YIL076W / SEC28

Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL076W / SEC28

Click on Significant Values for Screen Details ID:SGTC_229|Compound:benomyl|FD-Score:3.19|P-value:6.38E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.38|P-value:4.21E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.46|P-value:3.09E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.34|P-value:3.73E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-4.77|P-value:1.15E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.12|P-value:8.17E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.81|P-value:6.21E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:4.06|P-value:2.16E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.64|P-value:1.60E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.36|P-value:4.52E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.43|P-value:2.69E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.44|P-value:4.04E-6 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.28|P-value:4.72E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.18|P-value:8.29E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.32|P-value:7.01E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.68|P-value:1.04E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.10|P-value:8.81E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.81|P-value:6.17E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.37|P-value:3.46E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.13|P-value:8.03E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.27|P-value:8.52E-6 ID:SGTC_1925|Compound:st057770|FD-Score:-3.57|P-value:2.06E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.65|P-value:1.51E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.20|P-value:1.19E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.68|P-value:1.25E-6 ID:SGTC_2135|Compound:5326629|FD-Score:-4.17|P-value:1.80E-5 ID:SGTC_2187|Compound:6125751|FD-Score:-3.18|P-value:8.31E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.94|P-value:3.66E-5 ID:SGTC_2275|Compound:7947463|FD-Score:3.45|P-value:2.55E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.44|P-value:2.64E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.62|P-value:1.69E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.62|P-value:1.71E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.20|P-value:6.13E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:7.65|P-value:8.69E-15 ID:SGTC_2782|Compound:7736369|FD-Score:3.81|P-value:6.19E-5 ID:SGTC_2789|Compound:5281112|FD-Score:3.40|P-value:3.06E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-3.41|P-value:3.69E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.22|P-value:5.84E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.70|P-value:9.68E-5 ID:SGTC_3030|Compound:9087619|FD-Score:-3.48|P-value:2.95E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-3.63|P-value:1.65E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.19|P-value:6.54E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.02|P-value:2.56E-5 ID:SGTC_3188|Compound:9110789|FD-Score:-3.27|P-value:6.06E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.19|P-value:6.38E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.38|P-value:4.21E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.46|P-value:3.09E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.34|P-value:3.73E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-4.77|P-value:1.15E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.12|P-value:8.17E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.81|P-value:6.21E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:4.06|P-value:2.16E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.64|P-value:1.60E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.36|P-value:4.52E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.43|P-value:2.69E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.44|P-value:4.04E-6 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.28|P-value:4.72E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.18|P-value:8.29E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.32|P-value:7.01E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.68|P-value:1.04E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.10|P-value:8.81E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.81|P-value:6.17E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.37|P-value:3.46E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.13|P-value:8.03E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.27|P-value:8.52E-6 ID:SGTC_1925|Compound:st057770|FD-Score:-3.57|P-value:2.06E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.65|P-value:1.51E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.20|P-value:1.19E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.68|P-value:1.25E-6 ID:SGTC_2135|Compound:5326629|FD-Score:-4.17|P-value:1.80E-5 ID:SGTC_2187|Compound:6125751|FD-Score:-3.18|P-value:8.31E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.94|P-value:3.66E-5 ID:SGTC_2275|Compound:7947463|FD-Score:3.45|P-value:2.55E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.44|P-value:2.64E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.62|P-value:1.69E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.62|P-value:1.71E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.20|P-value:6.13E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:7.65|P-value:8.69E-15 ID:SGTC_2782|Compound:7736369|FD-Score:3.81|P-value:6.19E-5 ID:SGTC_2789|Compound:5281112|FD-Score:3.40|P-value:3.06E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-3.41|P-value:3.69E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.22|P-value:5.84E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.70|P-value:9.68E-5 ID:SGTC_3030|Compound:9087619|FD-Score:-3.48|P-value:2.95E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-3.63|P-value:1.65E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.19|P-value:6.54E-4 ID:SGTC_3153|Compound:9100258|FD-Score:4.02|P-value:2.56E-5 ID:SGTC_3188|Compound:9110789|FD-Score:-3.27|P-value:6.06E-4

Top fitness defect scores for YIL076W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2628 lathosterol 7.65 100.0 µM 8.69E-15 2 1.02E-14
2 SGTC_2131 toluylene red 4.68 5.3 µM 1.25E-6 60S ribosome export 8 1.42E-6
3 SGTC_1076 itraconazole 4.44 331.0 nM 4.04E-6 21 4.56E-6
4 SGTC_1148 3909-7663 4.32 27.7 µM 7.01E-6 8 7.89E-6
5 SGTC_1844 rapamycin 4.27 4.0 nM 8.52E-6 139 9.59E-6
6 SGTC_2127 5253358 4.20 187.9 µM 1.19E-5 19 1.34E-5
7 SGTC_913 3487-1245 4.06 167.0 µM 2.16E-5 24 2.42E-5
8 SGTC_3153 9100258 4.02 49.5 µM 2.56E-5 20 2.87E-5
9 SGTC_2215 7188065 3.94 200.0 µM 3.66E-5 5 4.10E-5
10 SGTC_1502 4534-4282 3.81 27.7 µM 6.17E-5 14 6.89E-5
11 SGTC_2782 7736369 3.81 71.4 µM 6.19E-5 47 6.91E-5
12 SGTC_789 1309-1135 3.81 70.6 µM 6.21E-5 ERG2 34 6.93E-5
13 SGTC_2885 9057732 3.70 52.0 µM 9.68E-5 16 1.08E-4
14 SGTC_1226 3909-7979 3.68 35.4 µM 1.04E-4 50 1.16E-4
15 SGTC_2275 7947463 3.45 200.0 µM 2.55E-4 iron homeostasis 54 2.83E-4
16 SGTC_2421 5690543 3.44 90.7 µM 2.64E-4 32 2.93E-4
17 SGTC_986 1493-0483 3.43 84.0 µM 2.69E-4 26 2.98E-4
18 SGTC_2789 5281112 3.40 71.4 µM 3.06E-4 67 3.39E-4
19 SGTC_1557 sumaresinolic acid 3.37 42.3 µM 3.46E-4 37 3.83E-4
20 SGTC_528 3492-0019 3.34 172.0 µM 3.73E-4 calcium & mitochondrial duress 274 4.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.17E-13 YER065C ICL1 hom Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
0.110 1.71E-10 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.102 2.86E-9 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.100 7.28E-9 YOL077C BRX1 het Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
0.096 2.17E-8 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.092 8.60E-8 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.092 1.05E-7 YPR193C HPA2 hom Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
0.091 1.37E-7 YOR337W TEA1 hom Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein
0.089 2.49E-7 YIL065C FIS1 hom Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation
0.088 3.45E-7 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.087 4.09E-7 YDR541C_p YDR541C_p hom Putative dihydrokaempferol 4-reductase
0.087 4.92E-7 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.087 5.21E-7 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.085 9.27E-7 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.082 1.71E-6 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage