YIL065C / FIS1

Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL065C / FIS1

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.18|P-value:5.84E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.26|P-value:4.58E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.61|P-value:1.15E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.00|P-value:2.22E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.88|P-value:3.77E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.65|P-value:9.81E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.64|P-value:1.11E-6 ID:SGTC_234|Compound:nsc-17383|FD-Score:5.35|P-value:2.35E-8 ID:SGTC_237|Compound:nikkomycin|FD-Score:-4.08|P-value:1.71E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:3.34|P-value:3.21E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.29|P-value:4.21E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.92|P-value:3.13E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.80|P-value:4.92E-7 ID:SGTC_547|Compound:1120-0019|FD-Score:3.35|P-value:3.06E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.68|P-value:8.66E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.50|P-value:1.76E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.57|P-value:1.33E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.45|P-value:2.13E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:10.10|P-value:2.12E-25 ID:SGTC_814|Compound:3342-0569|FD-Score:3.63|P-value:1.05E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:4.03|P-value:1.94E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.39|P-value:2.81E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.39|P-value:3.70E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:3.31|P-value:3.61E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.31|P-value:3.62E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.42|P-value:3.17E-6 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.12|P-value:7.15E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:5.14|P-value:7.61E-8 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.42|P-value:3.25E-6 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.09|P-value:7.92E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.72|P-value:7.24E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.16|P-value:6.21E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.29|P-value:3.90E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.47|P-value:1.98E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.87|P-value:4.13E-5 ID:SGTC_1629|Compound:st005085|FD-Score:-3.15|P-value:6.94E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-3.09|P-value:8.48E-4 ID:SGTC_1635|Compound:st007035|FD-Score:7.62|P-value:3.81E-15 ID:SGTC_1640|Compound:st009078|FD-Score:3.49|P-value:1.80E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.28|P-value:3.98E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.35|P-value:4.43E-6 ID:SGTC_1782|Compound:st039423|FD-Score:-3.23|P-value:5.20E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-3.12|P-value:7.54E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.59|P-value:1.20E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.83|P-value:4.53E-5 ID:SGTC_2079|Compound:5212404|FD-Score:-3.63|P-value:1.13E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-3.47|P-value:2.14E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.12|P-value:7.16E-4 ID:SGTC_2116|Compound:5511452|FD-Score:4.29|P-value:5.82E-6 ID:SGTC_2204|Compound:7233102|FD-Score:3.32|P-value:3.47E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.18|P-value:5.76E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.30|P-value:3.74E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.12|P-value:7.24E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.31|P-value:3.56E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.03|P-value:1.89E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.39|P-value:2.67E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.29|P-value:3.84E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:6.72|P-value:3.49E-12 ID:SGTC_3090|Compound:9117696|FD-Score:3.05|P-value:9.12E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.77|P-value:5.91E-5 ID:SGTC_3117|Compound:9124945|FD-Score:3.39|P-value:2.68E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.40|P-value:2.59E-4 ID:SGTC_3195|Compound:9113082|FD-Score:5.41|P-value:1.72E-8 ID:SGTC_3258|Compound:9138477|FD-Score:-3.05|P-value:9.70E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.18|P-value:5.84E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.26|P-value:4.58E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.61|P-value:1.15E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.00|P-value:2.22E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.88|P-value:3.77E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.64|P-value:1.02E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.65|P-value:9.81E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.64|P-value:1.11E-6 ID:SGTC_234|Compound:nsc-17383|FD-Score:5.35|P-value:2.35E-8 ID:SGTC_237|Compound:nikkomycin|FD-Score:-4.08|P-value:1.71E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:3.34|P-value:3.21E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.29|P-value:4.21E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.92|P-value:3.13E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.80|P-value:4.92E-7 ID:SGTC_547|Compound:1120-0019|FD-Score:3.35|P-value:3.06E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.68|P-value:8.66E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:3.50|P-value:1.76E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.57|P-value:1.33E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.45|P-value:2.13E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:10.10|P-value:2.12E-25 ID:SGTC_814|Compound:3342-0569|FD-Score:3.63|P-value:1.05E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:4.03|P-value:1.94E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.39|P-value:2.81E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.39|P-value:3.70E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:3.31|P-value:3.61E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.31|P-value:3.62E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.42|P-value:3.17E-6 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.12|P-value:7.15E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:5.14|P-value:7.61E-8 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.42|P-value:3.25E-6 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.09|P-value:7.92E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.72|P-value:7.24E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.16|P-value:6.21E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.29|P-value:3.90E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.47|P-value:1.98E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.87|P-value:4.13E-5 ID:SGTC_1629|Compound:st005085|FD-Score:-3.15|P-value:6.94E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-3.09|P-value:8.48E-4 ID:SGTC_1635|Compound:st007035|FD-Score:7.62|P-value:3.81E-15 ID:SGTC_1640|Compound:st009078|FD-Score:3.49|P-value:1.80E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.28|P-value:3.98E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.35|P-value:4.43E-6 ID:SGTC_1782|Compound:st039423|FD-Score:-3.23|P-value:5.20E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-3.12|P-value:7.54E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.59|P-value:1.20E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.83|P-value:4.53E-5 ID:SGTC_2079|Compound:5212404|FD-Score:-3.63|P-value:1.13E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-3.47|P-value:2.14E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.12|P-value:7.16E-4 ID:SGTC_2116|Compound:5511452|FD-Score:4.29|P-value:5.82E-6 ID:SGTC_2204|Compound:7233102|FD-Score:3.32|P-value:3.47E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.18|P-value:5.76E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.30|P-value:3.74E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.12|P-value:7.24E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.31|P-value:3.56E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.03|P-value:1.89E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.39|P-value:2.67E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.29|P-value:3.84E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:6.72|P-value:3.49E-12 ID:SGTC_3090|Compound:9117696|FD-Score:3.05|P-value:9.12E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.77|P-value:5.91E-5 ID:SGTC_3117|Compound:9124945|FD-Score:3.39|P-value:2.68E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.40|P-value:2.59E-4 ID:SGTC_3195|Compound:9113082|FD-Score:5.41|P-value:1.72E-8 ID:SGTC_3258|Compound:9138477|FD-Score:-3.05|P-value:9.70E-4

Top fitness defect scores for YIL065C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_778 3456-2434 10.10 196.0 µM 2.12E-25 mitochondrial response to ROS 6 1.68E-24
2 SGTC_1635 st007035 7.62 42.4 µM 3.81E-15 102 1.26E-14
3 SGTC_2628 lathosterol 6.72 100.0 µM 3.49E-12 3 8.93E-12
4 SGTC_3195 9113082 5.41 49.5 µM 1.72E-8 6 3.22E-8
5 SGTC_234 nsc-17383 5.35 10.7 µM 2.35E-8 ERG2 12 4.34E-8
6 SGTC_1175 0741-0056 5.14 27.6 µM 7.61E-8 4 1.35E-7
7 SGTC_528 3492-0019 4.80 172.0 µM 4.92E-7 calcium & mitochondrial duress 164 8.13E-7
8 SGTC_221 trifluoperazine 4.64 10.3 µM 1.11E-6 NEO1-PIK1 178 1.78E-6
9 SGTC_1027 k015-0025 4.42 8.7 µM 3.17E-6 20 4.89E-6
10 SGTC_1179 1021-1431 4.42 9.3 µM 3.25E-6 28 5.01E-6
11 SGTC_902 1120-0002 4.39 2.1 µM 3.70E-6 azole & statin 36 5.67E-6
12 SGTC_1728 st035614 4.35 33.8 µM 4.43E-6 35 6.75E-6
13 SGTC_2116 5511452 4.29 16.9 µM 5.82E-6 10 8.77E-6
14 SGTC_2581 avocatin a 4.03 64.0 µM 1.89E-5 sphingolipid biosynthesis & PDR1 50 2.73E-5
15 SGTC_886 0866-0150 4.03 153.0 µM 1.94E-5 22 2.79E-5
16 SGTC_115 0527-0192 4.00 112.0 µM 2.22E-5 68 3.18E-5
17 SGTC_518 1021-0119 3.92 62.6 µM 3.13E-5 ERG2 35 4.43E-5
18 SGTC_150 3970-0969 3.88 77.2 µM 3.77E-5 66 5.30E-5
19 SGTC_1844 rapamycin 3.83 4.0 nM 4.53E-5 169 6.34E-5
20 SGTC_3116 9124943 3.77 49.5 µM 5.91E-5 19 8.18E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.249 9.53E-49 YDL023C_d YDL023C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
0.193 1.81E-29 YIL098C FMC1 hom Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
0.192 2.65E-29 YKR016W FCJ1 hom Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane
0.191 7.90E-29 YIL041W GVP36 hom BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis
0.190 1.35E-28 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.182 2.91E-26 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.179 1.14E-25 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.167 2.10E-22 YGR257C MTM1 hom Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
0.160 1.28E-20 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.152 6.61E-19 YJR135W-A TIM8 hom Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome
0.151 1.33E-18 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.150 2.94E-18 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.148 5.97E-18 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.147 1.48E-17 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.146 1.59E-17 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p