YIL067C_p

Uncharacterized protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL067C / YIL067C

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.17|P-value:8.58E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.31|P-value:5.26E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.96|P-value:4.25E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:5.14|P-value:1.72E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.50|P-value:2.61E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.76|P-value:9.71E-12 ID:SGTC_456|Compound:gingerol|FD-Score:4.26|P-value:1.23E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:3.89|P-value:5.68E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.24|P-value:6.54E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.50|P-value:2.44E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:5.41|P-value:4.13E-8 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.21|P-value:6.84E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:5.11|P-value:2.04E-7 ID:SGTC_884|Compound:0851-0618|FD-Score:3.39|P-value:3.90E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.22|P-value:7.06E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-4.75|P-value:1.11E-6 ID:SGTC_1073|Compound:triclabendazole|FD-Score:5.90|P-value:2.38E-9 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.98|P-value:3.74E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.84|P-value:7.90E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.78|P-value:8.94E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.75|P-value:1.02E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.51|P-value:2.48E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.81|P-value:8.11E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.75|P-value:1.03E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.14|P-value:2.03E-5 ID:SGTC_1431|Compound:4049-0260|FD-Score:-3.35|P-value:4.29E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.32|P-value:4.98E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.78|P-value:8.45E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.83|P-value:7.42E-7 ID:SGTC_1722|Compound:st034304|FD-Score:3.29|P-value:5.64E-4 ID:SGTC_1730|Compound:st033808|FD-Score:5.99|P-value:1.44E-9 ID:SGTC_1742|Compound:st038235|FD-Score:5.19|P-value:1.29E-7 ID:SGTC_1816|Compound:st051957|FD-Score:-3.23|P-value:6.51E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.70|P-value:1.54E-6 ID:SGTC_1863|Compound:st057641|FD-Score:3.56|P-value:2.10E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.15|P-value:9.08E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.81|P-value:9.16E-7 ID:SGTC_1935|Compound:st074532|FD-Score:4.08|P-value:2.61E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.67|P-value:1.39E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.38|P-value:6.33E-6 ID:SGTC_2024|Compound:5144227|FD-Score:5.36|P-value:5.40E-8 ID:SGTC_2044|Compound:5102272|FD-Score:-3.32|P-value:4.65E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.47|P-value:2.90E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.40|P-value:3.81E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.21|P-value:7.44E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.27|P-value:8.41E-8 ID:SGTC_2570|Compound:licareol|FD-Score:3.32|P-value:5.03E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-3.49|P-value:2.54E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.12|P-value:9.45E-4 ID:SGTC_2866|Compound:9034245|FD-Score:4.35|P-value:8.23E-6 ID:SGTC_2952|Compound:9073731|FD-Score:-3.29|P-value:5.14E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.21|P-value:7.28E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.25|P-value:6.51E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.65|P-value:2.03E-6 ID:SGTC_3210|Compound:9128157|FD-Score:3.65|P-value:1.47E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.54|P-value:2.25E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.17|P-value:8.58E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.31|P-value:5.26E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.96|P-value:4.25E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:5.14|P-value:1.72E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.50|P-value:2.61E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.76|P-value:9.71E-12 ID:SGTC_456|Compound:gingerol|FD-Score:4.26|P-value:1.23E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:3.89|P-value:5.68E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.24|P-value:6.54E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:-3.50|P-value:2.44E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:5.41|P-value:4.13E-8 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.21|P-value:6.84E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:5.11|P-value:2.04E-7 ID:SGTC_884|Compound:0851-0618|FD-Score:3.39|P-value:3.90E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.22|P-value:7.06E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-4.75|P-value:1.11E-6 ID:SGTC_1073|Compound:triclabendazole|FD-Score:5.90|P-value:2.38E-9 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.98|P-value:3.74E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.84|P-value:7.90E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.78|P-value:8.94E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.75|P-value:1.02E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.51|P-value:2.48E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.81|P-value:8.11E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.75|P-value:1.03E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.14|P-value:2.03E-5 ID:SGTC_1431|Compound:4049-0260|FD-Score:-3.35|P-value:4.29E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.32|P-value:4.98E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.78|P-value:8.45E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.83|P-value:7.42E-7 ID:SGTC_1722|Compound:st034304|FD-Score:3.29|P-value:5.64E-4 ID:SGTC_1730|Compound:st033808|FD-Score:5.99|P-value:1.44E-9 ID:SGTC_1742|Compound:st038235|FD-Score:5.19|P-value:1.29E-7 ID:SGTC_1816|Compound:st051957|FD-Score:-3.23|P-value:6.51E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.70|P-value:1.54E-6 ID:SGTC_1863|Compound:st057641|FD-Score:3.56|P-value:2.10E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.15|P-value:9.08E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.81|P-value:9.16E-7 ID:SGTC_1935|Compound:st074532|FD-Score:4.08|P-value:2.61E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.67|P-value:1.39E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.38|P-value:6.33E-6 ID:SGTC_2024|Compound:5144227|FD-Score:5.36|P-value:5.40E-8 ID:SGTC_2044|Compound:5102272|FD-Score:-3.32|P-value:4.65E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.47|P-value:2.90E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.40|P-value:3.81E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.21|P-value:7.44E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.27|P-value:8.41E-8 ID:SGTC_2570|Compound:licareol|FD-Score:3.32|P-value:5.03E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-3.49|P-value:2.54E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.12|P-value:9.45E-4 ID:SGTC_2866|Compound:9034245|FD-Score:4.35|P-value:8.23E-6 ID:SGTC_2952|Compound:9073731|FD-Score:-3.29|P-value:5.14E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.21|P-value:7.28E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.25|P-value:6.51E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.65|P-value:2.03E-6 ID:SGTC_3210|Compound:9128157|FD-Score:3.65|P-value:1.47E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.54|P-value:2.25E-4

Top fitness defect scores for YIL067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 6.76 1.1 µM 9.71E-12 mitochondrial stress 124 6.76E-12
2 SGTC_1730 st033808 5.99 45.1 µM 1.44E-9 5 1.07E-9
3 SGTC_1073 triclabendazole 5.90 3.1 µM 2.38E-9 8 1.79E-9
4 SGTC_728 3030-5151 5.41 22.5 µM 4.13E-8 4 3.23E-8
5 SGTC_2024 5144227 5.36 134.0 µM 5.40E-8 12 4.25E-8
6 SGTC_2526 patulin 5.27 37.6 µM 8.41E-8 39 6.65E-8
7 SGTC_1742 st038235 5.19 28.9 µM 1.29E-7 mitochondrial stress 70 1.03E-7
8 SGTC_236 1509-0011 5.14 5.3 µM 1.72E-7 321 1.38E-7
9 SGTC_831 k061-1017 5.11 217.0 µM 2.04E-7 translation 20 1.63E-7
10 SGTC_173 1273-0061 4.96 2.7 µM 4.25E-7 mitochondrial stress 151 3.44E-7
11 SGTC_1087 pterostilbene 4.84 9.1 µM 7.90E-7 9 6.45E-7
12 SGTC_1921 5740136 4.81 50.0 µM 9.16E-7 TRP & mitochondrial translation 36 7.50E-7
13 SGTC_1834 st055981 4.70 52.8 µM 1.54E-6 RPP1 & pyrimidine depletion 15 1.27E-6
14 SGTC_3157 9099274 4.65 49.5 µM 2.03E-6 11 1.68E-6
15 SGTC_2866 9034245 4.35 58.4 µM 8.23E-6 4 6.95E-6
16 SGTC_456 gingerol 4.26 170.0 µM 1.23E-5 14 1.04E-5
17 SGTC_1332 1480-0653 4.14 17.5 µM 2.03E-5 TSC3-RPN4 13 1.74E-5
18 SGTC_1935 st074532 4.08 41.6 µM 2.61E-5 26 2.24E-5
19 SGTC_549 1661-1316 3.89 519.0 µM 5.68E-5 21 4.93E-5
20 SGTC_1218 1348-1416 3.81 30.7 µM 8.11E-5 SWF1 & branched chain AA biosynthesis 18 7.08E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.287 1.55E-64 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.287 1.86E-64 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.279 4.81E-61 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.276 1.06E-59 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.274 7.91E-59 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.267 8.88E-56 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.263 3.65E-54 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.262 1.08E-53 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.261 2.33E-53 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.260 1.13E-52 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.259 2.08E-52 YHR120W MSH1 hom DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis
0.258 3.14E-52 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.256 1.81E-51 YBR251W MRPS5 hom Mitochondrial ribosomal protein of the small subunit
0.254 1.15E-50 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.251 3.46E-49 YDR347W MRP1 hom Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein