HIPHOP chemogenomics database

YIL060W_p

Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene

Zygosity: Homozygous strain

fixedexpanded
Profile for YIL060W / YIL060W

Click on Significant Values for Screen Details

Top fitness defect scores for YIL060W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	12.20	5.3 µM	1.32E-26		148	2.10E-34
2	SGTC_1742	st038235	12.10	28.9 µM	2.00E-26	mitochondrial stress	5	3.66E-34
3	SGTC_310	1273-0058	10.90	1.1 µM	1.02E-21	mitochondrial stress	29	5.86E-28
4	SGTC_173	1273-0061	9.54	2.7 µM	4.24E-17	mitochondrial stress	44	7.02E-22
5	SGTC_10	0279-0212	7.89	42.6 µM	2.84E-12	TRP & mitochondrial translation	8	1.54E-15
6	SGTC_2406	ethylparaben	7.84	405.7 µM	3.74E-12		3	2.21E-15
7	SGTC_767	0929-0023	7.47	86.0 µM	3.50E-11	TRP & mitochondrial translation	14	4.16E-14
8	SGTC_832	4083-0019	5.96	164.0 µM	9.07E-8	translation	19	1.23E-9
9	SGTC_19	0279-0214	5.85	38.4 µM	1.52E-7	TRP & mitochondrial translation	13	2.40E-9
10	SGTC_413	propylparaben	5.53	100.0 µM	6.38E-7	amide catabolism	5	1.56E-8
11	SGTC_28	pentachloropyridine N-oxide	5.45	1.6 µM	9.17E-7	TSC3-RPN4	25	2.51E-8
12	SGTC_629	3448-6466	5.15	76.7 µM	3.27E-6		3	1.31E-7
13	SGTC_275	trichlorophene	5.12	5.7 µM	3.63E-6	mitochondrial stress	161	1.51E-7
14	SGTC_1921	5740136	5.06	50.0 µM	4.76E-6	TRP & mitochondrial translation	33	2.14E-7
15	SGTC_2603	homopterocarpin	4.93	100.0 µM	7.83E-6		14	4.10E-7
16	SGTC_2232	chlorophetanol	4.68	41.5 µM	2.06E-5	TRP & mitochondrial translation	94	1.44E-6
17	SGTC_1127	asiatic acid	4.61	681.4 nM	2.63E-5		12	1.98E-6
18	SGTC_148	3253-0744	4.46	288.0 µM	4.59E-5		10	4.07E-6
19	SGTC_2084	5306078	4.44	60.6 µM	4.89E-5		9	4.43E-6
20	SGTC_2320	7373003	4.40	200.0 µM	5.79E-5		18	5.52E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.463	1.88E-177	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.452	2.85E-168	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.443	1.58E-161	YLR069C	MEF1	hom	Mitochondrial elongation factor involved in translational elongation
0.436	1.28E-155	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.435	2.36E-155	YNL177C	MRPL22	hom	Mitochondrial ribosomal protein of the large subunit
0.430	1.74E-151	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.424	1.81E-146	YOL095C	HMI1	hom	Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.419	1.22E-142	YML061C	PIF1	hom	DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.417	2.22E-141	YPL183W-A	RTC6	hom	Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.416	1.60E-140	YDR298C	ATP5	hom	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.413	1.16E-138	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.412	1.11E-137	YPR100W	MRPL51	hom	Mitochondrial ribosomal protein of the large subunit
0.412	1.61E-137	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.412	2.18E-137	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.407	2.56E-134	YDR194C	MSS116	hom	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing