Putative protein of unknown function; identified by expression profiling and mass spectrometry
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YIL046W-A deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.191 | 8.57E-29 | YDR499W | LCD1 | het | Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress |
0.182 | 2.03E-26 | YDR411C | DFM1 | hom | Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p |
0.163 | 1.67E-21 | YML074C | FPR3 | hom | Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p |
0.153 | 4.54E-19 | YEL064C | AVT2 | hom | Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters |
0.153 | 5.11E-19 | YBR090C_p | YBR090C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus |
0.150 | 2.01E-18 | YKL116C | PRR1 | hom | Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor |
0.126 | 2.36E-13 | YJL051W | IRC8 | hom | Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc |
0.126 | 3.14E-13 | YGL002W | ERP6 | hom | Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication |
0.122 | 1.28E-12 | YMR286W | MRPL33 | hom | Mitochondrial ribosomal protein of the large subunit |
0.122 | 1.59E-12 | YMR150C | IMP1 | hom | Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p |
0.119 | 5.23E-12 | YEL017C-A | PMP2 | hom | Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication |
0.119 | 5.06E-12 | YJR127C | RSF2 | hom | Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress |
0.118 | 6.59E-12 | YPR160W | GPH1 | hom | Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway |
0.116 | 1.36E-11 | YKL221W | MCH2 | hom | Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport |
0.116 | 1.60E-11 | YLL063C | AYT1 | hom | Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis |