YIL066C / RNR3

Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL066C / RNR3

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.27|P-value:2.98E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:3.25|P-value:3.16E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:5.69|P-value:1.00E-9 ID:SGTC_276|Compound:colchicine|FD-Score:3.11|P-value:5.41E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.95|P-value:1.64E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.52|P-value:1.07E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.34|P-value:2.24E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.31|P-value:2.57E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:2.98|P-value:8.74E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.25|P-value:3.17E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.66|P-value:5.96E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:4.51|P-value:1.06E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:3.85|P-value:2.53E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.00|P-value:8.30E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.72|P-value:3.40E-7 ID:SGTC_873|Compound:0591-4978|FD-Score:3.29|P-value:2.70E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.01|P-value:7.80E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.04|P-value:7.20E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.96|P-value:1.27E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.19|P-value:3.99E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.32|P-value:2.07E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:2.95|P-value:9.93E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.37|P-value:2.10E-6 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.06|P-value:6.63E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.28|P-value:2.86E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.39|P-value:1.81E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.00|P-value:1.30E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.16|P-value:5.98E-6 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.87|P-value:2.40E-5 ID:SGTC_1675|Compound:st018485|FD-Score:-3.67|P-value:4.68E-5 ID:SGTC_1678|Compound:st019265|FD-Score:3.02|P-value:7.71E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.26|P-value:3.12E-4 ID:SGTC_1689|Compound:st020265|FD-Score:4.61|P-value:6.00E-7 ID:SGTC_1709|Compound:st033179|FD-Score:-2.92|P-value:9.42E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.16|P-value:4.47E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.34|P-value:2.21E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.16|P-value:4.52E-4 ID:SGTC_1985|Compound:st071382|FD-Score:2.99|P-value:8.62E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.11|P-value:5.50E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.11|P-value:5.55E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.31|P-value:2.11E-4 ID:SGTC_2272|Compound:7805186|FD-Score:2.97|P-value:9.10E-4 ID:SGTC_2273|Compound:7815444|FD-Score:4.06|P-value:9.75E-6 ID:SGTC_2290|Compound:7904846|FD-Score:3.51|P-value:1.11E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-4.00|P-value:1.07E-5 ID:SGTC_2350|Compound:9023895|FD-Score:5.54|P-value:2.69E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.63|P-value:6.79E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.43|P-value:1.58E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.79|P-value:3.33E-5 ID:SGTC_2792|Compound:7535235|FD-Score:2.99|P-value:8.35E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.08|P-value:8.83E-6 ID:SGTC_2844|Compound:9010103|FD-Score:4.42|P-value:1.64E-6 ID:SGTC_2894|Compound:9048625|FD-Score:2.95|P-value:9.65E-4 ID:SGTC_2895|Compound:9054447|FD-Score:4.81|P-value:2.06E-7 ID:SGTC_2972|Compound:9093619|FD-Score:-4.53|P-value:7.45E-7 ID:SGTC_3127|Compound:9126946|FD-Score:3.02|P-value:7.76E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-2.96|P-value:8.08E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.19|P-value:3.38E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.49|P-value:1.01E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.65|P-value:6.29E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-3.02|P-value:6.54E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.27|P-value:2.98E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:3.25|P-value:3.16E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:5.69|P-value:1.00E-9 ID:SGTC_276|Compound:colchicine|FD-Score:3.11|P-value:5.41E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.95|P-value:1.64E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.52|P-value:1.07E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.34|P-value:2.24E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.31|P-value:2.57E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:2.98|P-value:8.74E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.25|P-value:3.17E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.66|P-value:5.96E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:4.51|P-value:1.06E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:3.85|P-value:2.53E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.00|P-value:8.30E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.72|P-value:3.40E-7 ID:SGTC_873|Compound:0591-4978|FD-Score:3.29|P-value:2.70E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.01|P-value:7.80E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.04|P-value:7.20E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.96|P-value:1.27E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.19|P-value:3.99E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.32|P-value:2.07E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:2.95|P-value:9.93E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.37|P-value:2.10E-6 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.06|P-value:6.63E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.28|P-value:2.86E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.39|P-value:1.81E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.00|P-value:1.30E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.16|P-value:5.98E-6 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.87|P-value:2.40E-5 ID:SGTC_1675|Compound:st018485|FD-Score:-3.67|P-value:4.68E-5 ID:SGTC_1678|Compound:st019265|FD-Score:3.02|P-value:7.71E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.26|P-value:3.12E-4 ID:SGTC_1689|Compound:st020265|FD-Score:4.61|P-value:6.00E-7 ID:SGTC_1709|Compound:st033179|FD-Score:-2.92|P-value:9.42E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.16|P-value:4.47E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.34|P-value:2.21E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.16|P-value:4.52E-4 ID:SGTC_1985|Compound:st071382|FD-Score:2.99|P-value:8.62E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.11|P-value:5.50E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.11|P-value:5.55E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.31|P-value:2.11E-4 ID:SGTC_2272|Compound:7805186|FD-Score:2.97|P-value:9.10E-4 ID:SGTC_2273|Compound:7815444|FD-Score:4.06|P-value:9.75E-6 ID:SGTC_2290|Compound:7904846|FD-Score:3.51|P-value:1.11E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-4.00|P-value:1.07E-5 ID:SGTC_2350|Compound:9023895|FD-Score:5.54|P-value:2.69E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.63|P-value:6.79E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.43|P-value:1.58E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.79|P-value:3.33E-5 ID:SGTC_2792|Compound:7535235|FD-Score:2.99|P-value:8.35E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.08|P-value:8.83E-6 ID:SGTC_2844|Compound:9010103|FD-Score:4.42|P-value:1.64E-6 ID:SGTC_2894|Compound:9048625|FD-Score:2.95|P-value:9.65E-4 ID:SGTC_2895|Compound:9054447|FD-Score:4.81|P-value:2.06E-7 ID:SGTC_2972|Compound:9093619|FD-Score:-4.53|P-value:7.45E-7 ID:SGTC_3127|Compound:9126946|FD-Score:3.02|P-value:7.76E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-2.96|P-value:8.08E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.19|P-value:3.38E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.49|P-value:1.01E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.65|P-value:6.29E-5 ID:SGTC_3331|Compound:9141060|FD-Score:-3.02|P-value:6.54E-4

Top fitness defect scores for YIL066C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_237 nikkomycin 5.69 200.0 µM 1.00E-9 RSC complex & mRNA processing 6 6.20E-9
2 SGTC_2350 9023895 5.54 38.9 µM 2.69E-9 ergosterol biosynthesis 14 1.51E-8
3 SGTC_2895 9054447 4.81 58.4 µM 2.06E-7 2 7.52E-7
4 SGTC_871 0574-0004 4.72 149.0 µM 3.40E-7 28 1.18E-6
5 SGTC_1689 st020265 4.61 53.5 µM 6.00E-7 13 1.97E-6
6 SGTC_799 1310-0557 4.51 151.0 µM 1.06E-6 superoxide 13 3.29E-6
7 SGTC_2844 9010103 4.42 26.0 µM 1.64E-6 18 4.89E-6
8 SGTC_1228 0124-0032 4.37 52.5 µM 2.10E-6 10 6.11E-6
9 SGTC_1351 1496-0003 4.16 46.5 µM 5.98E-6 16 1.57E-5
10 SGTC_2831 7999036 4.08 19.5 µM 8.83E-6 41 2.23E-5
11 SGTC_2273 7815444 4.06 169.1 µM 9.75E-6 18 2.44E-5
12 SGTC_1317 1273-0028 4.00 910.0 nM 1.30E-5 azole & statin 51 3.17E-5
13 SGTC_329 k048-0121 3.95 21.3 µM 1.64E-5 RSC & ERG11 12 3.91E-5
14 SGTC_1497 4476-2978 3.87 41.3 µM 2.40E-5 11 5.50E-5
15 SGTC_808 0711-0032 3.85 135.0 µM 2.53E-5 14 5.79E-5
16 SGTC_2718 lomofungin 3.79 53.0 µM 3.33E-5 mitochondrial processes 11 7.41E-5
17 SGTC_683 panaxydol 3.66 45.0 µM 5.96E-5 sphingolipid biosynthesis & PDR1 46 1.25E-4
18 SGTC_3319 9138450 3.65 16.8 µM 6.29E-5 28 1.32E-4
19 SGTC_2582 agaric acid 3.63 100.0 µM 6.79E-5 redox potentiating 354 1.41E-4
20 SGTC_421 streptovitacin 3.52 30.0 mM 1.07E-4 35 2.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.65E-14 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.128 9.24E-14 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.115 2.24E-11 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.114 4.26E-11 YNL299W TRF5 hom Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p
0.107 5.05E-10 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.107 5.65E-10 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.105 9.13E-10 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.105 9.84E-10 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.104 1.41E-9 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.103 2.20E-9 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 2.79E-9 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.099 1.04E-8 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.098 1.35E-8 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.096 2.63E-8 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.094 4.24E-8 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1