HIPHOP chemogenomics database
YIL051C / MMF1 
Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YIL051C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.121 | 1.66E-12 | YNL277W-A_p | YNL277W-A_p | hom | Putative protein of unknown function |
| 0.118 | 7.70E-12 | YHR108W | GGA2 | hom | Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin |
| 0.116 | 1.34E-11 | YML097C | VPS9 | hom | A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin |
| 0.115 | 2.00E-11 | YJR150C | DAN1 | hom | Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth |
| 0.096 | 2.27E-8 | YAR027W | UIP3 | hom | Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family |
| 0.093 | 6.65E-8 | YER081W | SER3 | hom | 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication |
| 0.090 | 1.82E-7 | YGL039W | YGL039W | hom | Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols |
| 0.090 | 2.01E-7 | YNL301C | RPL18B | hom | Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication |
| 0.087 | 4.06E-7 | YKL106C-A_p | YKL106C-A_p | hom | Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi |
| 0.083 | 1.47E-6 | YDR107C | TMN2 | hom | Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments |
| 0.081 | 2.56E-6 | YDR491C_d | YDR491C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.081 | 2.93E-6 | YGL109W_d | YGL109W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C |
| 0.078 | 6.89E-6 | YPL134C | ODC1 | hom | Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation |
| 0.077 | 8.98E-6 | YPR091C | NVJ2 | hom | Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments |
| 0.077 | 9.01E-6 | YLR223C | IFH1 | het | Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing |