YIL059C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL059C / YIL059C

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.32|P-value:9.00E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:2.91|P-value:5.06E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.52|P-value:3.49E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:2.88|P-value:5.68E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.75|P-value:1.28E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.55|P-value:3.35E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:2.84|P-value:6.76E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.51|P-value:3.71E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.97|P-value:3.70E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:3.01|P-value:3.33E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:5.09|P-value:4.69E-9 ID:SGTC_891|Compound:0929-0073|FD-Score:2.86|P-value:6.18E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.23|P-value:1.33E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.76|P-value:1.18E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:2.97|P-value:3.99E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.35|P-value:7.81E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.80|P-value:9.03E-6 ID:SGTC_1739|Compound:st037196|FD-Score:-3.60|P-value:2.60E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.06|P-value:2.71E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.31|P-value:1.01E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.09|P-value:2.47E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-4.65|P-value:8.83E-8 ID:SGTC_2265|Compound:7929201|FD-Score:-3.70|P-value:1.63E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.14|P-value:1.62E-6 ID:SGTC_2414|Compound:st077232|FD-Score:-2.80|P-value:8.48E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:4.51|P-value:1.82E-7 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.75|P-value:9.63E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.77|P-value:1.04E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.74|P-value:0.00100 ID:SGTC_2576|Compound:guaiol|FD-Score:3.16|P-value:1.81E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.98|P-value:4.05E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.65|P-value:2.11E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.73|P-value:5.46E-8 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.57|P-value:3.00E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.64|P-value:1.96E-5 ID:SGTC_2947|Compound:9072639|FD-Score:2.74|P-value:9.77E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.05|P-value:2.85E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.40|P-value:6.69E-5 ID:SGTC_3340|Compound:9146634|FD-Score:2.94|P-value:4.42E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.32|P-value:9.00E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:2.91|P-value:5.06E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.52|P-value:3.49E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:2.88|P-value:5.68E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.75|P-value:1.28E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.55|P-value:3.35E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:2.84|P-value:6.76E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.51|P-value:3.71E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.97|P-value:3.70E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:3.01|P-value:3.33E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:5.09|P-value:4.69E-9 ID:SGTC_891|Compound:0929-0073|FD-Score:2.86|P-value:6.18E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.23|P-value:1.33E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.76|P-value:1.18E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:2.97|P-value:3.99E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.35|P-value:7.81E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.80|P-value:9.03E-6 ID:SGTC_1739|Compound:st037196|FD-Score:-3.60|P-value:2.60E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.06|P-value:2.71E-4 ID:SGTC_2007|Compound:4011539|FD-Score:-3.31|P-value:1.01E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.09|P-value:2.47E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-4.65|P-value:8.83E-8 ID:SGTC_2265|Compound:7929201|FD-Score:-3.70|P-value:1.63E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.14|P-value:1.62E-6 ID:SGTC_2414|Compound:st077232|FD-Score:-2.80|P-value:8.48E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:4.51|P-value:1.82E-7 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.75|P-value:9.63E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.77|P-value:1.04E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.74|P-value:0.00100 ID:SGTC_2576|Compound:guaiol|FD-Score:3.16|P-value:1.81E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-2.98|P-value:4.05E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.65|P-value:2.11E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.73|P-value:5.46E-8 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.57|P-value:3.00E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.64|P-value:1.96E-5 ID:SGTC_2947|Compound:9072639|FD-Score:2.74|P-value:9.77E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.05|P-value:2.85E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.40|P-value:6.69E-5 ID:SGTC_3340|Compound:9146634|FD-Score:2.94|P-value:4.42E-4

Top fitness defect scores for YIL059C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_886 0866-0150 5.09 153.0 µM 4.69E-9 4 1.78E-7
2 SGTC_2491 paeonol 4.51 100.0 µM 1.82E-7 4 3.25E-6
3 SGTC_669 0108-0021 3.97 26.2 µM 3.70E-6 fatty acid desaturase (OLE1) 80 3.56E-5
4 SGTC_1383 3049-0032 3.80 20.7 µM 9.03E-6 60S ribosome export 23 7.24E-5
5 SGTC_2493 resveratrol 3.77 26.1 µM 1.04E-5 9 8.13E-5
6 SGTC_2807 7945238 3.64 52.0 µM 1.96E-5 34 1.34E-4
7 SGTC_115 0527-0192 3.52 112.0 µM 3.49E-5 94 2.13E-4
8 SGTC_512 prima-1 3.51 270.0 µM 3.71E-5 DNA intercalators 37 2.23E-4
9 SGTC_1260 0700-1617 3.35 7.8 µM 7.81E-5 calcium & mitochondrial duress 53 4.05E-4
10 SGTC_4 0960-0234 3.32 25.7 µM 9.00E-5 Golgi 28 4.53E-4
11 SGTC_994 3910-0338 3.23 138.0 µM 1.33E-4 calcium & mitochondrial duress 82 6.20E-4
12 SGTC_2576 guaiol 3.16 23.1 µM 1.81E-4 68 7.90E-4
13 SGTC_2027 5150920 3.09 200.0 µM 2.47E-4 42 0.00101
14 SGTC_1750 st081859 3.06 2.4 µM 2.71E-4 endomembrane recycling 254 0.00109
15 SGTC_2954 9074818 3.05 52.7 µM 2.85E-4 69 0.00114
16 SGTC_720 r052-1644 3.01 49.9 µM 3.33E-4 TSC3-RPN4 65 0.00129
17 SGTC_1173 0443-0020 2.97 122.0 µM 3.99E-4 TSC3-RPN4 98 0.00149
18 SGTC_3340 9146634 2.94 11.1 µM 4.42E-4 59 0.00162
19 SGTC_17 0960-0276 2.91 49.8 µM 5.06E-4 101 0.00180
20 SGTC_131 0141-0277 2.88 33.9 µM 5.68E-4 113 0.00198

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 7.14E-23 YGL082W_p YGL082W_p hom Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
0.129 6.17E-14 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.113 6.33E-11 YJL070C_p YJL070C_p hom Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication
0.112 9.01E-11 YIR006C PAN1 het Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously thought to be a subunit of poly(A) ribonuclease
0.112 9.31E-11 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.111 1.38E-10 YOL163W_p YOL163W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.110 1.89E-10 YLR081W GAL2 hom Galactose permease, required for utilization of galactose; also able to transport glucose
0.109 2.38E-10 YGL235W_p YGL235W_p hom Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.107 4.78E-10 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.105 9.74E-10 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.103 2.09E-9 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.100 7.19E-9 YOL080C REX4 hom Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
0.099 8.81E-9 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.097 1.72E-8 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.097 1.79E-8 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p