YIL061C / SNP1

Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL061C / SNP1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.37|P-value:6.30E-4 ID:SGTC_5|Compound:0352-0601|FD-Score:-3.49|P-value:3.82E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.32|P-value:1.61E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-5.42|P-value:9.08E-8 ID:SGTC_77|Compound:0828-0286|FD-Score:-4.02|P-value:5.27E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:5.14|P-value:4.20E-7 ID:SGTC_108|Compound:0509-0257|FD-Score:4.13|P-value:3.79E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.69|P-value:1.86E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.77|P-value:1.52E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.47|P-value:4.47E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:7.58|P-value:1.74E-13 ID:SGTC_168|Compound:3970-0862|FD-Score:3.72|P-value:1.84E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.25|P-value:9.23E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.68|P-value:1.95E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.56|P-value:5.71E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:4.29|P-value:2.00E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.67|P-value:1.99E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:5.10|P-value:4.96E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:3.51|P-value:3.85E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.25|P-value:8.56E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.25|P-value:9.34E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.36|P-value:6.42E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.28|P-value:8.37E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.35|P-value:1.52E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.32|P-value:7.39E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.40|P-value:1.25E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:-4.46|P-value:8.67E-6 ID:SGTC_1347|Compound:1493-0251|FD-Score:-4.96|P-value:8.72E-7 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.30|P-value:7.98E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.55|P-value:3.33E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.65|P-value:2.33E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.66|P-value:2.31E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.56|P-value:3.26E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.74|P-value:1.69E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.48|P-value:4.37E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.40|P-value:5.58E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.43|P-value:5.17E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.35|P-value:1.39E-5 ID:SGTC_1797|Compound:st048695|FD-Score:-4.58|P-value:5.20E-6 ID:SGTC_1908|Compound:st060353|FD-Score:3.74|P-value:1.69E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.91|P-value:8.24E-5 ID:SGTC_1922|Compound:5578187|FD-Score:-3.63|P-value:2.33E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.42|P-value:4.88E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.81|P-value:1.34E-4 ID:SGTC_2033|Compound:5192550|FD-Score:6.19|P-value:1.42E-9 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-3.59|P-value:2.72E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.89|P-value:1.35E-6 ID:SGTC_2161|Compound:5662504|FD-Score:3.84|P-value:1.20E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.41|P-value:5.06E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.94|P-value:8.04E-5 ID:SGTC_2292|Compound:7671323|FD-Score:7.04|P-value:7.36E-12 ID:SGTC_2299|Compound:7976368|FD-Score:-3.46|P-value:4.27E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.50|P-value:3.72E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-4.35|P-value:1.36E-5 ID:SGTC_2455|Compound:5377712|FD-Score:5.09|P-value:5.29E-7 ID:SGTC_2459|Compound:5811157|FD-Score:3.30|P-value:7.81E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.44|P-value:1.07E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.59|P-value:2.88E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.70|P-value:7.27E-25 ID:SGTC_2929|Compound:9013348|FD-Score:-3.98|P-value:6.15E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.82|P-value:1.25E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.79|P-value:1.44E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.82|P-value:1.29E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.53|P-value:3.67E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-4.04|P-value:4.97E-5 ID:SGTC_1|Compound:0258-0098|FD-Score:3.37|P-value:6.30E-4 ID:SGTC_5|Compound:0352-0601|FD-Score:-3.49|P-value:3.82E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.32|P-value:1.61E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:-5.42|P-value:9.08E-8 ID:SGTC_77|Compound:0828-0286|FD-Score:-4.02|P-value:5.27E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:5.14|P-value:4.20E-7 ID:SGTC_108|Compound:0509-0257|FD-Score:4.13|P-value:3.79E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.69|P-value:1.86E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.77|P-value:1.52E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.47|P-value:4.47E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:7.58|P-value:1.74E-13 ID:SGTC_168|Compound:3970-0862|FD-Score:3.72|P-value:1.84E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.25|P-value:9.23E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.68|P-value:1.95E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.56|P-value:5.71E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:4.29|P-value:2.00E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.67|P-value:1.99E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:5.10|P-value:4.96E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:3.51|P-value:3.85E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.25|P-value:8.56E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.25|P-value:9.34E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.36|P-value:6.42E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.28|P-value:8.37E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.35|P-value:1.52E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.32|P-value:7.39E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.40|P-value:1.25E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:-4.46|P-value:8.67E-6 ID:SGTC_1347|Compound:1493-0251|FD-Score:-4.96|P-value:8.72E-7 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.30|P-value:7.98E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.55|P-value:3.33E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.65|P-value:2.33E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.66|P-value:2.31E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.56|P-value:3.26E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.74|P-value:1.69E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.48|P-value:4.37E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.40|P-value:5.58E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.43|P-value:5.17E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.35|P-value:1.39E-5 ID:SGTC_1797|Compound:st048695|FD-Score:-4.58|P-value:5.20E-6 ID:SGTC_1908|Compound:st060353|FD-Score:3.74|P-value:1.69E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.91|P-value:8.24E-5 ID:SGTC_1922|Compound:5578187|FD-Score:-3.63|P-value:2.33E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.42|P-value:4.88E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.81|P-value:1.34E-4 ID:SGTC_2033|Compound:5192550|FD-Score:6.19|P-value:1.42E-9 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-3.59|P-value:2.72E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.89|P-value:1.35E-6 ID:SGTC_2161|Compound:5662504|FD-Score:3.84|P-value:1.20E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.41|P-value:5.06E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.94|P-value:8.04E-5 ID:SGTC_2292|Compound:7671323|FD-Score:7.04|P-value:7.36E-12 ID:SGTC_2299|Compound:7976368|FD-Score:-3.46|P-value:4.27E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-3.50|P-value:3.72E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-4.35|P-value:1.36E-5 ID:SGTC_2455|Compound:5377712|FD-Score:5.09|P-value:5.29E-7 ID:SGTC_2459|Compound:5811157|FD-Score:3.30|P-value:7.81E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.44|P-value:1.07E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.59|P-value:2.88E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.70|P-value:7.27E-25 ID:SGTC_2929|Compound:9013348|FD-Score:-3.98|P-value:6.15E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.82|P-value:1.25E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.79|P-value:1.44E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.82|P-value:1.29E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.53|P-value:3.67E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-4.04|P-value:4.97E-5

Top fitness defect scores for YIL061C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2651 1327-0036 10.70 5.0 µM 7.27E-25 14 7.92E-27 0.10
2 SGTC_163 1327-0036 7.58 7.5 µM 1.74E-13 23 1.69E-14 0.04
3 SGTC_2292 7671323 7.04 168.1 µM 7.36E-12 RNA processing & uracil transport 1 9.77E-13 1.14
4 SGTC_2033 5192550 6.19 145.0 µM 1.42E-9 1 2.93E-10 1.33
5 SGTC_81 0411-0046 5.14 10.0 µM 4.20E-7 27 1.39E-7 0.18
6 SGTC_616 4092-0450 5.10 108.0 µM 4.96E-7 1 1.66E-7 0.63
7 SGTC_2455 5377712 5.09 9.8 µM 5.29E-7 1 1.78E-7 0.65
8 SGTC_2127 5253358 4.89 187.9 µM 1.35E-6 2 4.92E-7 0.44
9 SGTC_2565 isoliquiritigenin 4.44 100.0 µM 1.07E-5 8 4.60E-6 0.30
10 SGTC_1195 1502-0147 4.40 41.1 µM 1.25E-5 4 5.44E-6 0.05
11 SGTC_1038 k292-0204 4.35 154.0 µM 1.52E-5 3 6.72E-6 0.05
12 SGTC_435 c-PAF 4.29 6.7 µM 2.00E-5 13 9.08E-6 0.09
13 SGTC_108 0509-0257 4.13 621.1 µM 3.79E-5 12 1.81E-5 0.12
14 SGTC_2263 7948595 3.94 193.3 µM 8.04E-5 5 4.08E-5 0.35
15 SGTC_2161 5662504 3.84 8.5 µM 1.20E-4 tubulin folding & SWR complex 5 6.27E-5 0.04
16 SGTC_2936 9038235 3.82 15.6 µM 1.25E-4 8 6.59E-5 0.05
17 SGTC_3180 9109287 3.82 49.5 µM 1.29E-4 4 6.80E-5 0.05
18 SGTC_2021 4019055 3.81 173.0 µM 1.34E-4 endomembrane recycling 36 7.09E-5 0.04
19 SGTC_3091 9116372 3.79 49.5 µM 1.44E-4 16 7.68E-5 0.71
20 SGTC_124 0136-0217 3.77 7.1 µM 1.52E-4 mitochondrial stress 28 8.10E-5 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.284 2.29E-63 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.258 4.07E-52 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.252 1.04E-49 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.247 8.83E-48 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.246 1.46E-47 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.232 2.21E-42 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.229 2.86E-41 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.212 2.01E-35 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.175 1.34E-24 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
0.175 1.49E-24 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.175 1.55E-24 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.169 7.28E-23 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.162 3.34E-21 YPL209C IPL1 het Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest
0.158 2.78E-20 YIL031W ULP2 het Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.158 4.02E-20 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core