YIL083C / CAB2

Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YIL083C / CAB2

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-5.15|P-value:4.90E-8 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.88|P-value:2.23E-7 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.22|P-value:4.37E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.18|P-value:8.22E-11 ID:SGTC_159|Compound:3970-0959|FD-Score:9.33|P-value:2.56E-22 ID:SGTC_214|Compound:4373-3496|FD-Score:3.88|P-value:3.05E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:3.00|P-value:9.65E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.25|P-value:3.86E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.34|P-value:2.72E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.00|P-value:9.43E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-7.04|P-value:1.63E-13 ID:SGTC_377|Compound:3970-0964|FD-Score:3.34|P-value:2.79E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.53|P-value:1.36E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.78|P-value:4.64E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.45|P-value:1.85E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.10|P-value:6.78E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.13|P-value:6.16E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.26|P-value:3.82E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-6.37|P-value:2.14E-11 ID:SGTC_1136|Compound:pergolide|FD-Score:6.33|P-value:3.08E-11 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.17|P-value:5.28E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-6.05|P-value:1.97E-10 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.71|P-value:6.31E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.43|P-value:1.96E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.65|P-value:8.04E-5 ID:SGTC_1522|Compound:st012842|FD-Score:5.85|P-value:7.28E-10 ID:SGTC_1607|Compound:st000305|FD-Score:5.38|P-value:1.37E-8 ID:SGTC_1608|Compound:st001473|FD-Score:3.45|P-value:1.80E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.17|P-value:5.25E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.84|P-value:2.91E-7 ID:SGTC_1866|Compound:st057638|FD-Score:-4.57|P-value:1.13E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.57|P-value:1.14E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.68|P-value:7.05E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.10|P-value:6.96E-4 ID:SGTC_2035|Compound:5154463|FD-Score:5.43|P-value:1.03E-8 ID:SGTC_2117|Compound:5521686|FD-Score:3.67|P-value:7.59E-5 ID:SGTC_2332|Compound:7982454|FD-Score:5.56|P-value:4.60E-9 ID:SGTC_2335|Compound:9018011|FD-Score:4.17|P-value:8.27E-6 ID:SGTC_2472|Compound:5377652|FD-Score:3.52|P-value:1.39E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.07|P-value:1.34E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.82|P-value:3.85E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.23|P-value:4.11E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.45|P-value:1.82E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.66|P-value:7.59E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-3.88|P-value:3.02E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.80|P-value:4.25E-5 ID:SGTC_2822|Compound:7994718|FD-Score:4.75|P-value:4.58E-7 ID:SGTC_2826|Compound:7992541|FD-Score:3.09|P-value:7.08E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.50|P-value:1.49E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.32|P-value:3.07E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.79|P-value:3.67E-7 ID:SGTC_2965|Compound:9082772|FD-Score:-4.63|P-value:8.35E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-4.28|P-value:4.66E-6 ID:SGTC_3144|Compound:9087057|FD-Score:-3.97|P-value:1.97E-5 ID:SGTC_3353|Compound:9151644|FD-Score:3.14|P-value:5.99E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.15|P-value:4.90E-8 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.88|P-value:2.23E-7 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.22|P-value:4.37E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.18|P-value:8.22E-11 ID:SGTC_159|Compound:3970-0959|FD-Score:9.33|P-value:2.56E-22 ID:SGTC_214|Compound:4373-3496|FD-Score:3.88|P-value:3.05E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:3.00|P-value:9.65E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.25|P-value:3.86E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.34|P-value:2.72E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.00|P-value:9.43E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-7.04|P-value:1.63E-13 ID:SGTC_377|Compound:3970-0964|FD-Score:3.34|P-value:2.79E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.53|P-value:1.36E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.78|P-value:4.64E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.45|P-value:1.85E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.10|P-value:6.78E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.13|P-value:6.16E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.26|P-value:3.82E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-6.37|P-value:2.14E-11 ID:SGTC_1136|Compound:pergolide|FD-Score:6.33|P-value:3.08E-11 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.17|P-value:5.28E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-6.05|P-value:1.97E-10 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.71|P-value:6.31E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.43|P-value:1.96E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.65|P-value:8.04E-5 ID:SGTC_1522|Compound:st012842|FD-Score:5.85|P-value:7.28E-10 ID:SGTC_1607|Compound:st000305|FD-Score:5.38|P-value:1.37E-8 ID:SGTC_1608|Compound:st001473|FD-Score:3.45|P-value:1.80E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.17|P-value:5.25E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.84|P-value:2.91E-7 ID:SGTC_1866|Compound:st057638|FD-Score:-4.57|P-value:1.13E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.57|P-value:1.14E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.68|P-value:7.05E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.10|P-value:6.96E-4 ID:SGTC_2035|Compound:5154463|FD-Score:5.43|P-value:1.03E-8 ID:SGTC_2117|Compound:5521686|FD-Score:3.67|P-value:7.59E-5 ID:SGTC_2332|Compound:7982454|FD-Score:5.56|P-value:4.60E-9 ID:SGTC_2335|Compound:9018011|FD-Score:4.17|P-value:8.27E-6 ID:SGTC_2472|Compound:5377652|FD-Score:3.52|P-value:1.39E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.07|P-value:1.34E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.82|P-value:3.85E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.23|P-value:4.11E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.45|P-value:1.82E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.66|P-value:7.59E-5 ID:SGTC_2801|Compound:7907800|FD-Score:-3.88|P-value:3.02E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.80|P-value:4.25E-5 ID:SGTC_2822|Compound:7994718|FD-Score:4.75|P-value:4.58E-7 ID:SGTC_2826|Compound:7992541|FD-Score:3.09|P-value:7.08E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.50|P-value:1.49E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.32|P-value:3.07E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.79|P-value:3.67E-7 ID:SGTC_2965|Compound:9082772|FD-Score:-4.63|P-value:8.35E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-4.28|P-value:4.66E-6 ID:SGTC_3144|Compound:9087057|FD-Score:-3.97|P-value:1.97E-5 ID:SGTC_3353|Compound:9151644|FD-Score:3.14|P-value:5.99E-4

Top fitness defect scores for YIL083C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_159 3970-0959 9.33 50.0 µM 2.56E-22 3 5.10E-21 0.38
2 SGTC_1136 pergolide 6.33 1.1 µM 3.08E-11 5 1.23E-10 0.70
3 SGTC_1522 st012842 5.85 45.6 µM 7.28E-10 RNA pol III & RNase P/MRP 4 2.39E-9 0.17
4 SGTC_2332 7982454 5.56 138.9 µM 4.60E-9 3 1.34E-8 0.62
5 SGTC_2035 5154463 5.43 94.6 µM 1.03E-8 3 2.88E-8 0.55
6 SGTC_1607 st000305 5.38 50.6 µM 1.37E-8 1 3.74E-8 0.85
7 SGTC_1750 st081859 4.84 2.4 µM 2.91E-7 endomembrane recycling 22 6.59E-7 0.05
8 SGTC_2952 9073731 4.79 13.8 µM 3.67E-7 tubulin folding & SWR complex 8 8.18E-7 0.02
9 SGTC_2822 7994718 4.75 71.4 µM 4.58E-7 5 1.01E-6 0.70
10 SGTC_2335 9018011 4.17 154.2 µM 8.27E-6 7 1.52E-5 0.06
11 SGTC_2582 agaric acid 4.07 100.0 µM 1.34E-5 redox potentiating 30 2.39E-5 0.01
12 SGTC_214 4373-3496 3.88 70.0 µM 3.05E-5 19 5.19E-5 0.08
13 SGTC_2817 7995342 3.80 71.4 µM 4.25E-5 7 7.09E-5 0.03
14 SGTC_513 4245-1575 3.78 41.7 µM 4.64E-5 unfolded protein response 33 7.71E-5 0.08
15 SGTC_1271 0832-2808 3.71 169.0 µM 6.31E-5 9 1.03E-4 0.04
16 SGTC_2117 5521686 3.67 200.0 µM 7.59E-5 5 1.22E-4 0.18
17 SGTC_1309 pyrazolanthrone 3.65 13.4 µM 8.04E-5 12 1.29E-4 0.11
18 SGTC_1660 st012960 3.58 28.1 µM 1.07E-4 iron homeostasis 4 1.69E-4 0.33
19 SGTC_1941 st076221 3.57 61.8 µM 1.14E-4 sphingolipid biosynthesis & PDR1 11 1.80E-4 0.11
20 SGTC_403 arphamenine a 3.53 50.0 µM 1.36E-4 60S ribosome export 8 2.11E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.237 3.21E-44 YLL039C UBI4 hom Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress
0.228 1.09E-40 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.203 1.41E-32 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.193 2.24E-29 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.181 4.20E-26 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.180 8.28E-26 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.180 9.35E-26 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.157 5.08E-20 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.156 1.04E-19 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.156 1.19E-19 YKL022C CDC16 het Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
0.144 5.72E-17 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.140 4.53E-16 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.138 8.84E-16 YKL186C MTR2 het mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
0.135 3.40E-15 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.133 1.12E-14 YIL150C MCM10 het Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins