YIL055C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL055C / YIL055C

Click on Significant Values for Screen Details ID:SGTC_146|Compound:3448-8650|FD-Score:-3.23|P-value:6.42E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.78|P-value:7.91E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:4.43|P-value:4.82E-6 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.31|P-value:4.87E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.44|P-value:2.96E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:4.82|P-value:7.38E-7 ID:SGTC_574|Compound:1315-0397|FD-Score:3.88|P-value:5.29E-5 ID:SGTC_579|Compound:4491-1009|FD-Score:3.51|P-value:2.25E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.47|P-value:2.64E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:5.27|P-value:7.14E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:3.64|P-value:1.37E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.37|P-value:6.61E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.56|P-value:2.72E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:5.60|P-value:1.13E-8 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.95|P-value:4.14E-5 ID:SGTC_989|Compound:1501-0895|FD-Score:4.35|P-value:7.05E-6 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.34|P-value:4.20E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:6.05|P-value:7.42E-10 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.56|P-value:1.91E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.56|P-value:1.88E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.59|P-value:1.68E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.42|P-value:3.19E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:-3.39|P-value:3.62E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.40|P-value:3.36E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.22|P-value:6.39E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.28|P-value:5.26E-4 ID:SGTC_1774|Compound:st048371|FD-Score:-3.77|P-value:8.66E-5 ID:SGTC_1775|Compound:st081588|FD-Score:4.87|P-value:5.85E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.67|P-value:1.27E-4 ID:SGTC_1794|Compound:st048918|FD-Score:-3.77|P-value:8.49E-5 ID:SGTC_1866|Compound:st057638|FD-Score:3.43|P-value:3.06E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.19|P-value:7.15E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.10|P-value:9.72E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.45|P-value:2.80E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.56|P-value:1.89E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.81|P-value:7.38E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-3.27|P-value:5.57E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.37|P-value:3.81E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.41|P-value:3.41E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.89|P-value:5.18E-5 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.34|P-value:7.44E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:3.53|P-value:2.14E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.59|P-value:2.27E-6 ID:SGTC_2802|Compound:7925815|FD-Score:3.52|P-value:2.21E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.75|P-value:8.98E-5 ID:SGTC_2820|Compound:7989630|FD-Score:3.17|P-value:7.82E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.45|P-value:2.84E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.73|P-value:1.17E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-4.54|P-value:2.91E-6 ID:SGTC_3336|Compound:9143619|FD-Score:3.89|P-value:5.17E-5 ID:SGTC_3343|Compound:9148379|FD-Score:3.17|P-value:7.65E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.23|P-value:6.42E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.78|P-value:7.91E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:4.43|P-value:4.82E-6 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.31|P-value:4.87E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.44|P-value:2.96E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.70|P-value:1.08E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:4.82|P-value:7.38E-7 ID:SGTC_574|Compound:1315-0397|FD-Score:3.88|P-value:5.29E-5 ID:SGTC_579|Compound:4491-1009|FD-Score:3.51|P-value:2.25E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.47|P-value:2.64E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:5.27|P-value:7.14E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:3.64|P-value:1.37E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.37|P-value:6.61E-6 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.56|P-value:2.72E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:5.60|P-value:1.13E-8 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.95|P-value:4.14E-5 ID:SGTC_989|Compound:1501-0895|FD-Score:4.35|P-value:7.05E-6 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.34|P-value:4.20E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:6.05|P-value:7.42E-10 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.56|P-value:1.91E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.56|P-value:1.88E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.59|P-value:1.68E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.42|P-value:3.19E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:-3.39|P-value:3.62E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.40|P-value:3.36E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.22|P-value:6.39E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.28|P-value:5.26E-4 ID:SGTC_1774|Compound:st048371|FD-Score:-3.77|P-value:8.66E-5 ID:SGTC_1775|Compound:st081588|FD-Score:4.87|P-value:5.85E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.67|P-value:1.27E-4 ID:SGTC_1794|Compound:st048918|FD-Score:-3.77|P-value:8.49E-5 ID:SGTC_1866|Compound:st057638|FD-Score:3.43|P-value:3.06E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.19|P-value:7.15E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.10|P-value:9.72E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.45|P-value:2.80E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.56|P-value:1.89E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.81|P-value:7.38E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-3.27|P-value:5.57E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.37|P-value:3.81E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-3.41|P-value:3.41E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.89|P-value:5.18E-5 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.34|P-value:7.44E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:3.53|P-value:2.14E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.59|P-value:2.27E-6 ID:SGTC_2802|Compound:7925815|FD-Score:3.52|P-value:2.21E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.75|P-value:8.98E-5 ID:SGTC_2820|Compound:7989630|FD-Score:3.17|P-value:7.82E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.45|P-value:2.84E-4 ID:SGTC_3142|Compound:9086498|FD-Score:4.73|P-value:1.17E-6 ID:SGTC_3143|Compound:9086658|FD-Score:-4.54|P-value:2.91E-6 ID:SGTC_3336|Compound:9143619|FD-Score:3.89|P-value:5.17E-5 ID:SGTC_3343|Compound:9148379|FD-Score:3.17|P-value:7.65E-4

Top fitness defect scores for YIL055C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1177 0983-0204 6.05 23.6 µM 7.42E-10 1 7.06E-10
2 SGTC_965 1291-5240 5.60 308.0 µM 1.13E-8 9 1.09E-8
3 SGTC_753 1322-0200 5.27 289.0 µM 7.14E-8 3 6.88E-8
4 SGTC_1775 st081588 4.87 35.2 µM 5.85E-7 60S ribosome export 12 5.67E-7
5 SGTC_561 1550-0330 4.82 72.9 µM 7.38E-7 6 7.17E-7
6 SGTC_3142 9086498 4.73 49.5 µM 1.17E-6 iron homeostasis 21 1.14E-6
7 SGTC_2781 5567276 4.59 71.4 µM 2.27E-6 30 2.21E-6
8 SGTC_266 formosanin C 4.43 406.0 nM 4.82E-6 sphingolipid biosynthesis & PDR1 55 4.70E-6
9 SGTC_989 1501-0895 4.35 10.3 µM 7.05E-6 4 6.89E-6
10 SGTC_2724 maprotiline 4.34 69.6 µM 7.44E-6 ERG2 7 7.28E-6
11 SGTC_3336 9143619 3.89 71.4 µM 5.17E-5 22 5.08E-5
12 SGTC_574 1315-0397 3.88 40.0 µM 5.29E-5 39 5.20E-5
13 SGTC_157 1348-1695 3.78 65.8 µM 7.91E-5 iron homeostasis 84 7.79E-5
14 SGTC_2808 7946468 3.75 45.5 µM 8.98E-5 30 8.85E-5
15 SGTC_557 1315-0110 3.70 16.2 µM 1.08E-4 Golgi 26 1.06E-4
16 SGTC_912 3474-0017 3.64 2.2 µM 1.37E-4 31 1.35E-4
17 SGTC_1414 3917-0015 3.59 5.4 µM 1.68E-4 17 1.65E-4
18 SGTC_1236 0330-0013 3.56 258.0 µM 1.88E-4 25 1.85E-4
19 SGTC_2057 5236571 3.56 38.3 µM 1.89E-4 RPP1 & pyrimidine depletion 44 1.87E-4
20 SGTC_1225 1216-0074 3.56 20.6 µM 1.91E-4 37 1.89E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.093 6.21E-8 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.04E-7 YPL178W CBC2 hom Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
0.078 6.38E-6 YJL091C GWT1 het Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
0.078 6.66E-6 YLL020C_d YLL020C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1
0.074 1.97E-5 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.071 3.69E-5 YDR427W RPN9 het Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress
0.070 4.45E-5 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.070 4.91E-5 YPL021W ECM23 hom Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
0.069 5.81E-5 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.068 8.44E-5 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.067 9.87E-5 YJR037W_d YJR037W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces
0.066 1.37E-4 YGR019W UGA1 hom Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress
0.065 1.55E-4 YML092C PRE8 het Alpha 2 subunit of the 20S proteasome
0.065 1.62E-4 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.065 1.62E-4 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin