HIPHOP chemogenomics database
YIL072W / HOP1 
Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YIL072W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.140 | 4.36E-16 | YER066W_p | RRT13_p | hom | Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription |
| 0.132 | 1.61E-14 | YCR102W-A_d | YCR102W-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.102 | 3.05E-9 | YEL049W | PAU2 | hom | Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme |
| 0.098 | 1.39E-8 | YGL146C_p | RRT6_p | hom | Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins |
| 0.098 | 1.51E-8 | YER060W-A | FCY22 | hom | Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function |
| 0.097 | 1.69E-8 | YLR395C | COX8 | hom | Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain |
| 0.092 | 1.08E-7 | YPL160W | CDC60 | het | Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA |
| 0.089 | 2.73E-7 | YJR015W_p | YJR015W_p | hom | Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene |
| 0.087 | 4.44E-7 | YAL004W_d | YAL004W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C |
| 0.087 | 5.01E-7 | YNR067C | DSE4 | hom | Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother |
| 0.085 | 9.19E-7 | YNL244C | SUI1 | het | Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase |
| 0.083 | 1.56E-6 | YGR015C_p | YGR015C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion |
| 0.082 | 1.84E-6 | YML100W-A_p | YML100W-A_p | hom | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| 0.082 | 2.28E-6 | YJR010W | MET3 | hom | ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism |
| 0.081 | 2.98E-6 | YNL220W | ADE12 | hom | Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence |