YIL073C / SPO22

Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL073C / SPO22

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-5.63|P-value:5.96E-9 ID:SGTC_36|Compound:0335-0881|FD-Score:-6.89|P-value:1.29E-12 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.19|P-value:1.22E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.09|P-value:5.65E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.38|P-value:1.84E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.70|P-value:5.14E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:4.01|P-value:1.30E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:4.19|P-value:5.64E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:4.70|P-value:4.43E-7 ID:SGTC_671|Compound:0560-0003|FD-Score:3.03|P-value:6.83E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:5.40|P-value:8.66E-9 ID:SGTC_806|Compound:3966-4455|FD-Score:4.19|P-value:5.68E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:3.23|P-value:3.30E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.48|P-value:1.27E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:4.03|P-value:1.19E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:4.78|P-value:2.99E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:3.04|P-value:6.59E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.07|P-value:6.03E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.17|P-value:7.50E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.31|P-value:2.44E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.46|P-value:1.35E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.22|P-value:3.46E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.25|P-value:3.05E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.29|P-value:2.66E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.17|P-value:4.17E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.24|P-value:3.16E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.19|P-value:3.85E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.03|P-value:1.17E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.21|P-value:3.58E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.14|P-value:8.54E-4 ID:SGTC_2001|Compound:4023502|FD-Score:4.12|P-value:7.87E-6 ID:SGTC_2067|Compound:5224629|FD-Score:3.27|P-value:2.86E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-3.09|P-value:9.92E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.60|P-value:7.78E-5 ID:SGTC_2137|Compound:5261020|FD-Score:3.06|P-value:6.31E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.37|P-value:2.42E-6 ID:SGTC_2448|Compound:5185112|FD-Score:-3.44|P-value:2.76E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.41|P-value:1.67E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.89|P-value:2.24E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.87|P-value:5.06E-5 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.90|P-value:2.18E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.14|P-value:8.41E-4 ID:SGTC_3144|Compound:9087057|FD-Score:5.05|P-value:6.82E-8 ID:SGTC_3179|Compound:9107801|FD-Score:3.52|P-value:1.07E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.15|P-value:4.53E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.78|P-value:3.67E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.33|P-value:2.31E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-5.63|P-value:5.96E-9 ID:SGTC_36|Compound:0335-0881|FD-Score:-6.89|P-value:1.29E-12 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.19|P-value:1.22E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.09|P-value:5.65E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.38|P-value:1.84E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.70|P-value:5.14E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:4.01|P-value:1.30E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:4.19|P-value:5.64E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:4.70|P-value:4.43E-7 ID:SGTC_671|Compound:0560-0003|FD-Score:3.03|P-value:6.83E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:5.40|P-value:8.66E-9 ID:SGTC_806|Compound:3966-4455|FD-Score:4.19|P-value:5.68E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:3.23|P-value:3.30E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.48|P-value:1.27E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:4.03|P-value:1.19E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:4.78|P-value:2.99E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:3.04|P-value:6.59E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.07|P-value:6.03E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.17|P-value:7.50E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.31|P-value:2.44E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.46|P-value:1.35E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.22|P-value:3.46E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.25|P-value:3.05E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.29|P-value:2.66E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.17|P-value:4.17E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.24|P-value:3.16E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.19|P-value:3.85E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.03|P-value:1.17E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.21|P-value:3.58E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.14|P-value:8.54E-4 ID:SGTC_2001|Compound:4023502|FD-Score:4.12|P-value:7.87E-6 ID:SGTC_2067|Compound:5224629|FD-Score:3.27|P-value:2.86E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-3.09|P-value:9.92E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.60|P-value:7.78E-5 ID:SGTC_2137|Compound:5261020|FD-Score:3.06|P-value:6.31E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.37|P-value:2.42E-6 ID:SGTC_2448|Compound:5185112|FD-Score:-3.44|P-value:2.76E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.41|P-value:1.67E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.89|P-value:2.24E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.87|P-value:5.06E-5 ID:SGTC_2732|Compound:terfenadine|FD-Score:3.90|P-value:2.18E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.14|P-value:8.41E-4 ID:SGTC_3144|Compound:9087057|FD-Score:5.05|P-value:6.82E-8 ID:SGTC_3179|Compound:9107801|FD-Score:3.52|P-value:1.07E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.15|P-value:4.53E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.78|P-value:3.67E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.33|P-value:2.31E-4

Top fitness defect scores for YIL073C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_802 4112-3352 5.40 742.0 µM 8.66E-9 5 3.27E-8
2 SGTC_3144 9087057 5.05 49.5 µM 6.82E-8 6 2.25E-7
3 SGTC_931 2812-0076 4.78 566.0 µM 2.99E-7 9 8.94E-7
4 SGTC_535 2293-4129 4.70 48.2 µM 4.43E-7 NEO1 46 1.29E-6
5 SGTC_2185 6113692 4.37 200.0 µM 2.42E-6 ergosterol biosynthesis 11 6.30E-6
6 SGTC_523 1934-0222 4.19 13.7 µM 5.64E-6 28 1.39E-5
7 SGTC_806 3966-4455 4.19 5.9 µM 5.68E-6 16 1.40E-5
8 SGTC_2001 4023502 4.12 57.7 µM 7.87E-6 mitochondrial processes 13 1.89E-5
9 SGTC_1771 st048882 4.03 4.2 µM 1.17E-5 RPP1 & pyrimidine depletion 17 2.75E-5
10 SGTC_906 1165-0455 4.03 526.0 µM 1.19E-5 10 2.78E-5
11 SGTC_378 3970-0959 4.01 8.3 µM 1.30E-5 15 3.03E-5
12 SGTC_2732 terfenadine 3.90 20.0 µM 2.18E-5 ERG2 4 4.89E-5
13 SGTC_2532 xanthone 3.89 78.9 µM 2.24E-5 33 5.02E-5
14 SGTC_3207 9114163 3.78 49.5 µM 3.67E-5 35 7.96E-5
15 SGTC_344 k064-0035 3.70 6.4 µM 5.14E-5 60S ribosome export 26 1.09E-4
16 SGTC_2127 5253358 3.60 187.9 µM 7.78E-5 33 1.60E-4
17 SGTC_3179 9107801 3.52 49.5 µM 1.07E-4 19 2.16E-4
18 SGTC_886 0866-0150 3.48 153.0 µM 1.27E-4 35 2.53E-4
19 SGTC_1440 4100-1550 3.46 40.0 µM 1.35E-4 6 2.67E-4
20 SGTC_2463 5473429 3.41 200.0 µM 1.67E-4 ERG2 30 3.26E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.35E-13 YGR169C PUS6 hom tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
0.094 5.50E-8 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.092 8.50E-8 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.089 2.28E-7 YOR004W UTP23 het Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
0.082 2.06E-6 YNL067W-B_p YNL067W-B_p hom Putative protein of unknown function
0.081 2.41E-6 YER137C_p YER137C_p hom Putative protein of unknown function
0.080 3.25E-6 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.080 3.57E-6 YKR035W-A DID2 hom Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors
0.080 4.01E-6 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.079 4.24E-6 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.077 8.32E-6 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.074 1.70E-5 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.073 2.08E-5 YNR006W VPS27 hom Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.073 2.20E-5 YIL095W PRK1 hom Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication
0.073 2.57E-5 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)