YIL054W_p

Protein of unknown function; expressed at both mRNA and protein levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL054W / YIL054W

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:5.88|P-value:2.60E-9 ID:SGTC_23|Compound:0213-0011|FD-Score:3.12|P-value:9.85E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:6.29|P-value:2.01E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:3.18|P-value:8.02E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.28|P-value:5.72E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:3.21|P-value:7.27E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.57|P-value:2.00E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.21|P-value:7.24E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.52|P-value:2.42E-4 ID:SGTC_442|Compound:cape|FD-Score:4.02|P-value:3.34E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.31|P-value:5.11E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.32|P-value:4.88E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.52|P-value:2.39E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.49|P-value:2.70E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.93|P-value:4.71E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.52|P-value:2.38E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.17|P-value:7.77E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.33|P-value:8.47E-6 ID:SGTC_812|Compound:4251-0442|FD-Score:3.89|P-value:5.65E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.18|P-value:8.00E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.59|P-value:1.86E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.21|P-value:6.84E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.43|P-value:3.16E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.61|P-value:1.73E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-3.41|P-value:3.32E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.75|P-value:9.94E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.87|P-value:6.71E-7 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.41|P-value:6.03E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.15|P-value:1.87E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.17|P-value:8.39E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.86|P-value:6.37E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.37|P-value:4.18E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.95|P-value:4.38E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.64|P-value:2.02E-6 ID:SGTC_1744|Compound:st037937|FD-Score:-3.27|P-value:5.61E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.51|P-value:2.45E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-4.32|P-value:8.19E-6 ID:SGTC_1944|Compound:st076371|FD-Score:6.20|P-value:3.62E-10 ID:SGTC_2008|Compound:4012253|FD-Score:4.37|P-value:7.32E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-5.36|P-value:4.58E-8 ID:SGTC_2116|Compound:5511452|FD-Score:-3.50|P-value:2.45E-4 ID:SGTC_2117|Compound:5521686|FD-Score:6.80|P-value:6.99E-12 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.15|P-value:1.61E-7 ID:SGTC_2283|Compound:7944793|FD-Score:3.13|P-value:9.65E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.74|P-value:1.04E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.53|P-value:2.26E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.70|P-value:1.13E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.58|P-value:1.81E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-5.53|P-value:1.77E-8 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.81|P-value:7.83E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.28|P-value:5.28E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.78|P-value:8.63E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.71|P-value:1.08E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.14|P-value:8.78E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:-3.42|P-value:3.27E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.23|P-value:6.30E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.16|P-value:8.54E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.13|P-value:2.02E-5 ID:SGTC_3028|Compound:9087778|FD-Score:3.52|P-value:2.35E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.26|P-value:5.78E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.39|P-value:3.84E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.77|P-value:1.11E-6 ID:SGTC_3255|Compound:9139072|FD-Score:3.12|P-value:9.85E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.70|P-value:1.53E-6 ID:SGTC_5|Compound:0352-0601|FD-Score:5.88|P-value:2.60E-9 ID:SGTC_23|Compound:0213-0011|FD-Score:3.12|P-value:9.85E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:6.29|P-value:2.01E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:3.18|P-value:8.02E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.28|P-value:5.72E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:3.21|P-value:7.27E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.57|P-value:2.00E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.21|P-value:7.24E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.52|P-value:2.42E-4 ID:SGTC_442|Compound:cape|FD-Score:4.02|P-value:3.34E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.31|P-value:5.11E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.32|P-value:4.88E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.52|P-value:2.39E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.49|P-value:2.70E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.93|P-value:4.71E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.52|P-value:2.38E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.17|P-value:7.77E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.33|P-value:8.47E-6 ID:SGTC_812|Compound:4251-0442|FD-Score:3.89|P-value:5.65E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.18|P-value:8.00E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.59|P-value:1.86E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.21|P-value:6.84E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.43|P-value:3.16E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.61|P-value:1.73E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-3.41|P-value:3.32E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.75|P-value:9.94E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.87|P-value:6.71E-7 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.41|P-value:6.03E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.15|P-value:1.87E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.17|P-value:8.39E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.86|P-value:6.37E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.37|P-value:4.18E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.95|P-value:4.38E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.64|P-value:2.02E-6 ID:SGTC_1744|Compound:st037937|FD-Score:-3.27|P-value:5.61E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.51|P-value:2.45E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-4.32|P-value:8.19E-6 ID:SGTC_1944|Compound:st076371|FD-Score:6.20|P-value:3.62E-10 ID:SGTC_2008|Compound:4012253|FD-Score:4.37|P-value:7.32E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-5.36|P-value:4.58E-8 ID:SGTC_2116|Compound:5511452|FD-Score:-3.50|P-value:2.45E-4 ID:SGTC_2117|Compound:5521686|FD-Score:6.80|P-value:6.99E-12 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.15|P-value:1.61E-7 ID:SGTC_2283|Compound:7944793|FD-Score:3.13|P-value:9.65E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.74|P-value:1.04E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.53|P-value:2.26E-4 ID:SGTC_2523|Compound:spermine|FD-Score:-3.70|P-value:1.13E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.58|P-value:1.81E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-5.53|P-value:1.77E-8 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.81|P-value:7.83E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.28|P-value:5.28E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.78|P-value:8.63E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.71|P-value:1.08E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.14|P-value:8.78E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:-3.42|P-value:3.27E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.23|P-value:6.30E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.16|P-value:8.54E-4 ID:SGTC_2960|Compound:9079389|FD-Score:4.13|P-value:2.02E-5 ID:SGTC_3028|Compound:9087778|FD-Score:3.52|P-value:2.35E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.26|P-value:5.78E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.39|P-value:3.84E-4 ID:SGTC_3211|Compound:9128781|FD-Score:4.77|P-value:1.11E-6 ID:SGTC_3255|Compound:9139072|FD-Score:3.12|P-value:9.85E-4 ID:SGTC_3274|Compound:9138298|FD-Score:4.70|P-value:1.53E-6

Top fitness defect scores for YIL054W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2117 5521686 6.80 200.0 µM 6.99E-12 1 5.17E-12
2 SGTC_63 0099-0242 6.29 26.7 µM 2.01E-10 mitochondrial stress 23 1.54E-10
3 SGTC_1944 st076371 6.20 56.9 µM 3.62E-10 3 2.80E-10
4 SGTC_5 0352-0601 5.88 109.9 µM 2.60E-9 ERG2 4 2.05E-9
5 SGTC_2232 chlorophetanol 5.15 41.5 µM 1.61E-7 TRP & mitochondrial translation 72 1.33E-7
6 SGTC_1036 k216-0215 4.87 33.5 µM 6.71E-7 mitochondrial response to ROS 28 5.66E-7
7 SGTC_3211 9128781 4.77 49.5 µM 1.11E-6 41 9.42E-7
8 SGTC_3274 9138298 4.70 49.5 µM 1.53E-6 8 1.30E-6
9 SGTC_1742 st038235 4.64 28.9 µM 2.02E-6 mitochondrial stress 92 1.73E-6
10 SGTC_1197 1601-0112 4.41 267.0 µM 6.03E-6 8 5.23E-6
11 SGTC_2008 4012253 4.37 172.0 µM 7.32E-6 15 6.35E-6
12 SGTC_800 3448-7362 4.33 155.0 µM 8.47E-6 translation 135 7.37E-6
13 SGTC_1205 4161-2785 4.15 76.0 µM 1.87E-5 23 1.64E-5
14 SGTC_2960 9079389 4.13 6.0 µM 2.02E-5 24 1.78E-5
15 SGTC_442 cape 4.02 100.0 µM 3.34E-5 15 2.95E-5
16 SGTC_1682 st012968 3.95 530.0 nM 4.38E-5 18 3.88E-5
17 SGTC_754 3474-0146 3.93 171.0 µM 4.71E-5 copper-dependent oxidative stress 25 4.18E-5
18 SGTC_812 4251-0442 3.89 148.0 µM 5.65E-5 10 5.02E-5
19 SGTC_1646 st011709 3.86 75.6 µM 6.37E-5 13 5.68E-5
20 SGTC_2561 acetosyringone 3.81 100.0 µM 7.83E-5 30 6.99E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 3.23E-30 YDR519W FPR2 hom Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
0.178 2.67E-25 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.174 3.94E-24 YJL063C MRPL8 hom Mitochondrial ribosomal protein of the large subunit
0.173 6.76E-24 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.171 1.53E-23 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.167 2.04E-22 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.166 3.87E-22 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.164 9.72E-22 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.163 1.70E-21 YPR099C_d YPR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W
0.157 6.02E-20 YNR037C RSM19 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
0.153 5.35E-19 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.152 6.93E-19 YIL060W_p YIL060W_p hom Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene
0.152 7.14E-19 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
0.152 7.82E-19 YLR295C ATP14 hom Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress
0.152 8.87E-19 YLR091W GEP5 hom Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine