YIL074C / SER33

3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL074C / SER33

Click on Significant Values for Screen Details ID:SGTC_182|Compound:3448-4371|FD-Score:-3.65|P-value:3.76E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:7.27|P-value:2.33E-12 ID:SGTC_417|Compound:st075190|FD-Score:3.24|P-value:9.23E-4 ID:SGTC_433|Compound:pimozide|FD-Score:4.00|P-value:6.21E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.88|P-value:1.00E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-4.31|P-value:3.25E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.31|P-value:7.25E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.41|P-value:1.24E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.21|P-value:9.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.43|P-value:4.86E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:4.63|P-value:4.73E-6 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.87|P-value:1.65E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.45|P-value:4.64E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.38|P-value:1.40E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.29|P-value:7.87E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.81|P-value:1.27E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.51|P-value:3.75E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.59|P-value:2.82E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.84|P-value:1.15E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.38|P-value:5.85E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.68|P-value:3.84E-6 ID:SGTC_2207|Compound:7258803|FD-Score:3.25|P-value:8.79E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.79|P-value:1.38E-4 ID:SGTC_2234|Compound:tolnaftate|FD-Score:3.38|P-value:5.74E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.66|P-value:2.20E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.39|P-value:8.88E-4 ID:SGTC_2337|Compound:9009472|FD-Score:6.42|P-value:4.87E-10 ID:SGTC_2367|Compound:9070478|FD-Score:3.63|P-value:2.43E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.59|P-value:2.87E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.39|P-value:5.55E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.20|P-value:2.91E-5 ID:SGTC_2591|Compound:skatole|FD-Score:4.11|P-value:4.20E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:6.03|P-value:4.68E-9 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.33|P-value:6.79E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:4.25|P-value:2.36E-5 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.79|P-value:1.41E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.40|P-value:5.39E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.45|P-value:4.57E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.30|P-value:7.55E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.29|P-value:2.04E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.23|P-value:9.50E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-3.41|P-value:8.20E-4 ID:SGTC_2925|Compound:9010536|FD-Score:4.04|P-value:5.47E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-3.42|P-value:8.01E-4 ID:SGTC_3048|Compound:9093155|FD-Score:3.55|P-value:3.21E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.29|P-value:7.78E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.39|P-value:5.55E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.81|P-value:1.31E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.85|P-value:1.12E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.65|P-value:3.76E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:7.27|P-value:2.33E-12 ID:SGTC_417|Compound:st075190|FD-Score:3.24|P-value:9.23E-4 ID:SGTC_433|Compound:pimozide|FD-Score:4.00|P-value:6.21E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.88|P-value:1.00E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-4.31|P-value:3.25E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.86|P-value:1.08E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.31|P-value:7.25E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.41|P-value:1.24E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.21|P-value:9.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.43|P-value:4.86E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:4.63|P-value:4.73E-6 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.87|P-value:1.65E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.45|P-value:4.64E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.38|P-value:1.40E-5 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.29|P-value:7.87E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.81|P-value:1.27E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.51|P-value:3.75E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.59|P-value:2.82E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.84|P-value:1.15E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.38|P-value:5.85E-4 ID:SGTC_2185|Compound:6113692|FD-Score:4.68|P-value:3.84E-6 ID:SGTC_2207|Compound:7258803|FD-Score:3.25|P-value:8.79E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.79|P-value:1.38E-4 ID:SGTC_2234|Compound:tolnaftate|FD-Score:3.38|P-value:5.74E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.66|P-value:2.20E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.39|P-value:8.88E-4 ID:SGTC_2337|Compound:9009472|FD-Score:6.42|P-value:4.87E-10 ID:SGTC_2367|Compound:9070478|FD-Score:3.63|P-value:2.43E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.59|P-value:2.87E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.39|P-value:5.55E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.20|P-value:2.91E-5 ID:SGTC_2591|Compound:skatole|FD-Score:4.11|P-value:4.20E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:6.03|P-value:4.68E-9 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.33|P-value:6.79E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:4.25|P-value:2.36E-5 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.79|P-value:1.41E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.40|P-value:5.39E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.45|P-value:4.57E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.30|P-value:7.55E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.29|P-value:2.04E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.23|P-value:9.50E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-3.41|P-value:8.20E-4 ID:SGTC_2925|Compound:9010536|FD-Score:4.04|P-value:5.47E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-3.42|P-value:8.01E-4 ID:SGTC_3048|Compound:9093155|FD-Score:3.55|P-value:3.21E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.29|P-value:7.78E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.39|P-value:5.55E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.81|P-value:1.31E-4 ID:SGTC_3260|Compound:9137109|FD-Score:3.85|P-value:1.12E-4

Top fitness defect scores for YIL074C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_358 0075-0058 7.27 9.4 µM 2.33E-12 6 1.77E-13
2 SGTC_2337 9009472 6.42 200.0 µM 4.87E-10 4 6.79E-11
3 SGTC_2634 4'-methoxyflavone 6.03 100.0 µM 4.68E-9 8 8.40E-10
4 SGTC_1223 0764-0573 4.87 147.0 µM 1.65E-6 7 5.63E-7
5 SGTC_2185 6113692 4.68 200.0 µM 3.84E-6 ergosterol biosynthesis 6 1.43E-6
6 SGTC_1220 1838-0075 4.63 193.0 µM 4.73E-6 7 1.80E-6
7 SGTC_991 3996-0057 4.41 64.7 µM 1.24E-5 12 5.22E-6
8 SGTC_1269 0831-0796 4.38 3.0 µM 1.40E-5 60S ribosome export 10 6.00E-6
9 SGTC_2760 etidronate 4.29 98.0 µM 2.04E-5 18 9.10E-6
10 SGTC_2665 lovastatin 4.25 100.0 µM 2.36E-5 8 1.06E-5
11 SGTC_2583 asiatic acid 4.20 100.0 µM 2.91E-5 32 1.34E-5
12 SGTC_2591 skatole 4.11 100.0 µM 4.20E-5 27 2.02E-5
13 SGTC_2925 9010536 4.04 32.5 µM 5.47E-5 azole & statin 44 2.70E-5
14 SGTC_433 pimozide 4.00 108.0 µM 6.21E-5 15 3.10E-5
15 SGTC_547 1120-0019 3.88 610.0 nM 1.00E-4 azole & statin 34 5.27E-5
16 SGTC_785 1270-0111 3.86 65.3 µM 1.08E-4 26 5.70E-5
17 SGTC_3260 9137109 3.85 49.5 µM 1.12E-4 60S ribosome export 12 5.96E-5
18 SGTC_1940 st075990 3.84 51.1 µM 1.15E-4 60S ribosome export 25 6.13E-5
19 SGTC_1554 st069299 3.81 38.7 µM 1.27E-4 27 6.82E-5
20 SGTC_3154 9100113 3.81 49.5 µM 1.31E-4 34 7.05E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.83E-10 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.099 9.73E-9 YAR023C_p YAR023C_p hom Putative integral membrane protein, member of DUP240 gene family
0.089 2.79E-7 YNL318C HXT14 hom Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.087 4.70E-7 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.087 4.80E-7 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.087 4.91E-7 YHL007C STE20 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
0.086 5.30E-7 YBR149W ARA1 hom NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
0.086 5.39E-7 YPL256C CLN2 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
0.086 6.78E-7 YGL185C_p YGL185C_p hom Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.085 7.17E-7 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.081 2.94E-6 YHR014W SPO13 hom Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
0.080 3.74E-6 YOR013W_d IRC11_d hom Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
0.079 5.08E-6 YER045C ACA1 hom ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication
0.078 5.60E-6 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.078 5.89E-6 YBL002W HTB2 hom Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation