YIL062C / ARC15

Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL062C / ARC15

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:5.29|P-value:5.55E-9 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.21|P-value:2.82E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-4.14|P-value:4.28E-6 ID:SGTC_151|Compound:3013-0144|FD-Score:3.02|P-value:5.44E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.19|P-value:3.07E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.76|P-value:2.41E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.13|P-value:3.94E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.99|P-value:8.98E-6 ID:SGTC_458|Compound:nppb|FD-Score:2.89|P-value:9.10E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.33|P-value:1.60E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.27|P-value:2.08E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.54|P-value:6.72E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.42|P-value:1.11E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.44|P-value:1.01E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.50|P-value:7.99E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:2.89|P-value:8.98E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.68|P-value:3.56E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:2.99|P-value:6.07E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:4.26|P-value:2.09E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:3.53|P-value:7.00E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.97|P-value:6.59E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.10|P-value:1.82E-8 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.51|P-value:7.36E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.21|P-value:2.64E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.60|P-value:3.46E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.10|P-value:4.01E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.20|P-value:2.70E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.14|P-value:3.45E-4 ID:SGTC_1591|Compound:genipin|FD-Score:2.96|P-value:7.03E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.81|P-value:2.12E-5 ID:SGTC_1630|Compound:st005209|FD-Score:5.38|P-value:3.13E-9 ID:SGTC_1635|Compound:st007035|FD-Score:-3.28|P-value:2.15E-4 ID:SGTC_1636|Compound:st007707|FD-Score:5.71|P-value:3.74E-10 ID:SGTC_1647|Compound:st011722|FD-Score:3.52|P-value:7.16E-5 ID:SGTC_1686|Compound:st019653|FD-Score:2.91|P-value:8.30E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.63|P-value:4.37E-5 ID:SGTC_1824|Compound:st053723|FD-Score:3.09|P-value:4.19E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.85|P-value:1.59E-5 ID:SGTC_1898|Compound:st060199|FD-Score:3.00|P-value:6.05E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.23|P-value:2.43E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.03|P-value:5.35E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.66|P-value:3.90E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.49|P-value:8.19E-5 ID:SGTC_2289|Compound:7946404|FD-Score:2.91|P-value:8.18E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.02|P-value:6.96E-6 ID:SGTC_2434|Compound:5670830|FD-Score:3.00|P-value:6.04E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.09|P-value:4.18E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.02|P-value:5.89E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.87|P-value:1.48E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-3.13|P-value:3.83E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.05|P-value:5.01E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.93|P-value:7.73E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.06|P-value:5.13E-4 ID:SGTC_2854|Compound:9024559|FD-Score:2.96|P-value:6.89E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-5.69|P-value:4.63E-10 ID:SGTC_2952|Compound:9073731|FD-Score:3.23|P-value:2.45E-4 ID:SGTC_2986|Compound:9022445|FD-Score:5.85|P-value:1.36E-10 ID:SGTC_3072|Compound:9116419|FD-Score:2.87|P-value:9.60E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.90|P-value:6.03E-8 ID:SGTC_3284|Compound:9108171|FD-Score:2.97|P-value:6.62E-4 ID:SGTC_3316|Compound:9136639|FD-Score:4.52|P-value:5.43E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:5.29|P-value:5.55E-9 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.21|P-value:2.82E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-4.14|P-value:4.28E-6 ID:SGTC_151|Compound:3013-0144|FD-Score:3.02|P-value:5.44E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.19|P-value:3.07E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.76|P-value:2.41E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.13|P-value:3.94E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.99|P-value:8.98E-6 ID:SGTC_458|Compound:nppb|FD-Score:2.89|P-value:9.10E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.33|P-value:1.60E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.27|P-value:2.08E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.54|P-value:6.72E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.42|P-value:1.11E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.44|P-value:1.01E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.50|P-value:7.99E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:2.89|P-value:8.98E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.68|P-value:3.56E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:2.99|P-value:6.07E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:4.26|P-value:2.09E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:3.53|P-value:7.00E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.97|P-value:6.59E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.10|P-value:1.82E-8 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.51|P-value:7.36E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.21|P-value:2.64E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.60|P-value:3.46E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.10|P-value:4.01E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.20|P-value:2.70E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.14|P-value:3.45E-4 ID:SGTC_1591|Compound:genipin|FD-Score:2.96|P-value:7.03E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.81|P-value:2.12E-5 ID:SGTC_1630|Compound:st005209|FD-Score:5.38|P-value:3.13E-9 ID:SGTC_1635|Compound:st007035|FD-Score:-3.28|P-value:2.15E-4 ID:SGTC_1636|Compound:st007707|FD-Score:5.71|P-value:3.74E-10 ID:SGTC_1647|Compound:st011722|FD-Score:3.52|P-value:7.16E-5 ID:SGTC_1686|Compound:st019653|FD-Score:2.91|P-value:8.30E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.63|P-value:4.37E-5 ID:SGTC_1824|Compound:st053723|FD-Score:3.09|P-value:4.19E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.85|P-value:1.59E-5 ID:SGTC_1898|Compound:st060199|FD-Score:3.00|P-value:6.05E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.23|P-value:2.43E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.03|P-value:5.35E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.66|P-value:3.90E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.49|P-value:8.19E-5 ID:SGTC_2289|Compound:7946404|FD-Score:2.91|P-value:8.18E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.02|P-value:6.96E-6 ID:SGTC_2434|Compound:5670830|FD-Score:3.00|P-value:6.04E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.09|P-value:4.18E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.02|P-value:5.89E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.87|P-value:1.48E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-3.13|P-value:3.83E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.05|P-value:5.01E-4 ID:SGTC_2829|Compound:7992743|FD-Score:2.93|P-value:7.73E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.06|P-value:5.13E-4 ID:SGTC_2854|Compound:9024559|FD-Score:2.96|P-value:6.89E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-5.69|P-value:4.63E-10 ID:SGTC_2952|Compound:9073731|FD-Score:3.23|P-value:2.45E-4 ID:SGTC_2986|Compound:9022445|FD-Score:5.85|P-value:1.36E-10 ID:SGTC_3072|Compound:9116419|FD-Score:2.87|P-value:9.60E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.90|P-value:6.03E-8 ID:SGTC_3284|Compound:9108171|FD-Score:2.97|P-value:6.62E-4 ID:SGTC_3316|Compound:9136639|FD-Score:4.52|P-value:5.43E-7

Top fitness defect scores for YIL062C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2986 9022445 5.85 71.4 µM 1.36E-10 2 2.41E-9 1.43
2 SGTC_1636 st007707 5.71 68.9 µM 3.74E-10 3 5.79E-9 1.01
3 SGTC_1630 st005209 5.38 31.3 µM 3.13E-9 1 3.63E-8 0.72
4 SGTC_69 0096-0274 5.29 206.7 µM 5.55E-9 mitochondrial processes 27 5.96E-8 0.01
5 SGTC_1047 2043-3044 5.10 82.0 µM 1.82E-8 3 1.66E-7 0.97
6 SGTC_3222 9128301 4.90 49.5 µM 6.03E-8 60S ribosome export 5 4.68E-7 0.64
7 SGTC_1057 3448-5381 4.60 134.0 µM 3.46E-7 calcium & mitochondrial duress 12 2.12E-6 0.17
8 SGTC_3316 9136639 4.52 10.6 µM 5.43E-7 3 3.13E-6 0.66
9 SGTC_937 3122-0005 4.26 46.7 µM 2.09E-6 5 1.01E-5 0.56
10 SGTC_2307 7538926 4.02 6.3 µM 6.96E-6 21 2.85E-5 0.04
11 SGTC_2611 pyromycin 3.87 23.9 µM 1.48E-5 5 5.48E-5 0.04
12 SGTC_1860 st056228 3.85 74.6 µM 1.59E-5 6 5.82E-5 0.11
13 SGTC_355 1311-2252 3.76 105.0 µM 2.41E-5 3 8.36E-5 0.21
14 SGTC_679 0422-0091 3.68 41.4 µM 3.56E-5 Golgi 14 1.17E-4 0.02
15 SGTC_2241 6772625 3.66 37.8 µM 3.90E-5 11 1.27E-4 5.65E-4
16 SGTC_1760 st045453 3.63 10.4 µM 4.37E-5 NEO1-PIK1 4 1.40E-4 0.02
17 SGTC_625 k213-0058 3.54 121.0 µM 6.72E-5 translation 23 2.03E-4 0.01
18 SGTC_961 1252-1571 3.53 372.0 µM 7.00E-5 7 2.11E-4 0.01
19 SGTC_1647 st011722 3.52 22.4 µM 7.16E-5 13 2.15E-4 0.33
20 SGTC_1051 3253-3903 3.51 78.0 µM 7.36E-5 10 2.20E-4 0.31

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.64E-10 YAL017W PSK1 hom PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication
0.105 1.19E-9 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.097 1.71E-8 YOR351C MEK1 hom Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
0.087 4.01E-7 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.084 1.19E-6 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.079 4.65E-6 YMR316C-B_d YMR316C-B_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.078 5.85E-6 YDL017W CDC7 het DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p
0.077 8.54E-6 YKL017C HCS1 hom Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
0.074 1.69E-5 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.074 1.74E-5 YHR046C INM1 hom Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
0.074 1.82E-5 YOR225W_d YOR225W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.07E-5 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.073 2.23E-5 YBL030C PET9 het Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
0.073 2.42E-5 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.073 2.47E-5 YIL152W_p YIL152W_p hom Putative protein of unknown function