YIL053W / RHR2

Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL053W / RHR2

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:5.23|P-value:1.77E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:6.33|P-value:1.03E-8 ID:SGTC_139|Compound:0099-0334|FD-Score:3.55|P-value:8.06E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.73|P-value:5.13E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.98|P-value:5.62E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.60|P-value:6.84E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.78|P-value:3.98E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:5.05|P-value:3.76E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.96|P-value:6.08E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:4.02|P-value:1.77E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.49|P-value:9.67E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:3.66|P-value:5.74E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.67|P-value:6.14E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:5.40|P-value:8.58E-7 ID:SGTC_946|Compound:3434-1334|FD-Score:3.67|P-value:5.53E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.45|P-value:3.91E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.99|P-value:4.78E-6 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.33|P-value:6.13E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.20|P-value:9.78E-5 ID:SGTC_1518|Compound:st038567|FD-Score:3.87|P-value:2.91E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.03|P-value:6.47E-16 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.72|P-value:4.74E-4 ID:SGTC_1654|Compound:st012436|FD-Score:-4.79|P-value:1.20E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.81|P-value:3.60E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.63|P-value:6.30E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.94|P-value:2.37E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.79|P-value:3.88E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.55|P-value:8.04E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.80|P-value:3.70E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-5.36|P-value:1.15E-6 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-4.40|P-value:5.27E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-4.10|P-value:1.55E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.18|P-value:1.04E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-6.40|P-value:8.14E-9 ID:SGTC_2060|Compound:5238662|FD-Score:3.76|P-value:4.27E-4 ID:SGTC_2150|Compound:5556613|FD-Score:5.07|P-value:3.51E-6 ID:SGTC_2154|Compound:5570129|FD-Score:3.60|P-value:6.94E-4 ID:SGTC_2163|Compound:5671233|FD-Score:6.81|P-value:7.91E-10 ID:SGTC_2166|Compound:5933061|FD-Score:5.93|P-value:7.49E-8 ID:SGTC_2282|Compound:7944268|FD-Score:4.14|P-value:1.19E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.05|P-value:1.65E-4 ID:SGTC_2372|Compound:9071633|FD-Score:-3.65|P-value:6.54E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-3.91|P-value:2.83E-4 ID:SGTC_2459|Compound:5811157|FD-Score:4.82|P-value:9.65E-6 ID:SGTC_2505|Compound:galangin|FD-Score:3.64|P-value:6.05E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:4.01|P-value:1.85E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.37|P-value:5.32E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.07|P-value:1.51E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.91|P-value:2.55E-4 ID:SGTC_2683|Compound:piperine|FD-Score:-3.56|P-value:8.62E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:5.46|P-value:6.52E-7 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.92|P-value:2.49E-4 ID:SGTC_2840|Compound:9008771|FD-Score:5.15|P-value:2.50E-6 ID:SGTC_2845|Compound:9003024|FD-Score:8.27|P-value:1.20E-13 ID:SGTC_2846|Compound:9008642|FD-Score:4.57|P-value:2.48E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.52|P-value:8.79E-4 ID:SGTC_2940|Compound:9060638|FD-Score:5.22|P-value:1.82E-6 ID:SGTC_2997|Compound:9067075|FD-Score:5.03|P-value:4.12E-6 ID:SGTC_3031|Compound:9088762|FD-Score:3.52|P-value:8.78E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.54|P-value:8.37E-4 ID:SGTC_3116|Compound:9124943|FD-Score:4.04|P-value:1.68E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-6.24|P-value:1.90E-8 ID:SGTC_3137|Compound:9097352|FD-Score:4.48|P-value:3.54E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-4.61|P-value:2.46E-5 ID:SGTC_3217|Compound:9129673|FD-Score:7.27|P-value:5.74E-11 ID:SGTC_3219|Compound:9131112|FD-Score:-8.67|P-value:1.00E-14 ID:SGTC_3221|Compound:9128209|FD-Score:4.45|P-value:3.96E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:5.23|P-value:1.77E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:6.33|P-value:1.03E-8 ID:SGTC_139|Compound:0099-0334|FD-Score:3.55|P-value:8.06E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.73|P-value:5.13E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.98|P-value:5.62E-8 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.60|P-value:6.84E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.78|P-value:3.98E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:5.05|P-value:3.76E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.96|P-value:6.08E-6 ID:SGTC_425|Compound:3825-7017|FD-Score:4.02|P-value:1.77E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.49|P-value:9.67E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:3.66|P-value:5.74E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:-3.67|P-value:6.14E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:5.40|P-value:8.58E-7 ID:SGTC_946|Compound:3434-1334|FD-Score:3.67|P-value:5.53E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.45|P-value:3.91E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.99|P-value:4.78E-6 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.33|P-value:6.13E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.20|P-value:9.78E-5 ID:SGTC_1518|Compound:st038567|FD-Score:3.87|P-value:2.91E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.03|P-value:6.47E-16 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.72|P-value:4.74E-4 ID:SGTC_1654|Compound:st012436|FD-Score:-4.79|P-value:1.20E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.81|P-value:3.60E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.63|P-value:6.30E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.94|P-value:2.37E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.79|P-value:3.88E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.55|P-value:8.04E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.80|P-value:3.70E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-5.36|P-value:1.15E-6 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-4.40|P-value:5.27E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-4.10|P-value:1.55E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.18|P-value:1.04E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-6.40|P-value:8.14E-9 ID:SGTC_2060|Compound:5238662|FD-Score:3.76|P-value:4.27E-4 ID:SGTC_2150|Compound:5556613|FD-Score:5.07|P-value:3.51E-6 ID:SGTC_2154|Compound:5570129|FD-Score:3.60|P-value:6.94E-4 ID:SGTC_2163|Compound:5671233|FD-Score:6.81|P-value:7.91E-10 ID:SGTC_2166|Compound:5933061|FD-Score:5.93|P-value:7.49E-8 ID:SGTC_2282|Compound:7944268|FD-Score:4.14|P-value:1.19E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.05|P-value:1.65E-4 ID:SGTC_2372|Compound:9071633|FD-Score:-3.65|P-value:6.54E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-3.91|P-value:2.83E-4 ID:SGTC_2459|Compound:5811157|FD-Score:4.82|P-value:9.65E-6 ID:SGTC_2505|Compound:galangin|FD-Score:3.64|P-value:6.05E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:4.01|P-value:1.85E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.37|P-value:5.32E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.07|P-value:1.51E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.91|P-value:2.55E-4 ID:SGTC_2683|Compound:piperine|FD-Score:-3.56|P-value:8.62E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:5.46|P-value:6.52E-7 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.92|P-value:2.49E-4 ID:SGTC_2840|Compound:9008771|FD-Score:5.15|P-value:2.50E-6 ID:SGTC_2845|Compound:9003024|FD-Score:8.27|P-value:1.20E-13 ID:SGTC_2846|Compound:9008642|FD-Score:4.57|P-value:2.48E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.52|P-value:8.79E-4 ID:SGTC_2940|Compound:9060638|FD-Score:5.22|P-value:1.82E-6 ID:SGTC_2997|Compound:9067075|FD-Score:5.03|P-value:4.12E-6 ID:SGTC_3031|Compound:9088762|FD-Score:3.52|P-value:8.78E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.54|P-value:8.37E-4 ID:SGTC_3116|Compound:9124943|FD-Score:4.04|P-value:1.68E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-6.24|P-value:1.90E-8 ID:SGTC_3137|Compound:9097352|FD-Score:4.48|P-value:3.54E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-4.61|P-value:2.46E-5 ID:SGTC_3217|Compound:9129673|FD-Score:7.27|P-value:5.74E-11 ID:SGTC_3219|Compound:9131112|FD-Score:-8.67|P-value:1.00E-14 ID:SGTC_3221|Compound:9128209|FD-Score:4.45|P-value:3.96E-5

Top fitness defect scores for YIL053W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 9.03 42.4 µM 6.47E-16 89 8.84E-20
2 SGTC_2845 9003024 8.27 43.0 µM 1.20E-13 amide catabolism 5 6.83E-17
3 SGTC_3217 9129673 7.27 49.5 µM 5.74E-11 1 1.73E-13
4 SGTC_2163 5671233 6.81 125.0 µM 7.91E-10 5 4.85E-12
5 SGTC_103 0844-0104 6.33 51.8 µM 1.03E-8 ERAD & cell cycle 73 1.25E-10
6 SGTC_168 3970-0862 5.98 530.5 µM 5.62E-8 42 1.08E-9
7 SGTC_2166 5933061 5.93 31.5 µM 7.49E-8 tubulin folding & SWR complex 14 1.56E-9
8 SGTC_2726 cimetidine 5.46 79.3 µM 6.52E-7 2 2.42E-8
9 SGTC_722 3534-0461 5.40 190.0 µM 8.58E-7 PDR1 13 3.42E-8
10 SGTC_67 0335-0847 5.23 266.0 µM 1.77E-6 ubiquinone biosynthesis & proteasome 83 8.56E-8
11 SGTC_2940 9060638 5.22 45.9 µM 1.82E-6 amide catabolism 5 8.86E-8
12 SGTC_2840 9008771 5.15 71.4 µM 2.50E-6 3 1.32E-7
13 SGTC_2150 5556613 5.07 200.0 µM 3.51E-6 2 2.03E-7
14 SGTC_309 k408-0051 5.05 1.5 µM 3.76E-6 25 2.21E-7
15 SGTC_2997 9067075 5.03 71.4 µM 4.12E-6 unfolded protein response 29 2.49E-7
16 SGTC_1161 k007-0610 4.99 110.0 µM 4.78E-6 ERAD & cell cycle 81 3.00E-7
17 SGTC_2459 5811157 4.82 9.2 µM 9.65E-6 mitochondrial processes 4 7.30E-7
18 SGTC_2846 9008642 4.57 19.5 µM 2.48E-5 12 2.40E-6
19 SGTC_3137 9097352 4.48 49.5 µM 3.54E-5 26 3.76E-6
20 SGTC_951 1171-0579 4.45 82.7 µM 3.91E-5 cell wall 57 4.27E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.35E-20 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.147 1.33E-17 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.145 2.53E-17 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.141 1.99E-16 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.137 1.29E-15 YIL098C FMC1 hom Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
0.133 9.11E-15 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.131 2.63E-14 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.129 6.18E-14 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.121 2.24E-12 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.120 2.61E-12 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.115 2.06E-11 YDL023C_d YDL023C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
0.112 9.63E-11 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.110 1.53E-10 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.105 1.14E-9 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.104 1.51E-9 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p