YIL060W_p

Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL060W / YIL060W

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:7.89|P-value:2.84E-12 ID:SGTC_19|Compound:0279-0214|FD-Score:5.85|P-value:1.52E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.45|P-value:9.17E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:4.46|P-value:4.59E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.98|P-value:8.98E-6 ID:SGTC_172|Compound:1112-0046|FD-Score:-5.26|P-value:2.88E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:9.54|P-value:4.24E-17 ID:SGTC_204|Compound:1543-0184|FD-Score:3.65|P-value:6.81E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.01|P-value:2.18E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.20|P-value:1.32E-26 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.12|P-value:3.63E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:10.90|P-value:1.02E-21 ID:SGTC_343|Compound:4130-2827|FD-Score:4.04|P-value:1.94E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:5.53|P-value:6.38E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.66|P-value:3.05E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:4.34|P-value:7.18E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:4.26|P-value:9.20E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.06|P-value:1.84E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.54|P-value:9.21E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:5.15|P-value:3.27E-6 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.80|P-value:5.51E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:7.47|P-value:3.50E-11 ID:SGTC_800|Compound:3448-7362|FD-Score:3.62|P-value:7.38E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:5.96|P-value:9.07E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:3.80|P-value:4.27E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.75|P-value:4.97E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.71|P-value:5.51E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.61|P-value:2.63E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.29|P-value:8.50E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.83|P-value:3.83E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.67|P-value:6.32E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.52|P-value:9.90E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:-4.71|P-value:2.48E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:-4.15|P-value:1.82E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.91|P-value:3.02E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.83|P-value:3.81E-4 ID:SGTC_1742|Compound:st038235|FD-Score:12.10|P-value:2.00E-26 ID:SGTC_1749|Compound:st037932|FD-Score:-4.86|P-value:1.42E-5 ID:SGTC_1828|Compound:st055811|FD-Score:4.23|P-value:1.02E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-4.87|P-value:1.37E-5 ID:SGTC_1882|Compound:5615643|FD-Score:4.00|P-value:2.20E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.08|P-value:1.74E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.06|P-value:4.76E-6 ID:SGTC_1961|Compound:st076550|FD-Score:4.03|P-value:1.99E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-3.64|P-value:8.93E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.67|P-value:6.36E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.52|P-value:9.95E-4 ID:SGTC_2084|Compound:5306078|FD-Score:4.44|P-value:4.89E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.53|P-value:9.63E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.62|P-value:7.33E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.11|P-value:1.55E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.68|P-value:2.06E-5 ID:SGTC_2320|Compound:7373003|FD-Score:4.40|P-value:5.79E-5 ID:SGTC_2333|Compound:9017922|FD-Score:4.13|P-value:1.46E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-4.45|P-value:6.37E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-4.11|P-value:2.06E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:7.84|P-value:3.74E-12 ID:SGTC_2526|Compound:patulin|FD-Score:3.53|P-value:9.67E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.77|P-value:4.63E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.85|P-value:4.71E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.81|P-value:1.70E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.93|P-value:7.83E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.66|P-value:6.49E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-6.57|P-value:7.14E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.97|P-value:3.27E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.73|P-value:5.25E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.81|P-value:5.32E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-5.24|P-value:3.12E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-4.45|P-value:6.43E-5 ID:SGTC_2959|Compound:9079155|FD-Score:-4.43|P-value:6.89E-5 ID:SGTC_2963|Compound:9082507|FD-Score:4.17|P-value:1.26E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.59|P-value:7.94E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.79|P-value:4.42E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.62|P-value:9.38E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:7.89|P-value:2.84E-12 ID:SGTC_19|Compound:0279-0214|FD-Score:5.85|P-value:1.52E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.45|P-value:9.17E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:4.46|P-value:4.59E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.98|P-value:8.98E-6 ID:SGTC_172|Compound:1112-0046|FD-Score:-5.26|P-value:2.88E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:9.54|P-value:4.24E-17 ID:SGTC_204|Compound:1543-0184|FD-Score:3.65|P-value:6.81E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:4.01|P-value:2.18E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.20|P-value:1.32E-26 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.12|P-value:3.63E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:10.90|P-value:1.02E-21 ID:SGTC_343|Compound:4130-2827|FD-Score:4.04|P-value:1.94E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:5.53|P-value:6.38E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.66|P-value:3.05E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:4.34|P-value:7.18E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:4.26|P-value:9.20E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.06|P-value:1.84E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.54|P-value:9.21E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:5.15|P-value:3.27E-6 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.80|P-value:5.51E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:7.47|P-value:3.50E-11 ID:SGTC_800|Compound:3448-7362|FD-Score:3.62|P-value:7.38E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:5.96|P-value:9.07E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:3.80|P-value:4.27E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.75|P-value:4.97E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.71|P-value:5.51E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.61|P-value:2.63E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.29|P-value:8.50E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.83|P-value:3.83E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.67|P-value:6.32E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.52|P-value:9.90E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:-4.71|P-value:2.48E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:-4.15|P-value:1.82E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.91|P-value:3.02E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.83|P-value:3.81E-4 ID:SGTC_1742|Compound:st038235|FD-Score:12.10|P-value:2.00E-26 ID:SGTC_1749|Compound:st037932|FD-Score:-4.86|P-value:1.42E-5 ID:SGTC_1828|Compound:st055811|FD-Score:4.23|P-value:1.02E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-4.87|P-value:1.37E-5 ID:SGTC_1882|Compound:5615643|FD-Score:4.00|P-value:2.20E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.08|P-value:1.74E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.06|P-value:4.76E-6 ID:SGTC_1961|Compound:st076550|FD-Score:4.03|P-value:1.99E-4 ID:SGTC_1966|Compound:st070145|FD-Score:-3.64|P-value:8.93E-4 ID:SGTC_1972|Compound:st070201|FD-Score:3.67|P-value:6.36E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.52|P-value:9.95E-4 ID:SGTC_2084|Compound:5306078|FD-Score:4.44|P-value:4.89E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.53|P-value:9.63E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.62|P-value:7.33E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.11|P-value:1.55E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.68|P-value:2.06E-5 ID:SGTC_2320|Compound:7373003|FD-Score:4.40|P-value:5.79E-5 ID:SGTC_2333|Compound:9017922|FD-Score:4.13|P-value:1.46E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-4.45|P-value:6.37E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-4.11|P-value:2.06E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:7.84|P-value:3.74E-12 ID:SGTC_2526|Compound:patulin|FD-Score:3.53|P-value:9.67E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.77|P-value:4.63E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.85|P-value:4.71E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.81|P-value:1.70E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.93|P-value:7.83E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.66|P-value:6.49E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-6.57|P-value:7.14E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.97|P-value:3.27E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.73|P-value:5.25E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.81|P-value:5.32E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-5.24|P-value:3.12E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-4.45|P-value:6.43E-5 ID:SGTC_2959|Compound:9079155|FD-Score:-4.43|P-value:6.89E-5 ID:SGTC_2963|Compound:9082507|FD-Score:4.17|P-value:1.26E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.59|P-value:7.94E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.79|P-value:4.42E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.62|P-value:9.38E-4

Top fitness defect scores for YIL060W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 12.20 5.3 µM 1.32E-26 148 2.10E-34
2 SGTC_1742 st038235 12.10 28.9 µM 2.00E-26 mitochondrial stress 5 3.66E-34
3 SGTC_310 1273-0058 10.90 1.1 µM 1.02E-21 mitochondrial stress 29 5.86E-28
4 SGTC_173 1273-0061 9.54 2.7 µM 4.24E-17 mitochondrial stress 44 7.02E-22
5 SGTC_10 0279-0212 7.89 42.6 µM 2.84E-12 TRP & mitochondrial translation 8 1.54E-15
6 SGTC_2406 ethylparaben 7.84 405.7 µM 3.74E-12 3 2.21E-15
7 SGTC_767 0929-0023 7.47 86.0 µM 3.50E-11 TRP & mitochondrial translation 14 4.16E-14
8 SGTC_832 4083-0019 5.96 164.0 µM 9.07E-8 translation 19 1.23E-9
9 SGTC_19 0279-0214 5.85 38.4 µM 1.52E-7 TRP & mitochondrial translation 13 2.40E-9
10 SGTC_413 propylparaben 5.53 100.0 µM 6.38E-7 amide catabolism 5 1.56E-8
11 SGTC_28 pentachloropyridine N-oxide 5.45 1.6 µM 9.17E-7 TSC3-RPN4 25 2.51E-8
12 SGTC_629 3448-6466 5.15 76.7 µM 3.27E-6 3 1.31E-7
13 SGTC_275 trichlorophene 5.12 5.7 µM 3.63E-6 mitochondrial stress 161 1.51E-7
14 SGTC_1921 5740136 5.06 50.0 µM 4.76E-6 TRP & mitochondrial translation 33 2.14E-7
15 SGTC_2603 homopterocarpin 4.93 100.0 µM 7.83E-6 14 4.10E-7
16 SGTC_2232 chlorophetanol 4.68 41.5 µM 2.06E-5 TRP & mitochondrial translation 94 1.44E-6
17 SGTC_1127 asiatic acid 4.61 681.4 nM 2.63E-5 12 1.98E-6
18 SGTC_148 3253-0744 4.46 288.0 µM 4.59E-5 10 4.07E-6
19 SGTC_2084 5306078 4.44 60.6 µM 4.89E-5 9 4.43E-6
20 SGTC_2320 7373003 4.40 200.0 µM 5.79E-5 18 5.52E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.463 1.88E-177 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.452 2.85E-168 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.443 1.58E-161 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.436 1.28E-155 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.435 2.36E-155 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.430 1.74E-151 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.424 1.81E-146 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.419 1.22E-142 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.417 2.22E-141 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.416 1.60E-140 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.413 1.16E-138 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.412 1.11E-137 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.412 1.61E-137 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.412 2.18E-137 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.407 2.56E-134 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing