YIL051C / MMF1

Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL051C / MMF1

Click on Significant Values for Screen Details ID:SGTC_541|Compound:4513-1321|FD-Score:3.05|P-value:3.79E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-2.97|P-value:4.85E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.82|P-value:1.24E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:-2.83|P-value:8.49E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.44|P-value:7.40E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.68|P-value:2.31E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:-2.91|P-value:6.23E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.18|P-value:2.29E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:2.99|P-value:4.81E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.24|P-value:1.75E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.53|P-value:4.50E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.04|P-value:4.17E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:3.22|P-value:1.95E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.13|P-value:2.83E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.13|P-value:2.85E-4 ID:SGTC_1864|Compound:st057645|FD-Score:-3.28|P-value:1.40E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.25|P-value:1.70E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.09|P-value:3.13E-6 ID:SGTC_2289|Compound:7946404|FD-Score:2.86|P-value:8.05E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-2.83|P-value:8.43E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-2.88|P-value:7.09E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.30|P-value:1.35E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.21|P-value:2.01E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.76|P-value:1.57E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.37|P-value:1.01E-4 ID:SGTC_2899|Compound:9053889|FD-Score:5.21|P-value:4.41E-9 ID:SGTC_2975|Compound:9084847|FD-Score:-3.28|P-value:1.38E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.16|P-value:2.32E-4 ID:SGTC_3207|Compound:9114163|FD-Score:2.84|P-value:8.87E-4 ID:SGTC_3253|Compound:9135987|FD-Score:2.96|P-value:5.47E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.05|P-value:3.79E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-2.97|P-value:4.85E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.82|P-value:1.24E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:-2.83|P-value:8.49E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.44|P-value:7.40E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.68|P-value:2.31E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:-2.91|P-value:6.23E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.18|P-value:2.29E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:2.99|P-value:4.81E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.24|P-value:1.75E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.53|P-value:4.50E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.04|P-value:4.17E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:3.22|P-value:1.95E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.13|P-value:2.83E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.13|P-value:2.85E-4 ID:SGTC_1864|Compound:st057645|FD-Score:-3.28|P-value:1.40E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.25|P-value:1.70E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.09|P-value:3.13E-6 ID:SGTC_2289|Compound:7946404|FD-Score:2.86|P-value:8.05E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-2.83|P-value:8.43E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-2.88|P-value:7.09E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.30|P-value:1.35E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.21|P-value:2.01E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.76|P-value:1.57E-5 ID:SGTC_2891|Compound:9063876|FD-Score:3.37|P-value:1.01E-4 ID:SGTC_2899|Compound:9053889|FD-Score:5.21|P-value:4.41E-9 ID:SGTC_2975|Compound:9084847|FD-Score:-3.28|P-value:1.38E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.16|P-value:2.32E-4 ID:SGTC_3207|Compound:9114163|FD-Score:2.84|P-value:8.87E-4 ID:SGTC_3253|Compound:9135987|FD-Score:2.96|P-value:5.47E-4

Top fitness defect scores for YIL051C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2899 9053889 5.21 58.4 µM 4.41E-9 1 9.40E-8 1.58
2 SGTC_1978 st071761 4.09 42.0 µM 3.13E-6 TSC3-RPN4 5 2.12E-5 0.06
3 SGTC_1569 carminic acid 4.04 40.6 µM 4.17E-6 2 2.68E-5 0.57
4 SGTC_655 k060-0012 3.82 42.0 µM 1.24E-5 8 6.59E-5 0.09
5 SGTC_1001 4048-4355 3.44 44.4 µM 7.40E-5 copper-dependent oxidative stress 15 2.90E-4 0.00
6 SGTC_2891 9063876 3.37 19.5 µM 1.01E-4 3 3.77E-4 0.29
7 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 3.30 200.0 µM 1.35E-4 13 4.78E-4 0.06
8 SGTC_1882 5615643 3.25 20.0 µM 1.70E-4 TRP & mitochondrial translation 10 5.78E-4 0.00
9 SGTC_1509 1326-1131 3.24 80.0 µM 1.75E-4 9 5.92E-4 0.12
10 SGTC_1693 xanthone 3.22 101.9 µM 1.95E-4 DNA damage response 17 6.49E-4 0.02
11 SGTC_2462 5162487 3.21 171.8 µM 2.01E-4 10 6.66E-4 0.12
12 SGTC_1351 1496-0003 3.18 46.5 µM 2.29E-4 8 7.41E-4 0.00
13 SGTC_1760 st045453 3.13 10.4 µM 2.83E-4 NEO1-PIK1 8 8.85E-4 0.25
14 SGTC_1784 st039334 3.13 36.3 µM 2.85E-4 19 8.88E-4 0.05
15 SGTC_541 4513-1321 3.05 94.0 µM 3.79E-4 20 0.00113 0.12
16 SGTC_1353 1498-1206 2.99 8.1 µM 4.81E-4 mitochondrial response to ROS 18 0.00138 0.04
17 SGTC_3253 9135987 2.96 49.5 µM 5.47E-4 60S ribosome export 10 0.00153 0.03
18 SGTC_2289 7946404 2.86 165.1 µM 8.05E-4 36 0.00211 0.03
19 SGTC_3207 9114163 2.84 49.5 µM 8.87E-4 26 0.00229 0.01
20 SGTC_992 3909-8734 2.76 162.0 µM 0.00119 11 0.00293 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.66E-12 YNL277W-A_p YNL277W-A_p hom Putative protein of unknown function
0.118 7.70E-12 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.116 1.34E-11 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.115 2.00E-11 YJR150C DAN1 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
0.096 2.27E-8 YAR027W UIP3 hom Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
0.093 6.65E-8 YER081W SER3 hom 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication
0.090 1.82E-7 YGL039W YGL039W hom Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols
0.090 2.01E-7 YNL301C RPL18B hom Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication
0.087 4.06E-7 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.083 1.47E-6 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.081 2.56E-6 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.93E-6 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
0.078 6.89E-6 YPL134C ODC1 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
0.077 8.98E-6 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.077 9.01E-6 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing