YIL077C_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL077C / YIL077C

Click on Significant Values for Screen Details ID:SGTC_84|Compound:0443-0269|FD-Score:-4.31|P-value:2.54E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:5.52|P-value:1.26E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.42|P-value:6.47E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:7.16|P-value:1.15E-11 ID:SGTC_151|Compound:3013-0144|FD-Score:6.96|P-value:4.07E-11 ID:SGTC_156|Compound:3474-0145|FD-Score:3.36|P-value:8.67E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.51|P-value:5.45E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.59|P-value:4.16E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.33|P-value:9.52E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.37|P-value:8.44E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.86|P-value:1.43E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.42|P-value:6.42E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.02|P-value:7.98E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:5.58|P-value:9.45E-8 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.87|P-value:1.52E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.72|P-value:5.42E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.34|P-value:2.62E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.69|P-value:5.58E-8 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.63|P-value:7.92E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.56|P-value:1.06E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.48|P-value:6.00E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.92|P-value:1.28E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.68|P-value:6.47E-6 ID:SGTC_1635|Compound:st007035|FD-Score:11.60|P-value:9.28E-28 ID:SGTC_1655|Compound:st012546|FD-Score:-3.77|P-value:1.98E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.74|P-value:2.42E-4 ID:SGTC_1838|Compound:st055369|FD-Score:3.57|P-value:4.42E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.50|P-value:5.03E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.54|P-value:4.90E-4 ID:SGTC_1974|Compound:st069448|FD-Score:5.76|P-value:3.79E-8 ID:SGTC_2078|Compound:5212016|FD-Score:-3.35|P-value:8.23E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-3.54|P-value:4.39E-4 ID:SGTC_2141|Compound:5621638|FD-Score:4.76|P-value:4.51E-6 ID:SGTC_2159|Compound:5658611|FD-Score:4.58|P-value:9.50E-6 ID:SGTC_2303|Compound:7774051|FD-Score:4.79|P-value:3.94E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.81|P-value:1.89E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.90|P-value:1.36E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.01|P-value:9.35E-5 ID:SGTC_2842|Compound:9000675|FD-Score:3.58|P-value:4.20E-4 ID:SGTC_2883|Compound:9059145|FD-Score:4.81|P-value:3.55E-6 ID:SGTC_2977|Compound:9011197|FD-Score:-5.54|P-value:9.82E-8 ID:SGTC_2986|Compound:9022445|FD-Score:-5.88|P-value:1.72E-8 ID:SGTC_3085|Compound:9117376|FD-Score:3.69|P-value:2.94E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-4.37|P-value:2.00E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:-4.31|P-value:2.54E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:5.52|P-value:1.26E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.42|P-value:6.47E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:7.16|P-value:1.15E-11 ID:SGTC_151|Compound:3013-0144|FD-Score:6.96|P-value:4.07E-11 ID:SGTC_156|Compound:3474-0145|FD-Score:3.36|P-value:8.67E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.51|P-value:5.45E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.59|P-value:4.16E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.33|P-value:9.52E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.37|P-value:8.44E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.86|P-value:1.43E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.42|P-value:6.42E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.02|P-value:7.98E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:5.58|P-value:9.45E-8 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.87|P-value:1.52E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.72|P-value:5.42E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.34|P-value:2.62E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.69|P-value:5.58E-8 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.63|P-value:7.92E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.56|P-value:1.06E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.48|P-value:6.00E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.92|P-value:1.28E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.68|P-value:6.47E-6 ID:SGTC_1635|Compound:st007035|FD-Score:11.60|P-value:9.28E-28 ID:SGTC_1655|Compound:st012546|FD-Score:-3.77|P-value:1.98E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.74|P-value:2.42E-4 ID:SGTC_1838|Compound:st055369|FD-Score:3.57|P-value:4.42E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.50|P-value:5.03E-4 ID:SGTC_1964|Compound:st076914|FD-Score:3.54|P-value:4.90E-4 ID:SGTC_1974|Compound:st069448|FD-Score:5.76|P-value:3.79E-8 ID:SGTC_2078|Compound:5212016|FD-Score:-3.35|P-value:8.23E-4 ID:SGTC_2139|Compound:5578692|FD-Score:-3.54|P-value:4.39E-4 ID:SGTC_2141|Compound:5621638|FD-Score:4.76|P-value:4.51E-6 ID:SGTC_2159|Compound:5658611|FD-Score:4.58|P-value:9.50E-6 ID:SGTC_2303|Compound:7774051|FD-Score:4.79|P-value:3.94E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.81|P-value:1.89E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.90|P-value:1.36E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.01|P-value:9.35E-5 ID:SGTC_2842|Compound:9000675|FD-Score:3.58|P-value:4.20E-4 ID:SGTC_2883|Compound:9059145|FD-Score:4.81|P-value:3.55E-6 ID:SGTC_2977|Compound:9011197|FD-Score:-5.54|P-value:9.82E-8 ID:SGTC_2986|Compound:9022445|FD-Score:-5.88|P-value:1.72E-8 ID:SGTC_3085|Compound:9117376|FD-Score:3.69|P-value:2.94E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-4.37|P-value:2.00E-5

Top fitness defect scores for YIL077C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 11.60 42.4 µM 9.28E-28 63 1.75E-31
2 SGTC_150 3970-0969 7.16 77.2 µM 1.15E-11 11 4.07E-13
3 SGTC_151 3013-0144 6.96 2.3 µM 4.07E-11 iron homeostasis 7 1.72E-12
4 SGTC_1974 st069448 5.76 26.9 µM 3.79E-8 4 4.20E-9
5 SGTC_1453 4237-0541 5.69 195.0 µM 5.58E-8 heme biosynthesis & mitochondrial translocase 6 6.52E-9
6 SGTC_1126 isoteolin 5.58 1.0 µM 9.45E-8 9 1.19E-8
7 SGTC_93 0109-0045 5.52 59.2 µM 1.26E-7 DNA damage response 14 1.65E-8
8 SGTC_2883 9059145 4.81 45.5 µM 3.55E-6 3 7.41E-7
9 SGTC_2303 7774051 4.79 200.0 µM 3.94E-6 11 8.35E-7
10 SGTC_2141 5621638 4.76 7.7 µM 4.51E-6 tubulin folding & SWR complex 21 9.72E-7
11 SGTC_1177 0983-0204 4.72 23.6 µM 5.42E-6 7 1.20E-6
12 SGTC_1537 2',6'-dihydroxyflavanone 4.68 78.0 µM 6.47E-6 6 1.47E-6
13 SGTC_1483 3453-0561 4.63 55.9 µM 7.92E-6 10 1.85E-6
14 SGTC_2159 5658611 4.58 73.8 µM 9.50E-6 5 2.27E-6
15 SGTC_1495 4469-0029 4.56 237.0 µM 1.06E-5 84 2.59E-6
16 SGTC_1310 1188-0297 4.34 994.0 nM 2.62E-5 azole & statin 25 7.20E-6
17 SGTC_2780 5215298 4.01 71.4 µM 9.35E-5 33 3.07E-5
18 SGTC_1532 4',5'-dihydroxyflavone 3.92 78.7 µM 1.28E-4 Golgi 22 4.40E-5
19 SGTC_2705 st078069 3.90 42.8 µM 1.36E-4 7 4.71E-5
20 SGTC_1175 0741-0056 3.87 27.6 µM 1.52E-4 19 5.33E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.287 1.18E-64 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.260 4.33E-53 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.231 6.10E-42 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.217 3.57E-37 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.213 9.60E-36 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.208 5.65E-34 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.202 3.20E-32 YIL098C FMC1 hom Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
0.199 3.19E-31 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.198 4.10E-31 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.193 1.28E-29 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.177 4.48E-25 YGR257C MTM1 hom Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
0.173 4.55E-24 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.168 1.50E-22 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.163 1.95E-21 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.158 3.02E-20 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p