|Compound:chloral hydrate|FD-Score:9.77|P-value:8.86E-18 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.29|P-value:9.77E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:7.04|P-value:4.64E-10 ID:SGTC_533|Compound:1222-0222|FD-Score:4.31|P-value:9.10E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.71|P-value:6.33E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:4.36|P-value:7.71E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:5.22|P-value:2.81E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:9.79|P-value:7.77E-18 ID:SGTC_674|Compound:0498-0004|FD-Score:3.94|P-value:3.13E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.90|P-value:3.52E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:4.78|P-value:1.65E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.64|P-value:8.02E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.68|P-value:7.06E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.01|P-value:8.83E-8 ID:SGTC_830|Compound:4076-0286|FD-Score:6.37|P-value:1.51E-8 ID:SGTC_921|Compound:1561-0023|FD-Score:3.61|P-value:8.77E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:6.22|P-value:3.25E-8 ID:SGTC_960|Compound:1222-0186|FD-Score:4.29|P-value:9.61E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:4.63|P-value:2.88E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.79|P-value:4.98E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-5.77|P-value:2.23E-7 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.48|P-value:4.90E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:8.94|P-value:3.68E-15 ID:SGTC_1368|Compound:1852-0141|FD-Score:-6.65|P-value:3.10E-9 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.97|P-value:2.82E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-6.56|P-value:4.89E-9 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.94|P-value:3.12E-4 ID:SGTC_1521|Compound:st012942|FD-Score:4.57|P-value:3.62E-5 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.95|P-value:3.00E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-5.48|P-value:8.07E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:4.79|P-value:1.56E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-4.15|P-value:1.40E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.59|P-value:5.90E-7 ID:SGTC_1818|Compound:st052136|FD-Score:-4.00|P-value:2.30E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-4.21|P-value:1.16E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-3.75|P-value:5.16E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-4.55|P-value:3.43E-5 ID:SGTC_1968|Compound:st069590|FD-Score:3.80|P-value:4.84E-4 ID:SGTC_2004|Compound:4023728|FD-Score:6.72|P-value:2.60E-9 ID:SGTC_2011|Compound:4012611|FD-Score:7.73|P-value:8.86E-12 ID:SGTC_2017|Compound:5132927|FD-Score:5.33|P-value:1.83E-6 ID:SGTC_2067|Compound:5224629|FD-Score:4.12|P-value:1.72E-4 ID:SGTC_2089|Compound:5281248|FD-Score:4.35|P-value:7.99E-5 ID:SGTC_2307|Compound:7538926|FD-Score:5.18|P-value:3.33E-6 ID:SGTC_2309|Compound:7664088|FD-Score:3.89|P-value:3.70E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-5.78|P-value:2.12E-7 ID:SGTC_2388|Compound:9080168|FD-Score:-4.40|P-value:5.79E-5 ID:SGTC_2389|Compound:9091542|FD-Score:4.09|P-value:1.92E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:5.30|P-value:2.02E-6 ID:SGTC_2444|Compound:5485484|FD-Score:3.86|P-value:4.04E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.96|P-value:2.91E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-7.97|P-value:1.68E-12 ID:SGTC_2601|Compound:securinine|FD-Score:5.38|P-value:1.49E-6 ID:SGTC_2676|Compound:harmalol|FD-Score:3.96|P-value:2.90E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.01|P-value:2.25E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-5.35|P-value:1.45E-6 ID:SGTC_2781|Compound:5567276|FD-Score:4.39|P-value:6.80E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-4.93|P-value:8.05E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-3.62|P-value:7.54E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.98|P-value:2.76E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.71|P-value:6.39E-4 ID:SGTC_3026|Compound:9090633|FD-Score:6.41|P-value:1.24E-8 ID:SGTC_3037|Compound:9091026|FD-Score:-3.64|P-value:7.13E-4 ID:SGTC_3141|Compound:9094609|FD-Score:5.58|P-value:6.09E-7 ID:SGTC_3142|Compound:9086498|FD-Score:4.31|P-value:9.16E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-3.70|P-value:5.91E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.51|P-value:7.30E-7 ID:SGTC_3346|Compound:9158254|FD-Score:-3.92|P-value:2.99E-4

Top fitness defect scores for YIL039W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_625 k213-0058 9.79 121.0 µM 7.77E-18 translation 4 6.11E-23
2 SGTC_451 chloral hydrate 9.77 100.0 µM 8.86E-18 3 7.26E-23
3 SGTC_1354 1498-1681 8.94 81.0 µM 3.68E-15 1 1.99E-19
4 SGTC_2011 4012611 7.73 177.0 µM 8.86E-12 mitochondrial processes 4 5.45E-15
5 SGTC_525 k781-2675 7.04 26.7 µM 4.64E-10 redox potentiating 17 9.79E-13
6 SGTC_104 0074-0074 6.81 591.0 µM 1.61E-9 2 5.00E-12
7 SGTC_2004 4023728 6.72 41.9 µM 2.60E-9 4 9.37E-12
8 SGTC_3026 9090633 6.41 49.5 µM 1.24E-8 2 7.27E-11
9 SGTC_830 4076-0286 6.37 57.8 µM 1.51E-8 translation 10 9.42E-11
10 SGTC_935 2996-0153 6.22 430.0 µM 3.25E-8 PDR1 5 2.56E-10
11 SGTC_800 3448-7362 6.01 155.0 µM 8.83E-8 translation 49 9.48E-10
12 SGTC_381 3461-2219 5.84 42.7 µM 1.89E-7 copper-dependent oxidative stress 3 2.57E-9
13 SGTC_1785 bathophenanthroline 5.59 24.0 µM 5.90E-7 heme requiring 15 1.14E-8
14 SGTC_3141 9094609 5.58 49.5 µM 6.09E-7 iron homeostasis 10 1.19E-8
15 SGTC_2601 securinine 5.38 100.0 µM 1.49E-6 8 3.81E-8
16 SGTC_2017 5132927 5.33 60.6 µM 1.83E-6 7 4.98E-8
17 SGTC_2422 chlorphenesin carbamate 5.30 384.2 µM 2.02E-6 9 5.69E-8
18 SGTC_576 1073-0113 5.22 22.7 µM 2.81E-6 redox potentiating 31 8.75E-8
19 SGTC_2307 7538926 5.18 6.3 µM 3.33E-6 15 1.09E-7
20 SGTC_3 0833-0587 5.14 95.6 µM 3.93E-6 redox potentiating 12 1.36E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.217 5.85E-37 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.192 2.58E-29 YOL100W PKH2 hom Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
0.185 3.15E-27 YPL208W RKM1 hom SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)
0.171 2.09E-23 YBR162C TOS1 hom Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
0.171 2.36E-23 YDR516C EMI2 hom Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.170 4.47E-23 YGL251C HFM1 hom Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
0.169 8.25E-23 YGL236C MTO1 hom Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
0.160 1.22E-20 YGL167C PMR1 hom High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.139 7.25E-16 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.133 1.26E-14 YDR281C PHM6 hom Protein of unknown function, expression is regulated by phosphate levels
0.121 1.97E-12 YOR305W RRG7 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene
0.119 3.89E-12 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.116 1.45E-11 YIR021W-A_p YIR021W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.116 1.87E-11 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.108 3.12E-10 YIL038C NOT3 hom Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation