YIL045W / PIG2

Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL045W / PIG2

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.82|P-value:9.78E-5 ID:SGTC_80|Compound:0159-0065|FD-Score:3.24|P-value:7.62E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.89|P-value:1.49E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.07|P-value:1.05E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:3.56|P-value:2.59E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.43|P-value:4.03E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.26|P-value:7.08E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.22|P-value:8.09E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.36|P-value:5.10E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-4.08|P-value:7.40E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:-4.35|P-value:2.52E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.53|P-value:5.30E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:-3.49|P-value:6.11E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.67|P-value:1.73E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.93|P-value:6.45E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.72|P-value:2.71E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.42|P-value:4.14E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.54|P-value:5.03E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.33|P-value:5.66E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.48|P-value:3.37E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.98|P-value:1.07E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.45|P-value:3.77E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-4.39|P-value:2.10E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:-3.50|P-value:5.82E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.98|P-value:6.92E-7 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.46|P-value:6.66E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.90|P-value:7.32E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.45|P-value:3.81E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.62|P-value:3.84E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.21|P-value:8.35E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.38|P-value:4.79E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.56|P-value:2.60E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.29|P-value:6.54E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.87|P-value:1.61E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.42|P-value:4.16E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.61|P-value:4.05E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-4.07|P-value:7.56E-5 ID:SGTC_2081|Compound:5214970|FD-Score:-3.67|P-value:3.27E-4 ID:SGTC_2094|Compound:5332512|FD-Score:4.18|P-value:2.45E-5 ID:SGTC_2167|Compound:5876490|FD-Score:5.74|P-value:1.40E-8 ID:SGTC_2237|Compound:6667747|FD-Score:5.89|P-value:6.14E-9 ID:SGTC_2244|Compound:6635614|FD-Score:-5.88|P-value:1.73E-8 ID:SGTC_2350|Compound:9023895|FD-Score:6.25|P-value:8.18E-10 ID:SGTC_2357|Compound:9067248|FD-Score:-4.54|P-value:1.13E-5 ID:SGTC_2369|Compound:9071472|FD-Score:-3.41|P-value:7.80E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.10|P-value:3.35E-5 ID:SGTC_2424|Compound:5537928|FD-Score:4.93|P-value:9.01E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.77|P-value:1.21E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.86|P-value:1.25E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-3.89|P-value:1.47E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.36|P-value:9.25E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.19|P-value:2.31E-5 ID:SGTC_2803|Compound:7707263|FD-Score:4.00|P-value:5.03E-5 ID:SGTC_2831|Compound:7999036|FD-Score:4.12|P-value:3.10E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-4.87|P-value:2.70E-6 ID:SGTC_3002|Compound:9075603|FD-Score:4.18|P-value:2.45E-5 ID:SGTC_3167|Compound:9103034|FD-Score:-4.22|P-value:4.29E-5 ID:SGTC_3173|Compound:9105693|FD-Score:-4.10|P-value:6.60E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:3.82|P-value:9.78E-5 ID:SGTC_80|Compound:0159-0065|FD-Score:3.24|P-value:7.62E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.89|P-value:1.49E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.07|P-value:1.05E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:3.56|P-value:2.59E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.43|P-value:4.03E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.26|P-value:7.08E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.22|P-value:8.09E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.36|P-value:5.10E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-4.08|P-value:7.40E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:-4.35|P-value:2.52E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.53|P-value:5.30E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:-3.49|P-value:6.11E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.67|P-value:1.73E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.93|P-value:6.45E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.72|P-value:2.71E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.42|P-value:4.14E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.54|P-value:5.03E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.33|P-value:5.66E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.48|P-value:3.37E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.98|P-value:1.07E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.45|P-value:3.77E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-4.39|P-value:2.10E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:-3.50|P-value:5.82E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.98|P-value:6.92E-7 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.46|P-value:6.66E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.90|P-value:7.32E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.45|P-value:3.81E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.62|P-value:3.84E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.21|P-value:8.35E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.38|P-value:4.79E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.56|P-value:2.60E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.29|P-value:6.54E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.87|P-value:1.61E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.42|P-value:4.16E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.61|P-value:4.05E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-4.07|P-value:7.56E-5 ID:SGTC_2081|Compound:5214970|FD-Score:-3.67|P-value:3.27E-4 ID:SGTC_2094|Compound:5332512|FD-Score:4.18|P-value:2.45E-5 ID:SGTC_2167|Compound:5876490|FD-Score:5.74|P-value:1.40E-8 ID:SGTC_2237|Compound:6667747|FD-Score:5.89|P-value:6.14E-9 ID:SGTC_2244|Compound:6635614|FD-Score:-5.88|P-value:1.73E-8 ID:SGTC_2350|Compound:9023895|FD-Score:6.25|P-value:8.18E-10 ID:SGTC_2357|Compound:9067248|FD-Score:-4.54|P-value:1.13E-5 ID:SGTC_2369|Compound:9071472|FD-Score:-3.41|P-value:7.80E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.10|P-value:3.35E-5 ID:SGTC_2424|Compound:5537928|FD-Score:4.93|P-value:9.01E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.77|P-value:1.21E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.86|P-value:1.25E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-3.89|P-value:1.47E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.36|P-value:9.25E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.19|P-value:2.31E-5 ID:SGTC_2803|Compound:7707263|FD-Score:4.00|P-value:5.03E-5 ID:SGTC_2831|Compound:7999036|FD-Score:4.12|P-value:3.10E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-4.87|P-value:2.70E-6 ID:SGTC_3002|Compound:9075603|FD-Score:4.18|P-value:2.45E-5 ID:SGTC_3167|Compound:9103034|FD-Score:-4.22|P-value:4.29E-5 ID:SGTC_3173|Compound:9105693|FD-Score:-4.10|P-value:6.60E-5

Top fitness defect scores for YIL045W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2350 9023895 6.25 38.9 µM 8.18E-10 ergosterol biosynthesis 9 2.11E-10
2 SGTC_2237 6667747 5.89 47.2 µM 6.14E-9 5 1.88E-9
3 SGTC_2167 5876490 5.74 200.0 µM 1.40E-8 6 4.61E-9
4 SGTC_1324 1418-0026 4.98 34.4 µM 6.92E-7 3 3.15E-7
5 SGTC_2424 5537928 4.93 59.2 µM 9.01E-7 17 4.19E-7
6 SGTC_2651 1327-0036 4.86 5.0 µM 1.25E-6 116 5.95E-7
7 SGTC_2788 5282734 4.19 71.4 µM 2.31E-5 36 1.39E-5
8 SGTC_3002 9075603 4.18 71.4 µM 2.45E-5 16 1.48E-5
9 SGTC_2094 5332512 4.18 191.7 µM 2.45E-5 20 1.48E-5
10 SGTC_2831 7999036 4.12 19.5 µM 3.10E-5 39 1.91E-5
11 SGTC_2403 6032726 4.10 181.2 µM 3.35E-5 37 2.08E-5
12 SGTC_2803 7707263 4.00 71.4 µM 5.03E-5 29 3.22E-5
13 SGTC_1021 4476-0760 3.93 85.3 µM 6.45E-5 27 4.20E-5
14 SGTC_1492 4158-0558 3.90 28.5 µM 7.32E-5 60S ribosome export 16 4.82E-5
15 SGTC_25 0118-0223 3.82 35.7 µM 9.78E-5 18 6.58E-5
16 SGTC_2639 lactacystin 3.77 53.0 µM 1.21E-4 30 8.27E-5
17 SGTC_953 1188-0045 3.67 9.7 µM 1.73E-4 60S ribosome export 33 1.21E-4
18 SGTC_513 4245-1575 3.56 41.7 µM 2.59E-4 unfolded protein response 136 1.87E-4
19 SGTC_1893 st059353 3.56 36.1 µM 2.60E-4 35 1.88E-4
20 SGTC_1110 3-hydroxy-3'-methoxyflavone 3.48 1.2 µM 3.37E-4 iron homeostasis 66 2.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.92E-10 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.103 2.21E-9 YHR082C KSP1 hom Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress
0.103 2.34E-9 YDL015C TSC13 het Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
0.098 1.28E-8 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.097 1.63E-8 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.097 1.70E-8 YBR256C RIB5 het Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
0.095 3.47E-8 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.093 5.76E-8 YJR039W_p YJR039W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.092 8.55E-8 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.092 8.69E-8 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.090 2.03E-7 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.089 2.25E-7 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.089 2.67E-7 YGL073W HSF1 het Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
0.088 3.56E-7 YJR131W MNS1 hom Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation
0.085 7.59E-7 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function