YIL079C / AIR1

Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL079C / AIR1

Click on Significant Values for Screen Details ID:SGTC_101|Compound:0490-5701|FD-Score:3.33|P-value:6.21E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.79|P-value:1.17E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:-3.37|P-value:6.02E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.74|P-value:1.42E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.91|P-value:9.92E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.13|P-value:3.15E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:3.36|P-value:5.54E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.99|P-value:5.41E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:4.03|P-value:4.60E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:3.19|P-value:9.95E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.24|P-value:8.44E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.71|P-value:1.57E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.27|P-value:7.46E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.27|P-value:7.40E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.42|P-value:4.52E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.91|P-value:7.35E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.41|P-value:4.73E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.28|P-value:8.31E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.25|P-value:7.99E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.25|P-value:8.17E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.32|P-value:7.15E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.51|P-value:3.34E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.71|P-value:1.59E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.99|P-value:5.42E-5 ID:SGTC_2460|Compound:5552655|FD-Score:6.16|P-value:1.22E-9 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.49|P-value:3.50E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.37|P-value:1.13E-5 ID:SGTC_2856|Compound:9022925|FD-Score:5.13|P-value:3.35E-7 ID:SGTC_2871|Compound:9038510|FD-Score:-3.23|P-value:9.61E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.29|P-value:7.11E-4 ID:SGTC_3032|Compound:9089427|FD-Score:5.12|P-value:3.63E-7 ID:SGTC_3075|Compound:9116269|FD-Score:-3.26|P-value:8.78E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.34|P-value:5.97E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.53|P-value:3.06E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.37|P-value:6.10E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.47|P-value:3.82E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.33|P-value:6.21E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.79|P-value:1.17E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:-3.37|P-value:6.02E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.74|P-value:1.42E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.91|P-value:9.92E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.13|P-value:3.15E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:3.36|P-value:5.54E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.99|P-value:5.41E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:4.03|P-value:4.60E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:3.19|P-value:9.95E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.24|P-value:8.44E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.71|P-value:1.57E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.27|P-value:7.46E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.27|P-value:7.40E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.42|P-value:4.52E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.91|P-value:7.35E-5 ID:SGTC_1910|Compound:st062352|FD-Score:3.41|P-value:4.73E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.28|P-value:8.31E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.25|P-value:7.99E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.25|P-value:8.17E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.32|P-value:7.15E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.51|P-value:3.34E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.71|P-value:1.59E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.99|P-value:5.42E-5 ID:SGTC_2460|Compound:5552655|FD-Score:6.16|P-value:1.22E-9 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.49|P-value:3.50E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.37|P-value:1.13E-5 ID:SGTC_2856|Compound:9022925|FD-Score:5.13|P-value:3.35E-7 ID:SGTC_2871|Compound:9038510|FD-Score:-3.23|P-value:9.61E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.29|P-value:7.11E-4 ID:SGTC_3032|Compound:9089427|FD-Score:5.12|P-value:3.63E-7 ID:SGTC_3075|Compound:9116269|FD-Score:-3.26|P-value:8.78E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.34|P-value:5.97E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.53|P-value:3.06E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.37|P-value:6.10E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.47|P-value:3.82E-4

Top fitness defect scores for YIL079C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2460 5552655 6.16 174.2 µM 1.22E-9 amide catabolism 10 3.58E-10
2 SGTC_2856 9022925 5.13 19.5 µM 3.35E-7 9 1.44E-7
3 SGTC_3032 9089427 5.12 49.5 µM 3.63E-7 60S ribosome export 4 1.57E-7
4 SGTC_436 n,n-dimethylsphingosine 4.91 3.3 µM 9.92E-7 12 4.59E-7
5 SGTC_2842 9000675 4.37 19.5 µM 1.13E-5 15 6.12E-6
6 SGTC_449 xestospongin c 4.13 11.2 µM 3.15E-5 NEO1-PIK1 61 1.83E-5
7 SGTC_575 k072-0246 4.03 11.9 µM 4.60E-5 20 2.74E-5
8 SGTC_574 1315-0397 3.99 40.0 µM 5.41E-5 37 3.26E-5
9 SGTC_2343 7990716 3.99 14.8 µM 5.42E-5 18 3.27E-5
10 SGTC_1724 st037281 3.91 8.3 µM 7.35E-5 45 4.52E-5
11 SGTC_215 1287-0124 3.79 461.5 µM 1.17E-4 2 7.42E-5
12 SGTC_423 5-fluorouracil 3.74 457.0 µM 1.42E-4 exosome 29 9.12E-5
13 SGTC_1178 0988-0033 3.71 191.0 µM 1.57E-4 34 1.02E-4
14 SGTC_2191 5911152 3.71 200.0 µM 1.59E-4 20 1.03E-4
15 SGTC_3093 9117344 3.53 49.5 µM 3.06E-4 60S ribosome export 27 2.06E-4
16 SGTC_2166 5933061 3.51 31.5 µM 3.34E-4 tubulin folding & SWR complex 55 2.27E-4
17 SGTC_2639 lactacystin 3.49 53.0 µM 3.50E-4 39 2.38E-4
18 SGTC_3307 9126885 3.47 69.3 µM 3.82E-4 47 2.61E-4
19 SGTC_1660 st012960 3.42 28.1 µM 4.52E-4 iron homeostasis 54 3.13E-4
20 SGTC_1910 st062352 3.41 60.4 µM 4.73E-4 55 3.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.06E-11 YAR029W_p YAR029W_p hom Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.101 4.48E-9 YIL136W OM45 hom Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress
0.096 2.83E-8 YNR065C_p YNR065C_p hom Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene
0.087 4.61E-7 YAL033W POP5 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.086 6.31E-7 YKR055W RHO4 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
0.084 1.06E-6 YLR145W RMP1 het Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
0.083 1.47E-6 YKL125W RRN3 het Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo
0.080 3.67E-6 YPR062W FCY1 hom Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
0.077 8.21E-6 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.076 9.61E-6 YIR023W DAL81 hom Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
0.076 9.96E-6 YJR004C SAG1 hom Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
0.076 1.11E-5 YGL061C DUO1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.072 3.37E-5 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.070 5.23E-5 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.070 5.57E-5 YLR435W TSR2 hom Protein with a potential role in pre-rRNA processing