YIL078W / THS1

Threonyl-tRNA synthetase, essential cytoplasmic protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL078W / THS1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-5.68|P-value:5.12E-10 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.23|P-value:9.89E-9 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.90|P-value:7.47E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:2.98|P-value:6.93E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.03|P-value:5.92E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.97|P-value:1.06E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.27|P-value:2.24E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.03|P-value:5.77E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.38|P-value:1.47E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-9.47|P-value:1.37E-24 ID:SGTC_425|Compound:3825-7017|FD-Score:2.92|P-value:8.86E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.41|P-value:1.28E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.78|P-value:2.55E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:2.97|P-value:7.24E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.39|P-value:1.39E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.34|P-value:1.74E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.53|P-value:7.66E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-2.92|P-value:8.39E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.48|P-value:9.36E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.47|P-value:1.01E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.98|P-value:6.90E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.08|P-value:4.90E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-2.97|P-value:7.17E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.65|P-value:4.37E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-3.07|P-value:4.77E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.38|P-value:1.43E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.66|P-value:4.41E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.05|P-value:3.08E-8 ID:SGTC_1845|Compound:st056753|FD-Score:3.63|P-value:4.96E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.75|P-value:2.83E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.77|P-value:2.62E-5 ID:SGTC_2150|Compound:5556613|FD-Score:3.78|P-value:2.50E-5 ID:SGTC_2184|Compound:6075246|FD-Score:4.46|P-value:8.52E-7 ID:SGTC_2263|Compound:7948595|FD-Score:3.59|P-value:5.99E-5 ID:SGTC_2265|Compound:7929201|FD-Score:4.35|P-value:1.55E-6 ID:SGTC_2273|Compound:7815444|FD-Score:2.95|P-value:7.87E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.39|P-value:1.36E-4 ID:SGTC_2285|Compound:7945142|FD-Score:7.47|P-value:5.42E-16 ID:SGTC_2365|Compound:9042475|FD-Score:-3.26|P-value:2.34E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-5.24|P-value:9.07E-9 ID:SGTC_2424|Compound:5537928|FD-Score:3.61|P-value:5.49E-5 ID:SGTC_2428|Compound:5615643|FD-Score:-4.73|P-value:1.89E-7 ID:SGTC_2434|Compound:5670830|FD-Score:3.61|P-value:5.56E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-3.50|P-value:8.30E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.09|P-value:4.72E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:8.03|P-value:3.40E-18 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.80|P-value:2.36E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:13.00|P-value:9.08E-45 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.08|P-value:4.86E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-3.33|P-value:1.71E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.39|P-value:1.19E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.32|P-value:1.80E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.23|P-value:2.68E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.45|P-value:1.11E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.41|P-value:1.27E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.68|P-value:2.49E-7 ID:SGTC_3009|Compound:9080819|FD-Score:4.79|P-value:1.36E-7 ID:SGTC_3151|Compound:9099821|FD-Score:2.93|P-value:8.57E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-3.69|P-value:3.58E-5 ID:SGTC_3223|Compound:9129970|FD-Score:-4.18|P-value:3.45E-6 ID:SGTC_3316|Compound:9136639|FD-Score:3.36|P-value:1.58E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.59|P-value:6.00E-5 ID:SGTC_3327|Compound:9140648|FD-Score:4.02|P-value:8.31E-6 ID:SGTC_35|Compound:0133-0054|FD-Score:-5.68|P-value:5.12E-10 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.23|P-value:9.89E-9 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.90|P-value:7.47E-8 ID:SGTC_63|Compound:0099-0242|FD-Score:2.98|P-value:6.93E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.03|P-value:5.92E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.97|P-value:1.06E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.27|P-value:2.24E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.03|P-value:5.77E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.38|P-value:1.47E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-9.47|P-value:1.37E-24 ID:SGTC_425|Compound:3825-7017|FD-Score:2.92|P-value:8.86E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.41|P-value:1.28E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.78|P-value:2.55E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:2.97|P-value:7.24E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.39|P-value:1.39E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.34|P-value:1.74E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.53|P-value:7.66E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-2.92|P-value:8.39E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.48|P-value:9.36E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.47|P-value:1.01E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.98|P-value:6.90E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.08|P-value:4.90E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-2.97|P-value:7.17E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.65|P-value:4.37E-5 ID:SGTC_1676|Compound:st018489|FD-Score:-3.07|P-value:4.77E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.38|P-value:1.43E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.66|P-value:4.41E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:5.05|P-value:3.08E-8 ID:SGTC_1845|Compound:st056753|FD-Score:3.63|P-value:4.96E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.75|P-value:2.83E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.77|P-value:2.62E-5 ID:SGTC_2150|Compound:5556613|FD-Score:3.78|P-value:2.50E-5 ID:SGTC_2184|Compound:6075246|FD-Score:4.46|P-value:8.52E-7 ID:SGTC_2263|Compound:7948595|FD-Score:3.59|P-value:5.99E-5 ID:SGTC_2265|Compound:7929201|FD-Score:4.35|P-value:1.55E-6 ID:SGTC_2273|Compound:7815444|FD-Score:2.95|P-value:7.87E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.39|P-value:1.36E-4 ID:SGTC_2285|Compound:7945142|FD-Score:7.47|P-value:5.42E-16 ID:SGTC_2365|Compound:9042475|FD-Score:-3.26|P-value:2.34E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-5.24|P-value:9.07E-9 ID:SGTC_2424|Compound:5537928|FD-Score:3.61|P-value:5.49E-5 ID:SGTC_2428|Compound:5615643|FD-Score:-4.73|P-value:1.89E-7 ID:SGTC_2434|Compound:5670830|FD-Score:3.61|P-value:5.56E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-3.50|P-value:8.30E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.09|P-value:4.72E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:8.03|P-value:3.40E-18 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.80|P-value:2.36E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:13.00|P-value:9.08E-45 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.08|P-value:4.86E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-3.33|P-value:1.71E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.39|P-value:1.19E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.32|P-value:1.80E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.23|P-value:2.68E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.45|P-value:1.11E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.41|P-value:1.27E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.68|P-value:2.49E-7 ID:SGTC_3009|Compound:9080819|FD-Score:4.79|P-value:1.36E-7 ID:SGTC_3151|Compound:9099821|FD-Score:2.93|P-value:8.57E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-3.69|P-value:3.58E-5 ID:SGTC_3223|Compound:9129970|FD-Score:-4.18|P-value:3.45E-6 ID:SGTC_3316|Compound:9136639|FD-Score:3.36|P-value:1.58E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.59|P-value:6.00E-5 ID:SGTC_3327|Compound:9140648|FD-Score:4.02|P-value:8.31E-6

Top fitness defect scores for YIL078W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2533 agelasine 13.00 13.7 µM 9.08E-45 ERG2 1 3.74E-39 2.33
2 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 8.03 92.6 µM 3.40E-18 1 4.72E-16 1.70
3 SGTC_2285 7945142 7.47 200.0 µM 5.42E-16 2 3.90E-14 0.31
4 SGTC_1788 fluconazole 5.05 20.0 µM 3.08E-8 azole & statin 5 2.23E-7 0.82
5 SGTC_45 0kpi-0036 4.90 14.9 µM 7.47E-8 excess fatty acid 5 4.82E-7 0.20
6 SGTC_3009 9080819 4.79 71.4 µM 1.36E-7 3 8.15E-7 0.38
7 SGTC_2184 6075246 4.46 200.0 µM 8.52E-7 1 4.04E-6 0.70
8 SGTC_2265 7929201 4.35 200.0 µM 1.55E-6 5 6.80E-6 0.08
9 SGTC_3327 9140648 4.02 26.9 µM 8.31E-6 12 2.95E-5 0.11
10 SGTC_136 0097-0015 3.97 404.5 µM 1.06E-5 60S ribosome export 10 3.64E-5 0.15
11 SGTC_2531 methyl deoxycholate 3.80 70.1 µM 2.36E-5 6 7.37E-5 0.12
12 SGTC_2150 5556613 3.78 200.0 µM 2.50E-5 6 7.75E-5 0.08
13 SGTC_720 r052-1644 3.78 49.9 µM 2.55E-5 TSC3-RPN4 10 7.87E-5 0.14
14 SGTC_2129 girgensonine 3.77 121.0 µM 2.62E-5 heme biosynthesis & mitochondrial translocase 27 8.07E-5 0.03
15 SGTC_1728 st035614 3.66 33.8 µM 4.41E-5 8 1.27E-4 0.04
16 SGTC_1845 st056753 3.63 3.0 µM 4.96E-5 TSC3-RPN4 10 1.41E-4 0.08
17 SGTC_2424 5537928 3.61 59.2 µM 5.49E-5 14 1.54E-4 0.16
18 SGTC_2434 5670830 3.61 169.9 µM 5.56E-5 10 1.56E-4 0.15
19 SGTC_2263 7948595 3.59 193.3 µM 5.99E-5 6 1.66E-4 0.08
20 SGTC_3319 9138450 3.59 16.8 µM 6.00E-5 5 1.67E-4 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 2.84E-19 YOR370C MRS6 het Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress
0.140 3.20E-16 YDL154W MSH5 hom Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
0.134 6.63E-15 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.132 1.81E-14 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.131 2.83E-14 YFR019W FAB1 hom 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis
0.128 1.21E-13 YOR266W PNT1 hom Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
0.127 1.41E-13 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.126 2.39E-13 YER104W RTT105 het Protein with a role in regulation of Ty1 transposition
0.123 9.86E-13 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.122 1.07E-12 YMR159C ATG16 hom Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.121 1.77E-12 YPL231W FAS2 het Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.120 3.40E-12 YHR065C RRP3 het Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
0.109 2.47E-10 YJL090C DPB11 het DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress
0.108 3.60E-10 YGL074C_d YGL074C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
0.108 4.18E-10 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein