YIL046W-A_p

Putative protein of unknown function; identified by expression profiling and mass spectrometry

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL046W-A / YIL046W-A

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.92|P-value:2.42E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.74|P-value:5.28E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:3.27|P-value:3.46E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.87|P-value:3.03E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:4.01|P-value:1.57E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:3.19|P-value:4.72E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.56|P-value:1.11E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:3.31|P-value:3.02E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.35|P-value:2.58E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.85|P-value:3.27E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.13|P-value:5.72E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.35|P-value:2.52E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:4.05|P-value:1.30E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:3.32|P-value:2.91E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.29|P-value:3.17E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.70|P-value:6.09E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:-3.72|P-value:5.58E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.90|P-value:2.47E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:-4.01|P-value:1.53E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.59|P-value:9.66E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.67|P-value:6.71E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.56|P-value:1.09E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:7.44|P-value:5.62E-15 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.36|P-value:2.49E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-4.13|P-value:9.05E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-3.25|P-value:3.71E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.78|P-value:4.42E-5 ID:SGTC_1812|Compound:st052057|FD-Score:-3.45|P-value:1.70E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-3.09|P-value:6.62E-4 ID:SGTC_1825|Compound:st052143|FD-Score:-3.28|P-value:3.23E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.22|P-value:4.18E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.24|P-value:3.84E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:8.01|P-value:4.51E-17 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:5.36|P-value:1.31E-8 ID:SGTC_2735|Compound:sertaconazole|FD-Score:4.02|P-value:1.52E-5 ID:SGTC_2856|Compound:9022925|FD-Score:2.99|P-value:9.60E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.05|P-value:7.71E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-4.78|P-value:3.38E-7 ID:SGTC_3165|Compound:9101544|FD-Score:3.23|P-value:3.95E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.92|P-value:2.42E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.74|P-value:5.28E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:3.27|P-value:3.46E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.87|P-value:3.03E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:4.01|P-value:1.57E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:3.19|P-value:4.72E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.56|P-value:1.11E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:3.31|P-value:3.02E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.35|P-value:2.58E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.85|P-value:3.27E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.13|P-value:5.72E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.35|P-value:2.52E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:4.05|P-value:1.30E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:3.32|P-value:2.91E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.29|P-value:3.17E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.70|P-value:6.09E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:-3.72|P-value:5.58E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.90|P-value:2.47E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:-4.01|P-value:1.53E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.59|P-value:9.66E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.67|P-value:6.71E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.56|P-value:1.09E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:7.44|P-value:5.62E-15 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.36|P-value:2.49E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-4.13|P-value:9.05E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-3.25|P-value:3.71E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.78|P-value:4.42E-5 ID:SGTC_1812|Compound:st052057|FD-Score:-3.45|P-value:1.70E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-3.09|P-value:6.62E-4 ID:SGTC_1825|Compound:st052143|FD-Score:-3.28|P-value:3.23E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.22|P-value:4.18E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.24|P-value:3.84E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:8.01|P-value:4.51E-17 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:5.36|P-value:1.31E-8 ID:SGTC_2735|Compound:sertaconazole|FD-Score:4.02|P-value:1.52E-5 ID:SGTC_2856|Compound:9022925|FD-Score:2.99|P-value:9.60E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.05|P-value:7.71E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-4.78|P-value:3.38E-7 ID:SGTC_3165|Compound:9101544|FD-Score:3.23|P-value:3.95E-4

Top fitness defect scores for YIL046W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 8.01 100.0 µM 4.51E-17 6 5.66E-16
2 SGTC_1125 tnp00248 7.44 1.3 µM 5.62E-15 2 5.00E-14
3 SGTC_2635 hydroquinidine 5.36 100.0 µM 1.31E-8 5 4.13E-8
4 SGTC_184 1494-0393 4.56 24.7 µM 1.11E-6 46 2.56E-6
5 SGTC_412 gemfibrozil 4.05 100.0 µM 1.30E-5 DNA intercalators 7 2.52E-5
6 SGTC_2735 sertaconazole 4.02 140.0 nM 1.52E-5 plasma membrane duress 15 2.93E-5
7 SGTC_145 3737-0113 4.01 38.4 µM 1.57E-5 DNA intercalators 72 3.02E-5
8 SGTC_68 0986-0284 3.92 82.8 µM 2.42E-5 71 4.51E-5
9 SGTC_126 0417-1624 3.87 672.5 µM 3.03E-5 DNA intercalators 36 5.55E-5
10 SGTC_296 1222-0039 3.85 74.9 µM 3.27E-5 14 5.97E-5
11 SGTC_1808 st050063 3.78 61.5 µM 4.42E-5 14 7.91E-5
12 SGTC_115 0527-0192 3.74 112.0 µM 5.28E-5 83 9.32E-5
13 SGTC_1082 camptothecin 3.59 424.9 nM 9.66E-5 DNA damage response 56 1.64E-4
14 SGTC_1121 fusaric acid 3.56 630.5 nM 1.09E-4 47 1.83E-4
15 SGTC_1131 3454-3128 3.36 32.3 µM 2.49E-4 71 3.96E-4
16 SGTC_388 3',4'-dichloroisocoumarin 3.35 16.7 µM 2.52E-4 28 4.00E-4
17 SGTC_285 1486-1325 3.35 46.0 µM 2.58E-4 35 4.09E-4
18 SGTC_831 k061-1017 3.32 217.0 µM 2.91E-4 translation 103 4.58E-4
19 SGTC_236 1509-0011 3.31 5.3 µM 3.02E-4 439 4.74E-4
20 SGTC_950 1165-0508 3.29 94.1 µM 3.17E-4 49 4.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.191 8.57E-29 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.182 2.03E-26 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.163 1.67E-21 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.153 4.54E-19 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.153 5.11E-19 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.150 2.01E-18 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.126 2.36E-13 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.126 3.14E-13 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.122 1.28E-12 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.122 1.59E-12 YMR150C IMP1 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.119 5.23E-12 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.119 5.06E-12 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.118 6.59E-12 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.116 1.36E-11 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.116 1.60E-11 YLL063C AYT1 hom Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis