YIL071C / PCI8

Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL071C / PCI8

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.34|P-value:7.93E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-4.26|P-value:3.00E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:4.86|P-value:2.20E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:3.45|P-value:5.53E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.82|P-value:1.60E-4 ID:SGTC_277|Compound:nystatin|FD-Score:4.06|P-value:6.26E-5 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.57|P-value:3.70E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:7.82|P-value:7.59E-14 ID:SGTC_645|Compound:0845-0943|FD-Score:3.68|P-value:2.55E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.28|P-value:9.50E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.93|P-value:1.00E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.53|P-value:9.49E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.29|P-value:9.38E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.28|P-value:2.64E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.19|P-value:3.78E-5 ID:SGTC_1663|Compound:st014140|FD-Score:-3.64|P-value:3.04E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.79|P-value:1.69E-4 ID:SGTC_1819|Compound:st053448|FD-Score:4.54|P-value:9.01E-6 ID:SGTC_1910|Compound:st062352|FD-Score:5.02|P-value:1.06E-6 ID:SGTC_1912|Compound:st060209|FD-Score:-3.85|P-value:1.41E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-4.18|P-value:4.08E-5 ID:SGTC_1938|Compound:st074717|FD-Score:-3.35|P-value:8.07E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.53|P-value:4.24E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-3.94|P-value:1.03E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.64|P-value:2.95E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.41|P-value:6.42E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.46|P-value:5.43E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.53|P-value:4.23E-4 ID:SGTC_2317|Compound:5986382|FD-Score:4.58|P-value:7.61E-6 ID:SGTC_2339|Compound:9000433|FD-Score:4.08|P-value:5.72E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.45|P-value:5.58E-4 ID:SGTC_2377|Compound:9073351|FD-Score:5.20|P-value:4.42E-7 ID:SGTC_2483|Compound:5729050|FD-Score:-3.30|P-value:9.45E-4 ID:SGTC_2484|Compound:5809818|FD-Score:5.45|P-value:1.32E-7 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.21|P-value:4.32E-7 ID:SGTC_2523|Compound:spermine|FD-Score:-3.86|P-value:1.38E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.41|P-value:6.32E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.10|P-value:5.63E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.38|P-value:7.03E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.38|P-value:6.89E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.52|P-value:9.76E-6 ID:SGTC_3113|Compound:9123498|FD-Score:4.03|P-value:7.06E-5 ID:SGTC_3137|Compound:9097352|FD-Score:4.35|P-value:1.93E-5 ID:SGTC_3194|Compound:9111903|FD-Score:-3.34|P-value:8.15E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.71|P-value:4.33E-6 ID:SGTC_49|Compound:0717-0965|FD-Score:3.34|P-value:7.93E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-4.26|P-value:3.00E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:4.86|P-value:2.20E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:3.45|P-value:5.53E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.82|P-value:1.60E-4 ID:SGTC_277|Compound:nystatin|FD-Score:4.06|P-value:6.26E-5 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.57|P-value:3.70E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:7.82|P-value:7.59E-14 ID:SGTC_645|Compound:0845-0943|FD-Score:3.68|P-value:2.55E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.28|P-value:9.50E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.93|P-value:1.00E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.53|P-value:9.49E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.29|P-value:9.38E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.28|P-value:2.64E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.19|P-value:3.78E-5 ID:SGTC_1663|Compound:st014140|FD-Score:-3.64|P-value:3.04E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.79|P-value:1.69E-4 ID:SGTC_1819|Compound:st053448|FD-Score:4.54|P-value:9.01E-6 ID:SGTC_1910|Compound:st062352|FD-Score:5.02|P-value:1.06E-6 ID:SGTC_1912|Compound:st060209|FD-Score:-3.85|P-value:1.41E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-4.18|P-value:4.08E-5 ID:SGTC_1938|Compound:st074717|FD-Score:-3.35|P-value:8.07E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.53|P-value:4.24E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-3.94|P-value:1.03E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.64|P-value:2.95E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.41|P-value:6.42E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.46|P-value:5.43E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.53|P-value:4.23E-4 ID:SGTC_2317|Compound:5986382|FD-Score:4.58|P-value:7.61E-6 ID:SGTC_2339|Compound:9000433|FD-Score:4.08|P-value:5.72E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.45|P-value:5.58E-4 ID:SGTC_2377|Compound:9073351|FD-Score:5.20|P-value:4.42E-7 ID:SGTC_2483|Compound:5729050|FD-Score:-3.30|P-value:9.45E-4 ID:SGTC_2484|Compound:5809818|FD-Score:5.45|P-value:1.32E-7 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.21|P-value:4.32E-7 ID:SGTC_2523|Compound:spermine|FD-Score:-3.86|P-value:1.38E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.41|P-value:6.32E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.10|P-value:5.63E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.38|P-value:7.03E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.38|P-value:6.89E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.52|P-value:9.76E-6 ID:SGTC_3113|Compound:9123498|FD-Score:4.03|P-value:7.06E-5 ID:SGTC_3137|Compound:9097352|FD-Score:4.35|P-value:1.93E-5 ID:SGTC_3194|Compound:9111903|FD-Score:-3.34|P-value:8.15E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.71|P-value:4.33E-6

Top fitness defect scores for YIL071C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_641 4092-0595 7.82 30.0 µM 7.59E-14 2 2.65E-15
2 SGTC_2484 5809818 5.45 12.0 µM 1.32E-7 4 2.55E-8
3 SGTC_2500 5-alpha-androstan-3,17-dione 5.21 61.4 µM 4.32E-7 19 9.57E-8
4 SGTC_2377 9073351 5.20 62.6 µM 4.42E-7 ergosterol biosynthesis 9 9.83E-8
5 SGTC_1910 st062352 5.02 60.4 µM 1.06E-6 11 2.60E-7
6 SGTC_95 0471-0001 4.86 561.1 µM 2.20E-6 12 5.91E-7
7 SGTC_3203 9113543 4.71 49.5 µM 4.33E-6 15 1.26E-6
8 SGTC_2317 5986382 4.58 200.0 µM 7.61E-6 6 2.36E-6
9 SGTC_1819 st053448 4.54 58.6 µM 9.01E-6 amide catabolism 9 2.85E-6
10 SGTC_1171 0368-0077 4.53 21.4 µM 9.49E-6 14 3.02E-6
11 SGTC_2981 9013952 4.52 39.0 µM 9.76E-6 31 3.11E-6
12 SGTC_3137 9097352 4.35 49.5 µM 1.93E-5 31 6.67E-6
13 SGTC_1581 himbacine 4.28 57.9 µM 2.64E-5 Golgi 43 9.46E-6
14 SGTC_1589 2',5'-dimethoxyflavone 4.19 47.2 µM 3.78E-5 12 1.41E-5
15 SGTC_2339 9000433 4.08 200.0 µM 5.72E-5 33 2.24E-5
16 SGTC_277 nystatin 4.06 15.5 µM 6.26E-5 10 2.47E-5
17 SGTC_3113 9123498 4.03 49.5 µM 7.06E-5 10 2.83E-5
18 SGTC_1141 3253-0389 3.93 52.6 µM 1.00E-4 7 4.17E-5
19 SGTC_1808 st050063 3.79 61.5 µM 1.69E-4 13 7.48E-5
20 SGTC_645 0845-0943 3.68 5.4 µM 2.55E-4 60S ribosome export 15 1.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.096 2.56E-8 YLR280C_d YLR280C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.05E-7 YLR050C_p YLR050C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene
0.084 1.22E-6 YOR056C NOB1 het Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.081 2.47E-6 YPR110C RPC40 het RNA polymerase subunit AC40, common to RNA polymerase I and III
0.080 3.92E-6 YOR338W_p YOR338W_p hom Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication
0.079 4.60E-6 YPR054W SMK1 hom Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
0.078 6.65E-6 YOR018W ROD1 hom Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication
0.076 1.18E-5 YDR267C CIA1 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein
0.075 1.48E-5 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.073 2.46E-5 YCL001W-B_p YCL001W-B_p hom Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication
0.070 4.91E-5 YMR244C-A COA6 hom Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress
0.069 5.73E-5 YPL018W CTF19 hom Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2
0.069 6.36E-5 YNL120C_d YNL120C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
0.068 8.19E-5 YCR025C_d YCR025C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
0.068 8.68E-5 YKL150W MCR1 hom Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis