YIL043C / CBR1

Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL043C / CBR1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:6.98|P-value:9.47E-12 ID:SGTC_29|Compound:0299-0004|FD-Score:4.41|P-value:1.14E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.33|P-value:6.58E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.48|P-value:4.20E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.81|P-value:1.27E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.28|P-value:1.96E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:3.59|P-value:2.79E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.81|P-value:1.92E-6 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.67|P-value:2.56E-8 ID:SGTC_422|Compound:cantharidin|FD-Score:4.00|P-value:6.02E-5 ID:SGTC_442|Compound:cape|FD-Score:3.70|P-value:1.89E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:9.25|P-value:2.93E-19 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.28|P-value:8.14E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.99|P-value:6.33E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:5.45|P-value:8.22E-8 ID:SGTC_655|Compound:k060-0012|FD-Score:3.42|P-value:5.10E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.39|P-value:5.27E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.73|P-value:1.71E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:-4.84|P-value:1.48E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:3.43|P-value:4.94E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:4.40|P-value:1.18E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:6.84|P-value:2.41E-11 ID:SGTC_719|Compound:2810-4230|FD-Score:4.18|P-value:2.92E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:8.60|P-value:6.59E-17 ID:SGTC_791|Compound:1348-1292|FD-Score:4.17|P-value:3.10E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.38|P-value:5.40E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.29|P-value:7.85E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.82|P-value:1.21E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:6.25|P-value:9.62E-10 ID:SGTC_1052|Compound:3253-3998|FD-Score:5.40|P-value:1.06E-7 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.52|P-value:3.66E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.41|P-value:5.39E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.28|P-value:8.24E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.67|P-value:2.15E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.41|P-value:5.34E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.36|P-value:6.34E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-4.61|P-value:4.30E-6 ID:SGTC_1621|Compound:st003705|FD-Score:-3.79|P-value:1.27E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.72|P-value:1.77E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.25|P-value:9.05E-4 ID:SGTC_1923|Compound:st058458|FD-Score:5.31|P-value:1.68E-7 ID:SGTC_1925|Compound:st057770|FD-Score:3.48|P-value:4.16E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.84|P-value:1.12E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.90|P-value:8.22E-5 ID:SGTC_2264|Compound:7948757|FD-Score:4.12|P-value:3.78E-5 ID:SGTC_2352|Compound:9027995|FD-Score:3.33|P-value:6.93E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.28|P-value:8.28E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-6.57|P-value:1.20E-10 ID:SGTC_2403|Compound:6032726|FD-Score:4.20|P-value:2.79E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.98|P-value:6.53E-5 ID:SGTC_2460|Compound:5552655|FD-Score:-3.28|P-value:7.79E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.69|P-value:1.94E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.71|P-value:3.02E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-5.70|P-value:1.93E-8 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.08|P-value:4.49E-5 ID:SGTC_2646|Compound:retinol|FD-Score:3.54|P-value:3.36E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.36|P-value:7.50E-13 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.71|P-value:2.00E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.57|P-value:3.09E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.98|P-value:8.61E-7 ID:SGTC_2802|Compound:7925815|FD-Score:4.20|P-value:2.69E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.66|P-value:2.21E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.27|P-value:8.52E-4 ID:SGTC_3000|Compound:9075062|FD-Score:5.43|P-value:8.95E-8 ID:SGTC_3017|Compound:9080681|FD-Score:3.43|P-value:4.91E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.69|P-value:3.36E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-4.95|P-value:8.85E-7 ID:SGTC_3222|Compound:9128301|FD-Score:3.52|P-value:3.66E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.29|P-value:7.98E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:6.98|P-value:9.47E-12 ID:SGTC_29|Compound:0299-0004|FD-Score:4.41|P-value:1.14E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.33|P-value:6.58E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.48|P-value:4.20E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.81|P-value:1.27E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.28|P-value:1.96E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:3.59|P-value:2.79E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.81|P-value:1.92E-6 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.67|P-value:2.56E-8 ID:SGTC_422|Compound:cantharidin|FD-Score:4.00|P-value:6.02E-5 ID:SGTC_442|Compound:cape|FD-Score:3.70|P-value:1.89E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:9.25|P-value:2.93E-19 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.28|P-value:8.14E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.99|P-value:6.33E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:5.45|P-value:8.22E-8 ID:SGTC_655|Compound:k060-0012|FD-Score:3.42|P-value:5.10E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.39|P-value:5.27E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.73|P-value:1.71E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:-4.84|P-value:1.48E-6 ID:SGTC_684|Compound:1140-0066|FD-Score:3.43|P-value:4.94E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:4.40|P-value:1.18E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:6.84|P-value:2.41E-11 ID:SGTC_719|Compound:2810-4230|FD-Score:4.18|P-value:2.92E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:8.60|P-value:6.59E-17 ID:SGTC_791|Compound:1348-1292|FD-Score:4.17|P-value:3.10E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:-3.38|P-value:5.40E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.29|P-value:7.85E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.82|P-value:1.21E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:6.25|P-value:9.62E-10 ID:SGTC_1052|Compound:3253-3998|FD-Score:5.40|P-value:1.06E-7 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.52|P-value:3.66E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.41|P-value:5.39E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.28|P-value:8.24E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.67|P-value:2.15E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.41|P-value:5.34E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.36|P-value:6.34E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-4.61|P-value:4.30E-6 ID:SGTC_1621|Compound:st003705|FD-Score:-3.79|P-value:1.27E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.72|P-value:1.77E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.25|P-value:9.05E-4 ID:SGTC_1923|Compound:st058458|FD-Score:5.31|P-value:1.68E-7 ID:SGTC_1925|Compound:st057770|FD-Score:3.48|P-value:4.16E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.84|P-value:1.12E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.90|P-value:8.22E-5 ID:SGTC_2264|Compound:7948757|FD-Score:4.12|P-value:3.78E-5 ID:SGTC_2352|Compound:9027995|FD-Score:3.33|P-value:6.93E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.28|P-value:8.28E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-6.57|P-value:1.20E-10 ID:SGTC_2403|Compound:6032726|FD-Score:4.20|P-value:2.79E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.98|P-value:6.53E-5 ID:SGTC_2460|Compound:5552655|FD-Score:-3.28|P-value:7.79E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.69|P-value:1.94E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.71|P-value:3.02E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-5.70|P-value:1.93E-8 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.08|P-value:4.49E-5 ID:SGTC_2646|Compound:retinol|FD-Score:3.54|P-value:3.36E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.36|P-value:7.50E-13 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.71|P-value:2.00E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.57|P-value:3.09E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.98|P-value:8.61E-7 ID:SGTC_2802|Compound:7925815|FD-Score:4.20|P-value:2.69E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.66|P-value:2.21E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.27|P-value:8.52E-4 ID:SGTC_3000|Compound:9075062|FD-Score:5.43|P-value:8.95E-8 ID:SGTC_3017|Compound:9080681|FD-Score:3.43|P-value:4.91E-4 ID:SGTC_3148|Compound:9097893|FD-Score:4.69|P-value:3.36E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-4.95|P-value:8.85E-7 ID:SGTC_3222|Compound:9128301|FD-Score:3.52|P-value:3.66E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.29|P-value:7.98E-4

Top fitness defect scores for YIL043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_457 grayanotoxin iii 9.25 135.0 µM 2.93E-19 7 1.16E-20
2 SGTC_720 r052-1644 8.60 49.9 µM 6.59E-17 TSC3-RPN4 3 3.98E-18
3 SGTC_2651 1327-0036 7.36 5.0 µM 7.50E-13 43 9.42E-14
4 SGTC_9 0092-0002 6.98 10.4 µM 9.47E-12 5 1.45E-12
5 SGTC_715 0868-0130 6.84 184.0 µM 2.41E-11 1 3.98E-12
6 SGTC_1046 2001-0062 6.25 216.0 µM 9.62E-10 2 2.12E-10
7 SGTC_2688 kanamycin b 5.71 96.7 µM 2.00E-8 calcium & mitochondrial duress 178 5.57E-9
8 SGTC_272 doxorubicin 5.67 8.1 µM 2.56E-8 anthracycline transcription coupled DNA repair 6 7.27E-9
9 SGTC_644 1498-1197 5.45 63.3 µM 8.22E-8 1 2.56E-8
10 SGTC_3000 9075062 5.43 71.4 µM 8.95E-8 3 2.81E-8
11 SGTC_1052 3253-3998 5.40 198.0 µM 1.06E-7 4 3.38E-8
12 SGTC_1923 st058458 5.31 19.1 µM 1.68E-7 10 5.53E-8
13 SGTC_2781 5567276 4.98 71.4 µM 8.61E-7 23 3.22E-7
14 SGTC_151 3013-0144 4.81 2.3 µM 1.92E-6 iron homeostasis 10 7.65E-7
15 SGTC_2582 agaric acid 4.71 100.0 µM 3.02E-6 redox potentiating 243 1.24E-6
16 SGTC_3148 9097893 4.69 49.5 µM 3.36E-6 25 1.40E-6
17 SGTC_29 0299-0004 4.41 13.0 µM 1.14E-5 24 5.21E-6
18 SGTC_714 4296-0578 4.40 26.1 µM 1.18E-5 1 5.40E-6
19 SGTC_100 0086-0128 4.28 49.6 µM 1.96E-5 copper-dependent oxidative stress 38 9.33E-6
20 SGTC_2802 7925815 4.20 54.5 µM 2.69E-5 35 1.31E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.17E-19 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.136 3.29E-15 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.132 1.77E-14 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.127 1.28E-13 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.122 1.22E-12 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.120 3.68E-12 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.118 6.70E-12 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.114 3.09E-11 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.114 3.70E-11 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.109 2.74E-10 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.108 3.76E-10 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.105 1.25E-9 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.102 3.20E-9 YIL057C RGI2 hom Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose
0.100 7.49E-9 YIL124W AYR1 hom NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones
0.099 8.03E-9 YJL148W RPA34 hom RNA polymerase I subunit A34.5