YIL047C / SYG1

Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL047C / SYG1

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:3.23|P-value:4.45E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.98|P-value:2.08E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.81|P-value:4.29E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.36|P-value:2.75E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:4.22|P-value:6.92E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:6.03|P-value:2.52E-10 ID:SGTC_361|Compound:000s-0510|FD-Score:5.44|P-value:9.94E-9 ID:SGTC_364|Compound:0083-0097|FD-Score:3.61|P-value:1.01E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.23|P-value:4.51E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:4.53|P-value:1.48E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.37|P-value:2.56E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.29|P-value:4.86E-6 ID:SGTC_1253|Compound:0550-0034|FD-Score:6.34|P-value:3.03E-11 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.56|P-value:1.24E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.51|P-value:1.65E-6 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.37|P-value:2.65E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.27|P-value:3.85E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.76|P-value:4.51E-7 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.80|P-value:4.46E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.51|P-value:1.62E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.30|P-value:3.38E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.25|P-value:4.07E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.38|P-value:2.55E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-3.11|P-value:5.96E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.61|P-value:8.62E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.26|P-value:4.00E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.81|P-value:4.27E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.08|P-value:7.60E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.24|P-value:6.07E-6 ID:SGTC_2017|Compound:5132927|FD-Score:3.66|P-value:8.25E-5 ID:SGTC_2052|Compound:5265182|FD-Score:4.96|P-value:1.53E-7 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.69|P-value:7.08E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.10|P-value:1.18E-5 ID:SGTC_2259|Compound:7964009|FD-Score:3.36|P-value:2.72E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.83|P-value:4.00E-5 ID:SGTC_2391|Compound:6285546|FD-Score:-2.98|P-value:9.69E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.03|P-value:1.63E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.28|P-value:3.63E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:-3.29|P-value:3.06E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-4.25|P-value:5.03E-6 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.40|P-value:1.98E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.66|P-value:7.08E-5 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.12|P-value:6.57E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.06|P-value:8.11E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.30|P-value:3.46E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.87|P-value:2.85E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.58|P-value:1.13E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-4.45|P-value:1.90E-6 ID:SGTC_2980|Compound:9014342|FD-Score:3.40|P-value:2.35E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.19|P-value:5.16E-4 ID:SGTC_3147|Compound:9097027|FD-Score:5.08|P-value:7.98E-8 ID:SGTC_3155|Compound:9099265|FD-Score:3.59|P-value:1.10E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.01|P-value:9.83E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.23|P-value:4.45E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.98|P-value:2.08E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.81|P-value:4.29E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.36|P-value:2.75E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:4.22|P-value:6.92E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:6.03|P-value:2.52E-10 ID:SGTC_361|Compound:000s-0510|FD-Score:5.44|P-value:9.94E-9 ID:SGTC_364|Compound:0083-0097|FD-Score:3.61|P-value:1.01E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.23|P-value:4.51E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:4.53|P-value:1.48E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.37|P-value:2.56E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.29|P-value:4.86E-6 ID:SGTC_1253|Compound:0550-0034|FD-Score:6.34|P-value:3.03E-11 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.56|P-value:1.24E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.51|P-value:1.65E-6 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.37|P-value:2.65E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.27|P-value:3.85E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.76|P-value:4.51E-7 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.80|P-value:4.46E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.51|P-value:1.62E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.30|P-value:3.38E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.25|P-value:4.07E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.38|P-value:2.55E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-3.11|P-value:5.96E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.61|P-value:8.62E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.26|P-value:4.00E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.81|P-value:4.27E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.08|P-value:7.60E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.24|P-value:6.07E-6 ID:SGTC_2017|Compound:5132927|FD-Score:3.66|P-value:8.25E-5 ID:SGTC_2052|Compound:5265182|FD-Score:4.96|P-value:1.53E-7 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.69|P-value:7.08E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.10|P-value:1.18E-5 ID:SGTC_2259|Compound:7964009|FD-Score:3.36|P-value:2.72E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.83|P-value:4.00E-5 ID:SGTC_2391|Compound:6285546|FD-Score:-2.98|P-value:9.69E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.03|P-value:1.63E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.28|P-value:3.63E-4 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:-3.29|P-value:3.06E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-4.25|P-value:5.03E-6 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.40|P-value:1.98E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.66|P-value:7.08E-5 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.12|P-value:6.57E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.06|P-value:8.11E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.30|P-value:3.46E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.87|P-value:2.85E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.58|P-value:1.13E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-4.45|P-value:1.90E-6 ID:SGTC_2980|Compound:9014342|FD-Score:3.40|P-value:2.35E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.19|P-value:5.16E-4 ID:SGTC_3147|Compound:9097027|FD-Score:5.08|P-value:7.98E-8 ID:SGTC_3155|Compound:9099265|FD-Score:3.59|P-value:1.10E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.01|P-value:9.83E-4

Top fitness defect scores for YIL047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1253 0550-0034 6.34 176.0 µM 3.03E-11 3 1.16E-10
2 SGTC_353 1988-1175 6.03 58.3 µM 2.52E-10 unfolded protein response 9 8.45E-10
3 SGTC_361 000s-0510 5.44 1.4 µM 9.94E-9 7 2.65E-8
4 SGTC_3147 9097027 5.08 49.5 µM 7.98E-8 7 1.87E-7
5 SGTC_2052 5265182 4.96 7.1 µM 1.53E-7 10 3.46E-7
6 SGTC_1332 1480-0653 4.76 17.5 µM 4.51E-7 TSC3-RPN4 8 9.51E-7
7 SGTC_762 1165-0429 4.53 115.0 µM 1.48E-6 TSC3-RPN4 9 2.91E-6
8 SGTC_1341 1486-1360 4.51 280.0 µM 1.62E-6 14 3.17E-6
9 SGTC_1274 0865-0114 4.51 173.0 µM 1.65E-6 12 3.21E-6
10 SGTC_1205 4161-2785 4.29 76.0 µM 4.86E-6 19 8.88E-6
11 SGTC_1926 methyl fluorone black 4.24 53.6 µM 6.07E-6 DNA intercalators 51 1.09E-5
12 SGTC_247 mechlorethamine 4.22 29.7 µM 6.92E-6 DNA damage response 11 1.24E-5
13 SGTC_2250 alverine citrate 4.10 130.0 µM 1.18E-5 142 2.04E-5
14 SGTC_2396 5342950 4.03 42.8 µM 1.63E-5 RSC complex & mRNA processing 41 2.78E-5
15 SGTC_227 fluconazole 3.98 33.5 µM 2.08E-5 azole & statin 81 3.48E-5
16 SGTC_2357 9067248 3.83 200.0 µM 4.00E-5 22 6.44E-5
17 SGTC_1812 st052057 3.81 4.3 µM 4.27E-5 calcium & mitochondrial duress 30 6.85E-5
18 SGTC_230 MPP+ 3.81 141.7 µM 4.29E-5 18 6.88E-5
19 SGTC_1334 1486-0610 3.80 236.0 µM 4.46E-5 60S ribosome export 20 7.14E-5
20 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 3.69 49.5 µM 7.08E-5 25 1.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.36E-18 YER085C_p YER085C_p hom Putative protein of unknown function
0.099 1.02E-8 YPL038W MET31 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication
0.096 2.91E-8 YEL006W YEA6 hom Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
0.091 1.32E-7 YCR060W TAH1 hom Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
0.086 5.31E-7 YNL090W RHO2 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
0.083 1.48E-6 YFL013W-A_d YFL013W-A_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
0.083 1.42E-6 YDL112W TRM3 hom 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
0.082 1.90E-6 YPL175W SPT14 het UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
0.080 3.11E-6 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.080 3.71E-6 YGL075C MPS2 het Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.079 4.40E-6 YLR419W_p YLR419W_p hom Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene
0.079 4.49E-6 YAR047C_d YAR047C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.076 9.51E-6 YBR285W_p YBR285W_p hom Putative protein of unknown function; YBR285W is not an essential gene
0.076 1.13E-5 YPR009W SUT2 hom Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
0.075 1.21E-5 YDL001W RMD1 hom Cytoplasmic protein required for sporulation