YIL072W / HOP1

Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL072W / HOP1

Click on Significant Values for Screen Details ID:SGTC_106|Compound:0092-0003|FD-Score:-4.00|P-value:2.54E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.45|P-value:5.40E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.85|P-value:3.97E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.28|P-value:9.80E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:4.73|P-value:1.94E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:4.23|P-value:1.16E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:4.25|P-value:1.09E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.61|P-value:8.47E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:-5.25|P-value:2.57E-6 ID:SGTC_930|Compound:2810-3379|FD-Score:-4.20|P-value:1.32E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.72|P-value:6.08E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.57|P-value:9.70E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.86|P-value:1.16E-5 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.91|P-value:1.36E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.61|P-value:8.49E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:5.29|P-value:2.10E-6 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.57|P-value:3.53E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.21|P-value:1.23E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:5.29|P-value:2.09E-6 ID:SGTC_1449|Compound:4112-4002|FD-Score:7.14|P-value:2.57E-10 ID:SGTC_1456|Compound:k015-0012|FD-Score:6.73|P-value:2.42E-9 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.71|P-value:2.16E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:5.43|P-value:1.15E-6 ID:SGTC_1465|Compound:k213-0056|FD-Score:-4.73|P-value:1.99E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.92|P-value:9.17E-6 ID:SGTC_1485|Compound:3909-9022|FD-Score:4.53|P-value:4.01E-5 ID:SGTC_1500|Compound:4488-1866|FD-Score:7.60|P-value:1.92E-11 ID:SGTC_1521|Compound:st012942|FD-Score:6.73|P-value:2.36E-9 ID:SGTC_1759|Compound:st043059|FD-Score:3.70|P-value:6.36E-4 ID:SGTC_1834|Compound:st055981|FD-Score:5.55|P-value:6.89E-7 ID:SGTC_2017|Compound:5132927|FD-Score:3.77|P-value:5.24E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.18|P-value:1.36E-4 ID:SGTC_2066|Compound:5222451|FD-Score:6.20|P-value:3.51E-8 ID:SGTC_2334|Compound:9017922|FD-Score:-3.82|P-value:4.58E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.05|P-value:2.10E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.70|P-value:6.47E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.47|P-value:4.92E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.74|P-value:5.68E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-6.34|P-value:1.81E-8 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:4.28|P-value:9.89E-5 ID:SGTC_2674|Compound:ligustilide|FD-Score:-4.68|P-value:2.39E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:5.57|P-value:6.25E-7 ID:SGTC_2819|Compound:7996655|FD-Score:6.41|P-value:1.22E-8 ID:SGTC_2826|Compound:7992541|FD-Score:-3.80|P-value:4.77E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.76|P-value:5.25E-4 ID:SGTC_2960|Compound:9079389|FD-Score:5.91|P-value:1.34E-7 ID:SGTC_3013|Compound:9080133|FD-Score:-4.05|P-value:2.15E-4 ID:SGTC_3046|Compound:9092212|FD-Score:-4.98|P-value:7.43E-6 ID:SGTC_3047|Compound:9092122|FD-Score:6.43|P-value:1.13E-8 ID:SGTC_3049|Compound:9092223|FD-Score:-4.47|P-value:5.20E-5 ID:SGTC_3056|Compound:9094900|FD-Score:4.75|P-value:1.76E-5 ID:SGTC_3057|Compound:9095946|FD-Score:-3.86|P-value:3.97E-4 ID:SGTC_3232|Compound:9132874|FD-Score:4.64|P-value:2.71E-5 ID:SGTC_3299|Compound:9121982|FD-Score:6.11|P-value:5.41E-8 ID:SGTC_3315|Compound:9136395|FD-Score:4.07|P-value:2.01E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:-4.00|P-value:2.54E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.45|P-value:5.40E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.85|P-value:3.97E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.28|P-value:9.80E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:4.73|P-value:1.94E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:4.23|P-value:1.16E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:4.25|P-value:1.09E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.61|P-value:8.47E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:-5.25|P-value:2.57E-6 ID:SGTC_930|Compound:2810-3379|FD-Score:-4.20|P-value:1.32E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.72|P-value:6.08E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.57|P-value:9.70E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.86|P-value:1.16E-5 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.91|P-value:1.36E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.61|P-value:8.49E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:5.29|P-value:2.10E-6 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.57|P-value:3.53E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.21|P-value:1.23E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:5.29|P-value:2.09E-6 ID:SGTC_1449|Compound:4112-4002|FD-Score:7.14|P-value:2.57E-10 ID:SGTC_1456|Compound:k015-0012|FD-Score:6.73|P-value:2.42E-9 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.71|P-value:2.16E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:5.43|P-value:1.15E-6 ID:SGTC_1465|Compound:k213-0056|FD-Score:-4.73|P-value:1.99E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.92|P-value:9.17E-6 ID:SGTC_1485|Compound:3909-9022|FD-Score:4.53|P-value:4.01E-5 ID:SGTC_1500|Compound:4488-1866|FD-Score:7.60|P-value:1.92E-11 ID:SGTC_1521|Compound:st012942|FD-Score:6.73|P-value:2.36E-9 ID:SGTC_1759|Compound:st043059|FD-Score:3.70|P-value:6.36E-4 ID:SGTC_1834|Compound:st055981|FD-Score:5.55|P-value:6.89E-7 ID:SGTC_2017|Compound:5132927|FD-Score:3.77|P-value:5.24E-4 ID:SGTC_2024|Compound:5144227|FD-Score:4.18|P-value:1.36E-4 ID:SGTC_2066|Compound:5222451|FD-Score:6.20|P-value:3.51E-8 ID:SGTC_2334|Compound:9017922|FD-Score:-3.82|P-value:4.58E-4 ID:SGTC_2337|Compound:9009472|FD-Score:4.05|P-value:2.10E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.70|P-value:6.47E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.47|P-value:4.92E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.74|P-value:5.68E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-6.34|P-value:1.81E-8 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:4.28|P-value:9.89E-5 ID:SGTC_2674|Compound:ligustilide|FD-Score:-4.68|P-value:2.39E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:5.57|P-value:6.25E-7 ID:SGTC_2819|Compound:7996655|FD-Score:6.41|P-value:1.22E-8 ID:SGTC_2826|Compound:7992541|FD-Score:-3.80|P-value:4.77E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.76|P-value:5.25E-4 ID:SGTC_2960|Compound:9079389|FD-Score:5.91|P-value:1.34E-7 ID:SGTC_3013|Compound:9080133|FD-Score:-4.05|P-value:2.15E-4 ID:SGTC_3046|Compound:9092212|FD-Score:-4.98|P-value:7.43E-6 ID:SGTC_3047|Compound:9092122|FD-Score:6.43|P-value:1.13E-8 ID:SGTC_3049|Compound:9092223|FD-Score:-4.47|P-value:5.20E-5 ID:SGTC_3056|Compound:9094900|FD-Score:4.75|P-value:1.76E-5 ID:SGTC_3057|Compound:9095946|FD-Score:-3.86|P-value:3.97E-4 ID:SGTC_3232|Compound:9132874|FD-Score:4.64|P-value:2.71E-5 ID:SGTC_3299|Compound:9121982|FD-Score:6.11|P-value:5.41E-8 ID:SGTC_3315|Compound:9136395|FD-Score:4.07|P-value:2.01E-4

Top fitness defect scores for YIL072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1500 4488-1866 7.60 171.0 µM 1.92E-11 RPP1 & pyrimidine depletion 1 1.51E-14
2 SGTC_1449 4112-4002 7.14 201.0 µM 2.57E-10 RPP1 & pyrimidine depletion 3 4.56E-13
3 SGTC_1521 st012942 6.73 49.4 µM 2.36E-9 5 8.41E-12
4 SGTC_1456 k015-0012 6.73 13.0 µM 2.42E-9 4 8.69E-12
5 SGTC_3047 9092122 6.43 49.5 µM 1.13E-8 1 6.55E-11
6 SGTC_2819 7996655 6.41 46.4 µM 1.22E-8 1 7.24E-11
7 SGTC_2066 5222451 6.20 176.0 µM 3.51E-8 heme biosynthesis & mitochondrial translocase 7 2.91E-10
8 SGTC_3299 9121982 6.11 43.1 µM 5.41E-8 6 5.13E-10
9 SGTC_2960 9079389 5.91 6.0 µM 1.34E-7 5 1.69E-9
10 SGTC_1001 4048-4355 5.91 44.4 µM 1.36E-7 copper-dependent oxidative stress 11 1.71E-9
11 SGTC_2684 capsaicin 5.57 100.0 µM 6.25E-7 7 1.27E-8
12 SGTC_1834 st055981 5.55 52.8 µM 6.89E-7 RPP1 & pyrimidine depletion 8 1.44E-8
13 SGTC_1464 k208-0027 5.43 110.0 µM 1.15E-6 11 2.83E-8
14 SGTC_1448 4255-0083 5.29 152.0 µM 2.09E-6 ERG2 4 6.18E-8
15 SGTC_1147 3809-1045 5.29 12.3 µM 2.10E-6 3 6.20E-8
16 SGTC_1483 3453-0561 4.92 55.9 µM 9.17E-6 8 4.27E-7
17 SGTC_991 3996-0057 4.86 64.7 µM 1.16E-5 9 5.83E-7
18 SGTC_3056 9094900 4.75 49.5 µM 1.76E-5 8 1.00E-6
19 SGTC_536 3852-0578 4.73 10.6 µM 1.94E-5 13 1.14E-6
20 SGTC_3232 9132874 4.64 49.5 µM 2.71E-5 RPP1 & pyrimidine depletion 8 1.76E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 4.36E-16 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.132 1.61E-14 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.102 3.05E-9 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.098 1.39E-8 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.098 1.51E-8 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.097 1.69E-8 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.092 1.08E-7 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.089 2.73E-7 YJR015W_p YJR015W_p hom Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene
0.087 4.44E-7 YAL004W_d YAL004W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C
0.087 5.01E-7 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.085 9.19E-7 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.083 1.56E-6 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.082 1.84E-6 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.082 2.28E-6 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.081 2.98E-6 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence