YIL064W / SEE1

Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL064W / SEE1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.61|P-value:3.68E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.51|P-value:6.34E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.53|P-value:4.84E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.82|P-value:2.22E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:4.28|P-value:3.20E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.23|P-value:3.91E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:-4.44|P-value:2.17E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.93|P-value:1.22E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.79|P-value:2.45E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.64|P-value:3.29E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.36|P-value:8.38E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-4.28|P-value:4.01E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.39|P-value:7.65E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:-4.88|P-value:3.44E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.33|P-value:9.27E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-3.74|P-value:2.88E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.09|P-value:6.80E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.34|P-value:8.91E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.71|P-value:2.65E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.62|P-value:4.28E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.86|P-value:1.55E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.34|P-value:8.99E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-4.04|P-value:9.82E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.63|P-value:4.27E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.54|P-value:4.71E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.37|P-value:8.09E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.28|P-value:3.18E-5 ID:SGTC_2155|Compound:5570423|FD-Score:3.96|P-value:1.09E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.73|P-value:2.43E-4 ID:SGTC_2258|Compound:7960471|FD-Score:4.70|P-value:5.80E-6 ID:SGTC_2365|Compound:9042475|FD-Score:3.74|P-value:2.39E-4 ID:SGTC_2370|Compound:9071495|FD-Score:-4.30|P-value:3.77E-5 ID:SGTC_2384|Compound:9036245|FD-Score:4.64|P-value:7.33E-6 ID:SGTC_2390|Compound:9097792|FD-Score:3.51|P-value:5.10E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.55|P-value:5.53E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:5.25|P-value:4.88E-7 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.61|P-value:3.71E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-3.39|P-value:9.03E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.32|P-value:9.63E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.31|P-value:9.82E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.56|P-value:4.31E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.92|P-value:1.26E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-4.12|P-value:7.56E-5 ID:SGTC_3289|Compound:9119912|FD-Score:3.87|P-value:1.51E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.61|P-value:3.68E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.51|P-value:6.34E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.53|P-value:4.84E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.82|P-value:2.22E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:4.28|P-value:3.20E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.23|P-value:3.91E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:-4.44|P-value:2.17E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.93|P-value:1.22E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.79|P-value:2.45E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.64|P-value:3.29E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.36|P-value:8.38E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-4.28|P-value:4.01E-5 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.39|P-value:7.65E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:-4.88|P-value:3.44E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.33|P-value:9.27E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-3.74|P-value:2.88E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.09|P-value:6.80E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.34|P-value:8.91E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.71|P-value:2.65E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.62|P-value:4.28E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.86|P-value:1.55E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.34|P-value:8.99E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-4.04|P-value:9.82E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.63|P-value:4.27E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.54|P-value:4.71E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.37|P-value:8.09E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.28|P-value:3.18E-5 ID:SGTC_2155|Compound:5570423|FD-Score:3.96|P-value:1.09E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.73|P-value:2.43E-4 ID:SGTC_2258|Compound:7960471|FD-Score:4.70|P-value:5.80E-6 ID:SGTC_2365|Compound:9042475|FD-Score:3.74|P-value:2.39E-4 ID:SGTC_2370|Compound:9071495|FD-Score:-4.30|P-value:3.77E-5 ID:SGTC_2384|Compound:9036245|FD-Score:4.64|P-value:7.33E-6 ID:SGTC_2390|Compound:9097792|FD-Score:3.51|P-value:5.10E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.55|P-value:5.53E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:5.25|P-value:4.88E-7 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.61|P-value:3.71E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-3.39|P-value:9.03E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.32|P-value:9.63E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.31|P-value:9.82E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.56|P-value:4.31E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.92|P-value:1.26E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-4.12|P-value:7.56E-5 ID:SGTC_3289|Compound:9119912|FD-Score:3.87|P-value:1.51E-4

Top fitness defect scores for YIL064W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2538 3',7'-epoxycaryophyllan-6-one 5.25 100.0 µM 4.88E-7 8 7.53E-8
2 SGTC_2258 7960471 4.70 200.0 µM 5.80E-6 4 1.30E-6
3 SGTC_2384 9036245 4.64 200.0 µM 7.33E-6 21 1.70E-6
4 SGTC_2060 5238662 4.28 140.0 µM 3.18E-5 22 9.18E-6
5 SGTC_732 3970-1727 4.28 52.7 µM 3.20E-5 7 9.23E-6
6 SGTC_734 2023-0417 4.23 80.0 µM 3.91E-5 ergosterol biosynthesis 10 1.16E-5
7 SGTC_1352 1496-0991 4.09 99.0 µM 6.80E-5 tubulin folding & SWR complex 31 2.20E-5
8 SGTC_2155 5570423 3.96 76.0 µM 1.09E-4 ergosterol biosynthesis 10 3.78E-5
9 SGTC_915 methyl methanesulfonate (MMS) 3.93 110.0 mM 1.22E-4 DNA damage response 45 4.28E-5
10 SGTC_3212 9128307 3.92 49.5 µM 1.26E-4 45 4.47E-5
11 SGTC_3289 9119912 3.87 71.4 µM 1.51E-4 18 5.46E-5
12 SGTC_1782 st039423 3.86 80.6 µM 1.55E-4 25 5.63E-5
13 SGTC_2365 9042475 3.74 200.0 µM 2.39E-4 44 9.27E-5
14 SGTC_2179 6298986 3.73 200.0 µM 2.43E-4 heme requiring 21 9.47E-5
15 SGTC_1363 1636-0063 3.71 10.4 µM 2.65E-4 Golgi 36 1.05E-4
16 SGTC_954 1189-0853 3.64 2.9 µM 3.29E-4 endomembrane recycling 48 1.34E-4
17 SGTC_58 0957-0393 3.61 9.0 µM 3.68E-4 cell wall 415 1.52E-4
18 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 3.61 15.3 µM 3.71E-4 47 1.53E-4
19 SGTC_3200 9114385 3.56 49.5 µM 4.31E-4 50 1.82E-4
20 SGTC_2038 4100038 3.54 31.0 µM 4.71E-4 plasma membrane duress 69 2.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 6.17E-10 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.100 7.29E-9 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.096 2.48E-8 YLR326W_p YLR326W_p hom Putative protein of unknown function, predicted to be palmitoylated
0.094 5.17E-8 YOR034C-A_p YOR034C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.093 7.32E-8 YOR179C SYC1 hom Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication
0.091 1.21E-7 YDL162C_d YDL162C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly
0.084 1.12E-6 YDR195W REF2 hom RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes
0.083 1.40E-6 YKL046C DCW1 hom Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
0.078 6.61E-6 YBR286W APE3 hom Vacuolar aminopeptidase Y, processed to mature form by Prb1p
0.077 7.23E-6 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.076 1.09E-5 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.076 1.16E-5 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.076 1.18E-5 YJL212C OPT1 hom Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.075 1.22E-5 YPR184W GDB1 hom Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress
0.075 1.44E-5 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress