YIL063C / YRB2

Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL063C / YRB2

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-3.09|P-value:3.03E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.29|P-value:2.27E-9 ID:SGTC_153|Compound:4077-0274|FD-Score:3.49|P-value:5.78E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:-2.95|P-value:5.23E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:-2.95|P-value:5.25E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.32|P-value:1.14E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.08|P-value:3.45E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.66|P-value:2.45E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.01|P-value:4.47E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:6.44|P-value:5.61E-13 ID:SGTC_811|Compound:0416-0114|FD-Score:4.49|P-value:3.62E-7 ID:SGTC_912|Compound:3474-0017|FD-Score:3.48|P-value:6.21E-5 ID:SGTC_918|Compound:glabranin|FD-Score:3.89|P-value:8.88E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:3.46|P-value:6.66E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.71|P-value:2.12E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.30|P-value:1.37E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-2.93|P-value:5.77E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.09|P-value:3.23E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.06|P-value:3.63E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.63|P-value:3.03E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-3.18|P-value:2.11E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-2.97|P-value:4.83E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.15|P-value:2.51E-4 ID:SGTC_1701|Compound:st028638|FD-Score:-2.85|P-value:7.84E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.81|P-value:1.33E-5 ID:SGTC_1719|Compound:st032227|FD-Score:-3.05|P-value:3.64E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.69|P-value:2.36E-5 ID:SGTC_2035|Compound:5154463|FD-Score:3.23|P-value:1.80E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.45|P-value:6.40E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.38|P-value:9.65E-5 ID:SGTC_2341|Compound:7987486|FD-Score:2.90|P-value:6.77E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-2.91|P-value:6.24E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:2.92|P-value:6.47E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.27|P-value:1.08E-6 ID:SGTC_2957|Compound:9076800|FD-Score:-3.03|P-value:3.82E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.06|P-value:3.49E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.09|P-value:3.08E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.76|P-value:1.65E-5 ID:SGTC_3325|Compound:9138760|FD-Score:3.55|P-value:4.52E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.09|P-value:3.03E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.29|P-value:2.27E-9 ID:SGTC_153|Compound:4077-0274|FD-Score:3.49|P-value:5.78E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:-2.95|P-value:5.23E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:-2.95|P-value:5.25E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.32|P-value:1.14E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.08|P-value:3.45E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.66|P-value:2.45E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.01|P-value:4.47E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:6.44|P-value:5.61E-13 ID:SGTC_811|Compound:0416-0114|FD-Score:4.49|P-value:3.62E-7 ID:SGTC_912|Compound:3474-0017|FD-Score:3.48|P-value:6.21E-5 ID:SGTC_918|Compound:glabranin|FD-Score:3.89|P-value:8.88E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:3.46|P-value:6.66E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.71|P-value:2.12E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.30|P-value:1.37E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-2.93|P-value:5.77E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.09|P-value:3.23E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.06|P-value:3.63E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.63|P-value:3.03E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-3.18|P-value:2.11E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-2.97|P-value:4.83E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.15|P-value:2.51E-4 ID:SGTC_1701|Compound:st028638|FD-Score:-2.85|P-value:7.84E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.81|P-value:1.33E-5 ID:SGTC_1719|Compound:st032227|FD-Score:-3.05|P-value:3.64E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.69|P-value:2.36E-5 ID:SGTC_2035|Compound:5154463|FD-Score:3.23|P-value:1.80E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.45|P-value:6.40E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.38|P-value:9.65E-5 ID:SGTC_2341|Compound:7987486|FD-Score:2.90|P-value:6.77E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-2.91|P-value:6.24E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:2.92|P-value:6.47E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.27|P-value:1.08E-6 ID:SGTC_2957|Compound:9076800|FD-Score:-3.03|P-value:3.82E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-3.06|P-value:3.49E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.09|P-value:3.08E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.76|P-value:1.65E-5 ID:SGTC_3325|Compound:9138760|FD-Score:3.55|P-value:4.52E-5

Top fitness defect scores for YIL063C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_775 4577-0580 6.44 57.3 µM 5.61E-13 1 6.01E-11 1.44
2 SGTC_811 0416-0114 4.49 265.0 µM 3.62E-7 1 3.61E-6 0.74
3 SGTC_918 glabranin 3.89 770.7 nM 8.88E-6 7 5.07E-5 0.02
4 SGTC_1704 st028805 3.81 70.8 µM 1.33E-5 5 7.07E-5 0.26
5 SGTC_3153 9100258 3.76 49.5 µM 1.65E-5 8 8.48E-5 0.44
6 SGTC_1007 4101-0031 3.71 70.0 µM 2.12E-5 5 1.04E-4 0.10
7 SGTC_1999 st074831 3.69 12.5 µM 2.36E-5 plasma membrane duress 16 1.14E-4 0.17
8 SGTC_1414 3917-0015 3.63 5.4 µM 3.03E-5 2 1.40E-4 0.36
9 SGTC_3325 9138760 3.55 55.2 µM 4.52E-5 Golgi 5 1.95E-4 0.13
10 SGTC_153 4077-0274 3.49 519.7 µM 5.78E-5 10 2.39E-4 0.04
11 SGTC_912 3474-0017 3.48 2.2 µM 6.21E-5 8 2.53E-4 0.06
12 SGTC_958 1222-0007 3.46 33.0 µM 6.66E-5 10 2.68E-4 0.07
13 SGTC_2115 tiliquinol 3.38 12.8 µM 9.65E-5 6 3.65E-4 0.16
14 SGTC_1009 4106-0057 3.30 9.9 µM 1.37E-4 16 4.87E-4 0.09
15 SGTC_2035 5154463 3.23 94.6 µM 1.80E-4 17 6.12E-4 0.04
16 SGTC_1683 st010134 3.15 710.0 nM 2.51E-4 10 8.05E-4 0.02
17 SGTC_1132 3456-3614 3.09 2.5 µM 3.23E-4 tubulin folding & SWR complex 14 9.94E-4 0.01
18 SGTC_321 4534-3890 3.08 65.3 µM 3.45E-4 RPP1 & pyrimidine depletion 15 0.00105 0.14
19 SGTC_1133 3473-0247 3.06 50.0 µM 3.63E-4 RSC complex & mRNA processing 68 0.00109 0.08
20 SGTC_736 0958-0254 3.01 92.6 µM 4.47E-4 Golgi 12 0.00130 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 4.28E-16 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.139 5.08E-16 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.137 1.33E-15 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.133 8.89E-15 YOR370C MRS6 het Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress
0.130 3.80E-14 YDL120W YFH1 het Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia
0.130 3.93E-14 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.129 6.80E-14 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.129 7.99E-14 YKL036C_d YKL036C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
0.128 1.10E-13 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.127 1.32E-13 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.126 2.41E-13 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.125 3.40E-13 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.121 1.97E-12 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.118 8.09E-12 YER159C BUR6 het Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
0.117 1.03E-11 YNR017W TIM23 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel