YIL048W / NEO1

Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL048W / NEO1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:21.30|P-value:6.41E-84 ID:SGTC_68|Compound:0986-0284|FD-Score:14.10|P-value:7.10E-38 ID:SGTC_112|Compound:phenothiazine|FD-Score:-3.69|P-value:4.08E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.42|P-value:9.34E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:30.20|P-value:1.36E-165 ID:SGTC_156|Compound:3474-0145|FD-Score:8.79|P-value:7.40E-16 ID:SGTC_172|Compound:1112-0046|FD-Score:69.00|P-value:0 ID:SGTC_178|Compound:4092-0806|FD-Score:6.40|P-value:3.18E-9 ID:SGTC_197|Compound:4544-0043|FD-Score:13.70|P-value:4.87E-36 ID:SGTC_206|Compound:4546-0025|FD-Score:52.30|P-value:0 ID:SGTC_221|Compound:trifluoperazine|FD-Score:69.30|P-value:0 ID:SGTC_232|Compound:clozapine|FD-Score:53.20|P-value:0 ID:SGTC_270|Compound:tamoxifen|FD-Score:66.90|P-value:0 ID:SGTC_301|Compound:4119-0100|FD-Score:52.30|P-value:0 ID:SGTC_309|Compound:k408-0051|FD-Score:14.80|P-value:1.08E-41 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.67|P-value:4.27E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.80|P-value:2.76E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:36.80|P-value:1.60E-244 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.60|P-value:5.30E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:5.58|P-value:2.05E-7 ID:SGTC_397|Compound:arbidol|FD-Score:5.72|P-value:1.06E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:19.80|P-value:1.56E-72 ID:SGTC_443|Compound:clozapine|FD-Score:12.90|P-value:8.63E-32 ID:SGTC_445|Compound:e6 berbamine|FD-Score:21.80|P-value:1.18E-87 ID:SGTC_447|Compound:ml7|FD-Score:9.13|P-value:5.95E-17 ID:SGTC_449|Compound:xestospongin c|FD-Score:24.90|P-value:1.64E-113 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.12|P-value:1.63E-6 ID:SGTC_459|Compound:nigericin|FD-Score:3.87|P-value:2.20E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.76|P-value:3.29E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.82|P-value:6.54E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:68.10|P-value:0 ID:SGTC_542|Compound:3381-0244|FD-Score:7.11|P-value:5.48E-11 ID:SGTC_562|Compound:3772-2733|FD-Score:23.70|P-value:6.12E-103 ID:SGTC_568|Compound:1193-0097|FD-Score:3.94|P-value:1.77E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.68|P-value:4.17E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:28.20|P-value:1.62E-144 ID:SGTC_658|Compound:3253-0951|FD-Score:4.59|P-value:1.55E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.75|P-value:3.40E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:23.10|P-value:4.47E-98 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.75|P-value:3.26E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:-4.18|P-value:7.25E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:7.95|P-value:2.76E-13 ID:SGTC_887|Compound:0885-0007|FD-Score:14.00|P-value:2.61E-37 ID:SGTC_888|Compound:0916-0002|FD-Score:66.00|P-value:0 ID:SGTC_900|Compound:1112-0045|FD-Score:40.50|P-value:1.89E-295 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.55|P-value:6.33E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:59.50|P-value:0 ID:SGTC_944|Compound:3370-0224|FD-Score:-4.04|P-value:1.21E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:15.20|P-value:7.73E-44 ID:SGTC_999|Compound:4022-0066|FD-Score:4.19|P-value:7.28E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.35|P-value:5.99E-7 ID:SGTC_1070|Compound:indatraline|FD-Score:4.18|P-value:7.55E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:7.11|P-value:5.51E-11 ID:SGTC_1075|Compound:aripiprazole|FD-Score:10.50|P-value:1.13E-21 ID:SGTC_1092|Compound:toremifene|FD-Score:9.12|P-value:6.32E-17 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.71|P-value:3.80E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.57|P-value:6.02E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:58.10|P-value:0 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.04|P-value:8.31E-11 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.96|P-value:1.63E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:30.20|P-value:8.17E-166 ID:SGTC_1242|Compound:0402-0103|FD-Score:-5.39|P-value:4.85E-7 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.98|P-value:3.08E-6 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.04|P-value:1.22E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:25.90|P-value:1.45E-122 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.66|P-value:4.53E-4 ID:SGTC_1547|Compound:harmine|FD-Score:6.07|P-value:1.82E-8 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.28|P-value:5.21E-5 ID:SGTC_1612|Compound:st002233|FD-Score:10.70|P-value:1.24E-22 ID:SGTC_1665|Compound:st014639|FD-Score:52.20|P-value:0 ID:SGTC_1672|Compound:st016598|FD-Score:7.17|P-value:3.82E-11 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:66.90|P-value:0 ID:SGTC_1712|Compound:st032288|FD-Score:14.10|P-value:1.07E-37 ID:SGTC_1714|Compound:st033236|FD-Score:3.64|P-value:4.75E-4 ID:SGTC_1721|Compound:st082152|FD-Score:4.71|P-value:9.61E-6 ID:SGTC_1724|Compound:st037281|FD-Score:8.71|P-value:1.32E-15 ID:SGTC_1750|Compound:st081859|FD-Score:8.59|P-value:3.24E-15 ID:SGTC_1754|Compound:st042065|FD-Score:36.40|P-value:2.51E-239 ID:SGTC_1760|Compound:st045453|FD-Score:67.60|P-value:0 ID:SGTC_1781|Compound:st038725|FD-Score:73.10|P-value:0 ID:SGTC_1797|Compound:st048695|FD-Score:75.00|P-value:0 ID:SGTC_1800|Compound:st050079|FD-Score:14.20|P-value:2.10E-38 ID:SGTC_1801|Compound:st050089|FD-Score:30.60|P-value:3.80E-170 ID:SGTC_1803|Compound:st050068|FD-Score:26.70|P-value:3.06E-130 ID:SGTC_1809|Compound:st050081|FD-Score:8.89|P-value:3.65E-16 ID:SGTC_1818|Compound:st052136|FD-Score:6.88|P-value:2.09E-10 ID:SGTC_1848|Compound:st056003|FD-Score:4.09|P-value:1.04E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.54|P-value:6.63E-4 ID:SGTC_1933|Compound:st074711|FD-Score:6.94|P-value:1.47E-10 ID:SGTC_1991|Compound:st073000|FD-Score:69.00|P-value:0 ID:SGTC_1993|Compound:st073995|FD-Score:4.56|P-value:1.79E-5 ID:SGTC_2006|Compound:4011487|FD-Score:21.10|P-value:5.91E-82 ID:SGTC_2021|Compound:4019055|FD-Score:12.20|P-value:8.98E-29 ID:SGTC_2028|Compound:5153890|FD-Score:9.30|P-value:1.59E-17 ID:SGTC_2036|Compound:5160441|FD-Score:45.30|P-value:0 ID:SGTC_2249|Compound:haloperidol|FD-Score:24.70|P-value:2.15E-111 ID:SGTC_2250|Compound:alverine citrate|FD-Score:48.10|P-value:0 ID:SGTC_2257|Compound:7960413|FD-Score:26.40|P-value:1.30E-127 ID:SGTC_2268|Compound:7933382|FD-Score:5.08|P-value:1.99E-6 ID:SGTC_2283|Compound:7944793|FD-Score:4.16|P-value:7.94E-5 ID:SGTC_2359|Compound:9039622|FD-Score:6.79|P-value:3.55E-10 ID:SGTC_2409|Compound:alverine citrate|FD-Score:12.20|P-value:1.39E-28 ID:SGTC_2413|Compound:inermin|FD-Score:23.80|P-value:1.52E-103 ID:SGTC_2449|Compound:5812982|FD-Score:3.77|P-value:3.17E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.12|P-value:9.44E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.51|P-value:7.22E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.21|P-value:6.69E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.41|P-value:9.78E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:77.10|P-value:0 ID:SGTC_2679|Compound:rapamycin|FD-Score:11.60|P-value:5.06E-26 ID:SGTC_2694|Compound:st077685|FD-Score:9.05|P-value:1.07E-16 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:53.20|P-value:0 ID:SGTC_2699|Compound:st077704|FD-Score:4.49|P-value:2.32E-5 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:5.49|P-value:3.12E-7 ID:SGTC_2732|Compound:terfenadine|FD-Score:4.37|P-value:3.75E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:16.00|P-value:4.15E-48 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.92|P-value:1.85E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:6.75|P-value:4.43E-10 ID:SGTC_2790|Compound:5423970|FD-Score:17.00|P-value:9.62E-54 ID:SGTC_2849|Compound:9019321|FD-Score:-3.46|P-value:8.35E-4 ID:SGTC_2896|Compound:9052656|FD-Score:12.70|P-value:5.12E-31 ID:SGTC_2923|Compound:7992654|FD-Score:4.38|P-value:3.59E-5 ID:SGTC_2937|Compound:9044753|FD-Score:6.63|P-value:9.18E-10 ID:SGTC_2938|Compound:9059746|FD-Score:12.00|P-value:7.92E-28 ID:SGTC_2973|Compound:9094665|FD-Score:39.00|P-value:9.91E-275 ID:SGTC_2974|Compound:9094440|FD-Score:4.69|P-value:1.03E-5 ID:SGTC_2991|Compound:9074669|FD-Score:15.10|P-value:5.25E-43 ID:SGTC_3025|Compound:9087895|FD-Score:-3.72|P-value:3.68E-4 ID:SGTC_3037|Compound:9091026|FD-Score:21.00|P-value:1.37E-81 ID:SGTC_3152|Compound:9099253|FD-Score:16.70|P-value:3.42E-52 ID:SGTC_3218|Compound:9131285|FD-Score:6.71|P-value:5.83E-10 ID:SGTC_3316|Compound:9136639|FD-Score:10.80|P-value:6.49E-23 ID:SGTC_3320|Compound:9137005|FD-Score:5.18|P-value:1.32E-6 ID:SGTC_15|Compound:0266-0086|FD-Score:21.30|P-value:6.41E-84 ID:SGTC_68|Compound:0986-0284|FD-Score:14.10|P-value:7.10E-38 ID:SGTC_112|Compound:phenothiazine|FD-Score:-3.69|P-value:4.08E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.42|P-value:9.34E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:30.20|P-value:1.36E-165 ID:SGTC_156|Compound:3474-0145|FD-Score:8.79|P-value:7.40E-16 ID:SGTC_172|Compound:1112-0046|FD-Score:69.00|P-value:0 ID:SGTC_178|Compound:4092-0806|FD-Score:6.40|P-value:3.18E-9 ID:SGTC_197|Compound:4544-0043|FD-Score:13.70|P-value:4.87E-36 ID:SGTC_206|Compound:4546-0025|FD-Score:52.30|P-value:0 ID:SGTC_221|Compound:trifluoperazine|FD-Score:69.30|P-value:0 ID:SGTC_232|Compound:clozapine|FD-Score:53.20|P-value:0 ID:SGTC_270|Compound:tamoxifen|FD-Score:66.90|P-value:0 ID:SGTC_301|Compound:4119-0100|FD-Score:52.30|P-value:0 ID:SGTC_309|Compound:k408-0051|FD-Score:14.80|P-value:1.08E-41 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.67|P-value:4.27E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.80|P-value:2.76E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:36.80|P-value:1.60E-244 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.60|P-value:5.30E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:5.58|P-value:2.05E-7 ID:SGTC_397|Compound:arbidol|FD-Score:5.72|P-value:1.06E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:19.80|P-value:1.56E-72 ID:SGTC_443|Compound:clozapine|FD-Score:12.90|P-value:8.63E-32 ID:SGTC_445|Compound:e6 berbamine|FD-Score:21.80|P-value:1.18E-87 ID:SGTC_447|Compound:ml7|FD-Score:9.13|P-value:5.95E-17 ID:SGTC_449|Compound:xestospongin c|FD-Score:24.90|P-value:1.64E-113 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.12|P-value:1.63E-6 ID:SGTC_459|Compound:nigericin|FD-Score:3.87|P-value:2.20E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.76|P-value:3.29E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.82|P-value:6.54E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:68.10|P-value:0 ID:SGTC_542|Compound:3381-0244|FD-Score:7.11|P-value:5.48E-11 ID:SGTC_562|Compound:3772-2733|FD-Score:23.70|P-value:6.12E-103 ID:SGTC_568|Compound:1193-0097|FD-Score:3.94|P-value:1.77E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.68|P-value:4.17E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:28.20|P-value:1.62E-144 ID:SGTC_658|Compound:3253-0951|FD-Score:4.59|P-value:1.55E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.75|P-value:3.40E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:23.10|P-value:4.47E-98 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.75|P-value:3.26E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:-4.18|P-value:7.25E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:7.95|P-value:2.76E-13 ID:SGTC_887|Compound:0885-0007|FD-Score:14.00|P-value:2.61E-37 ID:SGTC_888|Compound:0916-0002|FD-Score:66.00|P-value:0 ID:SGTC_900|Compound:1112-0045|FD-Score:40.50|P-value:1.89E-295 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.55|P-value:6.33E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:59.50|P-value:0 ID:SGTC_944|Compound:3370-0224|FD-Score:-4.04|P-value:1.21E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:15.20|P-value:7.73E-44 ID:SGTC_999|Compound:4022-0066|FD-Score:4.19|P-value:7.28E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.35|P-value:5.99E-7 ID:SGTC_1070|Compound:indatraline|FD-Score:4.18|P-value:7.55E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:7.11|P-value:5.51E-11 ID:SGTC_1075|Compound:aripiprazole|FD-Score:10.50|P-value:1.13E-21 ID:SGTC_1092|Compound:toremifene|FD-Score:9.12|P-value:6.32E-17 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.71|P-value:3.80E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.57|P-value:6.02E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:58.10|P-value:0 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.04|P-value:8.31E-11 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.96|P-value:1.63E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:30.20|P-value:8.17E-166 ID:SGTC_1242|Compound:0402-0103|FD-Score:-5.39|P-value:4.85E-7 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.98|P-value:3.08E-6 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.04|P-value:1.22E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:25.90|P-value:1.45E-122 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.66|P-value:4.53E-4 ID:SGTC_1547|Compound:harmine|FD-Score:6.07|P-value:1.82E-8 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.28|P-value:5.21E-5 ID:SGTC_1612|Compound:st002233|FD-Score:10.70|P-value:1.24E-22 ID:SGTC_1665|Compound:st014639|FD-Score:52.20|P-value:0 ID:SGTC_1672|Compound:st016598|FD-Score:7.17|P-value:3.82E-11 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:66.90|P-value:0 ID:SGTC_1712|Compound:st032288|FD-Score:14.10|P-value:1.07E-37 ID:SGTC_1714|Compound:st033236|FD-Score:3.64|P-value:4.75E-4 ID:SGTC_1721|Compound:st082152|FD-Score:4.71|P-value:9.61E-6 ID:SGTC_1724|Compound:st037281|FD-Score:8.71|P-value:1.32E-15 ID:SGTC_1750|Compound:st081859|FD-Score:8.59|P-value:3.24E-15 ID:SGTC_1754|Compound:st042065|FD-Score:36.40|P-value:2.51E-239 ID:SGTC_1760|Compound:st045453|FD-Score:67.60|P-value:0 ID:SGTC_1781|Compound:st038725|FD-Score:73.10|P-value:0 ID:SGTC_1797|Compound:st048695|FD-Score:75.00|P-value:0 ID:SGTC_1800|Compound:st050079|FD-Score:14.20|P-value:2.10E-38 ID:SGTC_1801|Compound:st050089|FD-Score:30.60|P-value:3.80E-170 ID:SGTC_1803|Compound:st050068|FD-Score:26.70|P-value:3.06E-130 ID:SGTC_1809|Compound:st050081|FD-Score:8.89|P-value:3.65E-16 ID:SGTC_1818|Compound:st052136|FD-Score:6.88|P-value:2.09E-10 ID:SGTC_1848|Compound:st056003|FD-Score:4.09|P-value:1.04E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.54|P-value:6.63E-4 ID:SGTC_1933|Compound:st074711|FD-Score:6.94|P-value:1.47E-10 ID:SGTC_1991|Compound:st073000|FD-Score:69.00|P-value:0 ID:SGTC_1993|Compound:st073995|FD-Score:4.56|P-value:1.79E-5 ID:SGTC_2006|Compound:4011487|FD-Score:21.10|P-value:5.91E-82 ID:SGTC_2021|Compound:4019055|FD-Score:12.20|P-value:8.98E-29 ID:SGTC_2028|Compound:5153890|FD-Score:9.30|P-value:1.59E-17 ID:SGTC_2036|Compound:5160441|FD-Score:45.30|P-value:0 ID:SGTC_2249|Compound:haloperidol|FD-Score:24.70|P-value:2.15E-111 ID:SGTC_2250|Compound:alverine citrate|FD-Score:48.10|P-value:0 ID:SGTC_2257|Compound:7960413|FD-Score:26.40|P-value:1.30E-127 ID:SGTC_2268|Compound:7933382|FD-Score:5.08|P-value:1.99E-6 ID:SGTC_2283|Compound:7944793|FD-Score:4.16|P-value:7.94E-5 ID:SGTC_2359|Compound:9039622|FD-Score:6.79|P-value:3.55E-10 ID:SGTC_2409|Compound:alverine citrate|FD-Score:12.20|P-value:1.39E-28 ID:SGTC_2413|Compound:inermin|FD-Score:23.80|P-value:1.52E-103 ID:SGTC_2449|Compound:5812982|FD-Score:3.77|P-value:3.17E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.12|P-value:9.44E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.51|P-value:7.22E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.21|P-value:6.69E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.41|P-value:9.78E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:77.10|P-value:0 ID:SGTC_2679|Compound:rapamycin|FD-Score:11.60|P-value:5.06E-26 ID:SGTC_2694|Compound:st077685|FD-Score:9.05|P-value:1.07E-16 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:53.20|P-value:0 ID:SGTC_2699|Compound:st077704|FD-Score:4.49|P-value:2.32E-5 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:5.49|P-value:3.12E-7 ID:SGTC_2732|Compound:terfenadine|FD-Score:4.37|P-value:3.75E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:16.00|P-value:4.15E-48 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.92|P-value:1.85E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:6.75|P-value:4.43E-10 ID:SGTC_2790|Compound:5423970|FD-Score:17.00|P-value:9.62E-54 ID:SGTC_2849|Compound:9019321|FD-Score:-3.46|P-value:8.35E-4 ID:SGTC_2896|Compound:9052656|FD-Score:12.70|P-value:5.12E-31 ID:SGTC_2923|Compound:7992654|FD-Score:4.38|P-value:3.59E-5 ID:SGTC_2937|Compound:9044753|FD-Score:6.63|P-value:9.18E-10 ID:SGTC_2938|Compound:9059746|FD-Score:12.00|P-value:7.92E-28 ID:SGTC_2973|Compound:9094665|FD-Score:39.00|P-value:9.91E-275 ID:SGTC_2974|Compound:9094440|FD-Score:4.69|P-value:1.03E-5 ID:SGTC_2991|Compound:9074669|FD-Score:15.10|P-value:5.25E-43 ID:SGTC_3025|Compound:9087895|FD-Score:-3.72|P-value:3.68E-4 ID:SGTC_3037|Compound:9091026|FD-Score:21.00|P-value:1.37E-81 ID:SGTC_3152|Compound:9099253|FD-Score:16.70|P-value:3.42E-52 ID:SGTC_3218|Compound:9131285|FD-Score:6.71|P-value:5.83E-10 ID:SGTC_3316|Compound:9136639|FD-Score:10.80|P-value:6.49E-23 ID:SGTC_3320|Compound:9137005|FD-Score:5.18|P-value:1.32E-6

Top fitness defect scores for YIL048W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2658 polymyxin b sulfate 77.10 77.0 µM 0 NEO1 1 0 67.80
2 SGTC_1797 st048695 75.00 56.8 µM 0 NEO1 1 0 63.50
3 SGTC_1781 st038725 73.10 66.3 µM 0 NEO1 1 0 62.00
4 SGTC_221 trifluoperazine 69.30 10.3 µM 0 NEO1-PIK1 1 0 35.70
5 SGTC_172 1112-0046 69.00 2.6 µM 0 NEO1 1 0 62.40
6 SGTC_1991 st073000 69.00 8.9 µM 0 NEO1 1 0 58.80
7 SGTC_535 2293-4129 68.10 48.2 µM 0 NEO1 1 0 61.10
8 SGTC_1760 st045453 67.60 10.4 µM 0 NEO1-PIK1 1 0 37.60
9 SGTC_1680 diphenhydramine 66.90 100.0 µM 0 NEO1 1 0 60.20
10 SGTC_270 tamoxifen 66.90 5.5 µM 0 NEO1 1 0 58.60
11 SGTC_888 0916-0002 66.00 7.0 µM 0 NEO1 1 0 61.20
12 SGTC_940 3232-1287 59.50 54.8 µM 0 NEO1 1 0 53.80
13 SGTC_1130 3454-2858 58.10 15.9 µM 0 NEO1 1 0 45.40
14 SGTC_232 clozapine 53.20 119.0 µM 0 NEO1 1 0 49.30
15 SGTC_2697 mebhydrolin 53.20 72.4 µM 0 NEO1 1 0 48.20
16 SGTC_206 4546-0025 52.30 72.0 µM 0 NEO1 1 0 43.00
17 SGTC_301 4119-0100 52.30 24.5 µM 0 NEO1 1 0 46.60
18 SGTC_1665 st014639 52.20 11.4 µM 0 NEO1 1 0 45.90
19 SGTC_2250 alverine citrate 48.10 130.0 µM 0 1 0 31.20
20 SGTC_2036 5160441 45.30 105.0 µM 0 NEO1 1 0 24.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.685 0 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.653 0 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.614 0 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.599 0 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.585 1.88E-306 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.557 2.41E-272 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.549 1.06E-263 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.532 1.39E-244 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.528 1.45E-238 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.514 1.15E-225 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.506 9.01E-218 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.487 3.39E-199 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.477 1.36E-189 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.439 9.60E-158 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.425 3.30E-147 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin